국내 개발된 $N-tox^{(R)}$ 생물검정 시스템을 이용한 시안과 3, 5-이염화페놀의 발광박테리아(Vibrio fischeri)에 대한 혼합 독성 영향 연구

이정석,이규태,김찬국,김혜진,이창훈,이종현,Lee, Jung-Suk,Lee, Kyu-Tae,Kim, Chan-Kook,Kim, Hye-Jin,Lee, Chang-Hoon,Lee, Jong-Hyeon 환경독성보건학회 2007 환경독성보건학회지 Vol.22 No.1

Cyanides and dichlorophenols were important pollutants in industrial effluents of steel, petroleum, plastics, pesticides, synthetic dye and/or fiber manufacturing. The toxic effects of cyanide and 3, 5-dichlorophenol in the unary and binary solutions to Vibrio fischeri were determined using the newly developed $N-tox^{(R)}$ bioassay system. This bioassay system relies upon the attenuation of light intensity emitted by Vibrio fischeri exposed to various pollutants including metals and organic compounds. Most of studies dealing with toxicity of pollutants concerned single chemical species, while the organisms were typically exposed to pollutant mixtures. The present study showed that the toxicity of some binary combinations of cyanide and 3, 5-dichlorophenol significantly was lower than the predicted toxicity from the addicted model. This antagonistic interaction was well explained by chemical interaction model presented in this study.

한.양약 복용이 간기능에 미치는 영향-피부과치료 한약복용 환자를 중심으로-

이정석,이선동,Lee Jung-Seok,Lee Sun-Dong 대한예방한의학회 2004 대한예방한의학회지 Vol.8 No.1

We have conducted questionnaire and measured serum liver function tests on 153 patients whom have received a treatment at a local Oriental medicine clinic in Seoul from Sept. 1, 2002 to Dec. 31, 2002. Patients were categorized into the groups of control(10), decoction group(41), herbal group(5), western medicine group(45), and the group taking both herbal and western medicines(55) concurrently or separately. This study was conducted to investigate how these treatment methods can affect the liver functions. Following results were obtained : 1) Most of the research subjects were male(l03 individuals) living in large urban area, with drinking habit, highly educated, and with normal marriage. For the treatment history, 45 individuals received western medicine treatment(28.85%), 46 with Oriental medicine (29.49%), and 55 patients(35.26%) experienced both forms of treatment. 2) Measuring SD of serum liver functions for all the research subjects, T-protein was 6.95(0.73)g/dl, 4.07(0.51)g/dl for albumin, 0.44(0.19)mg/dl for T-bilirubin, 23.18(18.68)U/L for ALT, 27.42(27.43)U/L for AST, and 22l.27(64.58)mg/dl for LDH. 3) Among the research subjects with the liver functions outside of normal range were 0.64% for T-protein, 3.21% for T-bilirubin and ALT, 36.62% for AST, 0.64% for LDH, and none for Albumin. 4) Confusion variables which may affect the liver functions such as age, smoking, drinking, occupation, and residence were eliminated in calculation and no significant differences were witnessed between the control and experiment groups. 5) In measuring affects of treatment duration on the liver functions, no statistical significances were shown in multiple regression's ,${\beta}$(SE) values. 6) The values of odd ratio in the experiment groups compared to the control were in the range of $0.26(0.22){\sim}0.62(1.23)$. but T-bilirubin of the group receiving both Oriental and western medicine was 1.47(1.90) which showed statistical increase(p<0.001). 7) Factors affecting the liver functions are drinking volume per round duration of alcohol intake, western medicine treatment, gender, and age difference caused significant influences. 8) 57 individuals with serum liver functions out of normal range were mostly male, living in large urban area, median age of 38.89, with normal marriage, highly educated drinking less than once a week with less than 2 bottles per round, and with prior treatment in either western or Oriental medicine. Summarizing above results, we can carefully deduce that taking herbal medicine (both decoction and pills) or western medicine doesn't cause much affect in the liver functions. But taking two forms of medication simultaneously or altering dosage affect significant increase in the T-bilirubin level, thus one needs to take precaution when taking both. Further research is needed in this field to verify this evidence.

