위장관 ( 胃腸管 ) : 건강한 한국인에서 대장 통과시간

나용호(Yong Ho Nah),유석근(Seog Keun Yoo) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.3

N/A On the basis of colonic transit study using radiopaque markers, patients with constipation may be divided into three different groups. In the first, there is delay in the colon (colonic inertia). In the second, feces pass normally along the colon but are stored too long in the rectum (outlet obstruction). In the third, transit time of the radiopaque marker is normal. To distinguish between different types of constipation is the first step in the evaluation of patients with chronic constipation. There is the variability of colonic transit related to the intake of dietary fibers. As quite difference between Korean food and Western food, colonic transit in Korean may be different to that of in Western people. The aim of this study was to evaluate the colonic transit in healthy Korean. Segmental colonic transit with commercially available radiopaque markers was stuided in 60 healthy volunteers. Subjects ingested one capsule (20 radiopaque 0-rings) at 9:00 AM on each of 3 consecutive days while they are fully ambulatory. A plain radiograph of the abdomen was obtained on the 4th or 7th day. Total colonic transit was 10.57 (+12.80) hr (meanSD); segmental transit was 3.87 (+7.23) hr for the right colon, 3.31 (+- 5.01) hr for the left colon, 3.27 (+- 5.66) hr for the rectosigmoid. Sex did not influence transit significantly. This study shows that Koreans have markedly faster transit than Western and technique is simple and convenient for clinical usage.

구순부에 발생한 상피세포암의 치료

유병표,김동주,최현준,조경호,유석근 大韓成形外科學會 1995 Archives of Plastic Surgery Vol.22 No.5

The lip cancers are the most common form of oral squamous cell cancer. The aesthetic and functional restoration was required after wide excision of the lip cancers. Many procedures have been described to reconstruction of the upper and lower lip defects. Over the past 7 years we have used various local flap techniques for reconstruction of 12 cases after resection of the squamous cell cancer. We select the techniques for reconstruction of the ablative lip defect by it's size and location. It is desirable that if metastasis to the neck was suspected, regional lymph node biopsy should be performed before radical neck dissection.

압궤손상된 백서의 좌골신경에서 구형파 전기 자극이 기능회복에 미치는 효과

유석근 大韓成形外科學會 1997 Archives of Plastic Surgery Vol.24 No.1

Effects of square-pulse stimulation on the functional recovery following a nerve injury were examined in rats. A crush injury was made on the sciatic nerve under ketamine anesthesia and square-pulse stimulation with 5-7 V,0.2ms, 20 Hz, and 5 sec ON-OFF type was applied to the lesion site through teflon coated stainless steel wires(0.45mm in diameter) for 4 hours per day up to 2 days. Motor evoked potential(MEP) of the tibial nerve and somatosensory evoked potential (SSEP) of the T12 spinal cord were recorded. And their threshold, amplitude and latency were then analyzed. 1.Threshold off MEP was 41±5 uA, and that of SSEP was 39±13 uA. 2.MEP was composed of 3 waves, i.e.,N1,N2,N3,in which N1 was conducted by Aα fibers and the others by the synaptic fibers from the spinal cord. 3.SSEP was also composed of 3 waves, in which N1 was conducted by IA,N2 to Ⅱ, and N3 to Ⅲ fibers. 4.MEP and SSEP were abolished immediately after crush injury and SSEP was more sensitive. N1 disappeared faster than N2 and N3. 5.Evoked potentials were abolished by application of local anesthetics, in which N2 and N3 were more sensitive than N1. 6.Electrical stimulation decreased thresholds of evoked potentials down to50% in MEP, and 30% in SSEP. 7.Electrical stimulation increased amplitudes of evoked potentials and decreased latencies following an injury.

흰쥐의 좌골신경 절단손상후 기능회복에 대한 Acetyl-L carnitine의 효과

조주원,이정재,손유리,유영천,유석근 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3

A possible therapeutic effect of acetyl-L carnitine (ALCAR) on peripheral nerve injuries and the expression of Jun, the protein products of immediate-early genes(IEGs), in the spinal cord were investigated after sciatic nerve injury in Sprague-Dawley rats. Experimental animals were divided into 3 groups: intact sciatic nerve as a control group, surgical repair alone, and surgical repair with ALCAR treatment. Toe-spreading response, pinprick response, and compound action potential were measured to evaluate the recovery of sciatic nerve injury. Recovery of behavioral function and electrophysiological function both improved in the surgical repair with ALCAR treatment group. Weak basal expression of Jun was shown in the ventral horn the of spinal cord in the control group. In the surgical repair alone group or the surgical repair with ALCAR treatment group, Jun expression persisted until 28 days after injury in the ventral horn of the spinal cord. Moreover, the surgical repair with ALCAR treatment group showed more increased expression of Jun than the surgical repair alone group. These results suggest that ALCAR facilitates the functional recovery after peripheral nerve injury.

