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비용에서 Protease-activated Receptor 2의 발현:면역조직화학적 연구
이승균,박용수,전은주,조진희,박용진,강준명,김명원 대한이비인후과학회 2005 대한이비인후과학회지 두경부외과학 Vol.48 No.4
Background and Objectives:Protease-activated receptor 2 (PAR-2) has been known to play an important role in modulatinghomeostasis and inflammation in the airways. But only a little is known about the localization of PAR-2 in nasal mucosa andrelationship between PAR-2 and nasal mucosal inflammation. In this study, we investigated the localization of PAR-2 in nasalpolyp and turbinate mucosa and examined the relationship between the PAR-2 expression and eosinophil infiltration. Materialsand Method:Nasal polyp tissues were obtained from 20 nasal polyposis patients and inferior turbinate tissues were taken from12 nasal septal deviation patients as control. PAR-2 expression was assessed by immunohistochemical staining. We comparedPAR-2 immunoreactivity between nasal polyp and turbinate mucosa. Infiltrated eosinophils were counted ands its correlationwith the intensity of PAR-2 immunoreactivity in nasal polyp was determined. Also, we evaluated the PAR-2 expression in thepresence of allergic rhinitis. Results:PAR-2 immunoreactivity was detected in the nasal mucosal epithelium, endothelial cells,vascular myocytes, submucosal glands, fibroblasts and inflammatory cells. PAR-2 expression was similar between nasal polypand turbinate mucosa, but inflammatory cells of nasal polyp showed stronger immunoreactivity than those of turbinate. Immunoreactivityin inflammatory cells showed correlation with eosinophil infiltration in nasal polyp. There were no differences inthe PAR-2 expression between allergic rhinitis patients and non-allergic rhinitis patients. Conclusion:Increased expression ofPAR-2 in inflammatory cells of nasal polyp and its correlation with eosinophil infiltration raise the possibility that PAR-2 mayplay a role in pathophysiology of nasal polyposis.
이승균 한국골프학회 2007 골프연구 Vol.1 No.1
The purpose of this study was to compare physical fitness, isokinetic test(knee) for Korean professional golfers according to tour and semi, and to provide the data for injury prevention, fitness level evaluation. The subjects selected for this study were twenty pro-golfers. They didn't have any medical problem. The result were drawn as follow: 1) In physical fitness, the power, strength and agility of tour pros were significantly higher than in semi pros(p<.05) and flexibility, muscular endurance, balance, cardiovascular endurance were not significant differences according to group; 2) In 60° /sec, left knee extensor peak torque(Nm), flexor peak torque(Nm) and right knee flexor peak torque of tour pros were significantly higher than semi pros(p<.05); 3) In 180° /sec, left knee extensor peak torque(Nm), flexor peak torque(Nm), and right knee extensor peak torque(Nm), flexor peak torque of tour pros were significantly higher than semi pros(p<.05).
이승균,백병준,오천환 대한기관식도과학회 1998 大韓氣管食道科學會誌 Vol.4 No.2
Benign salivary gland tumors have relatively lower incidence, but it have various histopathologic diagnosis and biological behavior. Authors analyzed retrospectively 77 patients with benign salivary gland tumor who were treated surgically and had the following results. The most frequent age group was 5th decade, and sex distribution was not specific. The most common location was parotid gland(75.3%) and submandibular gland(20.8%) was next. Histopathologically, the most common salivary gland tumor was pleomorphic adenoma(82.7%) and Warthin's tumor(8.6%) was next. An asymptomatic mass was the most common presentation. Duration of symptoms and signs were mostly under the 5years(90.9%). Diameter of tumors was mostly under 4cm(76.7%). Parotid gland tumors were treated mostly with superficial parotidectomy and submandibular gland tumors were treated mostly with submandibular gland resection. The most common complication was facial nerve palsy(9 cases).
