국소 아밀로이드증(Amyloidosis)이 동반된 안와 점막연관 림프조직형 림프종(MALT lymphoma) 1예

유인정,우경인,김윤덕,In Jeong Lyu,Kyung In Woo,Yoon-Duck Kim 대한안과학회 2013 대한안과학회지 Vol.54 No.7

Purpose: To report a case of primary orbital MALT lymphoma with localized amyloidosis. Case summary: A 61-year-old male visited our clinic with diplopia, which had developed approximately 5 months earlier. Magnetic resonance imaging of the orbit showed an ill-defined well-enhanced mass in the left inferior orbit. Incisional biopsy of the orbital mass was performed. Histopathological examination revealed diffuse deposits of an amorphous, eosinophilic substance in the extracellular matrix and vessels with lymphocytes infiltration. Lymphocytes were positive for the immunohistochemical stain against the CD20 and κ-light chain antigens. The amorphous material stained positive for κ-light chain antigen, and Congo red staining showed birefringence. Conclusions: We report a rare case of primary orbital MALT lymphoma associated with localized amyloidosis.

정상안압녹내장의 빠른 시야손상진행 위험요인

유인정,이정민,기창원,In Jeong Lyu,Jung Min Lee,Changwon Kee 대한안과학회 2012 대한안과학회지 Vol.53 No.7

Purpose: To evaluate risk factors of rapid visual field progression in normal-tension glaucoma. Methods: The authors of the present study reviewed the medical records of patients with normal-tension glaucoma who were treated between 2001 and 2011. The rapid progression group was composed of patients who showed a visual field index progression rate of ≤ -2.0%/yr, and the slow progression group was composed of patients who showed a visual field index progression rate of > -1.0%/yr using a Humphrey visual field analyzer (HFA). Age, sex, diabetes, hypertension, migraine history, family history of glaucoma, refractive error, central corneal thickness, disc hemorrhage, beta-zone parapapillary atrophy, baseline mean deviation, pattern standard deviation, initial IOP, mean follow-up IOP, peak IOP, IOP fluctuation, and number of eye drops between the 2 groups were compared. Results: Among the 52 patients with normal-tension glaucoma, 26 were classified into the rapid progression group and 26 were classified into the slow progression group. The mean visual field index progression rate was -3.92%/yr and -0.42%/yr, respectively. In the univariable model, migraine history, disc hemorrhage, beta-zone parapapillary atrophy, and number of eye drops were associated with rapid visual field progression. According to multivariate analysis, disc hemorrhage and number of eye drops were statistically significant risk factors. Conclusions: Disc hemorrhage and number of eye drops were associated with rapid visual field progression in normal tension glaucoma patients. J Korean Ophthalmol Soc 2012;53(7):996-1001

Conjunctival Hypertrophic Scar Following Cryotherapy for Retinopathy of Prematurity

유인정,사호석,우경인,김윤덕 대한안과학회 2013 Korean Journal of Ophthalmology Vol.27 No.1

A 6-year-old boy was referred to our hospital with symblepharon and lateral canthal deformity in both eyes, which developed 6 years ago. The patient was born at 27 weeks gestation. He had received cryotherapy for retinopathy of prematurity. One month after cryotherapy, he developed a conjunctival scar with symblepharon in both eyes and underwent symblepharon lysis at another hospital 5 years prior. Ocular examination revealed an extensive conjunctival hypertrophic scar with symblepharon and limitation of extraocular movements. An excisional biopsy, lateral canthoplasty, and symblepharon lysis with conjunctival autograft from the contralateral eye were performed in the left eye. Histopathologic examination revealed diffuse proliferation and infiltration of collagenous tissue.

