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만성 B형 간염 환자의 간조직내 B형 간염바이러스 유전자와 유전자 발현양상과의 상관관계
한광협(Kwang Hyup Han),오승희(Seung Hee Oh),전재윤(Chae Yoon Chon),문영명(Young Myoung Moon),박인서(In Suh Park),박영년(Young Nyun Park),박찬일(Chan Il Park) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.2
N/A To understand the pathogenesis of hepatitis B virus(HBV)-induced chronic liver disease, we studied the relationship between HBV DNA and antigens and subsequent correlation with pathologic findings in liver tissue. Routine paraffin-embedded liver specimens from 52 patients with HBV related chronic liver diseases(HBV carrier 8, chronic persistent hepatitis 15, chronic active hepatitis 15, and liver cirrhosis 14) were evaluated by using in situ hybridization(ISH) and immunohistochemistry(IHC). Using the IHC techniques, we detected intrahepatic HBcAg in all of 37 HBeAg positive pa- tients and four of 15 HBeAg negative patients. However, regardless of the presence of HBeAg, HBsAg was detected in most of the patients. Using the ISH techniques, HBV DNA was dectected in 23 of 37 HBeAg postive patients and 4 of 15 HBeAg patients. Intrahepatic distri- bution of HBcAg correlated well with the distribution of HBV DN A whereas HBsAg did not correlate well. According to the progression of the liver disease, the distributional pattern of intrahepatic HBV DN A and antigens was different. In addition, the simultaneous in situ de- tection analyses revealed that some hepatocytes containing high levels of HBV DN A were de- void of detectable HBcAg suggesting a mechanism by which restricted expression of HBV an- tigens on infected hepatocytes may escape host immune surveillance system resulting persis- tent HBV infection. (Korean J Gastroenterol 1994; 26: 289 297)
만성 B형 활동성 간염환자에서 HBeAg과 임상양상에 따른 간조직내 B형 간염 바이러스 Core 항원의 발현양상
문희용(Hee Yong Moon),박상진(Sang Jin Park),한광협(Kwang Hyub Han),오승희(Seung Hee Oh),전재윤(Chae Yoon Chon),문영명(Young Myoung Moon),박인서(In Suh Park),박찬일(Chan Il Park) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.4
N/A Background/Aims: The expression of hepatitis H virus core antigen(HBcAg) in the liver reflects the state of viral replication and may influence the immune response of the host. Methods: We investigated the intrahepatic expression of HBcAg using immunohistochemistry in patients with biopsy proven chronic active hepatitis B(CAH-B) according to HBeAg status and clinical patterns. Results: The intrahepatic expression of cytoplasmic HBcAg(cHBcAg) in patients with CAH-B was significantly higher in the group of HBeAg positive than negative(p0.05). In patients with HBeAg negative CAH-B, the intrahepatic expression of cHBcAg was relatively higher in the group of sustained ALT elevation during follow-up than persistent normal ALT, but statistical signifi- cance was not observed. The pattern of intrahepatic expression of cHBcAg can be different in patients with CAH-B according to the timing of the liver biopsy and the level of transaminase following the liver biopsy. Conclusions: The intrahepatic expression of cHBcAg in patients with CAH-B was different according to the timing of liver biopsy and the level of transaminase following the liver biopsy as well as HBeAg status. (Korean J Gastroenterol 1996;28: 520 - 529)
대한간학회지 제2차 춘계학술대회 초록집 : 한국인 간질환 환자에서 G 형 간염 바이러스 감염
한광협 ( Han Gwang Hyeob ),박영년 ( Park Yeong Nyeon ),최원 ( Choe Won ),황영웅 ( Hwang Yeong Ung ),류왕식 ( Lyu Wang Sig ),오승희 ( O Seung Hui ),이관식 ( Lee Gwan Sig ),전재윤 ( Jeon Jae Yun ),문영명 ( Mun Yeong Myeong ),강진경 대한간학회 1996 Clinical and Molecular Hepatology(대한간학회지) Vol.2 No.2(S)