Poorer dynamic postural stability in patients with anterior cruciate ligament rupture combined with lateral meniscus tear than in those with medial meniscus tear

이진혁,Dae-Hee Lee,Jong-Hoon Park,Dong Won Suh,Eunseon Kim,장기모 대한슬관절학회 2020 대한슬관절학회지 Vol.32 No.-

Background: Only limited data are available regarding postural stability between anterior cruciate ligament (ACL)-injured patients with medial meniscus (MM) tear and those with lateral meniscus (LM) tear. The purpose of this study was to compare preoperative postural stability for both involved and uninvolved knees in ACL rupture combined with MM and LM tears. It was hypothesized that there would be a significant difference in postural stability between these two groups. Methods: Ninety-three ACL-injured patients (53 combined with MM tears vs. 40 combined with LM tears) were included. Static and dynamic postural stability were evaluated with the overall stability index (OSI), anterior–posterior stability index (APSI), and medial–lateral stability index (MLSI) using stabilometry. Knee muscle strength was evaluated using an isokinetic testing device. Results: In the static postural stability test, none of the stability indices showed significant differences between the two groups for both knees (p > 0.05). In the dynamic postural stability test for involved side knees, the OSI and APSI were significantly higher in the LM tear group compared to the MM tear group (OSI: 2.0 ± 0.8 vs. 1.6 ± 0.5, p = 0.001; APSI: 1.5 ± 0.6 vs. 1.3 ± 0.5, p = 0.023), but not the MLSI (p > 0.05). In the static and dynamic postural stability tests in each group, there were no significant differences between the involved and uninvolved side knees (p > 0.05). There was no significant difference in the knee muscle strength between the two groups (p > 0.05). All postural stability showed no significant correlation with knee muscle strength (p > 0.05). Conclusion: Dynamic postural stability was poorer in patients with ACL rupture combined with LM tear than in those with MM tear. Therefore, close monitoring for postural stability would be necessary during preoperative and postoperative rehabilitation, especially for patients with ACL rupture combined with LM tear.

Biological Effect of Metronidazole Resistance in Helicobacter Pylori

이진혁,이선미,남원희,김은실,김진호,강호영,정진용,Lee Gin Hyug,Lee Sun-Mi,Nam Won-Hee,Kim Eun Sil,Kim Jin Ho,Kang Ho Young,Jeong Jin-Yong Korean Society of Life Science 2005 생명과학회지 Vol.15 No.6

메트로니다졸은 인체 위장질환의 원인균인 헬리코박터 파일로리를 박별하기위해 처방하는 주요 약제이다 그러나 인체로부터 분리한 헬리코박터 파일로리 균주는 메트로니다졸에 내성을 가지는 경우가 일반적이며, 이러한 내성원인은 이 균주의 염색체 상에 존재하는 두 종류의 nitroreductase 유전자인 rdxA와frxA 유전자가 비활성화됨에 따라 유발된다. 본 연구에서는 헬리코박터 파일로리 균에서 rdxA 유전자에 변이를 도입하여 메트로니다졸에 내성을 가지는 균주를 구축하여, 메트로니다졸 내성이 균주에 미치는 생물학적 영향을 관찰하고자 하였다. In vitro상에서 메트로니다졸 내성균주는 대조균과 비교하여 exponential phase에서는 거의 차이 없이 증식하였으나 stationary phase에서는 빠르게 생육활성을 잃는 것을 관찰할 수 있었다. 또한 생쥐를 이용한 동물 실험에서 메트로니다졸 내성균주는 생쥐의 위장 내에서 서식하는 능력을 상실함을 알 수 있었다. 그러나 이러한 생육 활성을 회복시켜주는 compensate템 mutation을 가진 균주를 쉽게 얻을 수 있었으며 이 균주는 생쥐에 감염시키면 위장 내에서 서식하는 능력을 회복함을 알 수 있었다. Resistance to metronidazole, a key component of therapies against Helicobacter pylori, is common in clinical isolates. Resistance generally requires inactivation of rdxA (HP0954), and sometimes also frxA (HP0642), two related nitroreductase genes. Here we studied the effect of resistance to metronidazole on fitness of the gastric pathogen H. pylori. The effect of metronidazole resistance for H. pylori in culture was assessed first by looking at colonies formed by freshly constructed mutant derivatives of H. pylori strain 26695. Mutations resulting in metronidazole resistance caused premature death of H.pylori in stationary phase, but had no significant effect on early exponential growth. The effect of nitroreductase deficiencies on fitness in vivo was tested by infecting C57BL/6 mice with 1:1 mixtures of SS1 wild type and its isogenic metronidazole resistant derivatives. Inactivation of rdxA caused an inability to colonize mice in SS1 H. pylori strain. Derivatives of a metronidazole resistant strain that survived better in stationary phase, although remaining metronidazole resistant, could again colonize mice. In conclusion, metronidazole resistance diminishes H. pylori's fitness, but their costs can be suppressed by additional mutation.

