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염증성 장질환과 5-ASA 투여가 임신 및 태아에 미치는 영향울산대학교 의과대학 서울아산병원 내과학교실
최지훈 ( Ji Hun Choi ),유혜승 ( Hye Seung Yoo ),양석균 ( Suk Kyun Yang ),명승재 ( Seung Jae Myung ),조윤경 ( Yun Kyung Cho ),이윤정 ( Yun Jung Lee ),변정식 ( Jeong Sik Byeon ),이진혁 ( Gin Hyug Lee ),정훈용 ( Hwoon Yong Jung ) 대한장연구학회 2004 Intestinal Research Vol.2 No.1
Background/Aims: 5-Aminosalicylic acid (5-ASA) preparations are the first-line drugs in the treatment of inflammatory bowel disease (IBD). The aim of this study was to examine the influence of IBD and its treatment with 5-ASA on pregnancy and fetal outcome. Methods: A total of 56 patients (ulcerative colitis 41, Crohn``s disease 15) experienced 84 pregnancies among 634 female patients with IBD between June 1989 and August 2003. The outcomes of 42 pregnancies exposed to 5-ASA during pregnancy were compared with those of 42 non-exposed pregnancies. Results: Pregnancy outcomes were not different between the exposed and non-exposed pregnancies in terms of live birth (85.7% vs 80.9%), abortion (11.9% vs 19.0%), stillbirth (2.4% vs 0%), preterm delivery (11.1% vs 5.9%), low birth weight (11.1% vs 8.8%), congenital malformation (2.8% vs 2.9%), and aggravation of disease during pregnancy (21.4% vs 16.7%). These figures appear to be similar to those of general population. Conclusions: Neither ulcerative colitis nor Crohn``s disease has any significant impact on pregnancy outcome, and 5-ASA does not increase the risk of congenital malformation.
우리나라 고등학교의 정신건강이 학업성취도와 학업중단율에 미치는 영향
방은주(Eun Ju Bang),김두형(Du Hyung Kim),노법래(Beop Rae Roh),유혜승(Hye Seung Yoo),장지현(Ji Hyeon Jang),하경희(Kyung Hee Ha),박은진(Eun Jin Park),홍현주(Hyun Ju Hong) 대한소아청소년정신의학회 2016 소아청소년정신의학 Vol.27 No.3
Objectives: The purpose of this study was to explore the influence of high school students’ mental health on their academic achievement and school dropout rate by using longitudinal data. Methods: For this study, 153 high schools were randomly sampled on a nationwide scale. The descriptive data was collected from a school information internet site which is organized by the Korean Ministry of Education. We used the schools’ mean scores on the Adolescent Mental Health Problem-Behavior Questionnaire-II (AMPQ-II) scale which was used for estimating students’ mental health in the 2013 school-based mental health screening test. The data analysis was conducted by using hierarchical regression analysis. Results: The results of this study showed that the AMPQ-II scale’s mean scores have significant effects on the following year’s academic achievement and annual dropout rates. Especially, the AMPQ-II scale’s mean scores tend to increase the school dropout rate in vocational schools. Conclusion: The finding of this study is that Korean high school students’ mental health states significantly influence their academic achievement and school dropout rate.
HBeAg 음성, HBV DNA 양성인 만성 B형 간질환 환자에서 Lamivudine의 치료 효과
서동진,이영상,이한주,정영화,유혜승 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.4
Background/Aims: The aim of this study was to evaluate the efficacy of lamivudine in patients with HBeAg-negative and HBV DNA-positive chronic liver disease. Methods: Twenty-four chronic liver disease patients were enrolled whose serology had common characteristics of HBeAg (-), and anti-HBe (+) but HBV DNA (+). All had elevated alanine aminotransferase (ALT) levels. 150mg of lamivudine was given orally once daily for more than 6 months. The goal of this treatment was the elimination of HBV DNA in serum and normalization of ALT level. Once HBV DNA disappearance and ALT normalization were observed, lamivudine was continued for two additional months. HBeAg, anti-HBe, HBV DNA and ALT were followed up every 1-2 month during, and after, treatment. Results: Median duration of treatment was seven months. HBV DNA became undetectable after a median one month of treatment and ALT activity was normalized in all 24 patients within six months. Among the sixteen patients who were followed for more than 12 months after cessation of treatment, six relapsed. The cumulative relapse rate at 12 months was 37.5%. Conclusion: Lamivudine suppresses HBV replication effectively and normalizes serum ALT in patients with HBeAg-negative and HBV DNA-positive chronic liver disease. The relapse rate after cessation of treatment seems to be relatively low.(Korean J Hepatol 2000;6:488-494)