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Tape stripping을 이용한 세포증식이 자외선 B에 의한 일광화상세포 형성에 미치는 영향
윤재일(Jai Il Youn),김방순(Bang Soon Kim),문상은(Sang Eun Moon) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.2
index (%) in unirradiated mouse skin was 11.0+4.3. LI was significantly increased by tape stripping to 22.1+4.6. 2. The number of SBC in 1cm epidermis after 50mJ/cm UVB exposure was 28.2+4.1. The number of SBC was increased by tape stripping to 57.4+Cell proliferation, by evaluating sunburn cell (SBC) formation, was studied in mouse skin following tape stripping and ultraviolet light B (UVB) exposun.. 1-radiation was achieved using high pressure mercury are UVB. The results are summarized as follows. 1. Labeling 19.2. These results suggest that proliferating cells are more sensitive to UVB exposure. (Kor J Dermstol 1992;30(2): 162-167)
건선에서 acitretin과 etretinate의 치료 효과 비교
문상은(Sang Eun Moon),김방순(Bang Soon Kim),윤재일(Jai Il Youn),이유신(Yoo Shin Lee) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.3
Etretinate, an effective retinoid in the treatment of pustular, erythrodermic and chronic plaque type psoriasis, has the disadvantage of a long terminal elimination half-life. On the other hand, acitretin, the active metabolite of etretinate, has much shorter terminal elimination half-life and is being reported as an agent with good antipsoriatic activity by several authors. To evaluate the clinical efficacy of acitret.in in comparison with etretinate, we treated 10 patients wit,h acitretin at a dose of 30mg per day and 11 patients with etretinate at a same dose for 12 weeks. The PASI score at 12 week was significantly reduced in each group as compared with baseline PASI score. In the acitretin treated group the initial PASI score of 14.5 reduced to 3.9, while the etretinate group PASI score reduced from 12.0 to 3.1. The PASI score differ ences between the acitretin and etretinate groups at each time during therapy and the end of therapy were not statistically significant. The severity of adverse reactions with acitretin was similar to those with etretinate but their incidence was higher. The change in laboratory parameters in the acitretin group was simlar to that of the etretinate group. In view of these results and the known pharmacokinetic advantage of acitretin, that is the short terminal elimination half-life, it is conceivable that acitretin may be a useful alternative to etretinate in the treatment of psoriasis. (Kor J Dermatol 1992; 30(3): 354-361)
피부 악성 종양의 통계적 고찰 ( 1990년 - 1995년 )
문상은 ( Sang Eun Moon ),조광현 ( Kwang Hyun Cho ),황지환 ( Ji Hwan Hwang ),김정애 ( Jeong Aee Kim ),윤재일 ( Jai Il Youn ) 대한피부과학회 1998 大韓皮膚科學會誌 Vol.36 No.1
Background: There is concem about the rising incidence of skin cancer. However, few articles have reported the change in the clinical and epidemiological aspects of skin cancer. Objective : We performed this study in order to clarifiy the recent changes in cutaneous premalignant and malignant lesions. Methods : A statistical analysis was made using 101 cases of cutaneous premalignant lesions and 205 cases of ma]ignant tumors out of a total number of 20,175 new outpatients that visited the Department of Dermatology at the Seoul National University Hospital during a 6 year period(1990-1995). Results : The frequency of premalignant lesions was 0.50% and that of malignant tumors was 1.02%. The frequency showed an increasing tendency compared to previous reports. In the premalignant lesion cases, actinic keratosis was most common and represented a figure of 82.2%. Among the malignant tumors, basal cell carcinoma was most frequent at 24.4%. Age, sex and anatomical site distribution of basal cell carcinoma, malignant melanoma was no different. The mean age of squamous cell carcinoma was greater than in previous reports and main preceding lesions were actinic keratosis and cheilitis. The frequency of lymphoma was markedly increased but the reason for this remains to be determined. Conclusion: Our findings showed the continous increasing incidence of skin cancers and emphasize the need for public eduacation, early diagnosis and proper treatment. (Korean J Dermatol 1998;36(1): 7-15)
문상은(Sang Eun Moon),윤재일(Jai Il Youn),조광현(Kwang Hyun Cho) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.3
