Caffeic acid phenethyl ester의 처리에 의한 NSAID activated gene-1의 과대발현

장민정(Min-Jeong Jang),김효은(Hyo-Eun Kim),손성민(Seong-Min Son),김민정(Min-Jeong Kim),서을원(Eul-Won Seo),김영호(Young-Ho Kim),김종식(Jong-Sik Kim) 한국생명과학회 2009 생명과학회지 Vol.19 No.12

파이토케미칼의 일종인 CAPE가 암세포 생장에 미치는 영향과 유전자 발현을 연구하기 위하여, 인간 대장암 세포주 HCT116에 CAPE를 처리하였다. CAPE의 처리는 농도 의존적으로 암 세포 생존율을 감소시키고, 세포사멸을 유도함을 확인하였다. CAPE에 의해 차별적으로 발현되는 유전자를 분석하기 위하여, oligo DNA microarray 실험을 수행하였다. 그 결과, 20 μM CAPE를 24시간 동안 처리한 경우, 2배 이상 발현이 증가되는 유전자 266개, 2배 이상 발현이 감소되는 유전자 143개를 확인하였다. 발현이 증가되는 유전자중 3개(NAG-1, p21, GADD45A)를 선택하여, RT-PCR을 수행하였다. 그 결과, 모든 유전자의 발현이 마이크로어레이 실험결과와 일치하였다. 또한, CAPE를 농도 의존적으로 처리한 후, NAG-1 유전자와 단백질의 발현을 확인한 결과, mRNA 수준과 단백질 수준에서의 발현양상이 동일함을 확인하였다. 게다가, CAPE를 포함한 5개의 다른 종류의 파이토케미칼(resveratrol, genistein, daidzein, capsaicin)을 처리한 경우, 처리한 모든 파이토케미칼에 의해 NAG-1 유전자의 발현이 증가됨을 확인하였다. 이중 CAPE가 가장 낮은 농도의 처리임에도 불구하고 NAG-1의 발현을 가장 강하게 유도하였다. 결론적으로 이러한 연구결과는 CAPE에 의한 세포사멸은 항암유전자인 NAG-1의 과대발현과 밀접한 관련이 있음을 의미한다. To investigate whether caffeic acid phenethyl ester (CAPE) could affect cancer cell viabilities and gene expression, human colorectal HCT116 cells were incubated with CAPE. CAPE decreased cancer cell viabilities and induced apoptosis in a dose-dependent manner. To analyse differently expressed genes by CAPE, we performed oligo DNA microarray analysis. We found that 266 genes were up-regulated more than twofold, whereas 143 genes were down-regulated more than twofold by 24 hr of treatment with 20 μM CAPE. Among the up-regulated genes, we selected 3 genes (NSAID activated gene-1 [NAG-1], cyclin-dependent kinase inhibitor 1A [CDKN1A, p21] and growth arrest and DNA-damage-inducible alpha [GADD45A]) and performed reverse-transcription PCR to confirm microarray data. In addition, we found that CAPE increased NAG-1 gene and NAG-1 protein expression in a dose-dependent manner. And, several other phytochemicals (resveratrol, genistein, daidzein and capsaicin) also could induce NAG-1 expression in human colorectal HCT116 cells. However, CAPE was the highest inducer of NAG-1, even in low concentrations. Overall, these results imply that cancer cell death by CAPE is closely related with over-expression of NAG-1.

밤부산물(율피)의 주름개선 및 미백 효과

Min-Jung Jang(장민정),Soon-Ju Cheon(천순주),Hui-Yeong Kim(김희영),Dae-Jun Kwoen(권대준),Hak-Yoon Kim(김학윤),Sea-Hyun Kim(김세현),Jin-Tae Lee(이진태) 한국생명과학회 2011 생명과학회지 Vol.21 No.5

