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소아간질에서 성공적인 항경련제 치료에 영향을 미치는 인자
윤석중(SUK-JOONG YUN),이영혁(YOUNG-HYUK LEE) 대한소아신경학회 1994 대한소아신경학회지 Vol.2 No.1
Antiepileptic drugs were discontinued in 104 children with epilepsy of various causes. Their age was under 15 years. They had been free of seizures for two or more years. The subjects were then followed more than 1 years. Sixty patients relapsed. and 44 remained free of seizures. The clinical factors examined in this study were age of onset of seizure, sex, etiology, duration of seizure before treatment, type of seizure. EEG and brain C-T finding. Presence or absence of etiology, neurological findings before treatment, type of seizures and number of used antiepileptic drugs important in predicting outcome. Our results suggest cryptogenic epilepsy (p<0.0005), generalized type of seizure (p<0.01) and treatment with single antiepileptic drug (p<0.005) were favorable prognostic factors. We conclude that it seems resonable to consider discontinuing antiepileptic medications in children who fall into a favorable prognostic category after being free of seizures for two years. But children with a poorer prognosis should be maintained on medications more than two years.
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간장 및 담도 : 각종 간 질환에서 혈청 성장 호르몬치 및 L - dopa 자극에 대한 성장호르몬의 변화
조성원(Sung Won Cho),심찬섭(Chan Sup Shim),어수택(Soo Taek Uh),윤석중(Suk Joong Yun),황성규(Sung Kyu Hwang) 대한소화기학회 1986 대한소화기학회지 Vol.18 No.1
N/A To evaluate the basal serum growth hormone(GH) and GH response to L-dopa administration in various liver diseases, we measured serum GH by radioimmunoassay before and 30, 60, 90, and 120 minutes after L-dopa administration in 11 patients with liver cirrhosis, 4 patients with chronic hepatitis, 5 patients with acute hepatitis, and 5 normal control. The basal serum GH was significantly higher in liver cirrhosis(10.84+-2.90ng/ml), chronic hepatitis(3,35+-2.03ng/ml), and acute hepatitis(2.10+-0.92ng/ml) than in normal control (0.78+-0.29ng/ml) and higher in liver cirrhosis than in acute or chronic hepatitis. The increase in GH concentration after L-dopa administration was lower in liver cirrhosis than in chronic hepatitis, acute hepatitis, and normal control, but there were no significant differences. There were no correlation between basal serum GH and prothrombin time, albumin, and estradiol. We conclude that impaired CNS neurotransmission may play a significant role in elevated basal serum GH in liver diseases.
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B 형 급성간염에서 IgM Anti-HBc 의 진단적 의의
백승호,조성원,심찬섭,윤석중,나우균,박노춘 대한내과학회 1987 대한내과학회지 Vol.32 No.3
To investigate the diagnostic significance of IgM anti-HBc in acute hepatitis B, IgM anti-HBc was measured by radioimmunoassay in 41 pateitns with acute hepatitis B, 18 patients with chronic hepatitis, 29 patients with liver cirrhosis, 1S patients with primary hepatoma, and 23 healthy carriers. The results obtained were as follows; 1) Distribution of Hepatitis B virus markers in acute hepatitis B Of the 41 patients with acute hepatitis B, 29 patients (70.8%) were seropositive for HBsAg and IgM anti-HBc, 6 patients (14.6%) were seropositive for HBsAg and seronegative for IgM anti-HBc, 5 patients (12.2%) were seronegative for HBsAg and serapositive for IgM anti-HBc, and 1 patient (2.4%) was seronegative for HBsAg and IgM anti-HBc. 2) IgM anti-HBc in acute hepatitis B Of the 41 patients with acute hepatitis B, 34 patients (82.9%) were IgM anti-HBc positive. IgM anti-HBc was tested in 33 patients with positive IgM anti-HBc within 2 weeks after onset of jaundice, and tested in 7 patients with negative IgM anti-HBc more than 4 weeks after onset of jaundice. IgM anti-HBc titer decreased gradually with time in 12 patients with positive IgM anti-HBc in whom the follow up evaluation was available. In 3 patients, IgM anti-HBc became negative seroconversion at 4 weeks after onset of jaundice, In 3 patients, IgM anti-HBc became negative seroconversion at 9 weeks, 11 weeks, and 20 weeks after onset of jaundice, respectively. IgM anti-HBc was more frequently detected in acute hepatitis B compared with chronic liver diseases (p$lt;0.05) and 23 of 41 patients (56.1%) with acute hepatitis B had P/N ratio over 4. 3) IgM anti-HBc in chronic liver disease IgM anti-HBc was postitive in 2 of 1S patients (11.1%) with chronic hepatitis B, 5 of 29 patients (17.2%) with liver cirrhosis, 3 of 18 patients (~26.7%) with hepatoma, and 1 of 23 (4.3%) healthy carriers. Among these, only 2 patients (7%) with liver cirrhosis had P/N ratio over 4. 4) The relationship between HBeAg and IgM anti-HBc in acute hepatitis B There was no significant difference in positivity and P/N ratio of IgM anti-HBc between HBeAg positive and negative patients with acute hepatitis B(p$lt;0.1), In conclusion, IgM anti-HBc testing can aid in the diagnosis of acute hepatitis 8. But if IgM anti-HBc testing is performed more than 4 weeks after onset of jaundice, it could be negative in acute hepatitis B. And it should be careful to diagnose acute hepatitis B because there is false negative results on conventional radioimmunoassay in acute hepatitis B.
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성인성 호흡장애 증후군에서의 혈중 α₁-Antitrypsin 과 Elastase Inhibitory Capacity
양동호,이성희,어수택,박춘식,김치환,윤석중,안상용,정연태 대한내과학회 1986 대한내과학회지 Vol.30 No.6
To evlauate the hypothesis that adult respiratory distress syndrome(ARDS) is related to the imbalance between proteolytic enzymes and protease inhibitors, and to determine the prognostic value of α₁-antitrpsin(α₁-AT), Elastase lnhibitory Gapascity(EIC), and the ratio of EIC to α₁-AT in patients with ARDS, we measured the α₁-AT, EIC, and EIC/ α₁-AT daily from day 1 to day 9 on ventilator in serum of 16 patients with ARDS and 40 normal population. At the day 1 on ventilator, mean values of serum α₁-AT and EIC are higher in ARDS than that in normal control(p$lt;0,005). Among ARDS, recovered patients with ARDS have higher serum α₁-AT levels than those of non-recovered patients with ARDS(p4o.ps), but there were no difference of serum EIC and EIC/ α₁-AT between recovered and non-recovered patients with ARDS. There were no differences of serum a α₁-AT and EIC/ α₁-AT in recovered and non-recovered patients with ARDS from day 1 to day 9 on ventilator, but serum levels of EIC are significantly higher in recovered patients than those in non-recovered patients with ARDS from day 1 to day 9 on ventilator. These values suggest that serum EIC level of patients with ARDS have the value in predicting prognosis and serum level of α₁-AT are higher in patients with ARDS than those in normal control.
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