한약 및 천연물의 항암 임상연구 방법론에 대한 고찰

오혜경,이지영,류한성,윤성우,Oh, Hye Kyung,Lee, Jee Young,Ryu, Han Sung,Yoon, Seong Woo 대한암한의학회 2015 大韓癌韓醫學會誌 Vol.20 No.1

Objectives : The cancer incidence and cancer burden is increasing. In addition, the use of botanical agents in cancer care is increasing. This article aims to review a research strategy for botanical agents. Methods : The clinical studies of anticancer botanical agents and the papers about clinical research methodology of botanical agents were reviewed. Results : In phase I study, safety confirmation, optimal dose determination and drug interaction study are important. Most botanical agents have low toxicity and some have non-monotone dose response. Therefore, dose-response curve must be evaluated separately from the dose-toxicity curve to determine optimal dose. Although anticancer botanical agents can't shrink tumor size rapidly, they do extend survival. So, in phase II study, response should be evaluated by the survival. Conclusions : Clinical research of botanical agents in cancer is different from traditional methods and strategies. Considering the characteristics of botanical agents and experimental mechanism is necessary in conducting botanical based clinical trials.

한방병원에 입원한 노인암 환자의 치료 특성 분석

오혜경,이지영,류한성,윤성우,Oh, Hye-kyung,Lee, Jee-young,Ryu, Han-sung,Yoon, Seong-woo 대한한방내과학회 2016 大韓韓方內科學會誌 Vol.37 No.2

Objective: Because the number of geriatric cancer patients is on the rise but information on treatments for this population is limited, this study aimed to analyze clinical characteristics and the factors that influence treatment decisions among elderly cancer patients.Method: Data on elderly cancer patients (≥65 years of age) who were admitted to a traditional Korean medicine hospital from March 2014 to February 2016 were collected. We compared the clinical characteristics and overall survival rates of the chemotherapy group and the non-chemotherapy group.Results: Nineteen patients were included in this study. Nine people received chemotherapy, and ten people did not receive chemotherapy due to concerns about quality of life. Age, activities of daily living (ADL) score, and Eastern Cooperative Oncology Group (ECOG) performance status all showed differences between the two groups, although median survival times did not differ significantly between the two. Compared with chemotherapy alone, traditional Korean medicine combined with chemotherapy prolonged median survival times.Conclusion: Old age and low ECOG performance status and ADL scores appear to be influential factors for the decision to undergo chemotherapy. Further studies are needed to confirm that these factors influence decisions about cancer treatment methods among geriatric cancer patients.

아파트 실내공간의 차별화 계획에 관한 연구

오혜경,신지원 ( Hye Kyung Oh,Jee Won Shin ) 대한가정학회 1998 Family and Environment Research Vol.36 No.7

최근 입주된 수도권 아파트 거주자를 대상으로 본 규모별 실 구성 요구 분석

오혜경,함민정,Oh, Hye-Kyung,Ham, Min-Jung 한국주거학회 2008 한국주거학회 논문집 Vol.19 No.5

The purpose of this study was to suggest optimum guidelines apartment rooms by conducing survey among residence whose apartment floor size is between $66-198m^2$ and whose apartment is less than 3 years old. The effective numbers of survey questionnaire turned in was 226 and the survey analysis has been made by using of SPSS WIN 12.0. The results and conclusion of the studies are as follows; (1) $66{\sim}98m^2$ : The recommended numbers of bedroom is 2 and 3. The size of maser bedroom needs to be decreased whereas the size of living room be increased. (2) $99-131m^2$: The recommended numbers of bedroom is 3 and 4. The size of maser bedroom and maser bathroom needs to be decreased whereas the size of living room, 2nd bedroom, kitchen and dining room needs to be increased. (3) $132-164m^2$: The recommended numbers of bedroom is 3 and 4. The size of maser bedroom and bathroom needs to be decreased whereas the size of dress room, kitchen and dining room, and 2nd bedroom needs to be increased. (4) $165-197m^2$: The recommended numbers of bedroom is 3 and 4. The size of maser bedroom and maser bathroom needs to be decreased and the size of dressroom and kitchen /dinning room needs to be increased. (5) $198m^2$ and above: the recommended numbers of bedroom is 3,4 and 5. The size of dressroom needs to be increased. It is revealed that the number of bedroom doesn't need to be increased as the size of apartment is increased. Larger space is required for the public space for the family and dressroom. And smaller space is required for the maser bedroom and master bathroom.

