난소의 자궁내막종에 대한 다양한 치료적 적용에 따른 체외수정 및 배아이식술 결과의 비교 연구

이방현,권혁찬,이재현,김보현,이상희,박민혜,이병관,임정애,Lee, Bang-Hyun,Kwon, Hyuck-Chan,Lee, Jae-Hyun,Kim, Bo-Hyun,Lee, Sang-Hee,Park, Min-Hye,Lee, Byung-Kwan,Lim, Jung-Ae 대한생식의학회 2004 Clinical and Experimental Reproductive Medicine Vol.31 No.2

Objective: To compare COH characteristics and IVF outcomes among IVF-ET patients who were treated with various therapeutic modalities for ovarian endometriomas and to propose effective pre-cyclic therapeutic modalities to improve IVF-ET outcomes in the patients with ovarian endometriomas. Methods: All cases that had undergone IVF-ET after laparoscopy between January 1997 to August 2003 were reviewed. Forty-eight patients with tubal factor were assigned to Group I. Twenty seven, 22 and 38 patients diagnosed as severe pelvic adhesion with ovarian endometriomas by laparoscopy received only medical therapy (Group II), cyst aspiration (Group III), and sclerotherapy (Group IV), respectively. Laparoscopic cystectomy was performed in 20 patients (Group V). Resistance index was measured on day administering hCG. Results: As compared with Group I, in Group II resistance index increased (p<0.05) but number of oocytes, good-quality oocyte ratio (mature and intermediate oocytes/total retrieval oocytes), fertilization rate, and embryo development rate decreased (p<0.05). In Group III fertilization rate and embryo development rate decreased (p<0.05). There was no difference between Group IV and Group I in all parameters except basal FSH which increased (p<0.05). In Group V basal FSH, and resistance increased (p<0.05) and number of oocytes and good-quality oocytes ratio decreased (p<0.05). Conclusion: Sclerotherapy is an effective therapeutic option which can be done prior to IVF-ET cycles in the patients with ovarian endometriomas. Further studies on a large scale are necessary to confirm these data.

체외수정시술을 위한 과배란유도에 있어 GnRH Antagonist 다회투여법과 GnRH Agonist 장기요법의 비교연구

이방현 ( Bang Hyun Lee ),김정훈 ( Chung Hoon Kim ),오영미 ( Young Mi Oh ),김성훈 ( Sung Hoon Kim ),채희동 ( Hee Dong Chae ),강병문 ( Byung Moon Kang ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.6

목적 : 체외수정시술을 위한 과배란유도방법으로 GnRH antagonist 다회투여법을 표준화된 GnRH-a 장기요법과 비교 분석함으로써 이 방법의 효용성을 평가하기 위함이다. 연구 및 방법 : 체외수정시술 대상환자들 중 난관인자만이 불임의 원인으로 작용하였던 57명을 대상으로 하였다. 과배란유도를 위하여 GnRH antagonist 다회투여법이 시행되었던 연구군 (n=28)의 경우 가장 큰 난포의 평균직경이 14 mm에 도달한 날부터 hunan cho Objective : To evaluate the efficacy of GnRH antagonist multiple dose protocol (MDP) in controlled ovarian hyperstimulation (COH) for in vitro fertilization and embryo transfer (IVF-ET) comparing with the standard GnRH agonist long protocol (GnRH-a LP). M

