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B 형 만성활동성간염 치료제로서 합성 α - Interferon 의 효용성
이호심(Ho Sim Lee),임종찬(Jong Chan Lim),이일남(Il Nam Lee),조현덕(Hyun Duk Cho),유병철(Byung Chul Ryoo),박실무(Sill Moo Park) 대한내과학회 1990 대한내과학회지 Vol.39 No.3
N/A Fifty eight patiens with chronic active hepatitis were entered into a therapeutic trial of 12-week period of recombinant α-interferon therapy. All patients were positive for both HBsAg and HBeAg. During the 13 to 62-week period of follow-up, 24 of 58 (47%) treated patints became negative for serum HBeAg but in 9 of these HBeAg reappeared in their serum. Fifteen patients (30%) were also positive for serum Anti-HBe but 5 of this lost Anti-HBe from serum. 9 patents positive for initial HBV DNA lost their DNA from serum. Responders had a marked improvement in serm aminotransferase activities. Seroconversion rate of female (5/9, 56%) was seemed to be higher than that of male (19/43, 45%). Comparison of responders to non-responders indicated that a high initial level of serum aminotransferuse and a severe form of hepatic histology correlate best with response to interferon herapy. 45 of 58 (78%) patients showed various adverse reactions, such as myalgia (59%), fatigue (57%), fever (52%), nausea and anorexia. Transient decrease in peripheral leukocyte and platelet count were also noted. These findings suggest that α 12-week course of recombinant α-interferon therapy would be effective and safe in approximately half of patients with chronic active hepatitis B.
이호심(Ho Sim Lee),이성걸(Seong Geol Lee),이정선(Jeong Sun Lee),최창환(Chang Whan Choi),김용기(Young Ki Kim),김종숙(Jong Sook Kim),우제호(Je Ho Woo) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.4
Solid and papillary epithelial tumor that occurs chiefly in young woman. It is amenable to surgical resection and cure. Recurrence after operation and distant metastasis are rare. But, a few cases with recurrence or distant metastasis have been reported. We have encounted a case of solid and papillary tumor of the pancreas with distant metastasis and recurrence 7 years after resection in 34 years old female, so report it.
2 형 당뇨병 환자의 공복시 유리지방 농도에 대한 연구
박문규(Moon Kyu Park),이정선(Jeong Sun Lee),이성걸(Seong Geol Lee),이호심(Ho Sim Lee),김용기(Yong Ki Kim),이기호(Ki Ho Lee) 대한내과학회 1991 대한내과학회지 Vol.40 No.3
N/A After Randle has suggested glucose-fatty acid cycle in 1962, it has been inferred that elevated free fatty acid can impair glucose utilization through the Randle cycle in type II diabetes mellitus. However, in Korea, there are few reports concerning this matter, so we measured plasma glucose, FFA, c-peptide and triglycerides in 68 type II diabetic patients without insulin therpy and 42 normal controls after 12hrs fasting. The results were as follows; 1) FBS was significantly higher in the diabetic group (226.48 mg%) than that of the normal control group (95. 66mg%). (p<0.05) 2) FFA was significantly higher in the diabetic group (667.98 μEq/L) than in the normal control group (541.59 μEq/L). (p<0.05) 3) C-Peptide showed not significantly different between diabetic group (2.48 ng/ml) and the normal control group (2.55 ng/ml) (p>0.05). 4) Triglyceride was significantly higher in the diabetic group (143.09 mg/dl) than in the normal control group (113.38 mg/dl) (p < 0. 05). 5) There was significant correlation between FBS and FFA the in diabetic qroup(r=0.502). So, we can say that fasting blood sugar was affected by plasma FFA through the randle cycle, and insulin resistancs exists also in free fatty acid metabolism.
소화성궤양 환자에 있어서 공복시 혈청 Gastrin 및 Pepsinogen 1 측정치에 관한 연구
김호정(Ho Jung Kim),이호심(Ho Sim Lee),유병철(Byung Chul Yoo),박실무(Sill Moo Park) 대한내과학회 1989 대한내과학회지 Vol.37 No.4
N/A Fasting serum gastrin and group I pepsinogen levels were measured by radioimmunoassay in 42 patients with gastric ulcer, 111 patients with duodenal ulcer, 80 patients with chronic superficial gastritis and 25 patients with recurrent duodenal ulcer confirmed by endoscopic biopsy. The results were as follows: 1) There was no significant difference in fasting serum gastrin level between patients with peptic ulcer and chronic superficial gastritis. 2) A significant difference (p<0.05) was noted in fasting serum pepsinogen I levels between patients with duodenal ulcer and patients with gastric ulcer and also patients with chronic superficial gastritis, 3) The fasting serum pepsinogen I level was significantly higher (p<0.05) in patients with recurrent duodenal ulcer than in patients with duodenal ulcer. 4) There was no statistical correlation in fasting serum gastrin levels and fasting serum pepsinogen I levels in patients with gastric ulcer, duodenal ulcer, chronic superficial gastritis, and recurrent duodenal ulcer. The above results suggest that fasting serum pepsinogen I may be useful as a subclinical marker far recurrent duodenal ulcer.
