증례 : 소화기 ; 간내 담관암 환자에서 발생한 간기관지루 1예

김정훈 ( Jeong Hoon Kim ),배상훈 ( Sang Hoon Bae ),배영석 ( Young Seok Bae ),이광재 ( Kwang Jae Lee ),홍준호 ( Jun Ho Hong ),윤정빈 ( Jeong Bin Yoon ),제인수 ( In Soo Je ) 대한내과학회 2009 대한내과학회지 Vol.77 No.5S

저자들은 고열과 가래 그리고 객혈을 주소로 내원한 간내담관암 환자에서 화농성 간병변으로부터 간기관지루가 형성된 것을 농양조영술을 통해 확인하였고, 경피적 배농술과 항생제 치료로 증상을 호전시켰다. 이후 간내 담관암이 인접장기로 전이되어 보존적 수술을 시행하였고, 수술 후 특이 증상의 호소 없이 지내다가 담관염과 폐렴을 동반한 패혈증으로 인해 사망에 이르게 된 1예를 경험하였기에 문헌고찰과 함께 이를 보고하는 바이다. We report an uncommon hepatobronchial fistula in a patient with a liver abscess and cholangiocarcinoma. A 66-year-old man was admitted because of a fever, right upper quadrant pain, and hemoptysis with a fishy smell. At admission, computed tomography showed an intrahepatic abscess located near the dome. Diagnostic percutaneous transhepatic cavitography disclosed a hepatobronchial fistula and a biopsy revealed intrahepatic cholangiocarcinoma. After antibiotic therapy and percutaneous drainage of the hepatic abscess for 5 weeks, his symptoms disappeared. However, he died of sepsis from cholangitis and pneumonia despite surgery and intensive medical treatment. (Korean J Med 77:S1137-S1141, 2009)

사회적 취약계층 고용으로 인한 기대효과

김세원(Sea-won Kim),윤정빈(Jeong-bin Yoon),문선윤,최민진(Min-jin Choi),최훈(Hoon Choi),이용설(Yons-Seol Lee) 한국정보통신학회 2022 한국정보통신학회 종합학술대회 논문집 Vol.26 No.1

증례 : 소화기 ; 내시경 조직 생검 후 발생한 점막하 식도 박리 1예

김동현 ( Dong Hyun Kim ),윤정빈 ( Jeong Bin Yoon ),김동완 ( Dong Wan Kim ),장세원 ( Se Won Jang ),윤종민 ( Jong Min Yoon ),김민정 ( Min Jung Kim ),김상현 ( Sang Hyun Kim ) 대한내과학회 2011 대한내과학회지 Vol.81 No.6

점막하 식도 박리 발생의 위험인자는 혈소판감소증, 혈우병, 내시경 경화요법, 심부 정맥 혈전증으로 항응고치료를 받는 환자, 이물, 약물, 내시경 등의 기계적 손상 또는 자발적으로 발생한 점막하 출혈 및 혈종이 있다. 하지만 조직검사로 인한 증례는 아직 발표된 바가 없다. 저자들은 식도 조직검사 후 발생한 흉골하 통증을 주증상으로 내원한 환자에서 상부위장관 내시경 검사를 시행하여서 점막하 식도 박리증을 진단하였다. 금식 및 수액요법 등의 보존 치료로 증상이 호전된 드문 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. The incidence of gastrointestinal complications has increased as endoscopic biopsy has become a standard diagnostic technique. However, esophageal dissection is a rare complication. A 71-year-old man suffered retrosternal pain for 15 days. Fifteen days previously, he had undergone an endoscopic gastrointestinal examination at a local clinic and an esophageal biopsy to obtain microscopic confirmation of esophageal candidiasis. The patient then underwent a subsequent endoscopic examination, which showed features specific to esophageal submucosal dissection. The predisposing conditions for esophageal dissection are coagulopathy, iatrogenic trauma (variceal sclerotherapy), drugs (thrombolytic agents, aspirin), foreign bodies/certain foods (fish, chicken bones), and emesis. However, endoscopic biopsy is a rare predisposing condition. Here, we report a case of esophageal submucosal dissection that developed after esophageal biopsy. We observed the healing process of this lesion with a series of endoscopies as part of a conservative treatment plan. (Korean J Med 2011;81:759-763)