논문(論文) : 일제의 정신질환자에 대한 인식과 태도

이방현 ( Bang Hyun Lee ) 이화사학연구소 2012 梨花史學硏究 Vol.0 No.45

The purpose of this study is to find out the historical background of people``s negative perceptions on and attitudes to the persons with mental disorder in current Korean society, which perceive those persons as ``dangerous people who behave impulsively violent and aggressive`` and try to ``separate them from the local community`` by reviewing the changes of the environment surrounding them during Japanese Colonial period. For this purpose, I looked into the related movement at that times both in main land of Japan and its colony Chosun referring to ChosunChongdokbuKwanbo or the official gazette of Japanese Government-General of Korea, MaeilShinbo, ChosunIlbo, DongaIlbo and other Japanese publications. The study found that there was a procedure in which ``wandering`` persons with mental disorder were separated from the local community and confined to asylums by social hygienic perception and attitude of Japanese Imperialism under close cooperation between the colonial sanitary police and modern psychiatric system in the colony Chosun. In this procedure Japanese Imperialism gave image of ``dangerousness`` and ``impulsiveness`` to persons with mental disorder and it is inferred that it was due to the result of pursuing convenience to dominate Chosun as its colony. It is meaningful that this study deduced the historical background of perceptions and attitudes of separation and exclusion towards persons with mental disorder in current Korean society by reviewing organizing the series of incidents surrounding those people during Japanese Colonial period. However, it is not likely that such efforts of Japanese Imperialism would have directly affected perceptions and attitudes of people in Chosun at that times. While it is true that the policy and activities of Japanese Imperialism had much influence on Korean society due to the unique historical circumstance or the Colonial period, there could be a collision between the policy of Japanese Imperialism and the traditional custom of Chosun which had been inherited from the past. And in terms of medical sector, the activities of missionaries from western countries also have left significant marks after the ``OpenPort``ofChosun. Accordingly, the changes of people``s perception in the colony Chosun on the person with mental disorder can be found out and deeply understanding of the people``s attitudes towards those people in Korea after the Independence can be achievable only in the inter-relationship among the 3 active parties above.

자궁경부의 정상 및 종양 조직에서 EGF, TGF-α와 EGFR의 발현

이방현(Bang Hyun Lee),권동진(Dong Jin Kwon),김찬주(Chan Joo Kim),권용일(Yong Ill Kwon),박태철(Tae Chul Park),김진홍(Jin Hong Kim),이진우(Jin Woo Lee),김도강(Do Kang Kim),남궁성은(Sung Eun Namkoong) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.2

본 저자들은 자궁경부 상피 세포의 악성화 과정을 관찰하기 위하여 정상 자궁경부, 자궁경부상피내 종양과 자궁경부암 조직의 각 5예, 18예와 7예에서 면역조직염색법으로 EGF, TGF-α와 EGFR의 발현을 관찰하여 다음과 같은 결과를 얻었다. EGF 발현 양상은 정상 조직 및 CIN의 경우 기저부에서 약한 발현이 관찰되었으며 자궁경부암의 경우는 국소적인 부위에서 중등도의 발현이 관찰되었다. TGF-α 발현 양상은 정상 조직 및 CIN I의 경우 발현이 약했으며 CIN II와 III의 경우는 경도 또는 중등도의 발현이 기저부와 간질부 하부에서 관찰되었고 자궁경부암의 경우는 국소적인 부위에서 경도의 발현이 관찰되었다. EGFR 발현 양상은 정상 조직의 경우는 중등도의 발현이 관찰되었으나 CIN의 경우 질병이 진행함에 따라 발현의 강도가 증가하는 양상을 보였고 자궁경부암의 경우 대부분의 암세포에서 강한 발현이 관찰되었다. 이상의 결과를 볼 때 EGF, TGF-α와 EGFR는 자궁경부 상피 세포의 증식과 악성화 과정에 있어서 일부 관여하리라 생각되나 향후 이에 관한 실험이 좀더 이루어져야 할 것으로 사료된다. Objective : This study seeks to define the expression of epidermal growth factor(EGF) and transforming growth factor(TGF)-α and epidermal growth factor receptor(EGFR), and the relationship to the tumor progression of human cervical epithelial neoplasia. Methods : To confirm the expression of EGF, TGF-α and EGFR immunohistochemically in normal cervix, cervical intraepithelial neoplasms and cervical carcinomas, we used monoclonal antibodies to EGF, TGF-α and EGFR. Results : Immunohistochemical stainings using anti-EGF, anti-TGF-α and anti-EGFR antibodies showed weak or moderate stainings in all cases. Normal and CIN cases showed predominantly basal and parabasal expression of EGF, TGF-α and EGFR, and its expression decreased as the cells became increasingly differentiated toward the surface of the epithelium. In the cervical carcinoma EGF and TGF-α expressed weakly to moderately focally, and EGFR expressed intensely in all malignant cells. Conclusion : These results suggest that EGF, TGF-α and EGFR may involved in cellular proliferation of cervical squamous epithelium and have a significant role in the progression of cervical cancer.

