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      • KCI등재

        해독사물탕(解毒四物湯)이 피부 접촉성 과민반응에 미치는 영향(影響)

        전영균,정명,복영옥,이은혜,임규상,윤용갑,Jeon, Young-Kyun,Jung, Myung,Bok, Young-Ok,Lee, Eun-Hye,Lim, Kyu-Sang,Yun, Young-Gab 대한한방안이비인후피부과학회 2016 한방안이비인후피부과학회지 Vol.29 No.2

        Objectives : Haedoksamul-tang (HSTE), a water extract from a mixture of Phellodendri Cortex, Coptidis, Scutellariae Radix, Gardeniae Fructus, Angelica acutiloba Radix, Cnidii Rhizoma, Paeoniae Radix, Rehmanniae Radix, has been traditionally used for allergic skin diseases such as atopic dermatitis and contact dermatitis in oriental countries. However, little is known about the effects of aqueous extract of HSTE on trimellitic anhydride (TMA)-induced contact hypersensitivity (CHS) in a mouse model. Methods : In this study, we investigate the pharmacological effects of HSTE on TMA-induced CHS in Balb/c mice. Contact hypersensitivity was induced in mice by topically sensitizing and challenging with TMA in flank skin and ears during oral administration (for 17 days) and topical treatment (30 min before challenge) with HSTE. We examined the effects of HSTE on IgE and IgG1 levels, inflammatory parameters in ear tissues, CD4<sup>+</sup>/CD8<sup>+</sup> ratio, cytokine and chemokine production in sera, tissues, and immune cells from TMA-sensitized mice.Results : Oral and topical administration with HSTE reduced, in a dose dependent manner, thickness and leukocyte infiltration of ear tissues and IgE levels in serum from mice sensitized with TMA. In addition, auricula lymph node cells isolated from TMA-sensitized mice significantly elevated the expression ratio of CD4<sup>+</sup>/CD8<sup>+</sup> as well as increased the production of IL-4, IL-5, IL-13 and IFN-γ by ex vivo stimulation with antibodies against CD3 and CD28, and these inflammatory indexes, except for IFN-γ, were significantly suppressed by orally and topically administration of HSTE. Furthermore, stimulation of auricula lymph node cells from TMA-sensitized mice with antibodies against CD3 and CD28 increased the production of MCP-1/CCL2 and MIP-1α/CCL3, and these effects were inhibited in a dose-dependent manner in cells from mice treated with HSTE. Conclusions : These results suggest that HSTE can be used for treating contact hypersensitivity by inhibiting leukocyte infiltration as well as production of serum IgE and chemokine/Th2 cytokine in an animal model.

      • KCI등재

        동의보감(東醫寶鑑) 중(中) 행인(杏仁)이 주약(主藥)으로 배오(配伍)된 방제(方劑)의 활용(活用)에 대한 고찰(考察)

        전영균,국윤범,김윤경,윤용갑,Jeon Young-Kyun,Kook Yoon-Bum,Kim Yun-Kyung,Yun Young-Gab 대한한의학방제학회 2004 大韓韓醫學方劑學會誌 Vol.12 No.2

        This report describes 61 studies related to the use of Semen Armeniacae Amarum main blended prescriptions from Donguibogam. The following conclusions were reached through investigations on the prescriptions that use Semen Armeniacae Amarum as a key ingredient. Semen Armeniacae Amarum blended prescriptions are utilized for 16 therapeutic purposes, for example, in symptoms of cough, excrements, wind, and pediatrics. In particular, 52.46% of the prescriptions appear in the chapter of cough, and 9.84% of those appear in the chapter of excrements. Prescriptions that utilize Semen Armeniacae Amarum as the main ingredient are used in the treatment of cough, asthma, lung disease, and constipation, and they are also used for treating 15 different types of diseases. Semen Armeniacae Amarum is used in pathogenic factors such as wind, wind with cold, and wind with moisture, in pathologies related to lung and digestive systems, and in those related to weakness, extravasated blood, and alcoholic drink-food. The actual amount of Semen Armeniacae Amarum blended has ranged at a wide variety of amounts from 5 pun to 5 don. 47.62% of the prescriptions used 1 don. When Semen Armeniacae Amarum is combined with base prescriptions such as Samyotang, Banhaenghwan, ljintang, etc and Herba Ephedrae, Rhizoma Pinelliae, and Pericarpium Citri Reticulatae, it ceases cough and asthma. In addition, when Semen Armeniacae Amarum is combined with Fructus Ponciri Seu Aurantii and Fructus Cannabis, it brings a relief in constipation.