수복치에 있어서의 2차우식증의 관리

이정석,Lee, Jeong-Seok 대한치과의사협회 1990 대한치과의사협회지 Vol.28 No.4

TOFD UT 기법을 활용한 원자로 상부헤드관통부 J-groove 용접부 결함 검출 가능성 평가

이정석,이태훈,김용식,Lee, Jeong Seok,Lee, Tae Hun,Kim, Yong Sik 한국압력기기공학회 2015 한국압력기기공학회 논문집 Vol.11 No.2

A failure or degradation of reactor upper head penetration is a troublesome problem at Nuclear Power Plants. A flaw in the reactor upper head penetration can result in unplanned plant shutdown for repair, and cause serious economic losses on the plants. Consequently, a detection of flaws is a matter of more importance. Until now, only the base metal, not including J-groove weld, in reactor upper head penetration has been inspected in accordance with 10 CFR 50.55a and ASME code case N-729-1 requirements. Accordingly, it is rather difficult to detect manufacturing defects and repair defects in J-groove weld. This paper presents a case study on the application of Time of Flight Diffraction UT technique to examine the J-groove weld in reactor head penetration using reactor head penetration mockup with artificial flaws. We expect that this study result will offer a way to understand the non-destructive examination technology for J-groove weld in reactor upper head penetration.

Co기 초합금 ECY768에서 응고 조직 및 탄화물 형성 거동

이정석,김현철,이재현,서성문,조창용,Lee, J.S.,Kim, H.C.,Lee, J.H.,Seo, S.M.,Jo, C.Y. 한국재료학회 2003 한국재료학회지 Vol.13 No.6

Directional solidification experiments were carried out at 0.5-150 $\mu\textrm{m}$/s in the Co-base superalloy ECY 768. As increasing solidification rate, the dendrite length increased and it reached the maximum at 150 $\mu\textrm{m}$/s, where the tip temperature is close to the liquidus. The liquidus and eutectic temperatures could be estimated by comparing the dendrite lengths and the temperature gradients at the solid/liquid interface and those were estimated as $1424.6^{\circ}C$ and $1343^{\circ}C$ respectively. Between the dendrites just below final freezing temperature, MC carbide and $M_{23}$$C_{6}$ carbide were found. It was confirmed that the script or blocky shape was Ta or W-rich MC carbide, and the lamellar shape was Cr-rich eutectic carbide. The solid/liquid interface morphology clearly showed that the Cr-rich eutectic carbide formed just after the script type MC carbide.

유가식 발효기에서 sucrose 를 기질로 사용하는 E . coli W 의 고농도 배양

이정석,이상엽,박선원 ( Jeong Seok Lee,Sang Yup Lee,Sun Won Park ) 한국화학공학회 1996 화학공학의이론과응용 Vol.2 No.2

사과락(絲瓜絡)이 Triton Wr 투여로 유발되는 고지혈증(高脂血證) 예방에 미치는 영향에 대한 실험적 연구

이정석,소경순,정찬길,Lee Jeong-Seok,Soh Kyung-Sun,Jeong Chan-Gil 대한예방한의학회 2002 대한예방한의학회지 Vol.6 No.2

In order to study the effect of Luffae fasciculus vascularis(絲瓜絡) on hyperlipidemia, experimental study was performed on Hyperlipidemia induced by Triton WR-1339. Also the level of Total cholesterol, Triglyceride, HDL-cholesterol, Phospholipid and LDL-cholesterol were measured. The results are summarized as follow: In the model of hyperlipidemia Rats induced by Triton WR-1339, luffae fasciculus vascularis(絲瓜絡) had significantly decreasing effects on total cholesterol, triglyceride, phospholipid, LDL-cholesterol in serum and increasing effects on HDL-cholesterol level in serum but were not significant. These results show that Luffae fasciculus vascularis(絲瓜絡) has significantly inhibitory effects on hyperlipidemia and that it could be clinically applied for hyperlipidemia.

발생영역별 리스크 위계에 따른 투자개발형 해외건설사업의 핵심 리스크 인자 도출 및 평가

이정석,안병주,김재준,Lee, Jeong-Seok,Ahn, Byung-Ju,Kim, Jae-Jun 한국건설관리학회 2012 한국건설관리학회 논문집 Vol.13 No.2

