소음인(少陰人) 태음병(太陰病) 심하비증(心下?證)의 병증약리(病證藥理) 고찰

서영광,이지원,이준희,최원철,이의주,고병희,Seo, Young-Kwang,Lee, Ji-Won,Lee, Jun-Hee,Choi, Won-Cheol,Lee, Eui-Ju,Kho, Byung-Hee 사상체질의학회 2010 사상체질의학회지 Vol.22 No.3

1. Objective: Gastric Stuffiness (心下?證) in the Soeumin Taeeum symptomatology (少陰人 太陰病) in Sasang Constitutional Medicine shows an interesting evolutionary process. Originally found in the texts of Sanghanlun (傷寒論), the perspectives regarding the symptoms of Gastric Stuffiness were expanded by many medical scholars and Lee Jema. To comprehend the Jema's concept of Taeeum symptomatology and utilize his prescription clinically, it deserves to study on the Gastric Stuffiness in Donguisuseowon (東醫壽世保元). 2. Methods: Many texts including Sanghanlun (傷寒論) and Dongeuibogam (東醫寶鑑) were reviewed in order to track the evolutionary process concerning the symptoms of Gastric Stuffiness. Also, Lee Jema's works including the different versions of Donguisuseowon (東醫壽世保元) were reviewed to examine the development of Lee's concepts regarding the Gastric Stuffiness in the Soeumin Taeeum symptomatology. 3. Results and Conclusions: 1) Most of the previous concepts on Gastric Stuffiness were generally similar to those found in Sanghanlun, especially in that they addressed Yang deficiency of the middle triple energizeer as the central pathogenic process. 2) Lee Jema's views on the epigastric discomfort in the Soeumin Taeeum symptomatology evoloved over time and culminated in the finalized pathology and therapeutics appearing in his last work, the Shinchuk version of Donguisuseowon (東醫壽世保元). 3) 4 kinds of prescription which invented by Lee Jema to treat the Gastric Stuffiness in the Soeumin Taeeum symptomatology can be matched to the prescription of Sanghanlun respectively. However through evolutionary process of Jema's prescriptions, the indication of them expanded: not only to treat Gastric Stuffiness but to diverse symptoms of Soeumin.

'태음인(太陰人) 체열(體熱) 복만(服滿) 자리자(自利者)'를 치료(治療)한 증례(證例)

이준희,김상복,박계수,정용재,이수경,이의주,고병희,송일병,Lee, Jun-hee,Kim, Sang-bok,Park, Gae-soo,Jung, Yong-jae,Lee, Su-kyung,Lee, Eui-ju,Koh, Byung-hee,Song, Il-byung 사상체질의학회 2001 사상체질의학회지 Vol.13 No.3

This case is about 68-year-old woman patient, who suffered from 'fever of unknown origin, abdominal distension and diarrhea'. She was diagnosed as Taeumin and diarrhea as that of 'The Interior Disease of Taeumin'. So she was given Galgeunhaegitang and had gotten better in her symptoms.

동무(東武)와 노사(蘆沙)의 사상적(思想的) 연계 가능성에 대한 고찰 -이기(理氣)관계를 중심으로-

이준희,고병희,이의주,Lee, Jun-Hee,Koh, Byung-Hee,Lee, Eui-Ju 사상체질의학회 2011 사상체질의학회지 Vol.23 No.1

1. Objectives: This study reviews the general theory on Li-Qi (理-氣) found in Dongmu Lee Jema (東武 李濟馬) and Nosa Gi Jeongjin (蘆沙 奇正鎭)'s works and explores the associations between their philosophical systems. 2. Methods: The main ideas on Predisposition (氣稟論) found in Dongmu's works were explored in connection with the Li-Qi (理-氣) theory and compared with the perspectives suggested by Nosa. 3. Results and Conclusions 1) Nosa criticized the "weakened supervision of Li (理)" and the "separation of Li (理) and Qi (氣)", proposing that this problem can be overcome through "mutual embracement of Li and its manifestations (理分圓融 理分相涵)". 2) When Dongmu's theory on Predisposition (氣稟論) is interpreted in terms of Li-Qi (理-氣), the Seong-Li (laws governing the organ scheme) (性理(臟理)) represents the Li (理) while the formational variations in organ scheme(臟局短長) and and the level of self-cultivation (心地淸濁) represents the Qi (氣). 3) The concept of "Diversification of Li (理之異)", bearing similarities to Nosa's Li-Qi (理-氣) theory, was introduced for the first time in Dongmu's theory on Predisposition (氣稟論), which presumably built the fundamental theories in the Sasang Constitutional Typology. 4) Within Dongmu's theory of Predisposition (氣稟論) can be found a dichotomous division of "similitude between the morally unaccomplished and the morally accomplished" in the ontological plane and "dissimilitude between the morally unaccomplished and the morally accomplished" in the axiological plane; this dichotomy is more extensive and developed compared to Nosa's attempt to find a consistent logic in both the ontological and axiological plane through a Li-Qi (理-氣) structure with Li-predominance.

