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이재철 한국유전학회 2018 Genes & Genomics Vol.40 No.1
Osteoarthritis (OA) is a degenerative joint disease characterized by abrasion, and ultimately, destruction of the articular cartilage and trabecular bone loss. OA is still considered a devastating disease, which requires an aggressive therapeutic approach. Despite the therapeutic potential of human adipose-derived mesenchymal stem cells (AD-MSCs), the molecular parameters needed to define the “stemness” remain largely unknown. Using high-density oligonucleotide microarrays, the differential gene expression profiles between a fraction of human adipose-derived (AD) mononuclear cells and its MSC subpopulation were obtained. Of particular interest was a subset of 58 genes preferentially expressed at sevenfold or higher in the group treated with human AD-MSCs. This subset contained numerous genes involved in the inflammatory response, immune response, lipid metabolism, cell death, cell proliferation, and DNA repair. Additionally, four protein networks were constructed. The interaction network consisted of 46 proteins encoded by up-regulated genes. However, the interaction network also consisted of 38 proteins encoded by down-regulated genes. My results provide a basis for a more reproducible and reliable quality control using genotypic analysis for the definition of human AD-MSCs. Therefore, these results will provide a basis for studies on molecular mechanisms controlling the core properties of human MSCs.
An optimal design of wind turbine and ship structure based on neuro-response surface method
이재철,신성철,김수영 대한조선학회 2015 International Journal of Naval Architecture and Oc Vol.7 No.4
The geometry of engineering systems affects their performances. For this reason, the shape of engineering systems needs to be optimized in the initial design stage. However, engineering system design problems consist of multi-objective optimization and the performance analysis using commercial code or numerical analysis is generally time-consuming. To solve these problems, many engineers perform the optimization using the approximation model (response surface). The Response Surface Method (RSM) is generally used to predict the system performance in engineering research field, but RSM presents some prediction errors for highly nonlinear systems. The major objective of this research is to establish an optimal design method for multi-objective problems and confirm its applicability. The proposed process is composed of three parts: definition of geometry, generation of response surface, and optimization process. To reduce the time for performance analysis and minimize the prediction errors, the approximation model is generated using the Backpropagation Artificial Neural Network (BPANN) which is considered as Neuro-Response Surface Method (NRSM). The optimization is done for the generated response surface by non-dominated sorting genetic algorithm-II (NSGA-II). Through case studies of marine system and ship structure (substructure of floating offshore wind turbine considering hydrodynamics performances and bulk carrier bottom stiffened panels considering structure performance), we have confirmed the applicability of the proposed method for multi-objective side constraint optimization problems.
Bulk Density Measurement of Porous Functionally Graded Materials
이재철,안성훈 한국정밀공학회 2018 International Journal of Precision Engineering and Vol.19 No.1
Pores generated in inside of a Nickel-Alumina FGM (functionally graded material) fabricated by pressureless sintering method because of unperfected sintering. These pores change the mechanical properties of the material. To predict accurately variations of the mechanical property, there is a need for accurate measurement of porosity. Conventional method of measuring the porosity measures the outer diameter of the cylindrical specimen and calculated bulk density using it. However, this method did not consider an internal deformation of the specimen, thus the accuracy of its method is lowered. To measure a more accurate bulk density of each layer of the porous FGM than the conventional method, a method using Individual specimen and a method using the Image Processing of MATLAB (IPM) were proposed. To confirm accuracy of the proposed method, the bulk density of the entire FGM calculated by the proposed method was compared with the bulk density of the entire FGM measured by Archimedes' principle. In the comparison results, the result of the method using the IPM was closer to the result of the method using Archimedes principle than the result of the method using the Individual specimen. Thus, this author concludes that the method using IPM is more suitable for measurement of the bulk density of each layer of the FGM than the method using the individual specimens.
이재철 한국수산학회 1983 한국수산과학회지 Vol.16 No.2
한국 남서해 연안에서 여름에 발달했던 성충이 겨울철에 접어들면서 파괴되어 수직적으로 균일한 수온분포를 갖게 되는데 이러한 변화가 11월에 가장 활발하게 일어나는 것으로 나타났다. 이 변절기에 차고 염분이 낮은 연안 수괴가 대마난류와 접한 경계에 전선이 거의 수직으로 발달하며, 대마난류의 세력이 약한 제주해협의 중앙부를 제외하고는 수심 70∼90m의 해역에서 수온전선과 염분전선의 위치는 일치하였다. 1980년 11월에 남해연안 중앙부에서 투하한 해류병이 주로 완도 근해에서 회수된 결과는 전선의 연안쪽에 있는 수괴가 서쪽으로 이동하는 남해연안반류의 존재를 뒷받침 해 주었다. Off the southwest coast of Korea, changes in hydrographic fields from stratified state of summer to a vertically homogeneous one of winter appeared to occur most actively in November. During this transitional period coincident thermal and salinity fronts are formed along the boundary between the two water masses of cold coastal water with low salinity and of the Tsushima Current Water. Generally frontal zone lies where the bottom depth is about 70-90m except for the central region of the Cheju Strait in which the influence of the Tsushima Current is weak. Result of the drift bottle experiment in November 1980 supports the existence of the westward coastal current.
시스템 엔지니어링을 위한 자동화 도구의 변천 및 사례 조사
이재철,김용연,임기욱,Lee, Jae-Cheol,Kim, Yong-Yeon,Im, Gi-Uk 한국전자통신연구원 1996 전자통신동향분석 Vol.11 No.3
본 고는 시스템 엔지니어링의 유래부터 현재까지의 변천 및 자동화 도구의 발전 과정을 소개하고, 그 사례를 조사 분석하였다. 시스템 엔지니어링의 발전에 대한 조사 연구는 미국을 대상으로 서술하였으며, 적용되었던 자동화 도구(시스템 엔지니어링 소프트웨어)의 사례 조사 연구와 병행하여 발전 동향을 분석하였다.