정부는 최근 장기적인 관점에서 해외건설사업의 시장 활성화와 수주 경쟁력 강화에 주력하고 있다. 또한 중동 지방의 플랜트 프로젝트에 집중되어 있는 해외건설시장의 다각화를 추진하기 위하여 투자개발형 사업을 확대하기로 하였다. 하지만 현재까지 투자개발형 사업에 대한 리스크 분석 사례는 미미한 실정이다. 이에 본 연구에서는 투자개발형 해외건설사업들에 대한 리스크 분석의 필요성을 제기하고자 한다. 본 연구의 목적은 해외 투자개발형 사업에 대해서 AHP 및 퍼지이론을 적용하여 핵심 리스크 인자를 도출하기 위한 한 가지 방법론을 제시하는 것이다. 본 연구의 결과로써, 총 37개의 최종 핵심 리스크 인자들이 선정되었고, 이것들에 대한 특성을 분석하였다. 향후 연구에서는 본 연구의 결과를 토대로 해외 투자개발형 사업을 위한 리스크 관리 모델을 제안하고, 이것의 타당성을 검증할 예정이다. The Korean Government recently has been focused on strengthening competitiveness of order and stimulating construction market in the international construction industry. It has planned to extend the ODPs (overseas development projects) in order to diversifying the international construction market of which is domestic construction companies, placing too much emphasis on plant projects of the Middle East. However, literature review of risk analysis in the ODPs shows that the number of case study is several. Therefore, Authors asserted the necessity of risk analysis in the ODPs. The purpose of this study is to suggest a methodology that find KRFs (key risk factors) in the ODPs and analyze them, using AHP and Fuzzy theory. As a result, the 37 KRFs are selected and explained characteristics of them. A future direction of this study is to suggest a risk management model in the ODPs and prove feasibility of it.

국내산 저서 단각류를 이용한 퇴적물 독성시험법 개발에 관한 연구

이정석,이승민,박경수,Lee, Jung-Suk,Lee, Seung-Min,Park, Gyung-Soo 한국해양학회 2008 바다 Vol.13 No.2

A series of experiments were conducted to find standard test organisms and to develop test protocols for sediment toxicity tests using indigenous amphipods inhabited in Korean coastal environments. The indigenous amphipods Mandibulophoxus mai and Monocorophium acherusicum were well associated with various sediment substrates from sand to mud. The tolerance limits to various physico-chemical factors affecting bioassay results such as temperature, salinity and total ammonium as well as the sensitivities to contaminants in water and sediments were investigated using M. mai and M. acherusicum in the present study. These amphipods were tolerable to the adequate ranges of salinity ($10{\sim}30\;psu$), temperature ($10{\sim}25^{\circ}C$) and ammonia (<50 ppm). They have relevant sensitivities to the reference toxicants, dissolved cadmium as well as other metals and organic pollutants, when compared to the standard test species used in other countries. Field-sediment toxicity tests revealed that M. mai would be more sensitive to sediment-associated pollutants than M. acherusicum, while the sensitivity of M. acherusicum was comparable to those of other sediment test species in other countries. Overall results of this first attempt to develop an amphipod sediment toxicity test protocol in Korea indicated that M. mai and M. acherusicum should be applicable in the toxicity assessment of contaminated sediments, following the further evaluation encompassing various ecological and toxicological evaluation and the standardization of test method. 본 논문은 저서 단각류를 이용한 해양생태독성시험법 개발을 위하여 국내에 분포하는 후보종을 이용하여 수행된 일련의 생태독성시험결과를 제시하고, 이에 근거하여 퇴적물 독성시험을 위한 표준 시험종과 방법을 제시하였다. 퇴적물 독성평가를 위한 시험종으로는 저서단각류인 Mandibulophoxus mai, Monocorophium acherusicum 그리고 여러 국내산 단각류를 이용하였다. 시험법 개발 및 표준화를 위한 시험항목으로는 퇴적물 입도, 수온, 염분 및 암모니아에 대한 내성범위를 파악하기 위한 실험과 카드뮴과 같은 중금속이나 PAHs와 같은 유기오염물질에 대한 민감도를 파악하기 위한 실험이 포함되었다. 시험 결과 두 종 모두 여러 환경요인에 대한 적합한 내성과 민감도를 갖고 있어 퇴적물 시험종으로서 활용이 가능한 것으로 나타났다. 최종적으로 이들 저서 단각류의 현장 적용성 평가를 위해서 다양한 오염도를 갖는 현장 퇴적물에서 10일간 노출한 이후 사망독성을 평가하고, 오염정도와 생물반응의 관계성 등을 분석하였다. 두 종을 비교한 결과, 민감도의 측면에서는 M. mai가, 시험생물 공급, 배양, 유지 및 실험수행의 편의성에서는 M. acherusicum이 상대적으로 뛰어난 것으로 나타났다. 하지만, 두 종 모두 10일간의 퇴적물 사망 독성시험의 시험종으로서 충분한 적합성을 갖고 있는 것으로 판단할 수 있다. 본 연구결과는 향후 단각류를 이용한 퇴적물 공정시험법의 작성에 활용될 수 있을 것으로 판단된다.

북한 토목 인프라의 안전성 및 기술수준 고찰

이정석,Lee, Jeong-Seok 한국건설관리학회 2016 한국건설관리학회 논문집 Vol.17 No.2