율피를 기능성 화장품 소재로 활용하기 위하여 주름개선, 미백 및 수렴효과를 검증하였다. 주름개선 효과를 검증하기 위하여 elastase 저해활성과 collagenase 저해활성을 측정하였다. Elastase 저해활성을 측정한 결과 율피아세톤 추출물 100 ㎍/㎖에서 51.0%의 효과를 나타내었으며, collagenase 저해활성을 측정한 결과 아세톤 및 에탄올 추출물이 50 ㎍/㎖ 에서 96.4%, 94.3%의 저해활성을 나타내었다. 미백효과를 확인하기 위하여 tyrosinase 저해활성을 측정한 결과 아세톤 및 에탄올 추출물이 열수 추출물보다 높은 Tyrosinase 저해활성을 나타내었으나 대조군으로 사용한 Vitamin C와 비교시 약 50%의 효과를 나타내었다. 이상의 결과로 미루어 보아 율피 추출물의 주름개선 효과가 높음을 확인할 수 있었고, 주름개선 기능성 화장품 소재로서의 가능성을 확인하였다. Aging in humans is inexorable and inescapable. The progressive decrease of physiological capacity and the reduction of the ability to cope with environmental stresses lead to increased susceptibility and vulnerability to human disease. Recently, in the cosmetic industry, many researchers have paid considerable attention to delaying or improving the symptoms of skin aging. Since the early 1990’s, there have been various challenges in developing cosmeceutical products which have strong anti-aging effects, and this has been an important issue in the cosmetic industry. Meanwhile, development of anti-aging cosmetics supported by biochemical activities in the skin has been researched. Castanea crenata inner Shell solvent extracts were investigated for anti-wrinkle and whitening effects, in order to apply it as a functional ingredient for cosmetic products. For anti-wrinkle effect, elastase inhibition activity of Castanea crenata inner shell acetone extract (CA) was 51.0% at a concentration of 100 ㎍/㎖. The collagenase inhibition activity of CA and Castanea crenata inner shell ethanol extract (CE) was 96.4%, 94.3% at a concentration of 50 ㎍/㎖. The tyrosinase inhibitory effect, which is related to skin-whitening, was 47.2% and 45.8% in CA and CE at a concentration of 500 ㎍/㎖. All these results suggest that Castanea crenata inner shell can be effectively used as a cosmeceutical ingredient for the prevention of wrinkles.

브랜드 이미지 강화를 위한 패밀리 룩(Family Look) 패키지디자인에 관한 연구 : 제과 업계의 빙과류 제품을 중심으로

장민정(Jang Min-Jeong) 한국디자인학회 2012 한국디자인학회 학술발표대회 논문집 Vol.2012 No.5

한국 대학생의 칭찬 화행 응대에 대한 연구

장민정 ( Min Jung Jang ) 한국언어문화학회 2015 한국언어문화 Vol.0 No.58

This article provides the study of compliment responses of the Korean University Students. A compliment responses collected via a discourse completion task(DCT). The DCT was designed six situations in the data, as well as a prompt for a written responses to the compliments. In this article we have three main concerns. The first is to examine how matters of compliments subject are related to responses. Second, examining the participants’ relationships are reflected in speech. Third, examining gender is an important variable of compliment speech. The findings show that, First, there is a difference depending on the subject of compliment. Second, depending on the distance between people are related to responses. The third finding is that addressee’s gender is variables of the compliment responses.

리기다소나무(Pinus rigida Mill.) 내수피 추출물에 대한 화장품 소재로써의 항염 및 항균효과

장민정 ( Min Jung Jang ),김영훈 ( Young Hun Kim ),안봉전 ( Bong Jeum An ),이창언 ( Chang Eeon Lee ),이진태 ( Jin Tae Lee ),김세현 ( Sea Hyun Kim ),이병근 ( Byung Guen Lee ),이도형 한국산림과학회 2008 한국산림과학회지 Vol.97 No.3

한,중 특수교사의 여가활동과 생활만족도 실태에 관한 연구

장민정 ( Min Ting Zhang ),정재권 ( Jae Kweon Chung ) 한국특수교육문제연구소 2011 특수교육저널 : 이론과 실천 Vol.12 No.4