Small sized lung SBRT 치료시 폐 실질 조직에서의 계획선량 전달 정확성 평가

오혜경,손상준,박장필,이제희,Oh, Hye Gyung,Son, Sang Jun,Park, Jang Pil,Lee, Je Hee 대한방사선치료학회 2019 대한방사선치료학회지 Vol.31 No.1

목 적: 본 연구에서는 lung SBRT가 적용되는 작은 계획 표적 용적(PTV)에 처방 선량이 정확히 전달되는지 실험을 통하여 알아보고자 한다. 치료계획 시스템에서 계산된 선량분포와 실험을 통하여 필름에 측정된 선량분포를 비교 분석하여 정확성을 평가해보고, 폐 실질 조직 내에서 계획 표적 용적의 margin 유용성 평가를 하고자 한다. 대상 및 방법: CT 촬영으로 얻은 Rando phantom 3D 영상의 우측 폐에 직경 2, 3, 4, 5 cm인 가상의 구 표적을 만들어 계획 표적 용적에 처방선량의 95 %가 전달될 수 있도록 6MV-FFF VMAT Arc 2개로 치료계획을 수립하였으며, Eclipse TPS와 동일한 위치에서 선량 비교하기 위해서, 필름을 가상 표적의 회전중심점에 횡단면 방향으로 삽입하고 방사선을 조사하였다. Dose profile을 Eclipse에서 획득하고, 측정값과 계산값을 비교하기 위해 Center point에서의 절대 선량값을 계산하였으며, off-axis 선량 분포를 얻어 RMSE, Coverage ratio 등 비교 인자를 통해 상대 선량 및 선량분포를 비교 분석하였다. 결 과: 직경 2, 3, 4, 5 cm 크기별로 center point에서의 %difference 값은 직경 2 cm에서 -4.65 %로 가장 차이가 큰 값을 보였고, 직경 5 cm일 때 -1.46 %로 가장 차이가 작은 값을 보였다. RMSE값은 직경 2 cm일 때 3.43으로 가장 큰 값을 보였고. 직경 5 cm일 때 2.85로써 가장 작은 값을 보였다. 표적 커버리지를 비교하기 위해 처방선량 95 %가 들어가는 용적의 길이($D_{95}$)를 구하였고, 직경 2 cm일 때, TPS와 필름에서 각각 2.02 cm, 1.86 cm로 커버리지 비율이 92 %로 나타났고 가장 큰 차이를 보였다. 또한 계획 표적 용적 100% 이내에 들어가는 평균선량($D_{mean}$)을 비교했을 때, 직경 2 cm 인 경우 측정 평균선량이 95.72 %로 가장 낮은 값을 보였다. 결 론: 본 연구에서는 실험을 통하여 작은 계획 표적 용적에 처방 선량이 충분히 전달되는지 알아보았다. 실험 결과 모든 비교 인자에서 직경 2 cm인 용적이 가장 큰 차이를 보였다. 이는 표적 용적 중심에서의 선량 감소가 주요인이라 판단된다. 따라서 선량계산 시스템에서 저밀도 조직 내의 작은 용적 치료 계획시 2 mm 이상의 마진(margin)을 더 두거나, 치료 계획 최적화(optimization)시 최대선량을 제한하지 않는 방법으로 표적 내 중심 선량을 높일 수 있을 것이라 사료된다. Purpose: The purpose of this study is to evaluate beam delivery accuracy for small sized lung SBRT through experiment. In order to assess the accuracy, Eclipse TPS(Treatment planning system) equipped Acuros XB and radiochromic film were used for the dose distribution. Comparing calculated and measured dose distribution, evaluated the margin for PTV(Planning target volume) in lung tissue. Materials and Methods : Acquiring CT images for Rando phantom, planned virtual target volume by size(diameter 2, 3, 4, 5 cm) in right lung. All plans were normalized to the target Volume=prescribed 95 % with 6MV FFF VMAT 2 Arc. To compare with calculated and measured dose distribution, film was inserted in rando phantom and irradiated in axial direction. The indexes of evaluation are percentage difference(%Diff) for absolute dose, RMSE(Root-mean-square-error) value for relative dose, coverage ratio and average dose in PTV. Results: The maximum difference at center point was -4.65 % in diameter 2 cm size. And the RMSE value between the calculated and measured off-axis dose distribution indicated that the measured dose distribution in diameter 2 cm was different from calculated and inaccurate compare to diameter 5 cm. In addition, Distance prescribed 95 % dose($D_{95}$) in diameter 2 cm was not covered in PTV and average dose value was lowest in all sizes. Conclusion: This study demonstrated that small sized PTV was not enough covered with prescribed dose in low density lung tissue. All indexes of experimental results in diameter 2 cm were much different from other sizes. It is showed that minimized PTV is not accurate and affects the results of radiation therapy. It is considered that extended margin at small PTV in low density lung tissue for enhancing target center dose is necessary and don't need to constraint Maximum dose in optimization.

