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폐렴구균 수막뇌염 이후 급성 미만성 백질 병변으로 진행한 6개월 영아 1례
이훈상(Hoon Sang Lee),김경민(Kyung Min Kim),남상욱(Sang Ook Nam),김영미(Young Mi Kim),연규민(Gyu Min Yeon),이윤진(Yun Jin Lee) 대한소아신경학회 2016 대한소아신경학회지 Vol.24 No.4
폐렴구균 같은 세균성 뇌수막염은 소아나 성인에서 높은 사망률과 심각한 신경학적 합병증을 초래할 수 있다. 6개월의 여아가 3일간의 발열과 의식 쳐짐을 주소로 내원하였다. 내원 당시 시행한 뇌척수액 검사에서 세균성 뇌수막염이 의심되는 소견이 관찰 되어 항생제(vancomycin, cefotaxime)를 즉각적으로 투여 하였고,. 혈액과 뇌척수액 배양 검사에서 폐렴구균(S.pneumoniae )이 동정되었다. MRI 소견에서는 백질에 광범위한 다발성의 고음영 소견이 관찰되어 gammaglobulin (5-day course of 0.4 g/kg/day)와 고용량의 methylprednisolone (30 mg/kg/day)을 정맥 투여하였다. 하지만, 이런 치료에도 불구하고, 호흡이 불안정하게 되어 기계환기 치료를 하였고, 상태가 점점 악화되어 환아는 입원 60일경에 사망하였다. 저자들은 급속하게 비가역적인 미만성 백질의 침범이 있는 폐렴구균수막뇌염의 6개월 어린 영아를 경험하였기에 보고하는 바이다. Acute bacterial meningitis such as Streptococcus pneumoniae (S. pneumonia) continues to be a major cause of morbidity and mortality in both children and adults. A rapid aggravating invasion of diffuse white matter following bacterial meningoencephalitis may be a rare occurrence depending on patient’s immune response. A 6-month-old girl was referred to our hospital after 3-days of fever and appeared lethargic at the time of visit. Lumbar puncture was performed with the results of white blood cells of 60/mm3 (70% neutrophil), total protein 415 mg/dL, and glucose 51 mg/dL. Brain MRI showed very widely spreading signal abnormalities of diffuse white matters, basal ganglia and corpus callosum. Intravenous vancomycin and high dose cefotaxime as well as intravenous immunoglobulin (0.4 g/kg/day for 5 days), and high-dose methylprednisolone (30 mg/kg/day) were started on the first and third day after admission, respectively. On the 4th day after admission, the patient was intubated for ventilator care and despite aggressive treatment, the patient deteriorated rapidly and died after 60 days since admission. S. pneumoniae growth was noted from both blood and cerebrospinal fluid. We report this case with rapidly aggravating white matter lesion due to S. pneumoniae meningoencephalitis, as one of the youngest patient reported to date, with a fatal outcome.
내용기반 검색을 위한 비디오 데이터베이스 질의처리기 및 브라우저의 설계 및 구현
이훈순(Lee Hun Soon),김용걸(Kim Yong Keol),배영래(Bae Young Lae),진성일(Jin Seong Il) 한국정보처리학회 1999 정보처리학회논문지 Vol.6 No.8
As computing technologies are rapidly progressed and widely used, the needs of high quality information have been increased. To satisfy these needs, it is essential to develop a system which can provide an efficient storing, managing and retrieving mechanism of complex multimedia data, esp. video data. In this paper, we propose a metadata model which can support content-based retrieval of video data. And we design and implement an integrated user interface for querying and browsing, a query processor and browser for content-based retrieval in video database which can efficiently access and browse the video clip that user want to see. Proposed query processor and browser can support various user queries by integrating image feature, spatial temporal feature and annotation. Our system supports structure browsing of retrieved result, so users can more exactly and efficiently access relevant video clip. Without browsing the whole video clip, users can know the contents of video by seeing the storyboard. This storyboard facility makes users know more quickly the content of video clip.