선상태선의 임상, 병리조직 및 면역조직화학적 고찰

박지용(Ji Yong Park),윤정빈(Jeong Bin Yoon),이무형(Mu Hyoung Lee) 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.5

N/A Background:Lichen striatus is an uncommon dermatoses that generally affects children. The histopathology often shows a polymorphic epidermal reaction process of variable lichenoid and spongiotic changes having no specific histopathological criteria. The pathogenesis of lichen striatus is not well understood. A cell mediated immunologic mechanism is suggested as primary event in lichen striatus. Objective:The aim of our study was to evaluate clinical, histopathological and immunohistochemical findings that help to understand the characteristics and the pathogenesis of lichen striatus. Method:We clinically investigated 18 patients of lichen striatus that visited the department of dermatology at the Kyunghee medical center from January 1995 to June 1998. Among them, 15 patients had skin biopsies and were evaluated histopathologically and immunohistochemically. Results:The results were summarized as follows. 1. The male to female ratio was 1:1.2, and average age was 13.4 years. Interestingly three cases were adult onset lichen striatus. The areas in which the eruptions developed were(in descending order): upper extremity(61.1%), lower extremity (22.2%), and trunk(16.7%). Among them, two cases showed multiple skin lesions 2. Histopathologically, 9 cases showed superficial perivascular dermatitis, 5 cases interface dermatitis, 1 case nodular dermatitis. Six cases showed inflammation around hair follicle, 6 cases around eccrine sweat gland. 3. Immunohistochemically, 11 cases showed the predominance of CD8+ T cells beneath epidermis. In the epidermis, the Langerhans cells increased in 11 cases and the HLA-DR expression of keratinocytes showed in all cases. Conclusion:In our study, we were able to obtain the clinical and histopathological features of lichen striatus which help to understand the nature of lichen striatus. Immunohistochemical findings suggest that cell mediated immune mechanism is involved in pathogenesis of lichen striatus. (Korean J Dermatol 2000;38(5):600~606)

조도와 동공 영역의 측정 변화에 따른 굴절력과 수차의 비교

김봉환,한선희,박병규,황현주,배예솔,서정빈,여예은,윤민정,김학준,Kim, Bong-Hwan,Han, Seon-Hee,Park, Byeong-Gyu,Hwang, Hyeon-Ju,Bae, Ye-Sol,Seo, Jeong-Bin,Yeo, Ye-Eun,Yoon, Min-Jeong,Kim, Hak-Jun 한국임상보건과학회 2016 한국임상보건과학회지 Vol.4 No.2

Purpose. We compared with the refracting power and aberration according to the measurement change in illumination and the pupils area by using the auto refraction instruments. Methods. In this study it were examined 64 eyes without eye disease, 21.4 (${\pm}2.54$) age, 32 (male 10, female 22) patients. Experiments in general illumination using the auto refraction instruments (HRK-8000A, Huvitz, Korea) was measured in both eyes 3 times and after scotopic for 30 minutes in a dark room blocked the light was measured in the same way. Aberration were measured coma, spherical aberration, high and low order aberrations in a general illumination (3500 lux) and low illumination (5 lux) of the pupil area 3.96 mm and 5.96 mm. Results. In the general illumination for measuring of the pupil area, the refractive power, coma, spherical aberration and low order aberration was no significant difference. In the low illumination, spherical aberration of the pupil area was $0.005({\pm}0.015){\mu}m$ in a 3.96mm, $0.014({\pm}0.020){\mu}m$ in a 5.96 mm and appeared a significant difference(p = 0.003). In general and low illumination on the results of comparing the measured values of the refractive power and aberration at the pupil area 3.96 mm, high order aberrations was $0.205({\pm}0.145){\mu}m$ in general illumination, $0.132({\pm}0.075){\mu}m$ in low illumination and appeared a significant differences(p = 0.001). High order aberrations at the pupil area 5.96 mm was $0.278({\pm}0.244){\mu}m$ in general illumination, $0.150({\pm}0.092){\mu}m$ in low illumination and appeared a significant differences(p = 0.000). Conclusions. When the eye refractive power measured by the automatic refraction does not depend on the illumination conditions and size of the observation pupil area, it was found that aberrations are affected by the illumination and the observation pupil area. It was found that the eye examination chamber illumination to obtain accurate measurement produces better results to decrease than to increase.

