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과민성 장 증후군 아형에 따른 구불창자 수용성 적응도의 차이
전대원 ( Dae Won Jun ),이오영 ( Oh Young Lee ),양선영 ( Sun Young Yang ),한성희 ( Sung Hee Han ),노병주 ( Byung Joo Roh ),윤창옥 ( Chang Ok Yoon ),이항락 ( Hang Lak Lee ),윤병철 ( Byung Chul Yoon ),최호순 ( Ho Soon Choi ),함준수 ( 대한소화기기능성질환·운동학회 2005 Journal of Neurogastroenterology and Motility (JNM Vol.11 No.2
목적: 과민성 장 증후군의 병태 생리에 대해 많은 연구가 이루어져 왔으나 아직도 명확히 규명되어 있지 않다. 최근에는 과민성 장 증후군 환자에서 구불창자의 수용성 적응도(accommodation)에 대한 연구보고가 있지만 아직 연구가 미흡하며, 특히 아형에 따른 수용성 적응도의 차이는 알려져 있지 않다. 방법: 위장 증상이 없는 7명의 건강한 대조군(평균연령 36.7세, 남자 4명, 여자 3명)과 로마 II 기준에 의한 15명의 과민성 장 증후군 환자(평균연령 36.8세, 남자 8명, 여자 7명)를 대상으로 하였다. 구불창자에 풍선을 삽입하고 바로스타트(barostat) 를 이용하여 구불창자의 수용성 적응도를 측정 하였다. 시각상사척도를 이용하여 지난 3개월 동안 증상 정도와 주당 평균 배변 횟수를 측정였다. 결과: 15명의 과민성 장 증후군 환자 중 변비형이 8명(남자 2명, 여자6명), 설사형이 7명(남자 6명, 여자 1명)이었다. 구불창자의 수용성 적응도는 과민성 장 증후군 환자가 정상대조군에 비해서 통계적으로 유의하게 낮았다(정상 대조군 1.3 ml/s, 과민성 장 증후군 1.0 ml/s, p=0.024). 구불창자 수용성 조절능은 설사형 과민성 장 증후군 환자에서 보다 낮은 경향을 보였다(정상 대조군 1.3 ml/s, 설사형 과민성 장 증후군 0.9 ml/s, p=0.051). 변비형 과민성 장 증후군 환자의 경우 정상대조군(정상 대조군 1.3 ml/s, 변비형 과민성 장 증후군 1.1 ml/s, p=0.081)에 비해 통계적으로 유의한 차이를 보이지 않았다. 구불창자 수용성 조절능은 환자가 호소하는 소화기 증상과 배변횟수와 직접적인 연관성을 보이지 않았으나, 변비형 과민성 장 증후군 환자에서는 배변 횟수와 연관성을 보이는 경향이 있었다(r=0.7, p=0.052). 결론: 구불창자의 수용성 적응도는 과민성 장 증후군 환자가 정상대조군에 비해서 통계적으로 유의하게 낮았으며 특히 설사형 과민성 장 증후군 환자에서 구불창자의 수용성 적응도가 낮았다. Background/Aims: A contentious issue in medicine is whether or not patients with irritable bowel syndrome (IBS) have abnormal motor physiology, and also whether the sensory and motor physiologies are different between the patients suffering with the various subtypes of IBS. Our aim was to investigate if IBS patients have different sigmoid accommodation compared with the normal controls or if the differences exist in sigmoid accommodation according to the IBS subtype. Methods: Fifteen Rome II positive IBS patients and 7 normal controls were recruited for the study. A sigmoid bag catheter was endoscopically placed, and then bag inflation was performed via a barostat. Sigmoid accommodation was measured by using the rapid phasic distention method. Results: In the IBS patients, sigmoid accommodation (1.0 ml/s) was significantly lower than that of the controls (1.3 ml/s). There were no statistically significant differences in sigmoid accommodation according to the IBS subtype, but the IBS patients with predominate symptoms of diarrhea had a tendency for lower sigmoid accommodation (p=0.051). Gastrointestinal symptoms and stool frequency did not seem to have any correlation with sigmoid accommodation. However, for the IBS patients with predominate symptoms of constipation, the stool frequency tended to be associated with the sigmoid accommodation (p=0.052). Conclusions: Sigmoid accommodation was significantly lower in the IBS patients. The results are generally consistent with the finding that the IBS patients with predominate symptoms of diarrhea exhibit a tendency for lower sigmoid accommodation. (Kor J Neurogastroenterol Motil 2005;11:129-134)
전대원 ( Dae Won Jun ),이오영 ( Oh Young Lee ),조경란 ( Gyeong Lan Jo ),백상현 ( Sang Hyeon Baeg ),양선영 ( Sun Young Yang ),한성희 ( Sung Hee Han ),이항락 ( Hang Lak Lee ),전용철 ( Young Cheol Jeon ),한동수 ( Dong Soo Han ),손주 대한소화기기능성질환·운동학회 2005 Journal of Neurogastroenterology and Motility (JNM Vol.11 No.1
