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송준창 ( Joon Chang Song ),황현석 ( Hyeon Seok Hwang ),형복진 ( Bok Jin Hyoung ),이소영 ( So Young Lee ),전연주 ( Yeon Joo Jeon ),장세나 ( Se Na Chang ),윤혜은 ( Hye Eun Yoon ),최범순 ( Bum Soon Choi ),김용수 ( Yong Soo Kim ),양 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.1
After renal transplantation, we are more likely to encounter hyperkalemia rather than hypokalemia. We report a case of kidney transplantation recipient with hypokalemia and hypertension secondary to primary aldosteronism. A 48 year-old woman was presented with fatigue and weight loss that had lasted for 3 months. She was diagnosed as autosomal dominant polycystic kidney disease that ultimately progressed to end-stage renal disease. She was operated for renal transplantation before 6 months. She had hypokalemia and hypertension at that time. The ratio of plasma aldosterone over plasma renin activity was 851.7. The computed tomography (CT) revealed 2.4×1.7 cm sized adrenal mass on the right side. The pre-transplantation CT also showed that there had been adrenal mass in the same location even before the transplantation. Right adrenalectomy was performed. After she got discharged, she was again presented with nausea and vomiting. She developed hyperkalemia and was diagnosed as hyporeninemic hypoaldosteronism. She was prescribed with fludrocortisones and recovered from the disease, and resumed the state of normokalemia and normotension.
제2형 당뇨병 환자에서 당뇨병성 신증과 비당뇨병성 신질환의 임상적 차이
김병수 ( Byung Soo Kim ),장윤경 ( Yoon Kyoung Chang ),송호철 ( Ho Cheol Song ),이소영 ( So Young Lee ),장세나 ( Se Na Jang ),김형욱 ( Hyung Wook Kim ),신영신 ( Young Shin Shin ),최영진 ( Young Jin Choi ),진동찬 ( Dong Chan Jin 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.6
Purpose: It is important to differentiate non-diabetic renal diseases (NDRD) from diabetic nephropathy (DN) in type 2 diabetes. Our study was reviewing the clinical data and treatment strategies from diabetic patients performed renal biopsy to determine the clinical indicators suggestive of NDRD. Methods: We reviewed the medical records of type 2 patients who underwent renal biopsy from Jan. 1995 to Dec. 2007. Results: Seventy four patients were included. Mean age was 52.0±12.5 years and 41 (55%) patients were male suddenly developed. Nephrotic syndrome [34 cases (46%)] was the leading reason for renal biopsy. There were 37 cases (50%) with a pathologic diagnosis of DN, 31 (42%) with NDRD, and 6 (8%) with concurrent DN and NDRD. IgA nephropathy (35%) was the most common lesion found in patients with NDRD. Thirty one patients (84%) with DN and 26 (84%) with NDRD had follow-up periods of more than 6 months. Of 26 patients with NDRD, 12 were treated with immune suppressants and 6 achieved complete remission. Thirteen patients with DN and one with NDRD developed end-stage renal disease. Patients with NDRD tended to show shorter duration of diabetes, lower systolic blood pressure (SBP) and lower serum triglyceride, and had significantly lower incidence of diabetic retinopathy (DR). In the univariate regression analysis, diabetes duration, SBP, triglyceride and DR showed statistically significance. And SBP and DR were identified as independent correlating factors by multivariate regression analysis. Conclusion: In this study, the absence of retinopathy could predict the presence NDRD among NIDDM patients presenting with renal disease. And additional disease-specific therapies may be helpful for the patients with NDRD.
김민석 ( Min Suk Kim ),민현기 ( Hyun Gi Min ),이병주 ( Byeong Joo Lee ),장세인 ( Se In Chang ),김정규 ( Jeong Gyu Kim ),구남인 ( Na Min Koo ),박정식 ( Jeong Sik Park ),박관인 ( Gwan In Bak ) 한국환경농학회 2014 한국환경농학회지 Vol.33 No.2
BACKGROUND: Recent studies using various industrial wastes for heavy metal stabilization in soil were conducted in order to find out new alternative amendments. The acid mine drainage sludge(AMDS) contains lots of metal oxides(hydroxides) that may be useful for heavy metal stabilization not only waste water treatment but also soil remediation. The aim of this study was to investigate the applicability of acid mine drainage sludge for heavy metals stabilization in soils METHODS AND RESULTS: Alkali soil contaminated with heavy metals was collected from the agricultural soils affected by the abandoned mine sites nearby. Three different amounts(1%, 3%, 5%) of AMDS were applied into control soil and contaminated soil. For determining the changes in the extractable heavy metals, CaCl2 and Mehlich-3 were applied as chemical assessments for metal stabilization. For biological assessments, lettuce(Lactuca sativa L.) and chinese cabbage(Brassica rapa var. glabra) were cultivated and accumulation of heavy metals on each plant were determined. It was revealed that AMDS reduced heavy metal mobility and bioavailability in soil, which resulted in the decreases in the accumulation of As, Cd, Cu, Pb, and Zn in each plant. CONCLUSION: Though the high level of heavy metal concentrations in AMDS, any considerable increase in the heavy metal availability was not observed with control and contaminated soil. In conclusion, these results indicated that AMDS could be applied to heavy metal contaminated soil as an alternative amendments for reducing heavy metal mobility and bioavailability.
노인에서 상기도 감염후 발생한 급성감염후 급속진행성 사구체신염
오병선 ( Byoung Sun Oh ),박철휘 ( Cheol Whee Park ),장세나 ( Se Na Jang ),정현정 ( Hyun Jung Jung ),김경희 ( Kyoung Hee Kim ),박건우,정현화 ( Hyun Wha Chung ),한상우 ( Sang Woo Han ),장윤식 ( Yoon Sik Chang ) 대한신장학회 2006 Kidney Research and Clinical Practice Vol.25 No.6
Postinfectious streptococcal glomerulonephritis (PSGN) presenting as a rapidly progressive glomerulonephritis (RPGN) and nephrotic syndrome (NS) is a rare disease in elderly patients. Here we report a case of PSGN with RPGN and NS in an elderly male patient with a complete recovery from his illness. A 73-year-old man was admitted for dyspnea, oliguria and generalized edema appearing after acute upper respiratory infection. On admission, he presented nephrotic range of proteinuria, decreased renal function with elevated ASO, and decreased C3 and CH50 concentrations. The renal biopsy showed marked cellular crescents in the glomeruli with collapsed glomerular tufts and inflammatory cell infiltration. There were prominent and various sizes of humps in subepithelial areas in electron microscopy. Under the diagnosis of PSGN with RPGN, we successfully treated the patient with steroid pulse therapy and hemodialysis. We would suggest that early diagnosis and aggressive steroid therapy should be indicated in the treatment of PSGN with RPGN. (Korean J Nephrol 2006;25(6):1025-1028)