이온교환반응에 의한 양성자 고체 전해질 NH₄⁺-β"-alumina의 제조

이준희,한춘수,이성태,이기문,이대한,임성기,Lee, Jun-Hee,Han, Choon-Soo,Lee, Sung-Tae,Lee, Ki-Moon,Lee, Dae-Han,Lim, Sung-Ki 한국공업화학회 2011 공업화학 Vol.22 No.3

$K^{+}-{\beta}^{{\prime}{\prime}}$-alumina pellet를 이온교환 매체인 ammonium nitrate 수용액과 용융염으로 각각 이온교환하여, 고온형 PEMFC 전해질로 기대되는 무기소재인 $NH_4{^+}-{\beta}^{{\prime}{\prime}}$-alumina를 제조하였다. 고압반응기의 실험조건으로 온도는 130, 150, 170, $200^{\circ}C$ 에서, 시간은 2 h 간격으로 2 h에서 8 h까지 수열반응을 실시하였으며 이 때의 수용액의 농도는 5 M과 10 M을 사용하였다. 또한 $200^{\circ}C$의 가열기 위에서 ammonium nitrate를 완전히 녹여 용융염 상태의 ammonium nitrate를 이용하여 2 h 간격으로 2 h에서 8 h까지 이온교환을 실시하였다. 이온교환반응의 반복횟수에 따른 영향을 알아보기 위하여 재이온교환반응을 3차까지 반복해서 실험하였다. 이후 이온교환 된 $NH_4{^+}-{\beta}^{{\prime}{\prime}}$-alumina 구조체의 상 안정성, 이온교환율을 각각 X선 회절기(Rigaku Rint 2000, Japan)와 ICP-AES (Spectro, Modular EOP)를 사용하여 분석하였다. $NH_4{^+}-{\beta}^{{\prime}{\prime}}$-alumina which is expected to an inorganic solid electrolyte of high temperature polymer electrolyte membrane fuel cells (PEMFC) was prepared by ion-exchange reaction of $K^{+}-{\beta}^{{\prime}{\prime}}$-alumina pellet with $NH_4NO_3$ aqueous solution and molten $NH_4NO_3$ salts as an ion-exchange medium in the autoclave and the heating mentle reaction. In the autoclave reaction, the concentrations of $NH_4NO_3$ solution was chosen at 5 and 10 M. Each ion-exchange reaction was carried out at 130, 150, 170, and $200^{\circ}C$ for 2, 4, 6 and 8 h. In the heating mentle reaction, ion-exchange was performed at $200^{\circ}C$ for 2, 4, 6 and 8 h with molten $NH_4NO_3$ salts. In order to determine the effect of reaction times, each ion-exchange reaction was repeated 3 times. The phase stability and the ion-exchange rate of $NH_4{^+}-{\beta}^{{\prime}{\prime}}$-alumina were analyzed by XRD and ICP.

" 격치고(格致藁) . 유략(儒略)"에 관한 고찰(考察)

이준희,이수경,이의주,고병희,송일병,Lee, Jun-Hee,Lee, Soo-Kyung,Lee, Eui-Ju,Koh, Byung-Hee,Song, Il-Byung 사상체질의학회 2005 사상체질의학회지 Vol.17 No.2

