대기중 부유분진에 함유된 유기물의 분획별 돌연변이원성

장재연(Jae Yeon Jang),김박광(Bak Kwang Kim),정용(Yong Chung) 대한약학회 1989 약학회지 Vol.33 No.1

The extractable organic matter was extraced from airborne particulates collected in Seoul during 1986. It was fractionated to several fractions and mutagenicities of them were tested in Salmonella thyphimurium TA98 by Ames method. The neutral fraction showed the highest indirect acting mutagenicity while the highest direct acting mutagenicity was observed in the acidic fraction. Indirect acting mutagenicity of airborne particulate was attributed to its neutral fraction about 88% in average, to acidic about 10% in average and to basic fraction about 2% in average. Direct acting mutagenicity of airborne particulate was attributed to its neutral fraction about 70%, to acidic fraction about 29% and to basic fraction about 1%. Among five subtractions of neutral fraction, the proportion of mutagenicity of polynuclear aromatic hydrocarbon subtraction was 13.2% in indirect acting mutagenicity and 5.0% in direct acting mutagenicity.

노인의 치아우식증과 치주질환에 연관된 요인 분석

장재연 ( Jae Yeon Jang ),남영신 ( Young Shin Nam ) 한국치위생학회(구 한국치위생교육학회) 2012 한국치위생학회지 Vol.12 No.6

Objectives: The purpose of this study was to examine the factors related to the dental caries and periodontal diseases of Korean elderly people in terms of demographic characteristics, oral health promotion behavior and systemic diseases in an effort to provide information on national policy setting and policy evaluation about the prevention of tooth loss resulting from severe oral diseases and the promotion of elderly people`s oral health. Methods: The first-, second- and third-year raw data of the 4th National Health and Nutrition Survey were utilized, and the data of 3,882 elderly people who got a dental checkup were analyzed. The statistical package SPSS WIN 19.0 was employed to make a logistic regression analysis. Results: The senior citizens who did toothbrushing less frequently were more likely to have dental caries. As for periodontal diseases, the men were 1.34-fold more likely to have periodontal diseases than the women, and the respondents whose self-rated health state was worse were 1.40-fold more likely to have periodontal diseases than the others whose self-rated health state was better. The senior citizens who ever received treatment from unqualified people were 1.30-fold more likely to have peridontal diseases, and those who took neither vitamin compound nor minerals were 1.30-fold more likely to have periodontal diseases. Those who suffered from low High-density Lipoprotein cholesterol(HDL) were 1.35-fold more likely to have periodontal diseases than the others who didn`t. Conclusions: Those whose self-rated health status is worse should especially be concerned about periodontal diseases. Specifically, it`s needed to pay attention to the low-income classes, and the government should take measures to provide quality welfare services for elderly people not to receive treatment from unqualified people. Besides, research efforts should be made to determine the relationship between periodontal diseases and low HDL- cholesterolemia.

Governance of experts on the health impacts of climate change, Korean Forum for Climate Change and Health

Jae-Yeon Jang(장재연),Soo-nam Jo(조수남),Hyung-Nam Myung(명형남) 한국환경독성학회 2010 한국독성학회 심포지움 및 학술발표회 Vol.2010 No.11

우측난소임신의 복강경적 치료 중 우연히 발견된 선천성 좌측 난소난관 형성부전 환자

장재연 ( Jae Yeon Jang ),김윤숙 ( Yun Sook Kim ),황인철 ( In Chul Hwang ),한효상 ( Hyo Sang Han ),선우재근 ( Jae Gun Sunwoo ),배동한 ( Dong Han Bae ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.11

Asymptomatic unilateral absence of a portion of a fallopian tube with or without adjacent ovarian agenesis is a very rare condition. The true incidence is unknown. Two etiologic causes are possible. Asymptomatic segmental torsion of the uterine tube and ovarian pedicle may occur for certain reasons during adulthood, in childhood, or even during the fetal stages. Consequently, torsion may give rise to necrosis and autoamputation. Alternatively, the absence of these organs may be congenital. Ovarian pregnancy is a rare form of ectopic pregnancy occurring in 0.5~1% of all ectopic pregnancies. Moreover, ovarian pregnancy in patient with congenital unilateral tubal and ovarian agenesis has not been reported. But, the presenting symptom is very similar and difficult to distinguish with other forms of ectopic pregnancy. Early detection is important role in preserving fertility to avoid the ablation of functional ovarian tissue. We report a case of congenital unilateral tubal and ovarian agenesis diagnosed during laparoscopic treatment of ovarian pregnancy.