We report a case of anosacral cutaneous amyloidosis in a 74 year-old-man. The skin finding is a patch of the size of a childs palm on the sacral area, consisting of brownish macular lines that radiate frorn the anus. Histopathology revealed defiosits of homogenous eosinophilic mateial s in the papillary dermis. Congo red staining and dylon staining was positive. Immuohistochemical staining using anti SAP antibodies and anti-keratin antibodies showed positive reactions. (Kor J Derniiatel 1993; 31(3): 403-407)
특발성 망막전막 제거술 전후의 다국소 망막전위도 비교에 대한 연구
강재훈,최은수,윤재문,윤희성,Jae Hoon Kang,Eun Su Choi,Jae Moon Yoon,Hee Sung Yoon 대한안과학회 2008 대한안과학회지 Vol.49 No.1
`Purpose: To assess macular function before and after vitrectomy and membrane removal in epiretinal membranes by means of multifocal electroretinogram (mfERG). Methods: The mfERGs (RETIscan?, Roland, Germany) of 28 consecutive patients (28 eyes) with idiopathic epiretinal membranes were recorded before epiretinal membrane surgery and 3 to 6 months after surgery. The average retinal response density and implicit time of each local response were estimated as anatomic macular areas corresponding roughly to 5 rings. Preoperative and postoperative responses of mfERG were compared. The correlation of the change of retinal response density and postoperative macular configuration on optical coherent tomography (OCT) was statistically analyzed. Results: The postoperative value of P1 amplitude and implicit time were not statistically correlated with the preoperative value (p>0.05). There were no significant correlations between the changes of rings 1 and 2 with regard to the retinal response density of the mfERGs and visual acuity. There was no significant correlation between the change of retinal response density and postoperative macular configuration according to OCT. Conclusions: The use of mfERGs does not seem useful for predicting clinical prognosis after epiretinal membrane surgery. Further studies of influence of internal limiting membrane removal on mfERG response should be conducted.`
고우석(Woo Seok Koh),문상은(Sang Eun Moon),김방순(Bang Soon Kim),윤재일(Jai Il Youn) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.3
Hydrochlorothiazide is a diuretic drug used in the treatement of edema and hypertension. We report a case of hydrochlorothiazide induced photosensitivity in a 54 year old woman who had taken hydrochlorothiazide for 3 years for hypertension. She complained of itching and burning sensation with erythematous papules and lichenified plaques on light-exposed areas. Fhototest showed marked decrease of the minimal erythema dose(MED) for UVA. The symptoms subsided after the use of topical steroid and the substitution atenolol for hydrochlorothiazide. (Kor J Dermatol 1992; 30(3): 373-376)
건선 환자의 조갑 병변에 대한 임상적 , 진균학적 관찰
김정애 ( Jeong Aee Kim ),문상은 ( Sang Eun Moon ),이동윤 ( Dong Youn Lee ),윤재일 ( Jai Il Youn ) 대한피부과학회 1996 大韓皮膚科學會誌 Vol.34 No.4
Background: Nail involvement in psoriasis is common. But their manifestions may often be difficult to differntiate clinically from onychomycosis, and results on fungal infections in psoriatic nails are still conflicting. Objectiye : The purpose of this study was to observe the clinical signs and mycolgical profiles of psoriatic nails. Methods : The frequency and types of clinical signs were observed prospectively according to sex, age, site, and accompaning tinea pedis. Repeated direct micrscopic and culture examinations, and KONCPA(KOH+Nail Clipping+PAS) study were done in the nails showing subungual kera tosis, and/or onycholysis. Results : Fifty nine(59%) out of 100 patients with psoriasis had psoriatic nail changes. Nail changes were more common in fingers than in toes(55% vs 34%), in males than in females(68.9 % vs 43.6%). The types of frequent nail changes were different in fingers and in toes. Dermatophytes were isolated in 2 cases(8%) and yeasts and non-dermatophytic moulds were isolated in 20-40% of psoriatic nails Conclusion : Psoriatic nail changes of fingers and toes showed different clinical signs. Thus we recommended psoriatic nails to be diagnosed according to the involved site. The isolation of dermatophytes in the psoriatic patients were not so rare. Repeated culture was thought to be the most valuable test because yeasts and moulds were frequently isolated as saprophytes or contaminants. (Kor J Dermatol 1996;34(4): 629-636)