1. Objectives This study is purposed to find Lee Je-Ma's thoughts and intention proposed in the ${\ulcorner}$Gyukchigo격치고(格致藁) . 유략(儒略)${\lrcorner}$2. Methods It was researched through comparative and overall study on ${\ulcorner}$Gyukchigo격치고(格致藁) . 유략(儒略)${\lrcorner}$ 3. Results and Conclusions (1) On the assumption of Affairs. Mind. Body' Objects 사심신물(事心身物 ) as the principle of existence and correlation, there are basic dualistic structure such as 'Il(一)' (individual level) and 'Man만(萬)' (universal level) for explanation of ${\ulcorner}$Gyukchigo격치고(格致藁) . 유략(儒略)${\lrcorner}$ (2) Human who easily have individual inclination of mind(private . dissoluteness' idleness' desire) and wickedness (stinginess. extravagance' idleness' fraud) are the being making invidual ethics of behavior by earnestness' intelligence. capability . diligence성혜능동(誠慧能動) and universal ethics by Wisdom' Propriety. Justice. Humanity 지례의인(智禮義仁) through devotion' right . practice' concentration of mind' heart . body . power. (3) Human in the world having individual immanent psychological four element의려담지(意慮擔志) and universal exptessinal 외 four element청시언모(聽視言貌) are under a bias toward wickedness because of inclination of mind. So extending of individual ethics of behavior and completion of universal ethics are essential and indispensable (4) The final aim of human being in the universe is bringing universal ethics of behavior(Wisdom . Propriety' Justice. Humanity청시언모(智禮義仁) to perfection. (5) Devotion right practice concentration성정수일(誠正修一) of mind heart body power의심신력(意心身力) are developmental notions of earn emestness intelligence capability diligence성혜능동(誠慧能動), essential individual for living in the world, and preceding element for moral edification, social behavior and administration of the state.

이온빔 보조 증착법을 이용한 STS 316L 박막 합성에 관한 연구

이준희,송요승,이건환,이구현,이득용,윤종구,Lee, J.H.,Song, Y.S.,Lee, K.H.,Lee, K.H.,Lee, D.Y.,Yoon, J.K. 한국재료학회 2003 한국재료학회지 Vol.13 No.9

The thin films of 316L stainless steel were made on glass and S45C substrate by Ion beam assisted deposition with reactive atmosphere of argon and nitrogen. The films were deposited at the various conditions of ion beam power and the ratios of Ar/$N_2$gas. Properties of these films were analyzed by glancing x-ray diffraction method(GXRD), AES, potentiodynamic test, and salt spray test. The results of GXRD showed that austenite phase could be appeared by $N_2$ion beam treatment and the amount of austenite phase increased with the amount of nitrogen gas. The films without plasma ion source treatment had the weak diffraction peak of ferrite phase. But under the Ar plasma ion beam treatment, the strong diffraction peaks of ferrite phase were appeared and the grain size was increased from 12 to 16 nm. Potentiodynamic polarization test and salt spray test indicated that the corrosion properties of the STS 316L films with nitrogen ion source treatment were better than bulk STS 316L steel and STS 316L films with Ar ion source treatment.

동무(東武)의 "대학(大學)" 팔조목(八條目)에 대한 견해 고찰(考察)

이준희,이의주,송일병,고병희,Lee, Jun-Hee,Lee, Eui-Ju,Song, Il-Byung,Koh, Byung-Hee 사상체질의학회 2008 사상체질의학회지 Vol.20 No.3

1. Objectives This study was purposed to find Dong's thoughts about the eight items of the "The Great Learning(Ta hsueh)" 2. Methods It was researched through comparative and overall study on the Dong-mu's thoughts in "Gyukchigo(格致藁)" 3. Results (1) Dongmu reinterpreted the eight items of the "The Great Learning(Ta hsueh)" as the relations between the subject and the object from the ontologic assumption of Affairs Mind Body Objects as the principle of existence and correlation, summarized into four categories, and classified into the individual and subjective affairs, and the universal and objective affairs. The four categories of the eight items of the "The Great Learning(Ta hsueh)" are correlated with the individual and the universal ethics of behavior, and connected with the element for overcoming the individual inclination of mind and wickedness. (2) After the individual and subjective human was established, the eight items of the "The Great Learning(Ta hsueh)" were classified into two categories, and coupled up with each two items('Being sincere in their thoughts' with 'Extending to the utmost their knowledge', 'Rectifying their hearts' with 'Investigating things', 'Cultivating their persons' with 'Illustrating illustrious virtue throughout the kingdom', 'Regulating their families' with 'Ordering their own states'). Being based on this, 'Being sincere in their thoughts', 'Rectifying their hearts', 'Cultivating their persons' and 'Regulating their families' were understood as four individual and subjective human-basic-essential activity. Especially, mind, heart, body and family(power) were regarded as the four basic element in human existence and activity, and in correlation with universe and society, set up as the subjective element in Dongmu's epistemology, theory of nature and emotion, theory of morality and theory of moral cultivation.

