정신분열병과 기분장애 환자의 언어적 기억능력과 기억과정의 특성에 대한 연구

이소연,이분희,이정애,김계현,김용구,박선화,Lee, So-Youn,Lee, Bun-Hee,Lee, Jung-Ae,Kim, Kye-Hyun,Kim, Yong-Ku,Park, Sun-Wha 대한생물정신의학회 2005 생물정신의학 Vol.12 No.2

Objectives:This study was to compare verbal memory ability among patients with schizophrenia, bipolar manic patients and unipolar depressive patients, and to understand their charicteristics of memory process. Methods:All subjects were hospitalized patients and had been interviewed by using the Structured Clinical Interview for DSM-IV(SCID). Schizophrenic patients(N=40), bipolar manic patients(N=17), and unipolar depressive patients(N=20) were assessed with K-AVLT for verbal memory and with K-WAIS for verbal IQ. Three groups were compared regarding total immediate recall, delayed recall, delayed recognition, learning curve, memory retention, and retrieval efficiency under controlled verbal IQ. Multiple regression analysis was performed to find which clinical factors have an influence on verbal memory ability. Results:In MANCOVA, differences of verbal memory test scores among the groups were statistically significant(F=1.800, p<.05). In post hoc analysis, Patients with schizophrenia and bipolar mania showed poorer performance in immediate recall, delayed recall, delayed recognition, retrieval efficiency than unipolar depres- sive patients. And schizophrenics performed poorly in delayed recall, delayed recognition, retrieval efficiency than nonpsychotic affective disorder group, but no difference in total immediate recall, delayed recall, delayed recognition, retrieval efficiency between the schizophrenic group and the psychotic affective group. Conclusions:These results partially confirm previous reports of verbal memory ability among major psychiatric disorders. Our results showed that psychotic symptoms were related with verbal memory, and longer duration of illness was related with poorer performance in schizophrenia and unipolar depression.

Association between Lung Cancer Susceptibility Variants Identified by Genome-Wide Association Studies and Survival of Non-Small Cell Lung Cancer

이소연,( Mi Jeong Hong ),( Yi Young Choi ),( Hyo Sung Jeon ),( Seung Soo Yoo ),( Shin Yup Lee ),( Jaehee Lee ),( Seung Ick Cha ),( Chang Ho Kim ),( Eung Bae Lee ),( Jae Yong Park ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-

Introduction: A number of genome-wide association studies (GWASs) have identified chromosomal regions containing genes associated with the risk of lung cancer. Genetic polymorphisms influence not only the development of cancer, but also cancer progression and prognosis. Therefore, we investigated the impacts of genetic variants associated with susceptibility to lung cancer in GWASs on the prognosis of NSCLC. Materials and Methods: This study included patients (n=363) with stage I, II, or IIIA (micro-invasive N2) NSCLC who under-went curative surgical resection at the Kyungpook National University Hospital, Daegu, Korea between September 1998 and December 2007. Eight single nucleotide polymorphisms (SNPs) in the six chromosomal regions (CRP rs2808630, FAM13A rs7671167, HHIP rs1489759, GYPA rs2202507, TERT rs2736100, CLPTM1L rs402710, BAT3 rs1052486, and CHRNA5 rs16969968) were genotype by a PCR-RFLP analysis. Results: None of the eight SNPs were significantly associated with overall survival and disease-free survival. In addition, when the patients were categorized according to age, gender, smoking status, tumor histology and pathologic stage, there were no significant associations between the eight SNPs and survival outcomes. Conclusions: These results suggest that the genetic variants identified by GWASs for lung cancer susceptibility are not sig-nificantly associated with the prognosis of patients with early stage NSCLC.

