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실린더 라이너의 오일포켓 형성이 마찰특성에 미치는 영향에 관한 연구
서준호(JoonHo Seo),나병철(ByungChul Na),임대순(DeaSoon Lim),정장호(JangHo Jung),이석준(SeokJoon Lee),한정민(JungMin Han) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.11
Since the friction between piston rings and cylinder liner takes up the biggest part of the energy loss in engines, surface design of cylinder liner is a very important factor. There are many researches in progress because this directly relates to fuel consumption, emissions, and durability. This research confirmed the technology of storing lubricants on cylinder liner through creating oil pockets, and applying CrN+DLC Coating on piston rings. Auto parts that are actually used on real vehicles were experimentally put together, and Tribology characteristics of each combination were analysed to confirm friction reduction by application of CrN+DLC Coating technology. By applying CrN+DLC Coating and chemical micro texturing skills to actual vehicles, fuel consumption reduction, emissions reduction, vibration reduction, and improvement in durability are expected.
12-substituted deoxoartemisinin의 합성
이석준 關東大學校 醫科大學 醫科學硏究所 1999 關東醫大學術誌 Vol.3 No.1
12-(3'-Formylbenzyl)-deoxoartemisinin(11), 12-(2'- Formylbenzyl)- deoxoartemisinin(14), a versatile intermediate of non acetal-type artemsinin derivatives with antimalarial activity, anticancer activity and so on, was synthesized from artemisinic acid(2) as a good chiral building block, which was transformed to dihydroartemisinyl aldehyde (6) by esterification, stereoselective and regioselctive reduction with NaBH4, and reduction with DIBAL-H. The C-12 substituted dihydroartemisinyl alocohol (8) and (12) given by the Crignard reaction of compound (6) with 3-vinylbenzyl magnesium bromide or butenyl magnesium bromide were changed to 12-(3'-vinylbenzyl)-deoxoartemisinin(10), 12-butenyl- deoxoartemisinin(13) by photoxidation cyclization with signlet oxygen, which was transformed to target molecules (11) and (14) with ozonolysis.
이석준,오상태,신운섭 관동대학교 의과학연구소 2001 關東醫大學術誌 Vol.5 No.1
Angiogenesis, the process of new blood capillary formation, is an important component of a number of serious disease including cancer growth and metastasis, diabetic retinopathy, rheumatoid arthritis, and many others. Coronarin A, isolated from rhizomes of the Brazilian antirheumatic medicinal plant, and synthetic related compounds showed a significant cytotoxic effect against V-79 cell and sarcoma 180 ascites in Mice. In order to evaluate antiangiogenic effect of trans decaline type labdane compounds, 3, 4a, 5, 6 and 11 were synthesized from versatile chiral building blocks scalreol 1 and sclareolide 2 with appropriate synthetic methods. All tested materials have a mild growth inhibition effect on human endothelial cell line, ECV 304. We concluded that high antiangiogenic effect of coronarin A was caused by furan aromatic functional group on C-l2 position.
이석준 關東大學校 醫科大學 醫科學硏究所 1999 關東醫大學術誌 Vol.3 No.1
8-Hydroxystdnophen(17), 8-hydroxy-4-methlsydnophen and 8-hydroxy-4-phenylsydnophen(19) were synthesized by the cyclization of related N-nitroso-α--substituted-norephendrine analongs(14, 15, 16) under the hydrogen chloride catalyst in ether at 0~5℃, which were parepared from the reaction of norephedrine, CNS stimulator, with formaldehyde, acetaldethyde or benzaldhylde containing potassium cyanide under the hydrogen sulfate. 8-Hydroxysydnocarb(1), 8-hydroxy-4-methlsydnocarb(2) and 8-hydroxy-4-phenylsydnocarb(3) with noble phenyl carbamate functional group resulting from diverse biological activity, were given from the base catalized condensation of the various 8-hydroxy-4- substituted-sydnophen(17, 18, 19) with phenylisoctanate in isopropyl alcohol. The reaction of 8- hydroxystdnophen(17) with phenyisothiocyanate tave 8-hydroxythiosysydnocarb(20). The derivatives of 4-hydroxysydnocarb and 8-hydroxy-4-methlsy-sydnocarb with 3- hydroxyl or 4- hydroxyphenyl carbamate(4, 5, 6, 7), matabolities of 8- hydroxysydnocarb(1) and 8-hydroxy-4-methlsy-sydnocarb(2), were prepared from the reaction 8-hydroxydnophen(17) and 8-hydroxy-4-methylsydnophen(18) with 3-acetoxyphenylisocyantr(29) or 4-acetoxyphenlisocyanate(30) and successive hydrolysis.