Sensor-based Technology for Assessing Drought Stress in Two Warm-Season Turfgrasses

이준희,허재호,Lee, Joon-Hee,Trenholm, Laurie E.,Unruh, J. Bryan,Hur, Jae-Ho Turfgrass Society of Korea 2006 한국잔디학회지 Vol.20 No.2

본 연구는 토양 수분함량을 즉시 파악할 수 있는 Time Domain Radiometer(TDR)과 식물의 광합성 시 잎에서 반사되는 Reflectance를 통하여 식물의 상태를 파악할 수 있는 Multi-spectral radiometer(MSR)를 사용하여 난지형 잔디인 'Sea Isle 1' Seashore paspalum 과 'Floratam' St. Augustinegrass를 대상으로 토양수분함량과 Reflectance와의 상관관계를 파악하고자 시작하였다. 본 연구를 통해 토양 수분함량이 660, 694 wavelengths와 NDVI, LAI, stress index에서 높은 상관관계를 가지고 있음을 알 수 있었다. 이는 Sensor-based technology가 잔디의 수분요구 시점을 미리 파악할 수 있는 기술의 기초 자료로서 활용될 수 있으며 여러 다른 Sensor-based technology를 이용한 연구로 확대될 수 있을 것이다. This study was designed to determine what sensor-based technologies might reliably and accurately predict irrigation scheduling needs of warm-season turfgrass. 'Floratam' St. Augustinegrass[Stenotaphrum secundatum(Walt.) Kuntze] and 'Sea Isle I' seashore paspalum(Paspalum vaginatum Swartz) were established in tubs in the Envirotron Turfgrass Research Laboratory in Gainesville, FL in the spring of 2002. Each grass was subjected to repeated dry-down cycles where irrigation was withheld. Sensor-based data were collected and these evaluations were used to determine if irrigation scheduling could be determined based on plant response during dry-down. Results indicated that reflectance indices($P{\le}0.001$) and soil moisture($P{\le}0.0001$) throughout the dry-down cycle can predict the need for irrigation scheduling as turf quality declined below acceptable levels.

체질성정요법의 이론적 근거에 대한 고찰

이준희,Lee, Jun-Hee 사상체질의학회 2022 사상체질의학회지 Vol.34 No.3

Objective The Constitutional Seong-Jeong therapy is one of the important ways to prevent Sasang constitutional symptomatology. But, there are various interpretations and unclear aspects of the content and meaning, so there are many difficulties in applying it concretely in actual clinical practice. The purpose of this study is to clarify the physiology, pathology, treatment mechanism and its specific meaning. Method The pathology associated with constitutional symptomatology is known as Deepening-Seong and Exploding-Jeong. Therefore, related pathologies and corresponding treatment and prevention mechanisms were reviewed, focusing on the related contents of Donguisusebowon, and their specific meanings were considered. Results and Conclusions 1. Constitutional Seong-Jeong therapy is a regimen to prevent and manage Deepening-Seong and Exploding-Jeong. 2. Deepening-Seong and Exploding-Jeong are the inappropriate occurrences of Seong and Jeong in the poor area of the Heavenly-frame recognition and in the vulnerable area of Humanly-activity practice, and the antecedent cause is covetous desire. 3. Deepening-Seong and Exploding-Jeong cause the weakening in the power of ears-eyes-nose-mouth to perceive Heavenly frame and the power of lung-spleen-liver-kidney to practice Humanly activity in the four constitution's weak system, which lead to the Interruption in processing of four Qi in each weak system. 4. The four constitutions must be careful about the occurrence of covetous desire in the process of recognizing Heavenly frame and doing Humanly activity so that intellectual and behavioral abilities can be exerted to overcome the poor area of the recognition of Heavenly frame and the formation of Humanly activity to prevent deepening-Seong and exploding-Jeong from occurring.