식민지 조선에서의 정신병자에 대한 근대적 접근

이방현(LEE Bang Hyun) 대한의사학회 2013 醫史學 Vol.22 No.2

개화기(1876-1910) 의료복지활동에 관한 연구사적 분석

이희진 ( Hee Jin Lee ),이방현 ( Bang Hyun Lee ),이방원 ( Bang Won Lee ),양옥경 ( Ok Kyung Yang ) 이화여자대학교 사회복지연구소 2012 사회복지 실천과 연구 Vol.9 No.-

본 연구의 목적은 개화기(1876-1910)에 이루어졌던 의료복지활동의 양상을 살펴보고자 하는 것이다. 이를 위해 해당 시기를 연구한 선행 연구들을 중심으로 문헌고찰 하였다. 개화기의 시대적 상황과 공공 의료체제, 민간의 의료사업을 고찰하였고, 이들의 의료 복지 활동을 주체, 대상, 형태에 따라 탐색 및 정리하였다. 그 결과, 의료 복지 활동의 주체로는 크게 공공(조선 후기 정부, 대한제국 황실, 통감부)과 민간(선교사 단체, 한의사 단체) 주체가 두축이 되어 활동을 전개한 것으로 나타났다. 의료복지활동의 대상은 대부분 빈곤한 환자, 전염병자가 주를 이루었고 그 당시 사회적으로 소외된 계층이었던 여성, 고아를 포함한 어린이, 한센병자, 행려병자, 죄수, 무의무탁한 자, 군인, 그리고 농촌 지역주민들에 대한 복지활동이 펼쳐졌다. 활동의 형태는 주로 ``구료``, ``시료``로 표현되는 무료 진료, 무료 치료, 약제비무료 혹은 저가 치료와 순회 진료로 이루어졌다. 연구의 결과로 나타난 활동들은 그 시기에만 국한된 것이 아니라 현재까지 이어지는 하나의 연속선으로 볼 수 있었으며, 본 연구는 그와 같은 역사적 고리를 탐색하고 정리하였다는 것에서 의의를 가진다. 특히 현재 의료사 회복지의 역사에 관한 연구가 전무한 실정에서 본 연구의 결과는 추후 연구를 위한 초석을 마련했다는 점에서 함의가 클 것으로 사료된다. The aim of the research is to see how the medical welfare activities during the civilization age fared. To do this, we studied preceding researches with related documents. We studied on the situation of the age, public medical system, civil medical businesses and we broke down their activities into the subject, the object and the forms. As a result the public sector(later Chosun dynasty, the emperial Daehan Royalty, the Residence-General) and the civil(missionaries, the oriental medicine organizations) were shown to be thought of as two main bodies. The target of their activities were mostly poor patients, and poor patients with contagious diseases who were regarded as major body of patients and others include socially marginalized people who were women, children including orphants, people with Hansen``s disease, persons fallen sick on the road, criminals, people with no protector, soldiers, and people living in rural areas. The activities were practiced mainly as ``kuryo``, ``shiroy`` which mean free diagnosis, free treatment, free medication or low priced treatment and itinerant treatment. These activities were not confined to the mentioned age but have continued to the present arranged the historical link. Particularly given that there has been no research on the history of medical social welfare, this research is meaningful in that it laid the basis for further studies.

토양검정에 의한 유기자원 시비처방이 감자의 생육 및 양분이용효율에 미치는 영향

임진수,이방현,강승희,이태근,Lim, Jin-Soo,Lee, Bang-Hyun,Kang, Seung-Hee,Lee, Tae-Guen 한국작물학회 2020 한국작물학회지 Vol.65 No.4