목적: 과민성 장증후군은 약 6~10%의 유병율을 가지는 매우 흔한 소화기 질환이며, 정신사회학적 증상과 밀접한 관계를 가지는 것으로 알려져 있다. 그러나 과민성 장증후군 증상을 가지고 있는 사람 중 소수만이 의료기관을 방문하는 것으로 알려져 있다. 본 연구에서는 과민성 장증후군의 증상을 가지고 있는 사람 중 의료기관을 이용하여 치료를 받고 있는 군과 치료를 받지 않는 비치료군 간의 심리적 상태 및 장외증상의 차이에 대하여 알아보고자 하였다. 대상 및 Background/Aims: Only a relatively small portion of those people suffering with IBS, estimated at 25~50%, eventually seeks medical care. Yet little is known about the difference in the characteristics between the consulter and non-consulter IBS patients.
호흡부전과 신경학적 이상을 동반한 Acute Intermittent Porphyria
전대원(Dae Won Jun),최춘식(Choon Shik Choi),최호순(Ho Soon Choi),전용철(Yong Chul Jung),손주현(Joo Hyun Sohn),한동수(Dong Soo Han),윤병철(Byung Chul Yoon),함준수(Joon Soo Hahm),이민호(Min Ho Lee),이동후(Dong Hoo Lee),기춘석(Choon Shu 대한소화기학회 2000 대한소화기학회지 Vol.36 No.3
The acute intermittent porphyria (AIP) is characterized biochemically by increased excretion of porphyrins and porphyrin precursors, S-aminolevulinic acid (ALA) and porphobilinogen (PBG). AIP presents with abdominal pain, mental disturbances and neurologic dysfunction. A 24-year-old woman with a medical history of AIP was admitted to our hospital because of abdominal pain and proximal muscle weakness. She was treated by carbohydrate loading with intravenous glucose. Twenty five days later, she developed tachycardia, fluctuation of blood pressure and syndrome of inappropriate secretion of antidiuretic hormore (SIADH). On 90th day, intubation was required to control her breathing. Complete flaccid paralysis developed, and the patient became comatose. The neurologic effects of acute porphyria are generally reversible, but the clinical course of severe case is complicated with respiratory failure, fluid electrolyte imbalance. AIP should be considered in differential diagnosis of patient with unexplained respiratory failure. (Kor J Gastroenterol 2000;36:413 - 418)
섬유(Fiber) 요소와 비선형 전단스프링을 이용하여 바벨형 단면을 갖는 철근콘크리트 전단벽의 비선형 정적해석
전대한(Jun, Dae Han) 대한건축학회 2015 大韓建築學會論文集 : 構造系 Vol.31 No.9
Reinforced concrete shear walls are effective for resisting lateral loads imposed by wind or earthquakes. Observed damages of the shear wall in previous earthquakes in Chile(2010) and New Zealand(2011) exceeded expectations. Various analytical models have been proposed in order to incorporate such response features in predicting the inelastic response of RC shear walls. However, the model has not been implemented into widely available computer programs, and has not been sufficiently calibrated with and validated against extensive experimental data at both local and global response levels. In this study, reinforced concrete shear walls with a barbell-shaped cross section were modeled with fiber slices, where cross section and reinforcement details of shear walls can be arranged freely. Pushover analysis was performed by adding nonlinear shear spring elements that can represent shear deformation. This analysis result will be compared with the existing experiment results. To investigate the nonlinear behavior of reinforced concrete shear walls, reinforced concrete single shear walls with a barbell-shaped cross section were selected. Thus, the yield strength of the shear wall was almost the same in the experimental and the analytical results. However, the yielding displacement of the shear wall was still higher in the experiment than the analysis.
