http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
세로토닌 재흡수 억제제에 대한 아리피프라졸 및 부프로피온 부가요법의 우울증 세부증상에 대한 효과 비교 : 다기관, 개방표지, 무작위 연구
이가원,이광헌,박영우,이종훈,구본훈,이승재,성형모,천은진,Lee, Ga-Won,Lee, Kwang-Hun,Park, Young-Woo,Lee, Jong-hun,Koo, Bon-Hoon,Lee, Seung-Jae,Sung, Hyung-Mo,Cheon, Eun-Jin 대한불안의학회 2017 대한불안의학회지 Vol.13 No.2
우울증은 높은 유병률을 가지며 심각하고 만성화 될 수 있는 질병이다. 환자가 증상 없이 기능적 회복이 되어 일상을 영위하기 위해 임상가는 단독요법 이상의 치료 전략이 필요하다. 본 연구에서 SSRI와 aripiprazole 또는 bupropion 부가 요법은 우울증의 증상 호전을 보였다. SSRI와 aripiprazole 부가 요법은 우울증의 전반적 점수의 호전뿐 아니라 세부척도의 핵심 증상에서 bupropion 병합 요법에 비해 더 의미 있는 변화를 보였다. 또한 두 약제 모두 핵심 우울증상이라 할 수 있는 개별증상(우울한 기분, 일과 활동, 정신적 불안)에서 가장 큰 변화를 보였다 Objective : The purpose of this study was to examine the effects of adjunctive aripiprazole versus bupropion on specific symptoms of depression. Methods : Data were from 6-week, randomized, prospective, open-label multi-center study in 103 patients with major depressive disorders. Participants were randomized to receive aripiprazole (2.5-10 mg/day) or bupropion (150-300 mg/day) for 6 weeks. Change in four subscales of the 17-item Hamilton Depression Rating Scale (HAM-D17) that capture core depression symptoms was determined, and change in individual HAM-D17 items was also assessed. Changes in three composite subscales-anxiety, insomnia, and drive were also examined. Results : Within-group change in the four core subscales was large [effect size (ES)=1.30-1.47] and it was similar to that in the HAM-D17 total score. Differences between aripiprazole and bupropion were significant for each of the four core subscales and the HAM-D17 total score favored aripiprazole (p<0.001). On three composite scales, both treatments caused substantial changes in anxiety (within-group ES=1.10 (aripiprazole) vs. 1.00 (bupropion)], insomnia (ES=0.75 vs 0.50), and drive (ES=1.17 vs 1.15). Conclusion : This results suggested that both aripiprazole and bupropion adjunctive therapies with selective serotonin reuptake inhibitors resulted in significant and clinically meaningful changes in core symptom subscales for depression.
리스페리돈(Risperidone)을 투약 중인 정신분열병 환자에서 지프라시돈(Ziprasidone)으로 교체 투약 시 보이는 임상적 및 대사적 이득에 대한 전향적 개방 연구
이종훈(Jong Hun Lee),송진옥(Jin Ok Song),이승재(Seung Jae Lee),정성원(Sung Won Jung),구본훈(Bon Hoon Koo),이광헌(Kwang Heun Lee) 대한생물치료정신의학회 2009 생물치료정신의학 Vol.15 No.1
Objectives:The purpose of this study was to assess clinical effectiveness and metabolic benefits by switching from risperidone to ziprasidone in chronic stable schizophrenic patients. Methods:A total of 19 patients taking risperidone were switched to a 12-week, open label, flexible dose(80- 160㎎/day) of ziprasidone. Current psychiatric status was evaluated by Positive and Negative Syndrome Scale(PANSS), Clinical Global Impression(CGI), and Global Assessment of Functioning(GAF). Drug induced abnormal movements were assessed using various scales. Laboratory tests including lipid profiles, HbA1c, fasting plasma glucose and electrocardiography were carried out. Results:Of the 19 enrolled patients, 14 patients(73.7%) completed the study. Mean daily dose were 6.1±2.0㎎ for risperidone at the baseline and 123.1±8.1㎎ for ziprasidone at the end point of the study. Significant improvements were found on PANSS negative subscale scores(p<.05), with trends towards improved positive and psychopathology subscale scores. Among metabolic parameters, mean total cholesterol, triglyceride, and free fatty acid showed significant improvements(all ps<.05). In line with these findings, mean body weight and hip size significantly decreased from baseline(each p<.05). Regarding tolerability, frequency and severity of abnormal movements were not significantly different between two drugs. The ECG results showed no significant change from baseline in the QTc interval. Conclusion:Our findings supported the use of ziprasidone as a good option for the treatment of stable yet partially resolved outpatients with schizophrenia who has been taking risperidone continually, with benefits in efficacy particularly negative symptoms, reduction of body weight as well as hip size, and improvements in metabolic risk factors.