본 연구는 한국과 중국 특수교사의 여가활동과 생활만족도 실태를 알아보기 위해 중국과 한국 각각 146부씩 총 292명의 특수교사를 대상으로 설문조사를 실시하였다. 수집된 자료는 SPSS Windows Ver. 17.0을 이용하여 교차분석과 t 검증을 실시하였으며 다음과 같은 결론을 얻었다. 첫째, 한ㆍ중 양국 간 특수교사들의 여가활동 실태에 차이가 있다. 한국특수교사가 중국특수교사보다 여가활동을 위한 교습을 받은 경험과 휴일 여가활동 시간이 더 많고 중국특수교사가 한국특수교사보다 한 달에 사용하는 여가활동 비용이 좀 더 많다. 둘째, 한ㆍ중 양국 간 특수교사들의 생활만족도 실태에 차이가 있다. 의식주, 일(직업), 경제, 사회생활과 여가생활, 행복감, 자율성과 자아감 영역에서 중국특수교사가 한국특수교사보다 만족도가 더 높은 것으로 나타났고 신체 및 정신건강 영역에서 한국특수교사가 중국특수 교사보다 만족도가 더 높은 것으로 나타났다. This study is carried out doing surveys on 292 Special Education Teachers in order to find out their resort activities and their life satisfaction. The goals of this study are as follows: First, To know the difference between Korean and Chinese special education teachers about resort activities. Second, To know the difference between Korean and Chinese special education teachers about life-satisfaction. This study can be summarized as follows : First, there was a difference between Korean and Chinese special education teachers in resort activities. Chinese special education teachers had less training for resort activities contrast to Korean special education teachers but they had a lot more expenses using per month during resort activities. And Korean special education teachers had more resort activity time on day off. Secondly, there was a difference between Korean and Chinese special education teachers in life satisfaction. Chinese special education teachers had a lot higher satisfaction on their food, clothing and shelter. Whereas Korean special education teachers had a lot higher satisfaction on their physical and mental health. And while analysing the 5 categories of work, economic, social-life and resort activities, happiness, ego and autonomy it showed that Chinese special education teachers had higher satisfactions than Korean special education teachers.

전통 조각보를 응용한 패션문화상품 개발 (1) : 앞치마를 중심으로

장민정(Chang Min-Jung) 한복문화학회 2010 韓服文化 Vol.13 No.3

In this study, we try to find Korea’s traditional beauty and design elements by providing the identity of Korea for development and new challenges of Korea’s fashion industry. By reinterpret the culture products as modernistic, add avery Korean twist to a worldwide fashionable products form. As it is a great traditional works of art form which contains configuration of the refinement, the combination of colors, and also maker’s formative works of art, we need to put Korea's patchwork for design motif by applying to an apron within colors, materials, and textile etc. through out the process, our traditional beauty will be sufficient enough to revalue in the process of globalization and also be able to get a chance to let people know about our culture in worldwide by making and designing in public so that they could get closed to our traditional culture. Aprons, which can be used in various parts and functions, are very accessible item to people of all ages and have great uses. So if we seek it as a high value product then it will surely contribute to fashion industry but also let world know about our culture.

토크쇼 대화에 나타난 질문-응대의 전략 분석

장민정 ( Min Jung Jang ) 한국텍스트언어학회 2011 텍스트언어학 Vol.30 No.-

The aim of this paper is to address strategies for the adjacency pairs of ``question-answer`` in the TV talk-show, <People inside> which is very popular in Korea. First, we discuss a general theoretical frame. Second, we describe main characters in the show. There are two participants, one host and one guest in the talk show. The strategies of the semi-institutional conversation in one on one conversation has been found in this respect. As a result of analysis of the conversations in the talk show, there are three questions types which are namely confirming information, fact seeking and emotional expressions demand. According to the question types, various strategies for answer has also been found which has led to interlocutor`s roles and goals of the conversation.

