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송달원(Dal Won Song),김희준(Hee Jun Kim),이복수(Bok Su Lee),임만빈(Man Bin Yim) 대한두경부종양학회 1999 대한두경부 종양학회지 Vol.15 No.1
Neurinoma originates from any nerve covered with a Schwann cell sheath and can occur in any cranial, sympathetic, or peripheral nerve. Hypoglossal neurinomas are rare and most of them are intracranial, but they may extend extracranially. Most intracranial neurinoma arise from the sensory division of cranial nerve but a motor nerve such as hypoglossal nerve is rarely involved. Although the typical sign of hypoglossal neurinoma is ipsilateral hemiatrophy of the tongue, it is easily overlooked. For the diagnosis of hypoglossal nerve tumor, CT scanning with contrast enhancement and MRI should be included, and they are greatly aids in planning the radical removal of the tumor. We experienced a case of intracranial hypoglossal neurinoma with extracranial extension in a 43-year-old woman. The patient showed otherwise unremarkable except 4 months history of right infraauricular mass and right tongue hemiatrophy. Computed tomography and magnetic resonance imaging for local diagnosis was valuable and we could remove the mass by one stage operation via suboccipital transcervical approach.
급성림프구성백혈병의 면역학적 분류 및 림프아세포의 시험관내 분화유도에 관한 연구
서인석,조덕연,강원권,김삼용,이복희,이복수,백상기,김영진,이천배 충남대학교부설 생명공학연구소 1991 생물공학연구지 Vol.1 No.-
The theory that various hematologic malignancies, such as acute and chronic leukemias and lymphomas, are characterized by monoclonal expansion of neoplastic cells arrested at different levels along the hemo-lymphopoietic differentiation pathway is widly accepted. It has also been supported by immunoglobulin gene rearrangement and phenotyping with specific antibodies to surface markers of lymphocytes concerning the lymphoid malignancies. In cope with these developments, the immunologic classification of acute lymphocytic leukemia had become more clarified. The author studied the immunologic classification of 15 patients with acute lymphocytic leukemia(ALL) with monoclonal antibodies against surface markers for lymphoid cells, and tried the in vitro induction of differentiation of progenitor-B cell ALL and T-cell ALL with TPA(12-0-tetradecanoyl phobol-13-acetate), a well known tumor promoter and known as a differentiation inducer also. Monoclonal antibodies for surface markers, used in this study, were Leu-9 for T-cell All and anti-Ia, anti-CALLA, anti-SIg(surface immunoglobulin), anti-BI, and anti-B4 for B-cell lineage ALL. Leu-9 positive cases were classified as T-cell ALL, Ia only positive cases were classified as progenitor-B cell ALL, Ia and CALLA positive cases were classified as common ALL, and Ia and SIg positive cases were classified as B-cell ALL. The results were as followings. 1. In this study, 5 cases were classified as common ALL, 3 each cases were B-cell and progenitor-B cell ALL, and 4 cases were T-cell ALL. 2. All 3 cases of B-cell ALL were L2 by FAB classification, and this findings was discordant with the conventional knowledge. 3. Leukocyte count in pheripheral blood of T-cell ALL patients at diagnosis was higher than that of non-T cell ALL(p<0.05). 4. All 5 cases of common ALL and 3 cases of B-cell ALL, 2 of 3 cases of progenitor-B cell ALL, and 1 of 4 cases of T-cell ALL achieved complete remission. So, T-cell ALL showed lower remission rate than that of common ALL and B-cell ALL. 5. One case of progenitor-B cell ALL, which is positive to only Ia, newly expressed B4, CALLA, BI and SIg after culture with TPA. This results suggest that TPA induce the differentiation of progenitor B-cells to more differentiated stage. 6. One case of T-cell ALL, which is positive to only Leu-9, newly expressed T3 after culture TPA and PHA. This results suggest that TPA and PHA induce the differentiation of early thymocyte to mature thymocyte.