항우울제, 과연 자살 위험성을 증가시키나?

이서경 ( Seo Kyong Lee ),장환일 ( Hwan Il Chang ) 경희대학교 경희의료원 2007 慶熙醫學 Vol.23 No.2

정신분열병의 신경발달 내적표현형

이서경 ( Seo Kyong Lee ),김종우 ( Jong Woo Kim ) 경희대학교 경희의료원 2007 慶熙醫學 Vol.23 No.2

비전형적 항정신병 약물 사용중 마비성 장폐색증이 지속된 정신분열병 환자

이서경 ( Seo Kyong Lee ),반건호 ( Geon Ho Bahn ),윤도준 ( Doh Joon Yoon ) 경희대학교 경희의료원 2005 慶熙醫學 Vol.21 No.1

한국인과 중국 한족의 정신분열병 환자에서 Angiotensin 전환효소 유전자 Insertion/Deletion 다형성 연합 연구

이서경(Seo-Kyong Lee),김종우(Jong-Woo Kim),임성빈(Sung-Vin Yim),정주호(Joo-Ho Chung),송지영(Ji-Young Song) 대한생물치료정신의학회 2006 생물치료정신의학 Vol.12 No.2

목적 : ACE와 정신분열병과의 관련성에 대해서 현재까지 여러 연구가 있어 왔다. 본 연구에서는 한국인, 중국 한족간의 ACE 유전자 Insertion/Deletion(I/D) 다형성에 대한 민족간 비교 연구는 아직 시행되지 않았기에 이들을 대상으로 정신분열병과 ACE와의 관련성 및 ACE 유전자 I/D 다형성의 민족간 분포의 차이를 알아보고자 하였다. 방법 : 한국인 정신분열병 153명, 중국 한족 정신분열병 82명, 한국인 정상 대조군 154명, 중국 한족 정상 대조군 88명을 대상으로, 중합효소 연쇄반응으로 ACE 유전자의 I/D 다형성을 확인하였다. 결과 : 한국인 정신분열병 환자군과 정상 대조군 사이에 유전자형의 빈도(p=0.001)와 대립유전자의 빈도(p=0.021)는 유의한 차이가 있었다. 중국 한족 정신분열병 환자군과 정상 대조군 사이에 유전자형의 빈도(p=0.520)와 대립유전자의 빈도(p=0.313)에서 유의한 차이는 없었다. 한국인 정상 대조군과 중국한족 정상 대조군 사이에 유전자형의 빈도(p<0.001)와 대립 유전자의 빈도(p<0.01)에서 유의한 차이가 있었다. 결론 : 본 연구에서는 한국인의 ACE 유전자의 I/D 유전자 다형성과 정신분열병이 관련이 있음을 관찰하였고, 한국인과 중국인의 정상 대조군에서 ACE 유전자의 I/D 대립유전자의 비율이 의미 있게 차이가 있음을 알 수 있었다. 향후 더 많은 정신분열병 환자군을 대상으로 다양한 표현형을 분류하여 분석하는 연구, ACE와 관련이 있는 여러가지 신경전달물질에 대한 유전자와 같이 분석하는 연구 등을 실시하여 ACE 유전자 다형성을 분석한다면 더욱 의미 있는 연구가 될 것으로 생각된다. 또한 기존과 다른 결과에 대해서는 향후 다른 대조군에서의 검증이 필요할 것으로 생각한다. Objective:The purpose of this study was to investigate the association between Insertion/Deletion(I/D) polymorphism of Angiotensin-converting enzyme(ACE) gene and schizophrenia in Korean and Han Chinese population. Method:We examined the frequency of a polymophism characterized by the insertion of a 287bp in intron 16 of the ACE gene(located on chromosome 17q23). A sample of 153 Korean schizophrenics, 154 Korean healthy controls, 82 Han Chinese schizophrenics and 88 Han Chinese healthy controls were genotyped by size-analysis of polymerase chain reaction products. Results:There was significant difference in genotype frequencies and allelic frequencies of ACE I/D polymorphism between Korean schizophrenics and controls. There was no difference in genotype frequencies and allelic frequencies of ACE I/D polymorphism between Han Chinese schizophrenics and controls. There was significant difference in genotype frequencies and allelic frequencies of ACE I/D polymorphism between the Korean and Han Chinese controls. Conclusion:The present study reveals significant association of ACE gene I/D polymorphism in Korean schizophrenics. And there was ethnic diffence between the Korean and Han Chinese polulation.