두개골유합증과 연관된 V형 내사시 및 하사근기능항진의 수술적 교정

유인정 대한안과학회 2020 대한안과학회지 Vol.61 No.10

Purpose: We describe the use of bilateral medial rectus recession with inferior transposition and inferior oblique myectomy to treat a patient with craniosynostosis exhibiting V-pattern esotropia and inferior oblique overaction. Case summary: An 8-year-old girl with esotropia and a history of cranioplasty for craniosynostosis visited our clinic. Her best-corrected visual acuity (BCVA) was 0.5 and 0.3 in the right and left eye, respectively. Latent nystagmus was observed in both eyes. She exhibited 40 prism diopters (PD) of esotropia in the primary position, 30 PD during upgaze, and 45 PD during downgaze. Bilateral superior oblique underaction and inferior oblique overaction were observed. Fundus examination revealed excyclotorsion in both eyes. Computed tomography (CT) revealed superior displacement of both medial rectus muscles. She underwent 5.5-mm medial rectus recession with inferior transposition and inferior oblique myectomy in both eyes. After 9 months, she exhibited 5 PD of dissociated vertical deviation at far distance in the right eye, and 10 PD of exotropia with 5 PD of dissociated vertical deviation at near distance. Ductions and versions were within the normal range in both eyes. Conclusions: Bilateral medial rectus recession with inferior transposition and inferior oblique myectomy is useful in patients exhibiting V-pattern esotropia and inferior oblique overaction in association with craniosynostosis. 목적: 두개골유합증과 연관된 V형 내사시 및 하사근기능항진을 보이는 환자에서 양안 내직근후전 및 하방전위술, 하사근절제술을 시행한 1예를 보고하고자 한다. 증례요약: 두개골유합증으로 두개골성형술을 받은 8세 여아가 내사시를 주소로 내원하였다. 최대교정시력은 각각 우안 0.5, 좌안 0.3이었고, 양안에 현성잠복눈떨림이 관찰되었다. 프리즘교대가림검사에서 원거리 제1안위에서 40프리즘디옵터(prism diopters, PD), 상방주시때 30 PD, 하방주시때 45 PD의 내사시를 보였다. 양안 상사근기능저하 및 하사근기능항진이 관찰되었고, 안저사진에서 양안외회선이 보였다. 안와 전산화단층촬영검사에서 양안 내직근의 상방 편위가 확인되었다. 이에 양안 내직근을 5.5 mm 후전 및 하방전위하고, 양안 하사근절제술을 시행하였다. 9개월 후 눈 위치는 원거리에서 우안 5 PD의 해리수직편위, 근거리에서 우안 5 PD 해리수직편위 및 10 PD의 외사시 소견이 관찰되었고, 그 외 안구운동은 정상이었다. 결론: 두개골유합증과 관련된 V형 내사시 및 하사근기능항진을 보이는 환자의 수술적 치료에 있어 양안 내직근후전술 및 하방전위술, 하사근절제술이 효과적일 수 있다.

하지근력강화운동이 뇌성마비 아동의 균형과 보행에 미치는 영향

유인정,손경현,Ryu, In-Jung,Son, Kyung-Hyun 대한물리치료과학회 2011 대한물리치료과학회지 Vol.18 No.2

Purpose: The aim of this study was to ascertain the effects of the lower extremity muscle strengthening exercise on balance and ambulation of children with cerebral palsy. Methods: 10 subjects who participated in this research undertook the 12-week the lower extremity muscle strengthening exercise program, which consisted of a series of mat exercises and sling exercises. The statistical significances were examined by using Wilcoxon signed-rank test, a non-parametric test, for evaluating the improvement of balance and ambulation of the subjects. In order to evaluate the correlation among the variables, Pearson's correlation coefficients were also calculated. In all statistical analyses the significance level was selected as ${\alpha}$=0.05. Results: Berg balance scale(BBS) was significantly increased after the intervention(p<.05). Percentage weight bearing(PWB) was decreased after the intervention, but there was no significant difference. Time up and go test(TUG) value was significantly decreased(p<.05). Gait velocities was increased after the intervention, but there was no significance. Stride length, step lengths of the affected side and the sound side were significantly increased after the intervention(p<.05). In the correlation analyses of the measures before the intervention, TUG had significant negative correlation to BBS and gait velocity(p<.05). Stride length, step lengths of the sound side and the affected side had significant positive correlation between themselves(p<.01). In the correlation analyses of the measures after the intervention, TUG had significant negative correlation to BBS and gait velocity(p<.05). BBS revealed significant positive correlations to stride length, step lengths of the sound side and the affected side(p<.05). Stride length, step lengths of the sound side and the affected side had significant positive correlation between themselves(p<.01). Conclusion: Based upon the outcomes as above, it is likely that the muscle strength exercises have substantial effects on balance and ambulation of children with cerebral palsy. Thus various lower extremity muscle strengthening exercise programs are required to be studied and developed in order to contribute to functional improvements of children with cerebral palsy.

