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갱년기 발한과다를 호소하며 일개 한방병원에 입원한 환자 21명에 대한 치료 분석
이혜정,이수정,황덕상,이창훈,장준복,이진무,Lee, Hye-Jung,Lee, Su-Jeong,Hwang, Deok-Sang,Lee, Chang-Hoon,Jang, Jun-Bock,Lee, Jin-Moo 대한한방부인과학회 2020 大韓韓方婦人科學會誌 Vol.33 No.3
Objectives: Hot flush and sweating is the most of common symptoms and the main cause of treatment in Menopause. This study aims to report the therapeutic effect of Korean medicine for menopausal sweating by analysis for the patients hospitalized in a Korean Medicine Hospital. Methods: To analyze treatment of menopausal sweating, we studied 21 patients complaining of menopausal sweating hospitalized in Kyung Hee University Hospital at Gangdong from 1<sup>st</sup> January 2015 to 31<sup>th</sup> May 2020 with retrospective chart review. Results: All 21 subjects are treated by acupuncture, moxibustion and cupping therapy during hospitalization for an average of 11.3±9.14 days. The most common used korean herbal medicine was Gwibi-tang-gagambang, Soyo-san-gagambang, and Dangwiyukhwang-tang-gagambang, every 6 case (20%), followed by Ojeok-san with 2 cases (6.7%). The improvement rate averaged 56.4% for daytime sweating and 53.6% for night sweating. Conclusions: The results suggest that menopausal sweating could improve by treatment of korean medicine, confirming significant treatment effects.
부자이중탕과 보중익기탕의 억제성 및 흥분성 신경전달 물질에 의하여 활성화되는 이온통로 조절작용
이혜정,서정철,이재동,김이화,이충열,정주호,신민철,김현배,김연정,김창주,Lee, Hye-Jung,Seo, Jung-Chul,Lee, Jae-Dong,Kim, Ee-Hwa,Lee, Choong-Yeol,Chung, Joo-Ho,Shin, Min-Chul,Kim, Hyun-Bae,Kim, Youn-Jung,Kim, Chang-Ju 대한침구의학회 2000 대한침구의학회지 Vol.17 No.4
To research the characteristics of ion currents induced by Bujaijung-tang and Bojungikgi-tang, nystatin-perforated patch clamp technique under voltage-c(amp condition was used. Periaqueductal gray neuron was dissociated from Sprauge-Dawley rat, 10-15 days old. Cytotoxicity of Bujaijung-tang and Bojungikgi-tang showed incubation time and concentration dependent manner. Ion current activated by Bujaijung-tang and Bojungikgi-tang were inhibited by bicuculline and strychnine and CNQX. It can be suggested that Bujaijung-tang and Bojungikgi-tang modulate inhibitory and excitatory neurotransmitters-, GABA, glycine and non-NMDA, acticvated ion channels. Modulatory effect of Bujaijung-tang and Bojungikgi-tang was more greater in inhibitory neurotransmitters. Low concentration of Bujaijung-tang which dose not elicit ion current itself, activated GABA and glycine induced chloride currents. In this study, we can found that the activation of Bujaijung-tang and Bojungikgi-tang on non-NMDA subtypes of glutamate receptor is its major action mechanism and can be used as very effective Herb treatment on Myasthenia gravis patient.