Estrogen Receptor 1 유전자 내 2개의 단일염기 다형성과 한국인 여성 정신분열병 환자의 연합에 관한 연구

박진경,이서경,이상민,박준헌,김지영,조아랑,Park, Jin Kyung,Lee, Seo Kyong,Lee, Sang Min,Park, Jun Heon,Kim, Ji Yeong,Cho, Ah Rang 대한생물정신의학회 2007 생물정신의학 Vol.14 No.4

Objectives : Schizophrenia is equally distributed in both sexes. However, later-onset, milder psychopathology, and better outcome are associated with the females. This reason is thought to be partly due to the estrogen system. Recently, it was suggested that estrogen receptor 1(ESR1) gene polymorphisms might affect the expression of ESR1 and were associated with several psychiatric disorders. Thus, we investigated the association between two single nucleotide polymorphisms(SNPs) in the ESR1 gene and Korean schizophrenic patients in this study. Methods : Genotype, allele, and haplotype frequencies of the two SNPs(rs 2234693 and rs 2228480) were analyzed between 218 Korean controls and 158 Korean schizophrenic patients. Also, age of onset and negative symptom scale scores according to genotypes were analyzed in the patients with schizophrenia. Results : There was a significant difference in allele frequencies of rs 2234693 between the schizophrenic patients and the controls(p=0.03). Genotype distributions(p=0.03) and allele frequencies(p=0.01) of rs 2234693 were significantly different between the female schizophrenic patients and the female controls. The frequency of TC-CC genotypes compared with TT genotype in the female schizophrenic patients was significantly higher than that in the female controls(OR=2.36). The mean age of onset in the schizophrenic patients with TC-CC genotypes was significantly lower than that in the patients with TT genotype. The frequency of rs 2234693C- rs 2228480G haplotype in the female schizophrenic patients was relatively higher than that in the female controls. Conclusions : These results of our study support the possibility that the ESR1 gene polymorphisms might be involved in the susceptibility of females to schizophrenia and play a role in sex difference of schizophrenia.

제인 나노섬유 멤브레인을 이용한 6가 크롬 이온 흡착 평가

윤나경,곽효원,이민규,이서경,이기훈,Yun, Na Kyong,Kwak, Hyo Won,Lee, Min Gyu,Lee, Seo Kyung,Lee, Ki Hoon 한국섬유공학회 2014 한국섬유공학회지 Vol.51 No.2

Heavy metal pollution is a serious problem that harms the environment and human health. As a means of removing heavy metal ions, especially Cr(VI), from a solution, we prepared a nanofibrous membrane from zein protein which is derived from maize. The zein nanofibrous membrane (ZNM) was prepared by using an 80% ethanol solution as a solvent. The resulting fiber had a ribbon-like structure. The size of the nanofiber could be controlled by varying the concentration of the zein in the ethanol solution. The ZNM was mounted in a membrane holder and a Cr(VI) feed solution was then continuously passed through the ZNM. The adsorption of Cr(VI) reached equilibrium within 3 min, indicating the rapid adsorption of the Cr(VI). To regenerate the ZNM adsorbent, the adsorbed Cr(VI) was removed by adding 0.1 M NaOH. We believe that ZNM would be an effective means of removing Cr(VI) from industrial waste.

소아청소년 정신의학에서의 동물모델

이서경,반건호 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.4

In studying child and adolescent psychiatry (CAP), animal models are extremely useful to explore the pathogenesis of disorders or to experiment drugs as substitutes for the human body. Particularly in young children, the accuracy of their ex-pression can be low and there are many restrictions in experiments directly upon the patients including difficulties in medi-cation and tests. However, it is not easy to develop animal models because standards for diagnosis are phenomenological and based on behavioral descriptions. The biggest problem in research using animal models in CAP is that it is difficult to make representative models specific to each disorder. The present study reviewed articles about research with animal models in connection to disorders common in CAP such as autism , Tourette syndrome (TS), attention deficit/hyperactivity disorder (ADHD) and mental retardation (MR). Recent resear-ches through animal models are mainly focused on anatomical studies on sites related to disorders and genetic studies. Although there have been many researches for autism, they still seem to be away from establishing representative models. For TS, it is not easy to make specific animal models because of the complexity of the syndrome, but animal models have been greatly helpful to find pathogenesis and develop remedies for TS. In ADHD, Spontaneously Hypertensive Rats (SHR) model is recog-nized as a fine model. With regard to MR, a majority of studies are gene researches related to known abnormal chromosomes. Throughout this review, authors recognized that only few articles have been published using animal models for CAP in Korea. We hope that research using animal models will be more activated in Korea.

병식 평가 척도-한국판(SUMD-K)의 신뢰도와 타당도 검증

송지영,김기태,이서경,김용희,노준호,김종우,장환일,반건호,강원섭 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.4

Objectives : This study was conducted to evaluate the reliability and the validity of the Korean version of the Scale to Assessment Unawareness of Mental Disorder (SUMD-K). Methods : The subjects were 55 schizophrenic patients between ages of 26 and 58 who were recruited from the psychiatric unit of the university hospital and the out-patient clinic. The SUMD-K and insight scale of PANSS were applied to the patients. Results : The range of inter-rater (Spearman's rho) of the general items of SUMD-K were .97-.98 on the current illness and .58-.98 on the past illness. The correlation coefficient between the sum and the general items of the SUMD-K showed high scores. The concurrent validity between SUMD-K and insight item of PANSS was high (scores between .59-.96). However,the reliability and the validity of the attribution items of symptoms showed low scores compared to the current symptoms. Conclusion : The SUMD-K was confirmed in its reliability and validity. It can be a useful clinician-rating scale for evaluating insight in schizophrenic patients as well as patients with other neuropsychiatric conditions.