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Jeong, Jun Hyeok,Choi, Sungwook,Lee, Seul-Lee,Jeong, Sun Jae,Christian, Nouaze Joseph,Kim, Jihoon,Kang, Hyun Wook,Nam, Seung Yun,Oh, Junghwan,Lee, Yong Wook American Scientific Publishers 2017 Journal of nanoscience and nanotechnology Vol.17 No.11
<P>In this paper, we demonstrated a polarimetric fiber vibration sensor based on a polarization-diversified loop (PDL) with short polarization-maintaining photonic crystal fiber (PM-PCF) as a sensor head and investigated the dependence of its frequency response on the sensing fiber length. The fabricated PM-PCF vibration sensor is composed of a polarization beam splitter for forming the PDL, PM-PCF as a sensor head, and two wave plates such as a quarter-wave plate and a half-wave plate. A laser diode and a photodetector were also utilized for intensity-based vibration measurement. In particular, two kinds of PM-PCF segments with fiber lengths of similar to 6 and similar to 10 cm were employed to explore the effect of the sensor head length on the sensor frequency response. The frequency response was examined over 1-3000 Hz using a piezoelectric transducer that can apply single-frequency vibration to the sensor head. Every measured frequency response showed a resonance peak at each sensor head length, and cut-off frequencies were measured as similar to 1240 and similar to 794 Hz for PM-PCF lengths of similar to 6 and similar to 10 cm, respectively. That is, a higher cut-off frequency was obtained in a shorter sensor head length. Moreover, it was observed that the sensor head length dependence of the frequency response was maximized in a frequency range from 1000 to 2400 Hz and faded away beyond 2400 Hz. From the measurement results, it is concluded that the short sensor head can provide higher normalized sensitivity, i.e., better signal to noise ratio, at frequencies higher than the resonance frequency, let alone convenience of installation and in sensitiveness to external perturbations in a PDL-based PM-PCF vibration sensor. The phase shift per unit strain and the minimum detectable strain perturbation, regarded as sensitivity and resolution, were measured as similar to 0.377 mrad/mu epsilon and similar to 0.16 n epsilon/Hz(1/2) at 2000 Hz for similar to 6-cm-long PM-PCF, respectively.</P>
Yun-Hyeok Choi,Jung Ho Choi,Hee-Jung Yoo,Ill Chan Noh,Jeong-Min Lee,Jae Won Park,최완수 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.5
The inhibition of Interleukin-1beta (IL-1β) is of substantial interest for the treatment of rheumatoid arthritis. Using an in vitro assay with RAW 264.7 cells, oxo-acetic acid 2-ethoxy-4-(3-hydroxy-2-oxopropyl) phenyl ester (1) was isolated from the roots of Paeonia suffruticosa Andrews as an inhibitor of IL-1β with an IC50 value of 56 μM. Compound 1 is a novel phenylesteric compound from P. suffruticosa Andrews. Compound 1 was shown to inhibit the production of pro-inflammatory cytokines in RAW 264.7 cells. Thus, a possible new action of novel compound is provided explaining the anti-rheumatoid arthritic properties of P. suffruticosa Andrews.
( Yun Hee Baek ),( Hyo-soon Cheon ),( Su-jin Park ),( Khristine Kaith S. Lloren ),( Su Jeong Ahn ),( Ju Hwan Jeong ),( Won-suk Choi ),( Min-ah Yu ),( Hyeok-il Kwon ),( Jin-jung Kwon ),( Eun-ha Kim ),( 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.11
Recently, human infections caused by severe fever with thrombocytopenia syndrome virus (SFTSV), which can lead to fatality, have dramatically increased in East Asia. With the unavailability of vaccines or antiviral drugs to prevent and/or treat SFTSV infection, early rapid diagnosis is critical for prevention and control of the disease. Here, we report the development of a simple, rapid and sensitive portable detection method for SFTSV infection applying reverse transcription-loop mediated isothermal amplification (RT-LAMP) combined with one-pot colorimetric visualization and electro-free reaction platform. This method utilizes a pocket warmer to facilitate diagnosis in a resource-limited setting. Specific primers were designed to target the highly-conserved region of L gene of SFTSV. The detection limit of the RT-LAMP assay was approximately 10<sup>0</sup> viral genome copies from three different SFTSV strains. This assay exhibited comparable sensitivity to qRT-PCR and 10-fold more sensitivity than conventional RT-PCR, with a rapid detection time of 30 to 60 minutes. The RT-LAMP assay using SFTSV clinical specimens has demonstrated a similar detection rate to qRT-PCR and a higher detection rate compared to conventional RT-PCR. Moreover, there was no observed cross-reactive amplification of other human infectious viruses including Japanese Encephalitis Virus (JEV), Dengue, Enterovirus, Zika, Influenza and Middle East Respiratory Syndrome Coronavirus (MERS-CoV). This highly sensitive, electro- and equipment-free rapid colorimetric visualization method is feasible for resource-limited SFTSV field diagnosis.
( Jeong Han Kim ),( Yun Jung Choi ),( Hee Won Moon ),( Soon Young Ko ),( Won Hyeok Choe ),( So Young Kwon ) 대한간학회 2013 Clinical and Molecular Hepatology(대한간학회지) Vol.19 No.4
Background/Aims: Quantification of the hepatitis B surface antigen (HBsAg) is increasingly used to determine the treatment response in patients with chronic hepatitis B (CHB). However, there are limited data about the clinical implications of Quantification of HBsAg long-term nucleoside analogue treatment for CHB. We investigated the clinical correlation between HBsAg level and clinical course in patients with CHB who are treated long-term with nucleoside analogues. Methods: Patients with CHB who started lamivudine or entecavir monotherapy before June 2007 were enrolled. HBsAg was quantified at baseline, at 6 months, and at 1, 2, 3, 4, and 5 years of treatment. We compared data between the groups according to the presence or absence of a virological response (VR) and resistance. Results: Forty-eight patients were analyzed. There was no definite reduction in HBsAg level during the early period of treatment; differences in HBsAg levels between baseline and each time point were significant only at 5 years (P=0.028). In a subgroup analysis, this difference was significant only in non-resistant patients at 5 years (P=0.041). Conclusions: There was no definite decrease in the HBsAg level during the early period of nucleoside analogue treatment, with long-term treatment being required to observe a significant reduction.