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자색 마령서 에탄올 추출물의 비만 및 고지혈증 억제효능
윤성수,이연희,이은옥,이효정,장유성,이근성,원숙현,임학태,김성훈,Yoon, Sung-Soo,Lee, Yun-Hee,Lee, Eun-Ok,Lee, Hyo-Jung,Jang, Yu-Sung,Lee, Keun-Sung,Won, Sook-Hyun,Lim, Hak-Tae,Kim, Sung-Hoon 대한동의생리학회 2007 동의생리병리학회지 Vol.21 No.3
This experimental study was performed to evaluate the effects of ehtanol extract of Purple Solanum tuberosum L(EPSTL) on obesity and hyperlipidemia in rats induced by high fat diet. Sprague-Dawley rats were divided into normal group, control group, EPSTL (100 mg/kg and 200 mg/kg) treated group. EPSTL was orally administered to the obese rats by high fat diet for 6 weeks. The effect of EPSTL on obesity and hyperlipidemia were examined in vitro and in vivo as follows : EPSTL effectively inhibited the differentiation of 3T3-L1 adipocytes in a concentration dependent manner. EPSTL significantly lowered body weight of rats fe high fat diet for 6 weeks from 4 weeks treatment compared with untreated control. EPSTL significantly reduced the weight of retroperitoneal fat only at 100 mg/kg and epididymal fat pad in rats fed high fat diet for 4 weeks at 100 and 200 mg/kg. EPSTL significantly reduced the level of triglyceride at 200 mg/kg, while EPSTL tended to lower the levels of total lipid and phospholipid in rats fed high fat diet for 4 weeks with no significance. EPSTL significantly attenuated the level of total cholesterol, LDL and atherosclerosis index (Al) as well as increased the level of HDL at 200 mg/kg. EPSTL significantly reduced the levels of total lipid and triglyceride of hepatic tissues in rats fed high fat diet for 4 weeks at 200 mg/kg. EPSTL significantly lowered the level of insulin, while it did not affect leptin compared with untreated control. Taken together, these results suggest that EPSTL can be used for the treatment or prevention of hyperlipidemia and obesity.
실적공사비 적산 시스템 운영을 위한 실적 자료 관리 시스템 개발
정연철 ( Jung Yun Chul ),배연정 ( Bae Yun Jung ),윤성수 ( Yun Sung Soo ),이정재 ( Lee Jung Jae ) 한국농공학회 2000 한국농공학회 학술대회초록집 Vol.2000 No.-
This study is aimed to develop the historical data management system named "ACON"(Actual COst Network system) which can be used for collecting, analysis and modification of the historical data. ACON_Local is used for collecting the historical data at each spot place. It redueces the work potential of managers, spending time and cost. ACON_Analysis is to analyze the collection , modifies the data′s error and updates the historical database. ACON_Network is developed to transfer data from ACON to Web server or opposites. The proposed model, ACON, provide the easy way for the cost estimate system, "HiCOMS" to collect, analyze and modify the historical cost evaluated data, which is used to compose the historical data base.
유전자 알고리즘을 이용한 경지 구획 결정 지원 시스템 개발에 관한 연구
정연철 ( Jung Yun Chul ),윤성수 ( Yun Sung Soo ),이정재 ( Lee Jung Jae ) 한국농공학회 2001 한국농공학회 학술대회초록집 Vol.2001 No.-
For standard size of farmland in Korea is small, we have to consume huge labor for cultivation and efficiency of machine is low. We practice the project, which make size of farmland enlarge. For many factors have to consider in design process in case of large-scale farmland, there are difficulties for comparing alternatives if we design it manually. So we need to techniques for establishing various alternatives and choosing the optimum design by the computer. In this study, fixing the boundary of project using the RGIS (Rural Geographical Information System) which standard electronic map in Korea. In the boundary, we analysis the many characteristics of farm land, optimize the adjustment process of field unit of farmland. In this process, we develop automatic farmland division techniques. The results of adapting the developed system show the usefulness to enlarge the size of farmland about 200%.
허영수,강수환,윤성수,Huh, Young-Soo,Kang, Su-Hwan,Yun, Sung-Su 대한소아외과학회 1999 소아외과 Vol.5 No.2
Splenic cysts are uncommon and classified as either primary(true) or secondary(pseudo-) depending on the presence or absence of a true epithelial lining. True cysts (epidermoid cyst) of the spleen are very rare. Three cases of splenic cysts in childhood were treated at the Yeungnam University Hospital in the last eleven years(1989-1999). Two of patients were girls. The ages at diagnosis were 7, 12 and 15 years. Abdominal ultrasonography and computerized tomography were utilized for the diagnosis. Radionuclide scanning was performed in one patient. Surgical resection(one partial splenectomy and two total splenectomies) was performed. The sizes of cysts were 4, 6.5 and gem in maximum demension.
만성면역혈소판감소자색반에서의 Anti-D immunoglobulin 치료
김혜정 ( Hye Jeong Kim ),정윤진 ( Yun Jin Jung ),황의남 ( Eui Nam Hwang ),김영훈 ( Young Hoon Kim ),최진성 ( Jin Sung Choi ),남승현 ( Seung Hyun Nam ),김봉석 ( Bong Seog Kim ),오도연 ( Do Yeon Oh ),윤성수 ( Sung Soo Yoon ),박선양 대한내과학회 2008 대한내과학회지 Vol.74 No.2
목적: 성인 만성 면역혈소판감소자색반 환자에서 anti-D 면역글로불린을 투여하여 혈소판 상승에 대한 효과와 부작용을 확인하고자 본 연구를 시행하였다. 방법: 이전 치료에 반응을 하지 않거나 재발한 전체 14명의 성인 만성 면역혈소판감소자색반 환자를 대상으로 하였다. 14명 환자가 스테로이드 요법을 받았고, 10명의 환자는 비장절제술을 시행 받았다. Anti-D 면역글로불린의 주입량은 50~70 μg/kg이었으며 단 한번 주입하여 반응을 확인하였고, 치료 반응의 평가는 혈소판 및 혈색소 수치를 추적 검사하였다. 결과: 치료 반응이 확인된 경우는 전체 환자의 36% 인 5명이었고, 혈소판 상승이 지속된 기간은 평균 7일이었으며 심각한 합병증은 없었다. 결론: 본 연구에서는 성인의 만성 면역혈소판감소자색 반증에서 Fc 수용체 차단제인 anti-D 면역글로불린을 이용한 치료가 임상적 유용성이 있는 것으로 나타났다. Background/Aims: Immune thrombocytopenic purpura (ITP) is an autoimmune disease that is mediated by anti-platelet antibodies. Based on the pathogenesis of ITP we evaluated the efficacy of intravenous anti-D immunoglobulin for adult chronic ITP. Methods: Fourteen patients (4 without splenectomy and 10 with splenectomy) with refractory chronic ITP were treated with 50-70μg/kg of intravenous anti-D immunoglobulin only once. Treatment effects were evaluated by measuring the platelet counts and hemoglobin levels. Results: Five patients (36%) showed a response; improvement in the platelet count lasted for on average 7 days (range: 2~24 days). There were no serious adverse effects. Conclusion: Anti-D immunoglobulin, which is associated with an Fc receptor blockade, appeared to be safe and effective for the treatment of adults with chronic ITP. Further studies are needed to confirm these findings and define further potentially effective treatment protocols with intravenous anti-D immunoglobulin. (Korean J Med 74:176-180, 2008)