아파트 평형별 신발장의 내부구성에 관한 연구

오혜경(Oh Hye Kyung) 한국디자인학회 1999 디자인학연구 Vol.- No.28

아동실의 공간계획에 관한 연구

吳惠京(Oh Hye Kyung) 가정과삶의질학회 1992 가정과삶의질연구 Vol.10 No.1

알츠하이머병과 혈관성 치매 환자의 의미기억과 관련된 언어과제의 수행 차이

오혜경(Hye Gyoung Oh),최현주(Hyun Joo Choi),김수진(Soo-Jin Kim) 한국언어치료학회 2010 言語治療硏究 Vol.19 No.1

This study aimed to investigate the impairment in language features related to semantic memory between patients with Alzheimer's Disease(AD, n=15) and vascular dementia (VaD, n=15). The cognitive level tested by K-MMSE for all of patients were in the range mild-moderate. The semantically related language tests include confrontation naming test(Korean Boston Naming Test, K-BNT), category fluency, definition, naming by verbal definition and categorization test. The results from this study showed that confrontation naming test, definitions, naming byverbal definitions, categorization test, the performances were significantly higher in patients with VaD than in patients with AD, but no significant difference was detected in the category fluency test. Therefore, even though the general cognitive abilities were found to be similar between patients with VaD and patients with AD,the impairment in semantic memory was more significant in patients with AD than VaD.

실업계 고등학교 실내디자인 전공 담당교원의 신규 임용 및 재교육 프로그램에 관한 연구

오혜경(Oh Hye Kyung),천진희(Chun Jin-Hee),김대년(Kim Dae-Nyun) 한국디자인학회 2002 디자인학연구 Vol.- No.47

중용의 역동적 중(中)의 추구와 사회복지실천 -다차원성, 다양성, 역동성 중심으로-

오혜경 ( Hea Kyung Oh ) 가톨릭대학교 사회복지연구소 2011 사회복지리뷰 Vol.16 No.-

본 연구는 사회복지실천현장에서 사회복지사들이 인간의 본성을 이해하고, 한편으로 치우침이 없는 균형을 유지하는 사회복지실천에 관해 살펴보았다. 더불어 역동적 중(中)을 추구하며, 다양성을 존중하고, 균형과 조화를 중시하는 중용의 핵심 가치에 해당되는 양가성, 다차원성 역동성 등의 사회복지실천에서의 적용 가능성에 관해 살펴보았다. This study analyzes the applicability of Golden Mean to social work practice. In the field of social work practices, the meaning of the harmony and integration of humanity would be concerned by social workers. Also social work practice focused on respect of multiculuralism, diversity and dynamics. Simultaneously, this study were presented to explain the ethical issues of the social work based on the doctrine of the Golden Mean.