In this study, we verified the effects of organic amendment application based on soil testing in potato cultivation. The application rate of organic amendments was determined based on the inorganicization rate of nitrogen, phosphoric acid, and potassium in the organic amendments. There was no significant difference in the length, stalk number, stalk diameter, and leaf color of potato plants under organic amendment application compared with those under chemical fertilization. The quantity of potato tubers and yield of marketable tubers under organic amendment application were higher than those under chemical fertilization. The top fresh weight and top-to-root ratio were the highest under organic amendment application, followed by those under chemical fertilization and the control. The inorganic nitrogen content in the leaves and stems of potato plants was the highest under chemical fertilization. There was no difference in the phosphoric acid content between the potatoes under chemical fertilization and those under organic amendment application. The potassium content in potatoes was higher under chemical fertilization than that under organic amendment application. While the change trend of inorganic nitrogen content in the roots was similar to that in the leaves and stems, the potatoes under organic amendment application, with the highest yield, showed the highest dry weight. The tuber weight showed a positive correlation with plant length, stalk number, and stalk diameter. The higher the weight of the tuber, the higher the weight of the marketable tuber, and the higher the top fresh weight, the higher the yield. Therefore, to increase yield, it is necessary to supply nutrients to improve the top fresh weight to the optimal level. There was no difference in the utilization efficiency of nitrogen and potassium between the potatoes under chemical fertilization and those under organic amendment application. The utilization efficiency of phosphoric acid was increased by 0.1% in potatoes under organic amendment application compared with that under other treatments. Regarding soil chemistry after harvest, the soils under organic amendment application showed a higher electrical conductivity and higher nitrogen and phosphoric acid content than those under other treatments. Therefore, the organic amendment method used in this study can be an alternative to chemical fertilization. It is also advantageous for the cultivation of subsequent crops in potato fields.

한국여성에서 자궁경부암의 고위험군 인유두종 바이러스의 동정

이상희 ( Sang Hee Lee ),이방현 ( Bang Hyun Lee ),윤효진 ( Hyo Jin Yoon ),박민혜 ( Min Hye Park ),권혁찬 ( Hyuck Chan Kwon ),임정애 ( Jung Ae Lim ),이병관 ( Byung Kwan Lee ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.12

목적 : 한국 여성에서 자궁경부암과 관련되어 발현되는 하부생식기 HPV 형과 자궁경부암의 고위험군 HPV 형을 분류하고자 한다. 연구 방법 : 본원에서 자궁경부암 검사를 시행하는 환자들을 대상으로 Pap test와 PCR 방법에 의한 HPV- DNA 검사를 시행하였고 HPV-DNA 검사에서 양성으로 판명된 경우 sequencing 방법에 의한 HPV-genotyping과 자궁경부 조직검사를 시행하였다. 결과 : HPV 감염의 주된 연령군은 40대였고 ( Objective : To identify genital HPV types and high risk group of HPV associated with cervical cancer in Korean women. Methods : Both Pap test and HPV-DNA test using PCR assay were performed as screening test for cervical cancer in this clinic. When patien

난소의 생식세포 노화에 대한 세라마이드의 역할

김진홍 ( Jin Hong Kim ),이방현 ( Bang Hyun Lee ),김미란 ( Mi Ran Kim ),김민정 ( Min Jeong Kim ),김장흡 ( Jang Heub Kim ),조현희 ( Hyun Hee Choi ),황성진 ( Sung Jin Hwang ),권동진 ( Dong Jin Kwun ),유영옥 ( Young Ok You ),임용택 ( 대한폐경학회 2005 대한폐경학회지 Vol.11 No.3

배양된 생쥐의 과립막 세포에서 activin과 follistatin이 인슐린유사성장인자-1, 2, 인슐린유사성장인자 결합단백질-1, 2, 3의 mRNA 발현에 미치는 영향

채희동 ( Hee Dong Chae ),홍석호 ( Seok Ho Hong ),조윤현 ( Yun Hyun Cho ),오영미 ( Young Mi Oh ),이방현 ( Bang Hyun Lee ),김성훈 ( Sung Hoon Kim ),김정훈 ( Chung Hoon Kim ),강병문 ( Byung Moon Kang ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.3

목적 : Activin과 inhibin이 배양된 생쥐의 과립막 세포에서 인슐린유사성장인자 (insulin-like growth factor, IGF)-I, Ⅱ와 인슐린유사성장인자 결합단백질 (insulin-like growth factor binding protein, IGFBP)-1, 2, 3의 mRNA 발현에 어떠한 영향을 미치는 가에 대하여 알아보고자 본 연구를 시작하였다. 연구 재료 및 방법 : ICR 생쥐의 암컷에서 난소를 채취하고 과립막 세포 Objective : To investigate the influence of activin and follistatin on the expression of IGF (insulin-like growth factor)-I, Ⅱ, IGFBP (insulin-like growth factor binding protein)-1, 2, and 3 mRNA in cultured mouse granulosa cells Materials and Methods : T