배나리(Na-lee Bae),이광헌(Kwang-hun Lee),이관(Kwan Lee),곽경필(Kyung-phil Kwak) 대한노인정신의학회 2015 노인정신의학 Vol.19 No.2
Objective:This study was aimed to investigate the efficacy of cognitive training in community-dwelling elderly, and to sup-port mental health care system for the elderly. Methods:We investigated 1,994 and aged over 65 years elderly visiting senior center from April 2014 to July 2014. Their de-mographic data was investigated. Cognitive functions were evaluated by Korean Version of Mini Mental Status Examination for Dementia Screening (MMSE-DS) and Global Deterioration Scale. Quality of life was evaluated by Korean Quality of Life-Alzheim-er’s Disease (KQoL-AD) and depression by Short Korean Form of Geriatric Depression Scale. Before and after cognitive training, we analysed these data. Results:MMSE-DS, KQoL-AD were significantly higher in score after the cogintive training than before of that (p<0.001). SGDS-K were significantly lower in score after the cognitive training than before of that (p<0.001). Conclusion:Cognitive training resulted in improvement in cognitive functions, quality of life and depression for community-dwelling elderly. These results suggest that future mental health care policy has to consider the importance of community-dwelling elderly.
경상북도 거주 노인의 정신건강과 자살 위험인자에 관한 연구
김정령(Jeong Ryeong Kim),이광헌(Kwang Hun Lee),김상규(Sang Kyu Kim),곽경필(Kyung Phil Kwak),사공정규(Jeong Kyu Sakong) 대한생물치료정신의학회 2021 생물치료정신의학 Vol.27 No.3
Objectives:The purpose of this study was to identify suicide risk factors among elderly residents in Gyeongsangbuk-do and to reveal the relationships between them. In addition, the differences in suicide risk factors were analyzed between the cognitively impaired group and the cognitively normal group. Methods:We investigated 20,127 elderly over 65 years of age, from January 2019 to December 2019. Participants were asked to complete a questionnaire survey. Cognitive function, depression, anxiety, sleep disturbance, and suicidal ideation data were assessed using a Korean version of the Mini-Mental Status Examination for Dementia Screening (MMSE-DS), Short Geriatric Depression Scale for Korean version (S-GDS), Geriatric Anxiety Inventory (GAI), Athens Insomnia Scale (AIS), and Scale for Suicidal Ideation (SSI). Data were analyzed using the chi-squared test and logistic regression analysis to examine suicide risk factors and the relationships between them. Furthermore, differences in suicide risk factors according to cognitive function were examined. Results:Age, cognitive function, depression, anxiety, and sleep disturbance were identified as suicide risk factors among elderly residents in Gyeongsangbuk-do. Depression was the factor that increased risk of suicide the most, followed by anxiety, impaired cognitive function, sleep disturbance, and 65-74 years of age. In addition, depression increased risk of suicide by 1.86 times in the cognitively impaired group. Conclusions:Among elderly residents in Gyeongsangbuk-do, depression was the factor that contributed the highest risk for suicide. More active prevention and treatment measures for depressive symptoms should be implemented in the cognitively impaired group.
