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한국 남성 불임환자에서 Y 염색체상의 AZF Gene에 대한 분석 및 DAZ Gene의 발현 양상
이호준,이형송,송견지,변혜경,서주태,김종현,이유식,Lee, Ho-Joon,Lee, Hyoung-Song,Song, Gyun-Jee,Byun, Hye-Kyung,Seo, Ju-Tae,Kim, Jong-Hyun,Lee, You-Sik 대한생식의학회 1997 Clinical and Experimental Reproductive Medicine Vol.24 No.1
Cytogenetic observations of loss of the distal portion of the Y chromosome long arm were found to be associated with disrupted spermatogenesis. The existence of a gene involved in the regulation of spermatogenesis, the azoospermia factor (AZF), was postulated. In this study, we screened the AZF region including DAZ and DAZH genes and observed the expression pattern of DAZ and DAZH transcript in infertile men with azoospermia and oligospermia by using a sequence-tagged site (STS)-based PCR method. PCR primers were synthesized for 11 STSs that span Yq interval 6, SRY, DAZ, and DAZH, functional DAZ homologue on chromosome 3. Microdeletions were detected in 4/32 (12.5%) azoospermic men and 1/11 (9%) severe oligospermic men. Only 2 of 5 patients had microdeletions of Yq that contained the DAZ gene, whereas the other 3 patients had deletions extending from intervals 5L-6F proximal to the DAZ gene on Yq. Testis biopsies of the azoospermic patients revealed a variety from Sertoli cell-only syndrome to testicular maturation arrest. Of 4 men with clinical data available, average testis size was R: 13.8 cc, L: 13.8 cc, serum T was $4.0{\pm}1.25$ ng/ml, LH was $3.63{\pm}1.90$ mIU/ml, and FSH was $8.85{\pm}5.13$ mIU/ml. These values did not differ significantly from the remainder of the patients tested. We could not observed the DAZ transcript in 2 patients, who have no mature spermatozoa. In 11.6% of patients microdeletions of the AZF could be detected. These deletions in the AZF region seem to be involved causing spermatogenic failure. But the frequency of microdeletions proximal to DAZ suggests that DAZ is not the only gene associated with spermatogenic failure.
이호준(Ho-Ju Lee),염인수(In-Su Yeom) 대한전자공학회 2016 대한전자공학회 학술대회 Vol.2016 No.11
In this paper, the antenna for on body application by using EBG structure is proposed for WBAN application. Performance of a dipole antenna integrated with an EBG(electromagnetic band gap) substrate is described. The antenna operates at 2.4GHz wireless bands. The band gap array consist of just 6x6 elements. This paper has demonstrated that it is possible to apply to WBAN application.
표면 부착 영구자석형 구형모터의 비대칭 자계에 대한 연구
이호준(Ho Joon Lee),강동우(Dong Woo Kang),고성철(Sung Chul Go),박현종(Hyun Jong Park),이주(Ju Lee) 한국자동차공학회 2011 한국자동차공학회 부문종합 학술대회 Vol.2011 No.5
A surfaced permanent magnet spherical motor is capable of operating as three degree of freedom that used for the joints of the robot’s arm, leg, and eyes. Ongoing research like new concept is essential part of motor field, it will make a great contribution in the future the overall portion of the motor, is becoming expected. The author analysis torque characteristics in spherical motor with state of rotating and positioning. And future design direction is smaller motors with equivalent or higher output. Solutions as torque and efficiency improvements are selecting the core with special processing type like powder metallurgy materials. Their special characteristic is high permeability and low eddy current losses at high speed, so improved the torque and efficiency.
영구자석형 다자유도 구형전동기의 토크특성 분석과 효율 향상에 대한 연구
이호준(Ho-Joon Lee),김용(Yong Kim),장익상(Ik-Snag Jang),박현종(Hyun-Jong Park),강동우(Dong-Woo Kang),원성홍(Sung-Hong Won),이주(Ju Lee) 대한전기학회 2012 전기학회논문지 Vol.61 No.1
A surfaced permanent magnet spherical motor is capable of operating as three degree of freedom that used for the joints of the robot"s arm, leg, and eyes. Ongoing research like new concept is essential part of motor field, it will make a great contribution in the future the overall portion of the motor, is becoming expected. The author analysis torque characteristics in spherical motor with state of rotating and positioning. And future design direction is smaller motors with equivalent or higher output. Solutions as torque and efficiency improvements are selecting the core with special processing type like powder metallurgy materials. Their special characteristic is high permeability and low eddy current losses at high speed, so improved the torque and efficiency.