히알우론산나트륨 점안액의 장기 사용으로 인한 독성 각막염 1예

이은정,유인정,현주,임동희,정태영 대한안과학회 2015 대한안과학회지 Vol.56 No.2

목적: 히알우론산나트륨 점안액을 장기간 점안하여 이로 인해 독성각막염이 발생한 증례를 보고하고자 한다. 증례요약: 74세 여자 환자가 양안의 심한 안구통증 및 시력저하를 주소로 내원하였다. 내원 10년 전 양안 굴절교정수술 받았으며 수술후 발생한 건성안 조절을 위하여 히알우론산나트륨 점안액을 장기간 사용하였다. 검안상 양안 각막 중심부 및 하부에 표층각막염 소견을 보였고, 이에 과거력과 임상소견으로 독성 각막염을 의심하고 사용하던 점안약제를 중단한 후 자가혈청안약을 처방하고 1개월후 추적 관찰하였을 때 안경교정시력의 호전, 주관적인 불편감의 해소 및 부분적인 각막염의 호전을 관찰하였다. 결론: 장기간 점안하던 히알우론산나트륨 점안액의 사용을 중단한 후 각막염이 회복됨을 관찰하였기에 독성각막염의 가능성이 높다고 생각하며, 본 증례를 통해 히알우론산나트륨 점안제를 장기간 사용하는 경우의 위험성을 일깨우고, 적절한 안과 진료가 동반되어야 한다는 점을 되새겨 볼 수 있겠다. Purpose: To report a case of toxic keratitis due to chronic use of sodium hyaluronate eyedrops. Case summary: A 74-year-old female visited our clinic with severe ocular pain and decreased vision in both eyes. She had received refractive surgeries in both eyes 10 years prior. She had been using sodium hyaluronate eyedrops for the treatment of dry eye symptoms for 10 years. Slit-lamp examination revealed inferior punctate erosions in the inferior part of the cornea in both eyes. With her history of chronic use of sodium hyaluronate and after ophthalmologic examination, we suspected keratitis medicamentosa due to sodium hyaluronate eyedrops. We discontinued the eyedrops she was using and prescribed autologous serum. One month later, ocular discomfort and decreased vision were improved and corneal erosions were decreased. Conclusions: In the present case, toxic keratitis was assumed to be associated with the use of sodium hyaluronate eyedrops and corneal erosions improved after the eyedrops were discontinued. We suggest sodium hyaluronate eyedrops are potentially hazardous and recommend a regular follow-up should be performed by a qualified ophthalmologist.

장스팬 Virendeel Truss의 최적 설계에 관한 연구

박건태,유인정,박태준,박학길 대한건축학회지회연합회 2008 대한건축학회지회연합회 학술발표대회논문집 Vol.2008 No.1

Long-span girder system is used to that utilization of inner space. It has a good merit in the practical use. But because girder's stiffness and strength is law, a large deflection and a large mass problem follows. The purpose of this study is to improve the parameter influencing the deflection and strength, and to find the optimization of the section properties - the minimum -weighted structure. Pratt truss system weak to the shear resistance, so we used braces to increase shear stiffness. And optimization method is used to the model analysis in order to obtain the minimum-weight and the minimum deflection. The system is optimized virendeelizine to the non shear affected range.