황련아교탕(黃連阿膠湯)이 Free Cholesterol에 의한 혈관내피세포 손상에 미치는 영향

이소연,윤현덕,신오철,신유정,박치상,Lee, So-Yeon,Yoon, Hyun-Duk,Shin, Oh-Chul,Shin, Yoo-Jung,Park, Chi-Sang 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.3

Hwangryunagyotang is supposed to have significant effects on some sorts of cardiovascular diseases like atherosclerosis. For this study. ACAT inhibitor was put in LDLR -/- mice to derive free cholesterol from it. This was to examine the effectiveness of Hwangryunnagyotang on its protecting and recovering function with endothelial cells damaged by free cholesterol through experimental. The results reported below. Hwangryunagyotang suppressed the crystallization of reactive oxygen species in macrophages and the numbers of free cholesterol crystal plate structured and reduced fragmentation of nucleus in ECV 304 cell strain by ACAT inhibitor significantly. Hwangryunagyotang also suppressed the necrosis of tissue in LDLR -/- mice' (treated with ACAT inhibitor) inflammatory portion which is adjacent to aortic root, proximal aorta and carotid artery by immunohistochemistry and fluorescence microscopy. On the whole, Hwangryunagyotang suppressed the necrosis of endothelial cells and especially it's effcet for the necrosis of para-myocardial tissues by free cholesterol. With this result, I suggest Hwangryunagyotang might have protective and recovery effects on atherosclerosis, so we need to carry on this study henceforth clinically and experimentally as well.

『포의교집(布衣交集)』에 드러나는 금기 위반의 양상과 초옥의 욕망

이소연 ( Lee So-yeon ) 한국기호학회 2017 기호학연구 Vol.52 No.-

이 글은 『포의교집』의 여주인공 초옥의 욕망에 주목하여 초옥이 금기를 위반하게 된 원인과 방식을 살펴본 것이다. 금기는 사회 체제와 질서 유지를 위한 수단으로 작용하므로 금기를 위반하는 일은 사회를 위협하는 것으로 간주되었다. 금기는 항상 인간들의 강한 욕망을 제지하고 억압한다. 따라서 인간은 금기 위반의 욕구를 가지고 있으며, 인간은 금기와 욕망 사이에서 늘 갈등한다. 초옥은 자신의 오랜 소원이던 문장 잘하는 선비로 인식한 이생을 만나 그를 욕망한다. 그녀의 욕망은 작품 속에서 뚜렷이 드러나며, 너무도 강렬하여 당대 금기를 위반하기에 이른다. 이 글에서는 먼저 초옥의 금기 위반 양상을 살펴보고, 금기 위반이 그녀의 욕망에서 비롯되었다는 점을 밝히기 위해 그레마스(Algirdas Julius Greimas)의 행위소 모형(Actantial model)을 사용하여 작품의 의미 구조를 다각적으로 분석하였다. 다음으로 인간의 욕망이 모방에서 출발한다는 르네 지라르(Rene Girard)의 이론을 통해 초옥의 욕망 또한 모방 욕망(mimetic desire)에서 비롯되었음을 밝히고자 하였다. 지금까지 초옥은 젠더와 신분을 뛰어넘어 양반과의 지기를 욕망하는 진취적 주체이자, 스스로 사랑을 찾아 나서는 주체적인 여성이란 점에서 근대적 인물로 평가되어 왔다. 그러나 지라르의 이론에 따라 초옥의 욕망을 자세하게 살펴보면, 초옥은 중세적 윤리의식에 갇혀 있는 인물이다. 초옥이 꿈꾸는 이상적인 삶의 모델이 되는 여성 모습은 유교 텍스트에서 모범적인 여성상으로 제시되고 있는 인물들이다. 초옥이 욕망하는 이상적인 삶 또한 그녀가 습득한 지식을 기반으로 하고 있기에 전근대적이다. 초옥은 하층민 출신이지만, 높은 지적 수준을 갖게 되었기에 인식과 신분적 차이에서 오는 괴리감이 존재했다. 초옥은 괴리감을 줄이고자 동경하던 상류층 여성의 삶을 모방하고자 한다. 따라서 초옥의 윤리의식도 상당 부분 남성 중심적일 수밖에 없다. 초옥은 강력한 욕망을 실현하기 위해 금기를 위반하지만, 그녀의 욕망은 남성 중심적 윤리관을 바탕으로 하고 있다. 금기와 욕망의 충돌 사이에서 궁극적으로는 욕망이 포기되고, 초옥의 금기 위반은 새로운 세계를 열어주지 못하고 비극으로 끝을 맺는다. Purpose of this paper is to identify the reason and methods she violated the taboo by closely examining the desire of Cho-ok who was a heroine in Po-Eui-Gyo-Jip. Because the taboo acted as a way to maintain social system and orders, the violation of taboo was regarded to threaten the society. Taboo always restrains and suppresses strong human desire. Therefore, human beings have the desire to violate the taboo and are always conflicted between taboo and desire. Cho-ok met and desired Lee-saeong who was her long hope and recognized as a classical scholar with good writing. Her desire appears distinctly evident in her works and it came to violate the contemporary taboo because it was too strong. In order to examine the aspects of Cho-ok’s violation of taboo and show that taboo violation came from her desire, the meaning structure of the work was analyzed in various ways using Actantial model of Algirdas Julius Greimas. Next, through Rene Girard’s theory that human desire starts from the imitation, it was tried to show that Cho-ok’s desire also came from mimetic desire. Until now, Cho-ok has been evaluated as a modern character in the aspect that she was a progressive subject and subjective female who desired the friendship with yangban(the gentry) beyond her gender and class. However, closely looking at Cho-ok’s desire according to Girard’s theory, she is a character who is trapped in the medieval ethical consciousness. The female figure which was a model of the ideal life Cho-ok was dreaming is a character who is suggested as an exemplary female image in the Confucian texts. Ideal life Cho-ok was dreaming is also old-fashioned because it is based on her knowledge she acquired. As Cho-ok could have high intellectual level even though she was from lower class, there was a sense of alienation from the difference of recognition and identity. In order to reduce the sense of alienation, Cho-ok tries to mimic the life of high class women she has been longing. Therefore, the moral consciousness of Cho-ok cannot but man-centered in most parts. Cho-ok violates the taboos to realize her strong desire, but her desire is based on a man-centered ethics. Between taboos and desire, the desire was eventually abandoned and Cho-ok’s taboo violation finally ended in tragedy without opening a new world.