특집 : 세계화와 국민보건 ; 기후변화와 건강

장재연 ( Jae Yeon Jang ),김시헌 ( Si Heon Kim ) 대한보건협회 2008 대한보건연구 Vol.34 No.1

한국 종이산업의 국제경쟁력 결정요인

장재연(Jae Yeon Jang),윤여창(Yeo Chang Youn) 한국산림과학회 2001 한국산림과학회지 Vol.90 No.3

This study was conducted to propose the way to develop and strengthen competitiveness of the Korean paper industry by analysing current competitiveness and the factors which determine and influence it. Delphi method was employed to identify determining factors of international competitiveness of Korean paper industry and evaluate the level of competitiveness. The competitiveness both in the domestic and foreign markets was evaluated by analysing each product market faced by the Korean paper industry in light of each of the determining factors. Based on the Delphi survey results, in order of importance, product quality, manufacturing cost, transportation and storage, timely delivery, supply of raw materials, and marketing were identified as the factors determining international competitiveness. Among them, it was revealed that Korean paper industry has a certain level of competitiveness in the factors such as product quality and timely delivery service while supply of raw materials and manufacturing costs were found to be inferior to overseas manufacturers in both domestic and foreign markets.

서울시 대기중 부유분진의 입도별 돌연변이원성의 월변화

장재연(Jae Yeon Jang),김박광(Bak Kwang Kim),조성준(Seong Joon Jo),정용(Yong Chung) 대한약학회 1988 약학회지 Vol.32 No.5

Monthly variation of mutagenicity by airborne particulate were studied according to particle size of the particulate. Airborne particulates were collected in Shinchon of Seoul which is commocial and traffic area in 1986. And those were separately collected into two parts such as fine particle (less than 2.5mcm aerodynamic diameter) and coarse particle (greater than 2.5mcm). Extractable organic matters(EOM) were extracted and mutagenicity of the EOM was tested in Salmonella thyphimurium TA 98 by Ames method. While the concentration of coarse particle did not show the seasonal variation, that of fine particle showed great seasonal variation. The contents and mutagenicity of EOM in fine particles were higher than those of coarse particles. So fine particles were expected to contribute to the 90% of mutagenicity in atmosphere by suspended particulates. The content of EOM and mutagenicity by suspended particulates in atmosphere were highest in January all the year around and also higher as much as 6 and 30 times than in July, respectively.