Minority report; Pseudomonas aeruginosa의 정족수 인식(쿼럼 센싱) 신호물질로써의 Diketopiperazines과 Pyocyanin

이준희,Lee, Joon-Hee 한국미생물학회 2008 미생물학회지 Vol.44 No.2

Pseudomonas aeruginosa는 기회 감염성 병원균으로, Cystic fibrosis, 미생물 감염성 각막염,화상 부위 2차 감염 등의 다양한 질병을 초래한다. 정족수 인식(쿼럼 센싱)이라고도 알려져 있는 세포간 신호전달 기전이 이러한 감염에서 중요한 역할을 하기 때문에 P. aeruginosa의 정족수 인식 시스템들이 집중적으로 연구되어 왔다. P. aeruginosa의 정족수 인식 시스템들을 소개하는 많은 문헌들이 주로 두 개의 주요 acyl-homoserine lactone (AHL) 계열 정족수 신호물질들인 N-3-oxododecanoyl homoserine lactone (3OC12)과 N-butanoyl homoserine lactone (C4)에 초점을 맞추어 설명하고 있지만, 실제로는 몇 가지 새로운 신호물질들이 발견되어져 왔고, 그들이 P. aeruginosa의 병독성과 신호전달에 중요한 역할을 할 수 있음이 제안되어져 왔다. 그 중 하나가 PQS(Pseudomonas quinolone signal; 2-heptyl-3-hydroxy-4-quinolone)인데, 이 물질은 현재 P. aeruginosa의 잘 규명된 주요 신호물질로 인식되고 있다. 이에 더하여, 최근의 연구들은 또 다른 가능성 있는 P. aeruginosa신호물질들을 제안해 왔는데, diketopiperazines (DKPs)과 pyocyanin이 그들이다. DKPs는 환형 dipeptide로써 이를 구성하는 아미노산의 종류에 따라 다양한 구조를 가진다. P. aeruginosa의 배양액에서 검출된 몇몇 DKPs들이 기존에는 AHL에만 특이적으로 반응한다고 알려졌던 Vibrio 랸?N갸 LuxR biosensor를 활성화 시킬 수 있다는 것이 발견되어 새로운 신호물질로 제안되었다. Pyocyanin (1-hydroxy-5-methyl-phenazine)은 P. aeruginosa가 생산하는 여러 phenazine 화합물들 중의 하나로써, 특징적인 청록색을 띄는 산화-환원 활성물질이다. 이 물질도 정체 성장기 동안 일부 정족수 인식의 조절을 받는 유전자들의 발현을 증가시키는 최종 신호 인자로 최근 제안되었으며, 그 신호는 또 다른 전사 조절 인자인 SoxR에 의해 매개된다고 제안되었다. 본 논문에서는 P. aeruginosa에서 새롭게 발견, 제안되고 있는 이들 신호 전달 물질들에 대해 자세히 다루어 보기로 한다. Pseudomonas aeruginosa is an opportunistic human pathogen, causing a wide variety of infections including cystic fibrosis, microbial keratitis, and burn wound infections. The cell-to-cell signaling mechanism known as quorum sensing (QS) plays a key role in these infections and the QS systems of P. aeruginosa have been most intensively studied. While many literatures that introduce the QS systems of P. aeruginosa have mostly focused on two major acyl-homo serine lactone (acyl-HSL) QS signals, N-3-oxododecanoyl homoserine lactone (3OC12) and N-butanoyl homoserine lactone (C4), several new signal molecules have been discovered and suggested for their significant roles in signaling and virulence of P. aeruginosa. One of them is PQS (Pseudomonas quinolone signal; 2-heptyl-3-hydroxy-4-quinolone), which is now considered as a well-characterized major signal meolecule of P. aeruginosa. In addition, recent researches have also suggested some more putative signal molecules of P. aeruginosa, which are diketopiperazines (DKPs) and pyocyanin. DKPs are cyclic dipeptides and structurally diverse depending on what amino acids are involved in composition. Some DKPs from the culture supernatant of P. aeruginosa are suggested as new diffusible signal molecules, based on their ability to activate Vibrio fischeri LuxR biosensors that are previously considered specific for acyl-HSLs. Pyocyanin (1-hydroxy-5-methyl-phenazine), one of phenazine derivatives produced by P. aeruginosa is a characteristic blue-green pigment and redox-active compound. This has been recently suggested as a terminal signaling factor to upregulate some QS-controlled genes during stationary phase under the mediation of a transcription factor, SoxR. Here, details about these newly emerging signaling molecules of P. aeruginosa are discussed.