소아복벽원심성 지방위축증 2예

윤정빈,허충림,김낙인 경희대학교 1997 慶熙醫學 Vol.13 No.4

Kyrle 병 2 예

김낙인,윤정빈 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.12

Kyrle's disease is a rare disorder characterized by hyperkeratotic papules containing a central, cone-shaped plug on the extensor surface of the extremites. We describe two cases of Kyrle's disease. The first case is 65-year-old male patient. He had multiple pruritic hyperkeratotic papules with a central plug on both lower extremities. He has suffered from Diabetes mellitus for 20 years. The second case is 54-year-old male patient. He had multiple pruritic hyperkeratotic papules with a central plug on the back, upper and lower extremities. He has been suffered from Diabetes mellitus for 20 years and chronic renal failure for 6 months. Histopathologic findings showed central epidermal invagination filled with heavy keratotic, partly parakeratotic plug and basophilic debries. Many vacuolated cells and a few dyskeratotic cells were seen below the keratotic plug.

다발성 선상 태선 2예

이무형,윤정빈 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.7

Lichen striatus usually occurs in a solitary and unilateral fashion. Its multiple and bilateral distribution is a very rare finding. We report two cases of multiple lichen striatus. The first case is a 3 year-old boy, whose skin lesions were distributed bilaterally on both upper arms and buttock. The second case is a 6 year-old girl whose skin lesions were two separated linear lesions from left chest and left upper back to left arm.

천연색 필름 현상액에 의한 태선양 접촉피부염 1예

허충림,이무형,윤정빈 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.1

Color developing agents which are derivatives of p-phenylenediamine, e.g. KODAK CD-2(2- amino-5 diethylaminotoluene) and CD-3(4-amino-N-ethylN beta m-toluidine sesquisulfate monohydrate), are known to cause contact allergy. There are two types of reactions to these chemicals. The first one is an acute eczematous lesion, and the other is a lichenoid lesion. A 33-year-old man developed a lichenoid contact dermatitis on both forearms and posterior neck after exposure to a color developing agent. Patch test revealed positive reaction to CD-2. Histopathologic finding from the skin lesion showed a lichen planus-like appearance.

인슐린이 섬유아세포의 증식 및 세포주기에 미치는 영향

심우영,김성수,허충림,윤정빈 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.12

Background:Insulin exerts an effect on cell proliferation and inhibition of apoptosis. However, the actions of insulin on cell cycle progression and signal transduction pathway are not well understood and insulin shows diverse effects on cell proliferation depending on cell types. Objective:We attempted to understand the underlying mechanism by which insulin exerts this proliferative effect on 3T3 L1 fibroblasts by various markers of cell proliferation. Method:We investigated the effect of insulin on cell proliferation by [3H]thymidine incorporation, analyzing the cell cycle stages by flow cytometric measurement of DNA content per cell, cell counting, analysing cell division as well as the signal transduction pathway of insulin by measuring of phosphatidylinositol 3-kinase(PI3-kinase) and p44/42 mitogen-activated protein kinase (p44/42 MAPK/ERK) activity. Results:The results were as follows : 1. Total accumulated [3H]thymidine incorporation increased approximately two-fold with insulin over the 0.5% serum control at 48 h incubation, and the maximal rate of DNA synthesis was observed during 8-12 h incubation and continuously declined until 48 h without a second increase in DNA synthnesis. 2. The flow cytometric analysis of cell population distribution showed that insulin increased the cell population in S phase. 3. After insulin treatment for 48 h, cell number was increased approximately 45% in comparison with 0.5% serum control. 4. The cell division analysed after staining 3T3 L1 fibroblasts with carboxyfluorescein diacetate succinimidyl ester (CFSE). Cell division occured only once in 24h after insulin treatment. 5. Insulin stimulated PI3-kinase and p44/42 MAPK/ERK activity about three- and two-folds, respectively. Conclusion:Taken together, this data indicates that insulin stimulated the transit from G0/G1 to S phase, progressed cell cycle through G2/M phase, increased the cell number and PI3-kinase, p44/42 MAPK/ERK stimulate cell proliferation. However, under our experimental conditions, insulin has a limited efficacy for late cell cycle events required for completion of miosis and cell cycle progression into the second round and the increase of the cell number by insulin was much less than the increase of the PI3-kinase and p44/42 MAPK/ERK activity. Therefore, the authors think that another pathways other than PI3-kinase or p44/42 MAPK/ERK might be involved in the effect of insulin on cell proliferation.