다이옥신과 건강: 인체 노출 수준 및 건강영향에 대한 역학적 연구

장재연,권호장,Jang, Jae-Yeon,Kwon, Ho-Jang 대한예방의학회 2003 예방의학회지 Vol.36 No.4

다이옥신은 단일 화학물질이 아니라 비슷한 화학적 구조와 독성작용을 갖는 화학물질들의 그룹이다. 다이옥신 중에 가장 많은 연구가 이루어졌고 독성도 강한 물질이 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)인데, 다이옥신 혼합체의 독성을 평가할 때는 각 물질 별로 TCDD에 대한 상대독성을 고려하여 독성등가계수(TEQ)라는 지표를 만들어 사용한다. 일반인들의 평균적인 혈중 다이옥신에 대한 기준값은 명확하게 제시되지는 않고 있으나 관련 연구들을 종합할 때 대략 10-20 ppt $I-TEQ_{DF}$ 범위를 일반인의 평균적인 수준으로 볼 수 있다. 오염 가능지역의 주민들의 혈중 다이옥신 값은 지역에 따라 차이가 있으나 대부분 20ppt $I-TEQ_{DF}$ 이상의 값을 나타내고 있으며 특히 오염이 심한 지역의 주민들의 경우에는 직업적인 노출이 없는 일반 주민들임에도 불구하고 혈중 다이옥신 농도가 약 50 ppt $I-TEQ_{DF}$까지 상승할 수 있다. 다이옥신의 건강영향에 관해서는 수많은 역학적 연구들이 수행되었지만 혈액내에서 TCDD를 직접 측정하여 인체 노출을 비교적 정확하게 평가한 사업장 코호트나 세베소 지역 주민 코호트에서 나온 결과들이 보다 많은 신뢰를 받고 있다. 다이옥신 노출에 따른 건강영향은 크게 암발생과 암을 제외한 건강영향으로 구분할 수 있다. 국제암연구기구(IARC)나 미국 환경보호청(EPA) 모두 TCDD를 인체 발암물질로 분류하고 있으나 역학적 증거들이 충분한 상태는 아니다. TCDD를 제외한 나머지 다이옥신에 대해서는 IARC에서 발암성의 증거가 불충분한 물질(Group 3)로 분류하고 있다. 대부분의 장기에서 다이옥신의 건강영향에 대한 조사가 이루어져 왔다. 현재까지 비교적 다이옥신 노출과 관련성이 높은 것으로 평가되고 있는 것은 염소성여드름, 간 효소의 하나인 GGT의 상승, 그리고 생식호르몬의 변화 등이다. 그밖에 지질농도, 당뇨, 면역학적 영향, 심혈관계에 대한 영향, 갑상선기능, 신경계에 대한 영향, 소아 발달에 대한 영향 등에 대해서는 역학 연구들이 일관된 결과를 보여주지 못하고 있기 때문에 계속적인 연구를 필요로 하고 있다. 다이옥신의 독성은 수많은 동물실험을 통해 증명이 되었으나 인간을 대상으로 한 역학적 연구는 아직 기대만큼 명료한 결과들을 제시해주지 못하고 있다. 그러나 IARC나 EPA모두 인체발암물질로 분류하였고 다양한 건강영향에 대한 증거들이 있는 것은 분명한 만큼 다이옥신 노출을 최소화하려는 노력을 게을리 해서는 안 될 것이다. General information is summarized, that is necessary to introduce a scientific assessment of the human health and exposure issue concerning dioxin and dioxin-like compound. Scientific literatures were reviewed to assess the background exposures to the dioxin-like compounds for normal residents. Epidemiologic studies were also reviewed to assess malignant and nonmalignant sweets of dioxins. In 1997, the International Agency for Research on Cancer classified 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as a human carcinogen, primarily based on occupational cohort studies. The US Environmental Protection Agency made the same decision in it's Draft Dioxin Reassessment. Epidemiologic evidences point to a generalized excess of all cancers, without any pronounced excess at specific sites. Reported non-cancer effects included a range of conditions affecting most systems. Among them, chloracne, elevation in gamma glutamyl transferase(GGT), and alterations in reproductive hormones are related to TCDO, Other adverse outcomes, such as lipid concentrations, diabetes, circulatory and heart diseases, immunologic disorders, neurobehavioral effects, and developmental outcomes require further study before their respective relationships to TCDD can be more definitively assessed.

Azo색소(色素)와 양(陽)이온 계면활성제(界面活性劑)의 상호작용(相互作用)에 관한 연구(硏究)(II)

장재연,조영미,김박광,이왕규,Jang, Jae-Yeon,Cho, Yung-Mee,Kim, Bak-Kwang,Lee, Wang-Kyu 대한약학회 1984 약학회지 Vol.28 No.5

The interaction between azo dyes and cationic surfactant was studied by absorption spectroscopy and fluorescent Rayleigh scattering. In order to presume the structure of formed micelle, methyl orange and ethyl orange as azo dyes and cetyltrimethylammonium bromide (CTAB) as cationic surfactant were used. Infomations about interaction parameter including absorption maxima, optimal conditions, and intensity of fluorescent Rayleigh scattering were obtained. When azo dyes and CTAB are formed 1 : 1 complex, it showed the strongest intensity of fluorescent Rayleigh scattering. On going from mixed micelle to homomicell, It suggests successively several intermediate steps of complex structure which can be distinguished clearly from one another.

악취와 탈취방법

장재연,Jang, Jae Yeon 환경보전협회 1984 환경정보 Vol.6 No.14