핵소체 단백 B23과 세포질 단백 p80의 유사성에 관한 연구
이혜정,윤상인,최용천,안영수,Lee, Hye-Jeong,Yoon, Sang-In,Choi, Yong-Chun,Ahn, Young-Soo 대한약리학회 1995 대한약리학잡지 Vol.31 No.2
Protein B23 is one of the major nucleolar phosphoproteins associated with pre-ribosomal particles, and is localized in the granular region of the nucleolus. Recent studies suggest that protein B23 shuttles between nucleus and cytoplasm and also interacts with HIV Rev. These findings indicate that protein B23 is important in nucleocytoplasmic relationship and viral replication. However, the exact function of protein B23 is not clear yet. In acute nucleolar hypertrophy of rat liver, treated with thioacetamide, there was observed an increase of not only protein B23 but also B23-like protein p45 when anti-B23 monoclonal antibody (MAb) was used for identification. On the basis of the large B23 specific epitope structure composed of 68 amino acids, a hypothesis was formulated to examine that p45 is the pre-B23 resulting from excessive production of B23. In an attempt to investigate the precursor of B23, we analyzed the subcellular fractions and microsomal subfractions. Subsequently, we analyzed the finger printings of B23-like proteins using the tryptic peptide mapping. The results are summarized: 1) Using B23 MAb, we observed the presence of B23-like proteins in nucleolar fraction, nucleoplasmic fraction and microsomal fraction. 2) In the further microsomal subfractionation, we could partially purify B23-like protein in 2M layer of sucrose gradient. 3) When ion exchange chromatography was employed, there were protein species 80kDa(p80), 65kDa(p65) and 60kDa(p60). 4) Based on the tryptic map analysis of $^{125}I$ labeled proteins, the similarity between B23 and p80 was found only in 9 out of 14(B23) and 21(p80) peptides, and difference was found in the remaining peptides. p80 and p60 had 18 common peptides, and all the peptides of p60 were similar to those of p80. From these results, it is proposed that p45 is an abnormal metabolite resulting from carcinogenesis by thioacetamide, and it is not the precursor of B23. In addition, we suggest that p80 may be a precursor of p45.
근육 모델 기반 3D 얼굴 표정 생성 시스템 설계 및 구현
이혜정,정석태,Lee, Hyae-Jung,Joung, Suck-Tae 한국정보통신학회 2012 한국정보통신학회논문지 Vol.16 No.5
얼굴 표정은 상호간 의사소통에 있어 중요한 의미를 갖는 것으로, 인간이 사용하는 다양한 언어보다도 수많은 인간 내면의 감정을 표현할 수 있는 유일한 수단이다. 본 논문에서는 쉽고 자연스러운 얼굴 표정 생성을 위한 근육 모델 기반 3D 얼굴 표정 생성 시스템을 제안한다. 3D 얼굴 모델의 표정 생성을 위하여 Waters의 근육 모델을 기반으로 자연스러운 얼굴 표정 생성에 필요한 근육을 추가하여 사용하고, 표정 생성의 핵심적 요소인 눈썹, 눈, 코, 입, 볼 등의 특징요소들을 중심으로 얼굴 근육과 근육벡터를 이용하여 해부학적으로 서로 연결된 얼굴 근육 움직임의 그룹화를 통해 얼굴 표정 변화의 기본 단위인 AU를 단순화하고 재구성함으로써 쉽고 자연스러운 얼굴 표정을 생성할 수 있도록 하였다. Facial expression has its significance in mutual communication. It is the only means to express human's countless inner feelings better than the diverse languages human use. This paper suggests muscle model-based 3D facial expression generation system to produce easy and natural facial expressions. Based on Waters' muscle model, it adds and used necessary muscles to produce natural facial expressions. Also, among the complex elements to produce expressions, it focuses on core, feature elements of a face such as eyebrows, eyes, nose, mouth, and cheeks and uses facial muscles and muscle vectors to do the grouping of facial muscles connected anatomically. By simplifying and reconstructing AU, the basic nuit of facial expression changes, it generates easy and natural facial expressions.
이혜정,신형철,진수희,손양선,윤동학,임사비나,Lee, Hye-Jung,Shin, Hyung-Cheul,Jin, Soo-Hee,Son, Yang-Son,Yun, Dong-Hak,Lim, Sabina 대한침구의학회 2000 대한침구의학회지 Vol.17 No.4
Objectives : Acupuncture is expected to have somewhat like the efficacy parallel increasing activity of immune system in Western modem medicine. There, already, are many animal researches on activating effect of acupuncture for the immune system in peripheral organs. So, we carried out this experiment to see whether acupuncture has controlling effect on interleukin-6(IL-6) activity in rat's brain. Methods and Results : We had topical application of IL-6(1U=lpg, $10{\mu}l$) on brain of rat. It reduced afferent sensory transmission to the primary somatosensory(SI) cortex from periphery. Whereas, electrical stimulation(ES, 2Hz, 1.5V, 15min) of ST36(足三里) with application of IL-6 prominently activated afferent sensory transmission. ES of non-acupoint(proximal tail) with IL-6 showed suppression of afferent transmission. ES of ST36 without IL-6 application also exerted facilitation of afferent transmission to the SI cortex. Conclusions : Electoacupuncture(EA) on ST36 has noticeable influences on modulating activation of IL-6 in central nervous system, which do major role in immune system.