한방병원에 내원한 악관절 환자 52명에 관한 임상적 고찰

이진혁,설무창,민관식,진은석,정해찬,Lee, Jin-Hyuk,Sul, Moo-Chang,Min, Kwan-Sik,Jin, Eun-Seok,Jeong, Hae-Chan 척추신경추나의학회 2009 척추신경추나의학회지 Vol.4 No.1

Objectives : The propose of this study is to analyze characteristics with sex, age, motivation, symptom, Impression, treatment effect about temporomandibular disorder patients. Method : We performed a retrospective study of 52 patients who visited the Jaseng Hospital of Oriental Medicine, from August 2008 to October 2008. Result : Women occupied the most part. And 27 persons in the 20th are the most distribution of age. The majority of patients occured the symptom for no reason. In the distribution of symptoms, TMD pain(88.46%), Click sound(82.69%), neck pain(52.92%), headache(38.46%), lumbago(21.15%) happened. In the impression through radiological diagnoses, The majority of patients diagnosed Straightening of cervical lordotic curvature. Oriental medical treatment showed a very valuable effect on improvement of TMD symptom. Conclusion : The results showed a valuable treatment effect of temporotandibular disorders on Oriental medical treatment. Therefore this work have the necessity of continuous study and observation and will help us to understand the features of patients who visiting the TMD clinic of Jaseng Hospital of Oriental medicine.

엑시머레이저 치료를 경험했던 백반증 환자가 한방복합치료와 엑시머레이저 병행치료로 호전된 치험 4례

이진혁,김세윤,Lee, Jin-Hyuk,Kim, Se-Yoon 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.3

Purpose: This study aims to prove effects of an oriental medical complex therapy on vitiligo patients who have experienced the Eximer laser therapy. Method: The study conducted its investigation targeting these four patients who have not been observed with any satisfactory reaction to the Eximer laser therapy. The study analyzed the findings through the comparison on the pictures before and after the therapy. Result: After comparing the pictures, the study confirmed positive changes in the conditions of the patients. The oriental medical complex therapy turned out to be effective enough to treat the patients who have gone through the Eximer laser therapy before. Conclusion: Such result leads the study to a conclusion that the oriental medical complex therapy can be an effective way to treat these patients who do not have a satisfactory reaction to the Eximer laser therapy. In addition, the author of the study suggests that more clinical trials should be conducted.

교량 성능 모델의 개발 및 업데이트

이진혁,이원우,공정식,Lee, Jin-Hyeok,Lee, Won-U,Gong, Jeong-Sik 한국전산구조공학회 2016 전산구조공학 Vol.29 No.1

평위산가미방으로 치료한 만성 특발성 두드러기 환자의 추적조사

이진혁,김세윤,김정현,Lee, Jin-Huk,Kim, Se-Yon,Kim, Jeong-Hun 대한한방안이비인후피부과학회 2016 한방안이비인후피부과학회지 Vol.29 No.1

Objective : The purpose of this study is to investigate the recurrence rate of Chronic Idiopathic Urticaria patients treated with Pyungweesangamibang through long-term follow-up survey.Methods : This tracing study was conducted for sixty-seven Chronic Idiopathic Urticaria patients who received and have finished treatment with Pyungweesangamibang at Woobo Korean Medicine Clinic in 2013 and 2014.Result : 81.4% of the patients, who had spent over 1 year since the finish of treatment with Pyungweesangamibang, did not relapse. In case of more than 2 years elapse, 66.7% of the patients did not suffer relapse.Conclusion : The result of tracing recurrence of the Chronic Idiopathic Urticaria patients treated with Pyungweesangamibang describes that the Korean medical treatment (Pyungweesangamibang prescription) shows lower recurrence rate than other general treatment shows.

요추 추간판 탈출증 수술 실패 증후군 환자에 대한 보존적 치료 치험 3례

이진혁,민관식,김수영,김상주,Lee, Jin-Hyuk,Min, Kwan-Sik,Kim, Su-Young,Kim, Sang-Joo 척추신경추나의학회 2010 척추신경추나의학회지 Vol.5 No.2

Objectives : The propose of this study is to find out the clinical application of conservative treatment for Failed Back Surgery Syndrome(FBSS) patients. Methods : We examined 3 patients with Failed Back Surgery Syndrome(FBSS) who visited Jaseng Hospital of Oriental Medicine. We used Acupuncture, Bee venom, CHUNA manual therapy, Herbal medication for this patient. And we measured of NRS score to evaluate the conservative treatment effects. Results : In this study, patients sciatica and symptoms has improved. NRS score were also decreased. Conclusions : Conservative oriental medical treatment can be effective for improving symptoms of Failed Back Surgery Syndrome.