생각하는 힘을 키우는 독서논술

이소연,Lee, So-Yeon 대한출판문화협회 2006 출판저널 Vol.364 No.-

저회/석고 활용 긴급복구 유동성 채움재의 개발 및 현장적용 사례

이소연,정혁상,권순협,임대성,공진영,Lee, So-Yeon,Jung, Hyuk-Sang,Kwon, Soon-Hyeop,Lim, Dae-Sung,Kong, Jin-Young 한국건설순환자원학회 2018 한국건설순환자원학회지 Vol.13 No.3

한국 정상안 및 백내장안에서의 스트레이라이트의 연구

이소연,오중협,So Yeon Lee,Jung Hyub Oh 대한안과학회 2011 대한안과학회지 Vol.52 No.2

Purpose: To compare intraocular straylight in normal and cataractous eyes as the morphology and to compare straylight as the result of subjective symptoms in early cataract cases using the C-quant straylight meter, the only tool to measure light scattering in media. Methods: Straylight values were measured in 217 normal eyes and 138 cataractous eyes. Cataractous eyes were classified into posterior subcapsular opacity, anterior subcapsular opacity and nucleosclerosis. Straylight values of each group were measured. The 56 early cataractous eyes were categorized into two groups, depending on the presence of subjective symptoms, and each straylight value was measured. The preoperative and postoperative straylight values of early cataracts were also compared. Results: The mean straylight values of normal and cataractous eyes were 1.34 and 2.46, respectively. The value of posterior subcapsular opacity (2.81) was significantly higher than that of anterior subcapsular opacity (2.33) and nucleosclerosis (1.99). The straylight values of early cataracts were significantly higher in the group with subjective symptoms (2.02) than in the group without subjective symptoms (1.56). The postoperative straylight value decreased to 1.42. Conclusions: The posterior subcapsular cataract showed significantly high intraocular straylight, indicating that light scattering occurred to a greater extent in this group. Light scattering occurred more in early cataractous eyes with subjective symptoms than in eyes without symptoms, and light scattering was reduced after surgery. The C-quant straylight meter, which measures the light scattering in media, can be a useful tool to determine the time of cataract surgery and to evaluate the quality of vision. J Korean Ophthalmol Soc 2011;52(2):182-189

디지털 아카이빙의 표준화와 OAIS 참조모형

이소연,Lee, So-Yeon 한국과학기술정보연구원 과학기술정보센터 2002 Journal of Information Science Theory and Practice Vol.33 No.3