설계용 스펙트럼에 적합한 인공지진동의 에너지 응답특성의 평가
전대한,양창진,Jun, Dae-Han,Yang, Chang-Jin 대한건축학회 2012 대한건축학회논문집 Vol.28 No.5
It has long been recognized that energy input, absorption, and dissipation in seismic resistant design of structures are the most fundamental quantities controlling seismic performance. While the input energy($E_I$) is a reliable parameter for selecting the most demanding earthquake ground motion, it alone is not sufficient for proper seismic design of the structure. The importance of reliable estimation of the input energy of possible earthquake ground motions at the site of structure in order to select the proper design earthquake motion is emphasized. This paper discusses the characteristic of input energy concepts between the real recorded ground motion and the artificial ground motion in seismic resistant design of building structures. For long-period contents dominant earthquake ground motion, the input energy spectra are sensitive to the variation of the natural period of structures. It is concluded that the input energy quantities by the artificial ground motions used in this paper presented better stability than those by real recorded ground motions. Also, the artificial ground motions compatible with design spectrum are applicable as input ground motions for a seismic response analysis of building structures.
Cutaneous Metastases of Pancreatic Carcinoma as a First Clinical Manifestation
전대원 ( Dae Won Jun ),( Oh Young Lee ),( Chan Kum Park ),( Sung Hee Han ),( Sun Young Yang ),( Hang Lak Lee ),( Dong Su Han ),( Ju Hyeon Son ),( Young Chul Jun ),( Byung Chul Yoon ),( Ho Soon Choi ),( J 대한소화기학회 2004 대한소화기학회 추계학술대회 Vol.- No.-
설계용 스펙트럼에 적합한 인공지진동의 에너지 응답특성의 평가
전대한(Jun Dae-Han),양창진(Yang Chang-Jin) 대한건축학회 2012 大韓建築學會論文集 : 構造系 Vol.28 No.5
It has long been recognized that energy input, absorption, and dissipation in seismic resistant design of structures are the most fundamental quantities controlling seismic performance. While the input energy(EI) is a reliable parameter for selecting the most demanding earthquake ground motion, it alone is not sufficient for proper seismic design of the structure. The importance of reliable estimation of the input energy of possible earthquake ground motions at the site of structure in order to select the proper design earthquake motion is emphasized. This paper discusses the characteristic of input energy concepts between the real recorded ground motion and the artificial ground motion in seismic resistant design of building structures. For long-period contents dominant earthquake ground motion, the input energy spectra are sensitive to the variation of the natural period of structures. It is concluded that the input energy quantities by the artificial ground motions used in this paper presented better stability than those by real recorded ground motions. Also, the artificial ground motions compatible with design spectrum are applicable as input ground motions for a seismic response analysis of building structures.
면역억제제로 유발된 범혈구감소증 후관해에 이른 궤양성 대장염 1예
이준석 ( Jun Seok Lee ),박영숙 ( Young Sook Park ),김남인 ( Nam In Kim ),조윤주 ( Yoon Ju Jo ),김성환 ( Seung Hwan Kim ),이한효 ( Han Hyo Lee ),송문희 ( Moon Hee Song ),전대원 ( Dae Won Jun ) 대한장연구학회 2008 Intestinal Research Vol.6 No.1
Azathioprine (AZA) is widely used for the treatment of inflammatory bowel disease. Bone marrow suppression is a common side effect with AZA treatment. However, data from AZA trials has indicated that a leukocyte count less than 5,000/mm3 was a good predictor of induction and maintenance of remission. Moreover, there is evidence that eradication of sensitized leukocytes by leukapheresis or bone marrow transplantation improves inflammatory bowel disease. We report a case of a patient who had a chronic relapse of ulcerative colitis requiring the frequent use of systemic steroids, but presented prolonged remission following AZA-induced severe pancytopenia. Also colonoscopy showed accelerated healing of diffuse active ulcers following just recovery from pancytopenia. (Intest Res 2008;6:85-89)