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김주항,김현만,허갑범,이현철,김세광,황용,임승길,박용원 대한내과학회 1986 대한내과학회지 Vol.30 No.1
Two patients with metastatic choriocarcinoma had palpitation, dyspnea, and warm moist skin without goiter or exophthalmos. We performed thyroid function test which revealed markedly elevated levels of triiodothyronine, thyroxine and free thyroxine without the elevation of thyroid stimulating hormone. The improvement of hyperthyroidism closely paralleled the fall in human chorionic gonadotrophin (HCG) levels after anticancer chemotherapy. Recently evidence has been presented that HCG has intrinsic thyrotropic activity. It is considered that the development of biochemical and clinical hyperthyroidism in patients with choriocarcinoma depends upon the levels of HCG and the duration of the choriocareinoma.