OAIS Reference Model has become a basis for exchanging ideas and cooperating among institutions and various sectors concerned with digital archiving. It has been also recently approved as a new ISO standard. This paper reviews major concepts and issues that the reference addresses. It also introduces current activities of institutions and projects that have contributed to the development process of the model. Conclusion is devoted to address the importance of cooperation among cultural institutions. These institutions are taking the responsibility of preserving digital information for the long-term as authentic as possible and delivering it to the next generation. 디지털 정보보존 관련 분야와 기관간 의견교환과 협력의 기반이 되는 OAIS 참조모형이 최근 ISO 표준으로 인증 발표되었다. 이 논문은 OAIS 참조모형이 정의하고 있는 주요 모형들과 디지털 아카이빙에 관련된 문제들을 논의하고 이 모형의 개발에 참여한 주요 기관 및 프로젝트의 활동을 소개하였다. 귀중한 문화유산인 디지털정보를 진본 상태로 유지하면서 장기적으로 보존하여 현재와 후대의 인류에게 전승하는 책무를 맡고 있는 문화기관들의 협력 필요성에 대해서도 논의하였다.

새로운 학술커뮤니케이션 환경과 미래형 전자저널 컨소시엄 운영모형 : KESLI를 중심으로

이소연,Lee, So-Yeon 한국과학기술정보연구원 2008 Journal of Information Science Theory and Practice Vol.39 No.1

학술정보 커뮤니케이션 환경이 급변함에 따라 전자저널 컨소시엄이 그 본연의 기능을 다하기 위해서는 참여기관이 만족할 수 있는 서비스를 제공하기 위한 즉각적 전략과 함께, 전 세계적으로 벌어지고 있는 근본적 변화주도 움직임에 대처하기 위한 전략이 필요하게 되었다. 이 연구는 우리나라의 대표적인 전자저널 컨소시엄인 KESLI를 중심으로 한 미래형 컨소시엄 운용모형을 제안한다. 여기서 제안하는 미래형 컨소시엄 운영모형은 단기적 대응기능 강화 전략, 장기적 변화주도 전략, 그리고 추진체계를 세 축으로 하고 있다. As scholarly information environment rapidly changes, library consortia for electronic journal licensing come to require strategies to better address service needs of member institutions as well as to take parts in more progressive initiatives. This study aims to develop a more future-oriented and progressive business model for electronic journal licensing consortia. The model is based on three pillars: strategies for responding to immediate needs; long-term strategies for leading change; and organizational infrastructure.

A Functional Polymorphism in CSF1R Gene Is Associated with Risk of Lung Cancer among Never-smoking Females

이소연,( Hyo Gyoung Kang ),( Hyo Sung Jeon ),( Seung Soo Yoo ),( Shin Yup Lee ),( Myung Hoon Lee ),( Young Tae Kim ),( Yeul Hong Kim ),( Yeun Jun Chung ),( Yun Chul Hong ),( Jae Yong Park ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.0

Purpose: It has been estimated that the proportion of never-smokers among females with lung cancer is 53% worldwide and 75% in Korea. We conducted a two-stage study to identify genetic factors responsible for lung cancer susceptibility in female never-smokers. Material and Methods: In a discovery set, 2,228 potentially functional single nucleotide polymorphisms (SNPs) of 1,994 genes using the Affymetrix custom-made GeneChip, which were related to lung carcinogenesis in 181 female never-smokers with lung cancer and 179 controls. A replication study was performed on an independent cohort of 235 cases and 465 healthy controls. The functional effect of the rs10079250 was predicted through a three dimensional models of the CSF1R protein. Results: Among the 2,228 SNPs, 38 SNPs that were associated with lung cancer risk with P values lower than 0.05 in the discovery set were selected for validation. Among the 38 SNPs, the CSF1R rs10079250 was most significantly associated with lung cancer risk (in combined analysis, odds ratio=1.49, 95% confidence interval=1.16-1.92, p=0.002; under a dominant model for the variant allele). Homology-based model for CSF1R indicates that the rs10079250 lead to increase positive charge of CSF binding region of CS1FR, thereby increasing chance for binding of CSF to CSF1R. In addition, this SNP was found to increase phosphorylation of mitogen-activated protein kinase, JNK. Conclusions: Our results suggest that the CSF1R rs10079250 is functional and contribute to lung cancer susceptibility in never-smoking females.