위장관출혈부위와 혈청 Urea와 Creatinine 비의 관련성
이성걸(Seong Geol Lee),최창환(Chang Whan Choi),문현웅(Hyun Woong Moon),정영호(Young Ho Jeong),이호심(Ho Sim Lee),김용기(Yong Ki Kim),김종숙(Chong Sook Kim) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.3
N/A We evaluated the usefulness of serum urea and creatinine ratios to differentiate bleeding sites in 63 patients vith gastrointestinal bleeding from August 1991 to Viay 199Z, The follow- ing results were obtained: Serum urea and creat.inine ratios in the upper gastrointestinal group were significantly higher than those in t.he lower gastrointestinal bleeding and control. The ratios were higher in proportion to the volume of blood loss in the upper gastrointestina! Bleeding group. The percent of patients over 80 in the ratios was 77 % in t.he uppcr gastrointestinal bleeding gr oup, whereas was 6.2 % in the lower gastrointestinal bleeding. Thc upper gastrointestinal bleeding, the ratios below 80 were obtained in 11 cases which ha<l cases of small amount bleeding, shortening of intestinal transit tirne, correction of body I'luid arid electrolyte imbalance, and other unknown causes. Result,s of above studies indicated that de terrnination of serum urea and creatinine ratios was a simple and useful procedure fr diagno sis, but we need further study t.o det,ermine the presence of factors to the rat.io variability.(Ko rean J Gastroenterol 1994; 26: 432 436)
김종숙(Chong Sook Kim),이호심(Ho Sim Lee),정구영(Gu Yeong Jung),염경현(Kyeong Heon Yeum),권경수(Kyeong Su Kwan),이청숙(Chung Sook Lee),박철각(Cheol Kag Park),양연철(Yun Cheol Yang) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.3
There have been many reports on primary multiple cancer since Billroth reported it for the first time in 1889. Etiology ts not known, byt there are manu redisposing factors and developmental theories. The occurance of multiple primary malignant tumors is not just by coincidence, but significantly gigher in persons with a known cancer or with a history of cancer, than in the generel population. We report a case of double primary malignant tumors of esphageal squamous cell carcinoma and gastric adenocarinoma. The lesions were found during the gastrofiberscopic wxamination for the evaluation of dysphagia and epigastric pain. To descover occult malignancies, we emphasize the importance of special aggresive and diligent follow up of patients who are being treated for a known tumor. (Korean J Gastroenterol 1997; 29 : 411 -416)
총장골정맥과 하대정맥 전장이 폐쇄된 Budd-Chiari 증후군
최창환(Chang Whan Choi),정영호(Young Ho Jeong),문현웅(Hyun Woong Moon),김광철(Kwang Chul Kim),박무영(Mu Yeong Park),이성걸(Seong Geol Lee),이호심(Ho Sim Lee),김종숙(Jong Sook Kim) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.3
Budd-Chari syndrome is a rare clinical entity characterized by post-sinusoidal portal hypertension caused by the obstruction to the hepatic vein outflow. Membranous obstruction of the hepatic inferior vena cava is one of the common causes of Budd-Chiari syndrome. The diagnosis is usually confirmed by hepatic vena graphy, inferior vena cavography and biopsy. We have experienced a case of Budd-Chiari syndrome associated with complete obstruction of the inferior vena cava through various radiologic findings. This case of Budd-Chiari syndrome was confirmed by inferior venacavography, abdorninal CT, songoraphy and color doppler sonography. Radiologic findings showed right, left and mid hepatic vein obstruction, complete IVC obstruction, azygos & hemiazygos circulation and multiple collateral circulation via superficial route. We report this case of Budd-Chairi syndrome with review of literature. (Korean J Gastronterology 1994; 26: 601 606)
횡행결장에서 발견된 시위석 ( Diospyrobezoar )
최창환(Chang Whan Choi),정영호(Young Ho Jeong),문현웅(Hyun Woong Moon),이호심(Ho Sim Lee),김종숙(Chong Sook Kim) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.2
Diospyrobezoar I.I o type ot' hezcwir which ure hecomes concrete when vegetables or fruits such as persimmons are ingeited.. The diospyrohezoar dcvelops very rapidly and becornes large enough to cauuse the intestinal ohstructiomi, gastric hleedinig by the mech;mical irritation or uulceration and pert'oratioon. Frequuent loocationi of bez(xlr av. Fhic ileum attd thc jcjunnunn. Hercin, we dcscribc a rare case of diospyrohez(xir whicEi was recovvrcd from tEie transverse colon. The patient was a 68- year-old woman, who complainc.d of v;holc abdoininal pain and vomiting for 3 ciays. Plain obdo- minal filrn showed a fetus fist .iized mass-like .ihadow on the right 1ower quadrant. Abdominal C.'T scanning showed a solid muss on di.tal jejunum or proximal ileum. Upon operution, the large mass was observed in the mid-trun.evcrse colon, which wa.I renwived by uppendcctomy;md ceccctorny. (Korean 3 Gastroenterol 1995;27:256 260)