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완전동형암호 알고리즘 TFHE 스킴의 키 스위칭 하드웨어 구현
이관표(Kwan-Pyo Lee),박지웅(Ji-Woong Park),김동규(Dong Kyue Kim) 대한전자공학회 2022 대한전자공학회 학술대회 Vol.2022 No.11
To reduce noise, bootstrapping is essential in FHE (Fully Homomorphic Encryption). However, the secret key is changed during bootstrapping. We analyze the detailed structure of operation in Key switching which is needed to switch changed key to the original secret key. This paper proposes an implementation of Key switching hardware in TFHE.
B 형 바이러스성 만성 활동성 간염 환자에서 스테로이드 이탈요법 및 알파 인터페론 투여에 의한 면역상태의 변화
이관식(Kwan Sik Lee),한광협(Kwang Hyub Han),정준표(Jun Pyo Chung),전재윤(Chae Yoon Chon),이상인(Sang In Lee),문영명(Young Myung Moon),강진경(Jin Kyung Kang),박인서(In Suh Park),최흥재(Heung Jai Choi),신전수(Jeon Soo Shin),최인홍(In H 대한내과학회 1995 대한내과학회지 Vol.49 No.1
N/A Objectives: It has been suggested that cellular immune responses to the hepatitis B virus are of importance in the production of liver cell damage in chronic active hepatitis type B. Short-term corticosteroid withdrawal in patients with chronic active hepatitis type B is frequently associated with enhanced cellular immune responses to hepatitis B virus. Several clinical studies had suggested that short-term corticosteroid withdrawal followed by interferon treatment might enhance its antiviral efficacy. The present study was designed to investigate the change of immune parameters in patients with chronic active heptitis type B treatment with short-term corticosteroid withdrawal followed by interferon alpha(IFN-a). Methods: The subjects were 11 patients with chronic active hepatitis type B who were given prednisolone in decreasing daily doses of 60mg, 40mg and 20mg, each for 2 weeks, followed by a 4-week rest and l6 weeks of recombinant alpha 2a interferon (INF-α) was administered intramuscularly. Serum ALT level, serum HBV DNA level and serum sIL-2R level were assayed and CD4+ T cell/ CD8+T cell ratio, IL-2R+T cell/Total T cell(%), TLiSAI+T cell/Total T cell(%) and suppressor T cell activity were measured. Results: 1) The serum ALT level was increased significantly at 2 weeks after the end of prednisolone administration(p<0.005) and decreased significantly after the start of INF-α administration(p<0.005). 2) The serum HBV DNA level was increased significantly during the prednisolone administration(p<0.01) and decreased siginificantly after the end of prednisolone administration and resting period(p<0.05). 3) The serum sIL-2R level was increased significantly at 2 weeks after the end of prednisalone administration(p<0.05). After the end of prednisolone administration and the start of INF-α administration, the serum sIL-2R level was decreased significantly( p<0.05). 4) The increase of serum ALT level after the increase of IL-2R+T cell(%) and TLiSA1+ T cell/ Total T cell(%) after the increase of TLiSA1+T cell/ Total T cell(%) was significant. 5) The maximum increase of serum ALT level and the maximum decrease of suppressor T cell activity were observed in 4 of 5 patients(80.0%) at 2 weeks after the end of prednisolone administration. Conclusion: The serum HBV DNA level was decreased significantly by the immune rebound after the end of steroid administration. Probably increase of IL-2R+T cell/Total T cell(%) and TliSAl+T cell/ Total T cell(%) and decrease of suppresor T cell activity were related to the immune rebound.