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Synthesis and Reactions of Benzimidazoline-2-thione Derivatives
이태룡,김경태,Lee Tae Ryong,Kim Kyongtae Korean Chemical Society 1989 Bulletin of the Korean Chemical Society Vol.10 No.1
Two properties of sodium naphthalenide (2), i.e. a strong base and a good electron donor were utilized for one pot synthesis: 2-alkylthiobenzimidazoles were synthesized in excellent yields from the reactions of benzimidazoline-2-thione (1) with an equimolar amount of alkyl halides in the presence of 2. Continuous addition of a different alkyl halide without the isolation of 2-alkylthiobenzimidazoles afforded 1-alkyl-2-alkylthiobenzimidazoles having different alkyl groups at N and S atoms in excellent yields. Further addition of 2 to 1-alkyl-2-alkylthiobenzimidazoles gave excellent yields of 1-alkylbenzimidazoline-2-thiones. When 2 in THF was added to a suspension of 1-alkyl-2-alkylthiobenzimidazoles in THF, a bond cleavage between N and C of alkyl group as well as S and C of alkyl group occurred. This is in contrast to the observation in which only cleavage between S and C of alkyl group takes place in the homogeneous solution.
초고속 대용량 바이오 기술과 이의 화장품연구 활용 방안
이태룡 ( Tae Ryong Lee ) 대한화장품학회 2001 대한화장품학회지 Vol.27 No.2
최근 인간 유전체 사업(Human Genome Project)의 완성과 DNA Microarray,Proteomics, Bioinformatics 등의 초고속, 대용량 처리 바이오기술(High Throughput Biotechnology) 의 발전과 함께 생명과학 분야의 연구는 획기적인 변화의 시기를 맞이하게 되었다. 이미 의약품 분야는 이러한 기술을 활용한 연구가 보편화 되어있고 선진 외국 회사들의 화장품연구 또한 이를 활용한 연구가 본격화 되고 있다. 화장품개발에 있어서도 이러한 기술들의 활용이 불가피하게 되었다. 여기서는 이러한 새로운 바이오기술들에 관해 간단히 알아보고 향후 이러한 기술들의 효과적인 화장품개발 관련연구 활용범위와 활용방법에 대하여 알아본다.
폐콘크리트, 천연 제올라이트 및 전기화학적 공정 조합을 통한 광산폐수로부터 중금속 제거
이태룡 ( Tae-ryong Lee ),김홍태 ( Hong-tae Kim ),오상화 ( Sanghwa Oh ) 한국수처리학회(구 한국수처리기술연구회) 2018 한국수처리학회지 Vol.26 No.4
Three unit processes such as neutralization with wasted concrete (C), an electrochemical treatment (E), and an ion-exchange with natural zeolite (Z) were performed to estimate the potential for removal of heavy metals from acid mine drainage (AMD) and two combined processes consisting of C-Z-E-C reactors in series (type 1) and C-E-C-Z reactors in series (type 2) were also tested to enhance the removal efficiencies of heavy metals. Results show that heavy metals were effectively removed by precipitation at neutral pH with the aged wasted concrete and by ion exchange with the natural zeolite, but poorly removed by electrochemical treatment except Fe (64%). When it comes to enhance removal efficiencies of heavy metals, two combined processes were performed with high removal efficiencies of Fe 95.3%, Cu 96.5%, Mn 71.3%, Zn 93.7% and Al 58.2% by type 1 and Fe 94.2%, Cu 96.5%, Mn 96.3%, Zn 95.2% and Al 67.6% by Type 2, respectively.
Development and Application of Alternative Methods for Skin Sensitization in AmorePacific
이태룡 ( Tae Ryong Lee ),( Su Sun An ),( Seo Young Kim ),( Yun Hyeok Jeong ),( Yong Huh ) 한국동물실험대체법학회 2009 한국동물실험대체법학회 학술대회집 Vol.2009 No.1
In recent decades, the prevalence of allergic disease has increased considerably and has become an important health problem worldwide. The skin and lung are the most important targets for allergens. The use of cosmetics can occasionally cause allergic contact dermatitis (ACD). There is currently no general cure for allergic diseases. Therefore, prevention could be an effective approach to addressing the burden of this disease. To prevent ACD, evaluation of the skin sensitization potential is an important part of the safety assessment of new ingredients in cosmetics. The Council of the European Union has banned marketing cosmetics and its ingredients that tested on animals after March 2009. Because of this regulation, the cosmetic industry has been developing alternatives to animal experimentation to test the efficacy or toxicity of cosmetic ingredients and other products. Here, we briefly introduce the current status of the development and application of alternative methods for skin sensitization in AmorePacific.
