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흰쥐의 복강비만세포에서 ATP와 Compound 48/87에 의한 Histamine유리에 미치는 Econazole의 영향
장용운(Yong Un Jang),이윤혜(Yun Hye Lee),이승준(Seung June Lee),서무현(Moo Hyun Seo),윤정이(Jeong Yi Yoon),김창종(Chang Jong Kim),심상수(Sang Soo Sim) 대한약학회 2001 약학회지 Vol.45 No.3
3 investigate the different mechanism between ATP and compound 48/80 (C48/80)-induced histamine release, we observed effects of calcium antagonists in histamine release of rat peritoneal mast cells.Verapamil and diltiazgem (voltage-dependent calcium channel blocker) and TMB-8 (a blocker of intracellular calcium release) significantly inhibited ATP-induced histamine release, but did not inhibit C48/80 induced histamine release. Econazole (a blocker of receptor-operated calcium channel) dose-dependently inhibited both and C48/80-inducted histamine release,but inhibitory effect of econarole in ATP-induced histamine release was more potent than that in C48/80-induced histamine. EGTA dote-dependently inhibited ATP and C48/80-induced histamine release, and C48/80-induced histamine release was slightly inhibited by high concentrations (>2 mM) of EGTA. These results suggest that ATP·induced histamine release is related to both intraoellular calcium release and extracellular calcium influx via voltage-dependent calcium channel and receptor-operated calcium channel. C48/80-induced histamine release is related to extracellular calcium influx, specially recetor-operated calcium channel rather tllan voltage-dependent calcium channel.
장용운(Jang, Yong-un) 국방부 군사편찬연구소 2012 군사 Vol.- No.83
Recently, among the elements of serious threats to Korea such as nuclear, missile, special forces etc., asymmetric force of North Korea makes serious threat to the security in korea. In spite of the serious shortages of food and economic difficulty, North Korea has continued to develope nuclear weapon, missiles and trained strong special forces. Such North Korea"s asymmetric forces have enhanced the capability of total war and limited military threat to South Korea. But the concept of the asymmetric forces was not new. It has been used for along time in the war history of the world. If we want to prepare for North Korea"s asymmetric forces, we should make efforts and be prepared to deal with them. Because the future war will be more multi-sided and more asymmetric, these preparations must be made to respond to the total war and to the provocations in peace time. In short, these preparations should include military structure, strategy and tactics, weapon systems. Thus, we should be prepared to deal with various situations.
Ethanol이 횐쥐의 복강비만세포에서 Histamine유리에 미치는 영향
김창종(Chang Jong Kim),이윤혜(Yun Hye Lee),이승준(Seung June Lee),서무현(Moo Hyun Seo),장용운(Yong Un Jang),심상수(Sang Soo Sim) 대한약학회 2001 약학회지 Vol.45 No.6
To investigate action of ethanol on histamine release from rat peritoneal mast cells, we compared the inhibitory effect of ethanol with those of calcium antagonists in mechanism of between ATP and compound 48/80-induced histamine release. Ethanol dose- dependently inhibited 1007M ATP-induced histamine release, whereas did not inhibit 1 mcg/ml compound 4a/80-induced histamine release. Verapamil,TMB-8 and EGTA dose- dependently inhibited ATP-induced histamine release, but did not inhibit compound 48/80-induced histamine release. Such an inhibitory effect of calcium antagonist was similar to that of ethanol. These results suggest that the inhibitory effect of ethanol on histamine release from rat peritoneal mast cells is mediated via disturbance of calcium mobilization.