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부분 간 절제가 Dimethylnitrosamine으로 인한 간 병변에 미치는 영향에 대한 연구
은희경,김진만,강대영 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.1
In an attempt to elucidate the pathological effects of dimethylnitrosamine (DMN) administration following partial hepatectomy (1/3), the present study was undertaken in male Sprague-Dawley rats. The evidence of hyperplastic nodules, the number and nuclear size of dysplastic cells, and the ratio of liver weight compared to body weight were evaluated, especially emphasizing on the difference among several groups. Rats were partially hepatectomized and DMN(10mg or 20mg per Kg) was administered at 20 hours or 40 hours after partial hepatectomy, and then weekly injected three times. Eight weeks after initial DMN injection group of these animals was placed on a diet containing phenobarbital 50mg per 10ml H_20. The animals were sacrified on 60, 90, and 120 days after DMN injection. The results were as follows; 1. The hyperplastic nodules in the DMN treated groups at 20 hours after partial hepatectomy (PH) were more prominent than those of the DMN treated groups at 40 hours after PH. 2. The number of dysplastic hepatocytes increased in the DMN treated groups at 20 hours after PH, compared to those of the DMN treated groups at 40 hours after PH. 3. The hyperplastic nodules and the numbers of dysplastic hepatocytes were more prominent than those of the control, and also proportional to the amount of treated DMN. 4. The average nuclear size of dysplastic cells was much larger (about 1.5 to 1.6 times) than that of the control. 5. The ratio of liver weight compared to body weight in phenobarbital groups was much larger than that of no phenobarbital treated groups. In summary, the result obtained by the present study indicates dimethylnitrosamine(DMN) induced hyperplastic nodules accompained by liver cell dysplasia. The observation provided some evidence supporting that proliferation hepatocytes rose to a peak at the G_1-S border phase and phenobarbital promoted DMN induced liver cell hyperplasia or dysplasia.
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殷熙慶,朴一洙,李台鎬 慶北大學校 醫科大學 1984 慶北醫大誌 Vol.25 No.3
1981年부터 1983年까지 本大學 産婦人科敎室에서 施行한 192例의 帝王切開例를 對象으로 感染症에 中點을 두어 術後 合倂症을 檢討한 바 그 成績을 아래와 같이 要約할 수 있었다. 帝王切開率은 産母 1308名中 192名으로 14.7%이었다. 高危險 産母인 20歲以下 및 35歲以下의 頻度는 各各 0.31% 및 1.6%이었다. 體重 2,500 gm 以下는 20.8%, 4,001 mg 以上은 7.8%이었다. 選擇對 應急 帝王切開術의 比는 177% 對 82.3%이었다. 合倂症 總數는 38例로 19.8%이었고 이 中 感染症이 28例로 14.5%이었으며, 이는 全 合倂症이 73.7%를 占하였다. 破水 6時間을 境界로 그 前後의 感染率은 前者가 4.9%, 候者가 31.3%로 有意差(p<0.005)를 認定할 수 있었다. 分娩開始 16時間을 境界로 그 前後의 感染率을 比較한 바 前者 및 候者의 그것이 각각 4.0% 및 17.9%로 有意差(p<0.025)를 認定할 수 있었다. 選擇 및 應急 帝任切開群別의 合倂症을 比較한 바 各各 11.8%와 21.5%로 候者의 增加 傾向을 觀察할 수 있었으나 有意差를 認定할 수 없었다. 感染症을 除外한 其他 合倂症中 가장 많았던 것은 麻痺性 腸重첩症이 全 合倂症의 18.4%로 比較的 높았으나, 全例가 輕症이었다. Analysis was made on complication of 192 cases of cesarean section which was conducted during 1981 to 1983 and particular attention was focused febrile morbidity. The results summarioed were as follows. Frequency of cesarean section was 192 cases out of 1308 deliveries revealed 14.7%. Frequency of high risk gravida which include age of under 20 and over 35 was 4 cases or 0.31 and 21 cases or 1.6% respectively. Fetal body weight under 2500gm was 40 cases or 20.8% and over 4,000gm was 15 cases or 7.8% respectively. Ratio between elective and emergency cesarean section was 34 cases vs. 158 cases revealed 17.7% and 82.3%. Total complication number was 38 cases or 19.8% among which febrile morbidity was 28 cases or 14.5% and was 73.7% that of total complication. Complications 16 hours before and after rupture of membrane was 4.9% and 31.3% revealed statistical difference. Complication rate before and after 16 hours from labor onset febrile morbidity was 4.0% and 17.9% showed statistic significance. Complication rate between elective and emergency cesarean section was 11.8% and 21.5% showed trend of increment of rate on the later group but failed to reveal statistical difference. Other than febrile morbidity leading factor was paralytic ileus which occupied 18.4% of total number of complication, but they were slight.
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은희경(HK Eun),정기묵(KM Chung),박일수(IS Park),이태호(TH Lee) 대한산부인과학회 1983 Obstetrics & Gynecology Science Vol.26 No.6
Among the total number of 1927 deliveries at Kyungpook National Unⅳersity Hospital during five years from Jan.1 1978 to Dec. 31 1982 fetal body weight 3800 gm or more were 100 cases. Their clinical characteristics were analysed various aspects and results obtained were summarized as follows. Frequency of excessⅳe sized baby, 3800gm or more was l00 cases out of 1927 total deliveries revealed 5.2%. Among their mean body weight by gestational age at delivery and standard deviation, the biggest were 4155gm at 42 weeks gestation and ±311.4gm at 39 weeks gestation with fetal weight 3998gm. There was no significant sex difference, revealed male 48.0% whereas female 52.0% respectively, The most frequent occurance of excessⅳe baby by gestational age was gestational age at 40~41 weeks or 60.0%. There was tendency that the more was the parity, the more was the frequency. ln relation between maternal age and fetal body weight, the age group 25~29 occupied 57.0%, the most ln medical complications of excessive baby, anemia was the most frequently encountered with 5.0% and followed by overt diabetes with 4.0%. ln obstetrical complication PROM was the most frequent with 23.2% followed by pre-celampsia 15.0%. Presentation of excessive baby, cephalic presentation was overwhelming with 86.0%. Concerning to the method of delivery non specific delivery was the most frequent with 44.0% followed by C-section with 36.0% Among indications of C-section for excessive baby CPD was the leading cause with 55.6%, previous C-section with 19.4% was the second. Indication of CPD in excessive baby was also much higher than that of control group. The perinatal mortality rate was 9.0% and it was thought unusual high rate. Among 9 cases perinatal death 7 cases were still birth with 3 cases of uterine rupture. Neonatal death was 2 cases.
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