통합교육에 대한 한국과 중국 일반아동의 인식

장민정 ( Zhang Min Ting ),임봉숙 ( Lim Bong Suk ),정재권 ( Chung Jae Kweon ) 대구대학교 특수교육재활과학연구소 2014 특수교육재활과학연구 Vol.53 No.1

본 연구는 통합교육에 대한 한국과 중국 일반아동의 인식을 알아보고, 어떤 차이가 있는지를 분석하여 성공적인 통합교육의 기초자료를 제공하는데 그 목적이 있다. 구체적인 연구 목적으로서는 통합교육에 대한 한국과 중국 일반아동의 인식 차이를 밝히고자 하였다. 이를 위해 한국과 중국 각 국가별 200명으로 선정하였고, 연구자가 직접 작성한 일반아동용 설문지를 배포하여 그 중 회수된 한국 일반아동 175부와 중국 일반아동 180부의 설문지를 본 연구의 분석 대상으로 통계 처리하였다. 자료처리는 양국 인식비교에서 독립표본 t 검증을 실시하였다. 연구 결과를 통해 얻어진 결론은 다음과 같다. 첫째, 전체적으로 통합교육에 대한 한국과 중국 일반아동들의 전체 인식에 차이가 나타났으며, 통합교육에 대한 심리적 인식, 학습적 인식, 생활적 인식에서 모두 중국 일반 아동들이 한국 일반아동들보다 통합교육에 대하여 높게 인식하는 것으로 나타났다. 둘째, 통합교육에 대한 한국과 중국 일반아동의 변인에 따른 인식은 다양하게 나타났다. 전체적으로 볼 때 중국 일반아동들이 한국 일반아동들보다 통합교육 대하여 더 긍정적인 인식을 가지고 있다. The purpose of this study was to provide the basic data for successful integrated education by looking into the perception towards the integrated education among ordinary children of Korea and China and analyzing the difference in such perception. Specifically, the objective of this study was to determine the difference in perception towards the integrated education among the ordinary children of Korea and China. For that, 200 subjects, each from Korea and China, were selected for this study, and the survey sheets designed for ordinary children, which had been produced by this researcher, were distributed. 175 questionnaire sheets were collected from Korean ordinary children and 180 questionnaire sheets were collected from Chinese ordinary children. The collected questionnaires were analyzed statistically. For the processing fo data, the independent sample t-test was conducted to analyze the perception among the ordinary children of each country. Based on the results of this study, the following conclusion was drawn: First, a difference was found in overall perception towards the integrated education among the ordinary children from Korea and China. In relation to the psychological perception, learning perception, and everyday life perception with respect to the integrated education, the ordinary children of China was found to have higher perception toward the integrated education than the ordinary children of Korea. Second, the diversity was found to exist in the perception of ordinary children of Korea and China towards the integrated education based on the variables. In overall way, ordinary children of China had more positive perception towards the integrated education than the ordinary children of Korea.

초현실주의 특징이 반영된 한국 복식 디자인 연구

장민정(Chang Min-Jung) 한복문화학회 2017 韓服文化 Vol.20 No.3

Surrealism is adopted in design as a way to create unique and distinct design deviated from ordinary things, and it serves as a means to quench contemporary persons’ thirst for novelty and individuality. Derived from surrealism, there emerged costume reflecting characteristics of surrealism, and progressive design costumes applying surrealism styles have continuously come to surfaces up to today. Such costumes resulted in diversification of expression deviated from traditional costume with formality, and they lay out unprecedented experimental and progressive design based on designer’s creativeness and imagination. Surrealism is well suited to articulating individuality in that it is differentiated from traditional artistic formality and offers to broaden the possibilities of free expression and creation, this research is focused on designing and producing Korean costume reflecting characteristics of surrealism. Among Korean costumes, “Po (a generic term referring to an outer robe)” was selected given that it involves many compositions and its long length allows various designs and styles. This also reflects on concept and developments of surrealism, and also includes analysis on the characteristics of surrealism to design and produce Korean costume reflecting it. The purpose of this research is to blend traditional Korean costume with Western artistic movement surrealism to offer broadened views on Korean costume design. In succession to Korean costume, this offers experimental and various designs in line with changing trends, and proposes a new concept meeting contemporary persons’ emotional needs and carves out Korean costume market, thereby setting the direction for Korean costume design and serving as a reference for creative research on Korean costume design down the road. These are where the values of this research lie in. Hopefully, this research could also lay a foundation for another attempt towards novel design work by mixing Korean costume with Western art trend other than surrealism which would lead to Korean costume design in line with changing trends and befitting contemporary persons’ individuality, thereby further lifting up Korean costume.