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토끼에서 αvβ5 인테그린 항체의 결막하주사에 의한 각막신생혈관 억제효과
윤경철,임성규,오한진,안규윤,김경근,Kyung-Chul Yoon,Seong-Kyu Im,Han-Jin Oh,Kyu-Youn Ahn,Kyung-Keun Kim 대한안과학회 2005 대한안과학회지 Vol.46 No.11
Purpose: To investigate the efficacy of a subconjunctival injection of αvβ5 integrin antibody on corneal angiogenesis induced by chemical epithelial denudation in a rabbit eye model. Methods: One week after debridement by heptanol, rabbits were treated with a subconjunctival injection of αvβ5 integrin antibody or control immunoglobulin G weekly for 2 weeks. Rabbits that did not receive injection after debridement served as the untreated group. The percentage of neovascularized corneal area was calculated by biomicroscopy, and the sectioned area and number of new vessels were calculated by histological examinations. Results: At 7 days after the first injection, αvβ5 integrin antibody-treated eyes had 9.5% (P=0.02) and 6.8% (P=0.03) less neovascularized corneal area than vector-treated eyes and untreated eyes, respectively. At 7 days after the second injection, αvβ5 integrin antibody-treated eyes had 21.1% (P=0.02) and 18.3% (P=0.02) less neovascularized corneal area than vector-treated eyes and untreated eyes, respectively. Light microscopic examination showed a smaller neovascularized corneal area and a reduced number of new vessels in the αv β5 integrin antibody-treated eyes compared to the control eyes. Conclusions: Subconjunctival injection of αvβ5 integrin antibody effectively reduces experimental corneal neovascularization induced by chemical injury, and could be used as a corneal angiogenesis inhibitor in the future.
김종연,윤경철,박영걸,조남천,유인천.Jong Youn Kim. MD. Kyung Chul Yoon. MD. Yeoung Geol Park. MD. Nam Chun Cho. MD. In Cheon You. MD 대한안과학회 2010 대한안과학회지 Vol.51 No.7
Purpose: To evaluate the age-related risk factors, clinical manifestations, and prognosis in infectious keratitis. Methods: Records of patients with infectious keratitis who visited one of the two tertiary medical centers at Jeolla-do from January 2000 to December 2007 were reviewed. Risk factors depending on patient age distribution standardized over and under the age of 60 were reviewed retrospectively by analyzing sex, age, previous history of trauma, systemic disease, previous ocular disease, causative organism and treatment. Results: A total of 757 patients (757 eyes) visited either one of the two tertiary medical centers. The mean age was 58.2±18.0 (4 to 93) years, and patients included 437 males (57.7%), and 320 females (42.3%). The most common risk factor among all age groups was trauma, especially due to vegetable matter. The second most frequent risk factor among the younger patients was contact lens use (19.2%), and common risk factors among the elderly were previous ocular disease (20.0%), systemic disease (15.5%), and ocular surgery (9.7%). The most prevalent causative organisms among all age groups were Gram-positive bacteria, in particular Staphylococcus epidermidis. Elderly patients had a higher frequency of corneal perforation than did younger patients. In addition, elderly patients had a worse prognosis and more often required surgical treatment. Conclusions: Infectious keratitis has more severe clinical manifestations and complications and a worse prognosis in elderly than in younger patients. Elderly patients have more diverse risk factors. Prevention should aim at avoiding ocular trauma, especially by vegetable matter, and at controlling ocular surface diseases, such as exposure keratitis and bullous keratopathy.
각막신생혈관에 대한 버테포르핀을 이용한 광역학치료의 동물실험
나현주,윤경철,임욱빈,안규윤,서만성,Hyeon-Ju Nah,M,N,Kyung-Chul Yoon,Wook-Bin Im,Kyu-Youn Ahn,Man-Seong Seo 대한안과학회 2005 대한안과학회지 Vol.46 No.4
Purpose: To determine the efficacy of photodynamic therapy (PDT) with verteporfin (Visudyne?, Norvatis Ophthalmics AG, Hettingen, Switzerland), a benzoporphyrin derivative, in the treatment of corneal neo- vascularization (CN) in a rabbit eye model. Methods: CN was induced by placing instrastromal sutures in the cornea. Two weeks after suturing, verteporfin was administrated intravenously and 1 hour later, the right eye (treated group) was exposed to a laser with a 689 nm wavelength, and the left eye was used as the control. The changes in CN were analyzed using biomicroscopy and optical microscopy in twelve rabbits. Results: The mean percentages of the neovascular area in the control and treated groups were 96.4±1.9% and 90.3±3.5% (P=0.009) at three days after the PDT, 88.6±4.6% and 71.6±6.2% (P<0.001) at one week, and 76.8±4.4%와 43.6±15.1% (P<0.001) at two weeks, respectively. Optical microscopy showed significant differences between the control and treated group in terms of the area and number of CN (P<0.05). Conclusions: PDT with verteporfin is a safe and effective procedure for regressing CN. However, a further study will be necessary.
김기태(Kim Ki-Tae),박기연(Park Ki-Youn),윤경철(Youn Kyung-Chul),유환희(Yoo Hwan-Hee) 대한공간정보학회 2009 한국지형공간정보학회 학술대회 Vol.2009 No.4
도시의 재개발 및 주거환경개선사업지구에 위치한 노후 건축물을 효과적으로 관리하기 위해 휴대용 비디오에 GPS가 장착된 시스템을 이용하여 도시기반시설을 관측하였다. 현장에서 대상 건물에 접근하여 다양한 방향으로 관측하고, 여기서 관측된 동영상과 GPS자료 등을 이용하여 건축물 관리에 필요한 정보를 처리 및 생성함으로서 유비쿼터스개념의 시설물관리가 될 수 있는 기반기술을 제시하였다.