창상치유에 관한 복합마데카솔의 효과

유영천,유석근 大韓成形外科學會 1998 Archives of Plastic Surgery Vol.25 No.8

This study was designed to assess the effects of compound madecassol(madecassic acid with neomycin sulfate and hydrocortisone acetate) on the wound healing. Madecassol is a titrated extract of centella asiatica and the clinical effects of madecassol are stated to the enhancement of wound healing and the prevention and relief of excessive scar formation. Compound madecassol is composed of madecassol and neomycin sulfate and hydrocortisone acetate. Neomycin sulfate has antibiotic effect and hydrocortisone acetate has antiinflammatory and antiallergic effects. So, compound madecassol has a synergistic effect of madecassol as well as neomycin sulfate and hydrocortisone acetate. Using 54 rats, we compared the effect of compound madecassol on wound healing at 3rd, 7th, 14th, and 21th postoperative days. This study examined the histologic findings and the gross findings which were wound size, epithelization and quality of granulation tissue. In this study, compound madecassol showed lower degree of inflammatory infiltration, shorter inflammatory phases and less wound contraction. The number of the myofibroblast in the group of compound madecassol were fewer than other groups. Granulation tissue of the compound madecassol was relatively healthier than others. There were no significant difference of re-epithelization between compound madecassol and other groups. In conclusion, compound madecassol can reduce excessive wound contraction and promotes wound healing process.

백서 성체 창상에서 antisense TGF-β₁oligodepxynucleotides가 TGF-β₁의 유전자 발현과 교원질 합성에 미치는 영향

박석돈,유병표,김형민,정헌택,최병민,최현준,유석근 大韓成形外科學會 1996 Archives of Plastic Surgery Vol.23 No.2

Adult wounds heal with scar formation, whereas fetal wounds heal without scarring and with a lesser inflammatory and cytokine response. Resently transforming growth factor (TGF) -βis known to play an important role in scar formation following tissue injury. Therefore we suggest that antisense TGF-β₁oligodeoxynucleotides (ODNs) complementary to TGF-β₁mRNA might decrease expression of TGF-β₁gene in dermal wound of the mouse. To evaluate this concept, we tested the effects of antisense ODNs targeted to TFG-β₁mRNA by topical application of the chemical on the skin wound. Phosphorothioate antisense ODNs were employed to retard their degradation. Northern blot analysis of on set of animals showed that the wounded skin treated with antisense ODNs exhibited no detectable levels of TFG-β₁mRNA, whereas the wounded skin treated with sense TGF-β₁ODNs expressed significant amounts of TGF-β₁ODNs treated wound tissue contained much less collagen than did the control wounds. In conclusion, our results indicate that antsense TGF-β₁ODNs could be used for ameliorating scar formation during wound healing.

투시영상기 조영하에서 외부 강선견인술을 이용한 관골궁 골절의 비관혈적 정복술

조경호,유석근,유병표,최현준 大韓成形外科學會 1997 Archives of Plastic Surgery Vol.24 No.1

Recently, facial traumas are increasing due to expansion of motor vehicles and complexity of social life pattern. The zygoma bone is a prominent part of the midface and prone to be traumatized. Numerous approaches for reduction and fixation of zygomatic fractures have been described. Each reduction method has its advantages and disadvantages. The authors employed the extemal wire traction with fluoroscopy in cases of non-comminuted zygomaticarch fracture. The advantages of this method are a more accurate reduction under direct vision and takes a very short time. This procedure also can reduce the pain and edema after postoperation and possible under local anesthesia. With such method, we obtained satisfactory results cosmetically and functionally.

메치실린 내성 황색 포도상구균(MRSA)에 대한 소독제 및 항생제의 살균력 효능

이화중,나영천,유석근,김동철,김신무 大韓成形外科學會 2002 Archives of Plastic Surgery Vol.29 No.6

메치실린 내성 황식 포도상구균(MRSA)에 대한 소독제 및 항생제의 살균력 효능

이희중,나영천,유석근,김동철,김신무 大韓成形外科學會 2002 Archives of Plastic Surgery Vol.29 No.6

Triamcinolone acetonide와 colchicine이 Balb/C 3T3 섬유모세포에 미치는 영향

유석근,최현준,임기영,유병표 大韓成形外科學會 1994 Archives of Plastic Surgery Vol.21 No.5

Several forms of treatment have been utilized for keloids and hypertrophic scars with varying degrees of success. Intralesional steroid injection, pharmacologic treatment, has been used most commonly and proved its efficacy in experimental and clinical. In colchicine, there are no animal and human data to substantiate the efficacy of systemic colchicine in the treatment of keloid. To investigate the effect of triamcinolone and colchicine, cultured Balb/C 3T3 fibroblasts in the media containing various of triamcinolone and colchicine were assayed by colometric screenings of tetrazolium MTT assay. The results obtained were as follows. 1. Triamcinolone and colchicine induced the dose dependent decrease of the activity of mitochondrial succinic dehydrogenase. 2. Inhibiting effect of colchicine were 10 times higher than those of triamcinolone at the same dose. 3. The combined triamcinolone with colchicine of treated groups showed higher inhibiting effect than the triamcinolone or colchicine of treated group.