김문범(Moon Beom Kim),이광헌(Kwang-Hun Lee),이관(Kwan Lee),곽경필(Kyung-Phil Kwak) 대한생물치료정신의학회 2018 생물치료정신의학 Vol.24 No.3
Objectives:The purpose of this study was to investigate the prevalence and risk factors of suicidality among community-dwelling elderly. Methods:The participants were 2,201 elderly people whose ages were over 65. The participants were asked to complete questionnaires, including Mini International Neuropsychiatric Interview(MINI), module C, Short Geriatric Depression Scale of Korean version(SGDS-K), Korean Geriatric Anxiety Inventory(K-GAI), The Korean Health Status Measure for Elderly V 1.0, Korean version of Mini-Mental Status Examination for Dementia Screening(MMSE-DS). Their sociodemographic factors were investigated. The data were analyzed using the chi-square test and the logistic regression test to examine the relationship between suicidality and participants’ risk factors. Results:The prevalence rate of suicidality was 23.3%. In multiple logistic regression, depressive symptoms (OR=3.301, 95% CI : 2.453-4.440), anxiety symptoms(OR=3.289, 95% CI : 2.515-4.303), low physical function (OR=1.606, 95% CI : 1.229-2.098), no spouse(OR=1.571, 95% CI : 1.037-1.690), elderly aged 80 years or older (OR=1.506, 95% CI : 1.094-1.740) were independently associated with suicidality. Conclusion:Suicidality in community-dwelling elderly was quite high, particularly related to depressive symptoms. The results of this study can be useful for development of community-based prevention and management programs for suicidality.
지역사회의 치매 및 경도인지장애 독거노인에 대한 인지강화프로그램의 효과
김태우(Tae Woo Kim),이광헌(Kwang-Hun Lee),이 관(Kwan Lee),곽경필(Kyung-Phil Kwak) 대한노인정신의학회 2017 노인정신의학 Vol.21 No.2
Objective:This study aims to investigate the efficacy of 48-sessioned cognitive stimulation programs (CSP) in solitary elderlies with mild cognitive impairment (MCI) and dementia. Methods:Among 194 subjects, 125 were CSP participants and 69 were controls. Korean version of Mini-Mental Status Examination for Dementia Screening (MMSE-DS), Global Deterioration Scale, Seoul-Instrumental Activities of Daily Living (S-IADL) and Korean version of Geriatric Depression Scale-Short Form, Korean Quality of Life-Alzheimer’s Disease (KQoL-AD) were assessed. Outcomes were measured at baseline and after 48th session. we analyzed these collected data. Results:In CSP group, MMSE-DS (p<0.001), KQoL-AD (p=0.021) were significantly improved compared with their baseline. MMSE-DS was significantly improved in CSP group compared with controls, but KQoL-AD was not (p=0.078). Relative risk (RR) of MCI and dementia in CSP group was 0.491 [95% confidential interval (CI)=0.380-0.633] and that of activities of daily living (ADL) impairment (S-IADL>8) was 0.873 (95% CI=0.773-0.985). Conclusion:CSP improved cognition and quality of life in solitary elderly individuals with MCI or dementia. Also, CSP reduced relative risk of MCI and dementia by 50.8% and ADL impairment by 12.7%. Although we expect CSP might be helpful to prevent cognitive problems of them, appropriate public mental health programs are still needed for their emotional wellbeing.
인지훈련이 지역사회 노인의 도구적 일상 활동에 미치는 효능
이성민(Sung-Min Lee),이광헌(Kwang-Hun Lee),이 관(Kwan Lee),곽경필(Kyung-Phil Kwak) 대한노인정신의학회 2016 노인정신의학 Vol.20 No.2
Objective:This study was aimed to investigate the effectiveness of cognitive training to Instrumental Activities of Daily Living (IADL) in community-dwelling elderly. Methods:The participant were 786 elders who were aged over 59 years visiting local rest area from February 2015 to November 2015. The demographic data was collected. IADL were evaluated by Seoul-Instrumental Activities of Daily Living (S-IADL). Cognitive functions were evaluated by Korean Version of Mini Mental Status Examination for Dementia Screening (MMSE-DS). Before and after cognitive training, we analysed these data. Results:In all 15 items of S-IADL, 4 items (using the telephone, grooming, managing belongings, talking recent events) were specially improved (p<0.05). Conclusion:After cognitive training, indoor activities of S-IADL were improved but some items, especially outside activities were not improved for community dwelling elderly. In future, other programs to increase outside activities or social activities should be included in cognitive training programs for community dwelling elderly.