Overexpression of the OsbZIP66 transcription factor enhances drought tolerance of rice plants

윤수인,이동근,유인정,김연식,최양도,김주곤 한국식물생명공학회 2017 Plant biotechnology reports Vol.11 No.1

Drought stress is a major constraint of crop development and productivity. Plants have evolutionally developed several mechanisms at the molecular, cellular, and physiological levels to overcome drought stress. The basic leucine zipper (bZIP) transcription factor (TF) family members are starting to be concerned about their roles in drought stress responses. In this study, we functionally characterized OsbZIP66, a rice group-E bZIP TF, to be associated with rice drought tolerance mechanisms. Expression of OsbZIP66 was significantly induced upon treatments of rice plants with drought, high salinity, and ABA. These observations and the fact that the OsbZIP66 promoter contains ten ABA-responsive cis-elements suggest that OsbZIP66 is up-regulated by drought stress in an ABA-dependent manner. Overexpression of OsbZIP66 both in a whole plant body and specifically in roots enhanced drought tolerance of rice plants, indicating that the rice drought tolerance positively correlates with the expression levels of OsbZIP66. Thus, our results demonstrated that OsbZIP66 has a potential for use in biotechnological development of high-yielding rice plants under drought conditions.

굴절부등근시환자에서의 우세안과 굴절이상의 관계

이승기,김성진,유인정 대한안과학회 2019 대한안과학회지 Vol.60 No.5

Purpose: To investigate the relationship between dominant eye and refractive error in patients with myopic anisometropia. Methods: This study population consisted of myopes less than 15 years old who were followed up for anisometropia defined as interocular difference of spherical equivalent (SE) ≥1.0 diopter (D). All patients underwent the hole-in-the-card test at far and near to determine ocular dominance. The data were analyzed for statistical significance using Fisher’s exact test. Results: A total of 102 eyes in 51 patients were analyzed. The mean age of the patients was 10.4 ± 1.4 years and 54.9% were male. The mean SE was -2.97 ± 1.95 D in the right eye and -3.02 ± 1.92 D in the left eye. The right eye was the dominant eye in 43.1% and 37.3% at distance and near, respectively. The agreement of dominancy between distant and near was 82.4%. The near dominant eyes showed statistically significant accordance with more myopic eyes (p = 0.009). On the other hand, there was no statistically significant relationship between more myopic eyes and distant dominant eyes (p = 0.09). Conclusions: The near dominant eye was more myopic eye in patients with myopic anisometropia. This was considered to be related with the lag of accommodation in dominant eye with near distance. 목적: 굴절부등근시환자에서 우세안과 굴절이상의 관계를 확인하고자 하였다. 대상과 방법: 굴절이상으로 경과 관찰 중인 15세 이하의 소아근시환자 중 양안 구면 대응치(spherical equivalent) 값의 차이가 1.0 디옵터(diopter, D) 이상이며, hole-in-the card test 방법을 이용하여 원거리 및 근거리의 눈우세검사(ocular dominancy test)를 시행한 환자를 대상으로 하였다. 통계 분석은 Fisher’s exact 검정을 이용하였다. 결과: 총 51명, 102안의 자료를 분석하였다. 평균 나이는 10.4 ± 1.6세였으며 남아가 54.9%였다. 평균 구면 대응치는 우안에서 -2.97 ± 1.95 D, 좌안에서 -3.02 ± 1.92 D였다. 원거리 우세안이 우안인 경우는 43.1%, 근거리 우세안이 우안인 경우는 37.3%였다. 원거리 우세안과 근거리 우세안의 일치도 82.4%였다. 근거리 우세안은 근시가 더 심한 눈에서 더 높은 빈도를 보였고 이는 통계적으로 유의하였다(p=0.009). 반면 원거리 우세안이 근시가 더 심한 눈인 경우는 62.7%였으나 통계적으로 유의하지는 않았다(p=0.09). 결론: 굴절부등근시환자에서 근거리 우세안은 근시가 더 심한 눈이었다. 이는 근거리 작업 시 우세안에서 이루어지는 조절 부족(lag of accommodation)과 관련될 것으로 생각된다.

편마비 환자의 보행에 대한 외회전 감소운동의 효과

김아람,박철주,유인정,최정욱,현주협,조남정,유병국,정종희,이호준 대한임상전기생리학회 2008 대한임상전기생리학회지 Vol.6 No.1