발레전공자와 한국무용 전공자의 슬관절 등속성 근력 비교
이승균,이용진 한국체육과학회 2006 한국체육과학회지 Vol.15 No.2
The Purpose of this study was to compare and analyze the knee joint and isokinetic strengths such as peak torque, total work/BW, Peak torque/BW, set total work deficit Ballet Dancers and Traditional Korean Dancers. The subjects were divided into two group : 30 Baller Dancers(Group I) and 30 Traditional Korean Dancers(Group II) The results of this study were as follows: 1. Peak torque of group I were 104.91±24.04(Right Extension), 92.56±20.32(Left Extension), 52.81±(Right flexion), 48.26±9.18(Left Flexion) and that of group II were 103.93±17.28(Right Extension),104.57±22.29(Left Extension), 53.53±10.25(Right Flexion) 51.37±13.04(Left Flexion) at 60°/sec, Group I showed 62.47±17.22(Right Extension), 58.22±12.50 (Left Extension), 37.17±11.19(Right Flexion), 35.53± 8.36(Left Flexion), whereas Group II showed 69.03± 13.56(Right Extenson), 65.03±20.74(Left Extension), 47.03±19.08(Right Flexion), 37.10± 10.42 (Left Flexion).The extension peak torque between at 60°/sec, showed significant difference between Group I and Group II(p<.05) 2. Total work/BW of Group I were 246.65±59.08(Right Extension). 214.31±62.25(Left Extension), 137.93±32.05(Right Flexion), 129.13±34.12(Left Flexion) and that of Group II were 218.88±41.36(Right Extension). 210.68±41.36(Left Extension),134.55±28.99(Right Flextion), 131.84±26.54(Left Flexion) at 60/sec, At 60/sec, Group I showed 168.5±43.68(Right Extension), 146.8±34.41(Left Extension), 93.93±26.75(Right Flextion), 91.84±21833(Left Flexion). 1) 2) 세종대학교143-747 서울특별시 광진구 군자동 98번지1. 2. Sejong University98 Gunjadong Kwangjingu Seoul 143-747 Korea
편도적출술 후 투여한 Rofecoxib가 통증 및 출혈에 미치는 효과
이승균,황성재,박용수,김명원,김규백,조정해,전은주 대한이비인후과학회 2004 대한이비인후과학회지 두경부외과학 Vol.47 No.12
Background and Objectives:Nonsteroidal anti-inflammatory durgs (NSAIDs) are now widely accepted analgesics for posttonsillectomy patients, but their ability to inhibit platelet cyclooxygenase (COX) may be associated with a risk of increased bleeding after tonsillectomy. Rofecoxib, the recently introduced selective COX-2 inhibitor, may have advantages for analgesics in tonsillectomy in that they produce minimal effects on platelet aggregation. But the analgesic efficacy of rofecoxib in tonsillectomy has not been made known yet. The aim of our randomized prospective study was to compare the analgesic efficacy of rofecoxib, the selective COX-2 inhibitor, and ibuprofen, the classic NSAID, for the posttonsillectomy pain management. We also evaluated the influence of both drugs on the posttonsillectomy bleeding. Subjects and Method:Thirty-eight adult patients undergoing tonsillectomy were randomly divided into either ibuprofen or rofecoxib group. Patients received either oral ibuprofen (600 mg, three times a day) or oral rofecoxib (25 mg, twice a day). Patients recorded pain levels twice daily for 7 days using a visual analogue scale. Posttonsillectomy hemorrhage was recorded in each groups. Results:Pain scores for the 7 days were not significantly different between two groups, but the rofecoxib group reported less pain. Rofecoxib group felt more satisfactorily about early control of postoperative pain. There was no significant difference in the incidence of postoperative hemorrhage between two groups. Conclusion:Rofecoxib is as effective as ibuprofen for postoperative pain control in adult tonsillectomy, which might be beneficial for avoiding the adverse effects of NSAIDs.