국내 도심지 매설가스배관의 지진취약도 분석 연계 GIS 정보 가시화 기술

이진혁,차경화,송상근,공정식,Lee, Jinhyuk,Cha, Kyunghwa,Song, Sangguen,Kong, Jung Sik 한국전산구조공학회 2015 한국전산구조공학회논문집 Vol.28 No.2

도시기반 라이프라인은 지진발생시 시설물의 붕괴뿐만 아니라 붕괴로 인한 도시기능 마비, 대형화재와 같은 2차 피해를 동반하여 막대한 사회 경제적 손실을 야기할 것으로 예측된다. 이에 대한 대비책으로 국내에서는 지진재해대응시스템을 운영 중이며, 지진재해대응시스템은 각 시설물별 지진취약도 모델을 통해서 시설물의 파괴확률을 산정하고, 지진재해 정도를 평가한다. 따라서 본 논문에서는 국내 지반특성을 고려하여 도시기반 라이프라인 시설물 중 매설가스배관의 시간이력 해석을 수행하였고, 확률론적인 해석방법인 최우도추정법을 이용하여 지진취약도 모델을 개발하였다. 해석모델은 국내 대표도시인 서울지역에 매설된 고압관과 중압관으로 선정하였으며, 지반의 모델링은 Winkler foundation 모델을 이용하였다. 또한 개발된 취약도 모델의 GIS 적용방안을 제시하였다. City-based Lifeline is expected to cause significant social and economic loss accompanied the secondary damage such as paralysis of urban functions and a large fire as well as the collapse caused by earthquake. Earthquake Disaster Response System of Korea is being operated with preparation, calculates the probability of failure of the facility through Seismic Fragility Model and evaluates the degree of earthquake disaster. In this paper, the time history analysis of buried gas pipeline in city-based lifeline was performed with consideration for ground characteristics and also seismic fragility model was developed by maximum likelihood estimation method. Analysis model was selected as the high-pressure pipe and the normal-pressure pipe buried in the city of Seoul, Korea's representative, modeling of soil was used for Winkler foundation model. Also, method to apply developed fragility model at GIS is presented.

Silicon Wafer 의 Hydrogen Plasma Dry Cleaning 시 수소 원자 재결합 반응

이진혁,김영채 ( Jean Hyouc Lee,Young Chai Kim ) 한국화학공학회 1996 화학공학의이론과응용 Vol.2 No.1

남성 입원환자들의 맥파속도에 따른 요통 호전도의 비교 연구

이진혁,설무창,민관식,이한,정호석,Lee, Jin-Hyuk,Sui, Mu-Chang,Min, Kwan-Sik,Lee, Han,Jeong, Ho-Seok 척추신경추나의학회 2009 척추신경추나의학회지 Vol.4 No.2

Objectives : The aim of this study is to compare the improvement of Low back pain (LBP) depending on male Inpatient's Brachlalankle Pulse Wave Velocity (baPWV), Method : We evaluated 35 LBP inpatients who took pulse wave velocity test during admission at Jaseng hospital from November 2008 to september 2009. We used applanation tonometry method to measure pulse wave velocity and numerical rating scale to measure patient's improvement. Result : At admission, standard deviation of normal group's NRS was $7.44{\pm}1.67$ and high risk group's was $7.57{\pm}2.09$(P=0.678). After 5 days of admission, standard deviation of normal group's NRS was $5.67{\pm}1.94$ and high risk group's was $6.00{\pm}2.17$(P=0.680). After 10 days of admission, standard deviation of normal group's NRS was $4.00{\pm}1.80$ and high risk group's was $4.95{\pm}1.96$(P=0.281). After 15 days of admission, standard deviation of normal group's NRS was $2.89{\pm}1.62$ and high risk group's was $4.10{\pm}1.92$(P=0.124). At discharge, standard deviation of normal group's NRS was $5.11{\pm}1.69$ and high risk group's was $4.86{\pm}2.08$(P=0.504). Comparison between admission and discharge, standard deviation of normal group's NRS was $5.11{\pm}1.69$ and high risk group's was $4.86{\pm}2.08$(P=0.504) Conclusion : Low back patients with high Brachialankle Pulse Wave Velocity, showed slower improvement rate compare to patients within normal rate. But statically, had no significance.