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만성간질환을 가진 환자에서 중합효소연쇄반응법 ( Polymerase Chain Reaction : PCR ) 을 이용한 HBV DNA 의 검출
한기수(Ki Su Han),이효랑(Hyo Rang Lee),박중원(Joong Won Park),유병철(Byung Chul Yoo),박실무(Sill Moo Park) 대한내과학회 1996 대한내과학회지 Vol.51 No.3
N/A Objectives: The detection of serum HBV DNA is important for the assessment of the disease activity and for the evaluation of the infectivity in chronic HBV infection. The goal of this study is to determine the detection rate of serum HBV DNA in Korean patients with chronic liver diseases by the PCR Southern blot analysis and to compare it with profiles of HBV serolosic markers. Methods: Serum samples from 306 Korean adults with chronic liver diseases(186 HBsAg(+ ) patients and 120 HRsAg( - ) patients)were tested for type B viral hepatits markers by RIA and HBV DNA by Polymerase Chain Reaction(PCR) Results : 1) In HBsAg(+ ) patients the detection rate of HBV DNA was 89.6%(164/186), Among these patients, in 96.1% of HBsAg(+), HBeAg(+)patients, 73.8% of HRsAg(+), anti-HBe (+)patiens, and 94.4% of HBsAg(+), HReAg( - ), anti- HBe( - )patients, HBV DNA was detected in their serum. 2) In HBsAg( - ) patients the detection rate of HBV DNA was 21,6%(26/120). Among these patients, 52.2% of anti-HBc(+), anti-HBs( - )patients, 13.0% of anti-HBc(+), anti-HBs(+)patients had HBV DNA in their serum. None of the HBsAg( - ), anti-HBc ( - ), anti-HBs( + ) patients had HBV DNA in their serum. Conclusion - HBV DNA was detected not only in HBsAg(+)patients but also in a significant portion(21.6%) Of HBSAg( - )patients, especially in anti-HBc(+)patients. Therefore hepatitis B virus may be related to HBsAg( - ) chronic liver diseases in Korea. Among anti-HBs(+)patients HBV DNA was detected in 13.0%, so that they may have some live virus even though they have obtained immunity against the virus. In 73.8% of HBsAg(+ ), anti-HBe(+ )patients, HBV DNA was deteced.
박실무(Sill Moo Park),유병철(Byung Chul Yoo),이상재(Sang Jae lee),장세경(Se Kyung Chang),정혁(Hyeok Jeong),정우식(Woo Sik Jeong),손창재(Chang Jae Son),이효랑(Hyo Rang Lee),박중원(Chung Won Park) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.6
N/A Recently, colorectal cancer is one of the major public health problems and the annual incidence has been increased in Korea. We reviewed 175 cases of primary colorectal cancer who were diagnosed at Chungang University Hospital during a 10 year period from January 1982 to December 1991. The ratio of male to female was 1.2:1 and the peak incidence occured in the seventh decade (29.3 %) The location of cancer occurence were rectum (28. 6%), sigmoid colon (26.3%), ascending colon (25. 1%), transverse colon (6.9%), cecum (6.3%) and descending colon (5.7%) in the order of frequency. The most frequent symptoms were abdominal pain in the right sided colon lesions, bowel habit change in the left side colon and rectal lesions. The accuracy of preoperative diagnosis among barium enema (95.4%), sigmoidoscopy or colonoscopy (95. 9%) and computerized tomography (89.6%) was similar. Operation was performed in 86.8% and surgical resection of primary cancer was possible in 88.1% of operation cases. The most common histopathologic type was well differentiated adenocarcinorna(42.3%) and the prevalence of synchronous polyp was 15.4%. According to Dukes' classfication, the distribution was as follows; class A: 1.3%, class B: 48.1%, class C: 35.7%, class D: 14.9%