이호준(Ho-Joon Lee),강동우(Dong-woo Kang),박현종(Hyun-jong Park),원성홍(Sung-hong Won),김솔(Sol Kim),이주(Ju Lee) 대한전기학회 2010 대한전기학회 학술대회 논문집 Vol.2010 No.7
In this paper study of three degrees of freedom spherical permanent motor which can be placed joints of the robot's arm or leg how to reduce the torque ripple and what makes the torque ripple. Such as three degrees of freedom motors that drive rotation and tilting device is essential for reduction of torque ripple rotating without tilt. Also rotation with a certain tilting angle is the same. Due to interpret of three degree of freedom spherical motor's characteristic, this paper explain the motor's structure and the current expression flowing through the coil. And analyze tendency of X and Y coordinate torque by untilt and tilt. Finally this paper proposes design model of reduce the torque ripple.
이호준(Ho-Jun Lee),김성미(Seong-Mi Kim),임주현(Ju-Hyun Lim),권선영(Seon-Young Kwon),정철호(Chul-Ho Jung) 대한생물치료정신의학회 2009 생물치료정신의학 Vol.15 No.1
본 연구에서는 우리나라 소아 청소년의 불안장애에서 동반되는 신체증상의 특성을 알아보고, 불안장애에 동반된 신체증상에 대한 특성을 밝혀 실제 임상에서 도움이 되는 기초자료를 제공하고자 하였다. 연구 대상은 대구지역 병의원 정신과 3곳을 방문한 소아 청소년 불안장애 환자와 정신과적 증상이 없다고 평가된 대조군 각 34명으로 하였다. 불안장애 환자군은 대조군보다 하나 이상의 신체증상을 호소한 사람의 수가 더 많았고, 평균 호소하는 신체증상의 수도 더 많았다. 또한 불안장애 환자군 내에서 남녀간 신체증상 수의 차이는 없었으나 13세 이상의 환자가 13세 미만의 환자보다 더 많은 수의 신체증상을 호소하였다. 동반된 신체증상 중에서는 어지러움, 심계항진, 복통의 순으로 많았다. 불안장애의 정도는 신체증상 수, 신체증상의 정도와 서로 관련성이 있었으며, 불안감정의 정도 또한 신체증상 수와 신체증상 정도와 관련성이 있었다. 이러한 결과는 외국 연구와 일치되게 나타났다. 또한 신체증상의 정도는 불안감정의 정도를 가장 잘 예측해주는 변인으로 나타났다. 소아 청소년 불안장애에 동반된 신체증상의 특성이 소아 청소년 불안장애의 양상 파악과 진단 및 치료에 도움을 줄 것으로 생각된다. Objectives:This study investigated the prevalence of somatic symptoms in children and adolescent with anxiety disorder. Methods:The subjects were 34 children and adolescents diagnosed with anxiety disorder in 3 psychiatric clinics in Daegu, and the control group were 34 normal children and adolescents. Participating subjects were assessed by psychiatrist using the Pediatric Anxiety Rating Scale. Results:The prevalence of somatic symptoms was 94.1% in anxiety disorder, and was 50% in normal control group. The mean numbers of somatic symptoms were 5.6 in anxiety group and 1.6 in control group. There was no significant difference in the number of somatic symptoms between boys and girls in anxiety group. However, there were significant differences in the numbers of somatic symptoms by age;7.4 somatic symptoms in the age group of 13 or more in comparison to 4.0 in the age group of 12 or less. The reported somatic symptoms were dizziness(70.6%), palpitation(67.6%), abdominal pain or discomfort(58.8%), chest pain or discomfort(55.9%), and chills(50%). Additionally, there were close relationships between the severity of anxiety and the number of somatic symptoms, and between the severity of anxiety and the severity of somatic symptoms. The severity of somatic symptoms could predict the severity of anxiety. Conclusion:This study shows that somatic symptoms in children and adolescents with anxiety disorders are common and that there are significant relations between somatic symptoms and severity of anxiety.