생물막반응조를 이용한 퍼클로레이트 처리에서 EBCT의 영향
이태룡 ( Tae Ryong Lee ),이영도 ( Young Do Lee ),김홍태 ( Hong Tae Kim ),최혁순 ( Hyeok Sun Choi ) 한국수처리학회 2011 한국수처리학회지 Vol.19 No.3
Perchlorate contamination generates from the disposal of ammonium perchlorate(AP), a highly energetic compound produced for use in solid rocket propellant of missile. Typical water treatment technologies such as ion exchange, carbon adsorption, and air stripping seem not to be economical for perchlorate removal, which is extremely stable in water and does not react to adsorbents. Biofilm processes have been considered as a cost effective treatment for perchlorate and other anions. The purpose of this research was to investigate the optimum EBCT in a fixed biofilm reactor for destruction of perchlorate. A synthetic water containing average 277μg/L perchlorate was reduced to 40μg/L, 8μg/L, 10μg/L, and 52μg/L perchlorate at 5.4hr, 2.7hr, 1.4hr, and 0.5hr of EBCT in a fixed biofilm reactor. A fixed biofilm reactor with internal recirculation(2:1) reduced perchlorate from 277μg/L to below detection, 4μg/L, 11μg/L, and 47μg/L at 5.4hr, 2.7hr, 1.4hr, and 0.5hr EBCT. Perchlorate removal efficiencies in a plug flow biofilm reactor and internal recirculation biofilm reactor were not significantly different during this experiment.
폐기왓장과 황산염 환원 미생물을 이용한 산성 광산 폐수 처리
김홍태 ( Hong Tae Kim ),이태룡 ( Tae Ryong Lee ),이영도 ( Young Do Lee ),김광덕 ( Kwang Deok Kim ),조영탁 ( Young Tak Jo ),김영태 ( Young Tae Kim ) 한국수처리학회 2010 한국수처리학회지 Vol.18 No.6
The removal of heavy metals such as Fe, Mn, Zn, Pb, Cu, and Cr from the acid mine drainage (AMD) with wasted tiles and sulfate reducing bacteria (SRB) was investigated. NaHCO3 in phase 1 and the waste tiles in phase 2 were used to adjust pH of AMD to neutral and weak base in the first reactor and to remove some heavy metals, followed by anaerobic reactor containing SRB to additionally remove them. The HRT was 3 days in phase 1 and 2 days in phase 2. The pH adjustment in phase 1 and 2 was compared each other. The pH increased from 3 to 5 in phase 1 and 2, indicating the wasted tiles (phase 2) was as effective in pH increase as NaHCO3 (phase 1). The removal efficiencies of Fe, Mn, Zn, Pb, Cu and Cr in phase 1 were 80, 30, 60, 61, 44 and 40%, respectively, and 90, 40, 70, 80, 62 and 45% in phase 2, respectively, indicating higher removal efficiencies of heavy metals in phase 2 than those in phase 1. In addition, Fe, Mn, Cr and Cu are removed with higher efficiencies in pH 5~7 compared to those in pH 7~8, although some heavy metals were easily to be precipitated at higher pH. It indicates that the heavy metal removal by SRB might be dominant to the removal of the heavy metals at low pH.
역상 액체 크로마토그래피에 의한 구절초 중 Chlorogenic Acids와 Linarin의 동시 정량분석
김택제,이태룡,박호군,Kim, Taek-Jae,Lee, Tae-Ryong,Park, Ho-Koon 대한화학회 1991 대한화학회지 Vol.35 No.6
액상 액체 크로마토그래피(HPLC)에 의해 구절초 중 chlorogenic acid (CA), 3,4-o-dicaffeoyl quinic acid (3,4-DCQA), 4,5-o-dicaffeoyl quinic acid (4,5-DCQA)와 linarin의 동시 정량분석법이 새로히 확립되었다. 시료를 20ml 메탄올로 4시간 추출하고 그 추출물을 Sep-Pak $C_18$ cartridge와 용출액으로 4 ml 메탄올-물(1:1)을 사용해서 분리, 정제하였다. HPLC 정량법으로 Bondapak $C_18$ 컬럼(30 cm ${\times}$ 3.9 mm i.d., 10 ${\mu}m$)과 이동상으로 메탄올 -5mM 인산수용액(30:70)의 기울기 용출방식이 사용되었다. 위 정량분석법을 이용해서 시중 구절초 중 그 함량범위는 CA에서 0.35~0.55%, 3,4-DCQA에서 0.46~0.76%, 4,5-DCQA에서 0.077~0.231% 및 linarin에서 0.16~2.72%이었다. Simultaneous determination of chloragenic acid (CA), 3,4-o-dicafeoyl quinic acid(3,4-DCQA), 4,5-o-dicaffeoyl quinic acid (4,5-DCQA) and linarin in Chrysanthemum sibiricum Fisher was newly established by a reversed-phase high performance liquid chromatography (HPLC). Sample was extracted with 20 ml methanol for 4 hrs. The extract was cleaned up by using Sep-Pak $C_18$ cartridge and 4 ml methanol-$H_2$O(1 : 1) as eluent. Their determination was performed by means of RP-HPLC with Bondapak $C_18$ column (30 cm ${\times}$ 3.9 mm i.d., 10 ${\mu}m$ and gradient elution mode as methanol-5 mM $H_3PO_4$ solution (30 : 70). The established method was applied to various samples purchased. As a result, their content ranges showed to be 0.35~0.55% for CA, 0.46~0.76% for 3,5-DCQA, 0.077~0.23% for 4,5-DCQA and 0.16~2.72% for linarin, respectively.