      • KCI등재후보

        IEC Pub. 60068 기후적 환경시험 규격의 개정 전,후 비교

        전영균 ( Young Kyun Jeon ),김명수 ( Myung Soo Kim ),나윤균 ( Yoon Kyoon Na ) 대한설비관리학회 2009 대한설비관리학회지 Vol.14 No.2

        Revised were cold, dry heat, and damp heat, cyclic(12h+12h cycle) tests of IEC Pub. 60068 climatic environmental test standards in 2007, but as of today the revision of the corresponding KS has not been followed yet. The revised test standards are compared with the prerevision ones in terms of the types of tests and test severities. This study shows the difference between the prerevision and the postrevision standards, which will provide the latest information to the industries and be helpful in revising the KS.

      • KCI등재후보

        "동의보감(東醫寶鑑)" 중(中) 빈랑(檳?)이 주약(主藥)으로 배오(配伍)된 방제(方劑)의 활용(活用)에 대한 고찰(考察)

        임대환,전영균,이주희,Lim, Dai-Hwan,Jeon, Young-Kyun,Lee, Ju-Hee 대한한의학방제학회 2009 大韓韓醫學方劑學會誌 Vol.17 No.1

        This report describes 46 studies related to prescriptions which are mainly used Semen Arecae from Dongeuibogam. The following conclusions were reached through investigations on the prescriptions that use Semen Arecae as a main component. 19.6% of a malaria, 17.4% of an evacuation problem, recorded the largest number of clinical frequency of the prescriptions in therapeutic use when Semen Arecae was taken as a main component in prescriptions Prescriptions that utilize Semen Arecae as the main ingredient are used in the treatment of a malaria, an evacuation problem and a malignant dermatosis. they are also used for treating 11 different types of diseases. The prescriptions are compounded with Semen Arecae as a main component which can be applied to an affection by wind-cold, a heat(fire) syndrome, a cold-stroke, a phlegm-retention syndrome, a constipation induced by apoplexy, a stagnation of vital energy, an asthenia of the spleen and the stomach, a convulsion caused by improper diet, a parasitic infestation and a traumatic disease. The dosage of Semen Arecae is 2.5pun(nearly 0.94g) to 3don(nearly 11.25g), however 1don(nearly 3.75g) has been taken the most for clinical application. When Semen Arecae is combined with basic prescriptions such as Ijintang and Bulium, it applies symptoms of malaria. In addition, when Semen Arecae is combined with basic prescriptions such as Daemainhwan, Soseungkitang and Samatang, it utilizes an evacuation problem.

      • KCI등재후보

        동의보감(東醫寶鑑) 중(中) 형개(荊芥)가 주약(主藥)으로 배오(配伍)된 방제(方劑)의 활용(活用)에 대한 고찰(考察)

        임대환,전영균,김원채,Lim, Dae-Hwan,Jeon, Young-Kyun,Kim, Won-Chae 대한한의학방제학회 2009 大韓韓醫學方劑學會誌 Vol.17 No.2

        This report describes 86 prescriptions related to the use of Herba Schizonepetae main blended from Dongeuibogam. The following conclusions were drawn through investigations on the prescriptions that use Herba Schizonepetae as a key component. Prescriptions that Herba Schizonepetae was taken as a monarch drug are utilized for22 therapeutic purposes, for example, eye disease, abscess disease, head and tooth, and woman disease. In particular, 16.3% of prescriptions appear in the chapter of eye. Prescriptions that utilize Herba Schizonepetae as the main component are used in the treatment of eye, abscess and woman disease, head disease, tooth disease and they are also used for treating 56 different types of disease. Herba Schizonepetae is used in pathogenic factors such as wind and used in pathology related to the liver and stomach system. The dosage of Herba Schizonepetae is 1pun 3li(about 0.49g) to 4don(about 14g), however 5pun 3li(about 1.99g)~1don(about 3.75g) has been taken the most for clinical application. Bangpungtang and Saenglyosamultang are the most useful base prescriptions which use the Herba Schizonepetae as the main ingredient.

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