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만성 B형 활동성 간염환자에서 HBeAg과 임상양상에 따른 간조직내 B형 간염 바이러스 Core 항원의 발현양상
문희용(Hee Yong Moon),박상진(Sang Jin Park),한광협(Kwang Hyub Han),오승희(Seung Hee Oh),전재윤(Chae Yoon Chon),문영명(Young Myoung Moon),박인서(In Suh Park),박찬일(Chan Il Park) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.4
N/A Background/Aims: The expression of hepatitis H virus core antigen(HBcAg) in the liver reflects the state of viral replication and may influence the immune response of the host. Methods: We investigated the intrahepatic expression of HBcAg using immunohistochemistry in patients with biopsy proven chronic active hepatitis B(CAH-B) according to HBeAg status and clinical patterns. Results: The intrahepatic expression of cytoplasmic HBcAg(cHBcAg) in patients with CAH-B was significantly higher in the group of HBeAg positive than negative(p0.05). In patients with HBeAg negative CAH-B, the intrahepatic expression of cHBcAg was relatively higher in the group of sustained ALT elevation during follow-up than persistent normal ALT, but statistical signifi- cance was not observed. The pattern of intrahepatic expression of cHBcAg can be different in patients with CAH-B according to the timing of the liver biopsy and the level of transaminase following the liver biopsy. Conclusions: The intrahepatic expression of cHBcAg in patients with CAH-B was different according to the timing of liver biopsy and the level of transaminase following the liver biopsy as well as HBeAg status. (Korean J Gastroenterol 1996;28: 520 - 529)
Sjo¨gren 증후군 환자 3예에서의 식도 운동 검사 소견
김범수,박효진,이수곤,서정기,문희용,문병수,박인서 대한내과학회 1997 대한내과학회지 Vol.53 No.3S
저자들은 Sjo¨gren 증후군 환자 3예에서 식도체부의 수축력 저하 및 타액분비의 감소로 인한 산청소능의 저하 소견을 관찰할 수 있었기에 문헌고찰과 함께 보고하는 바이다. A number of factors protect the esophagus from acid-mediated injury. Among these, acid clearance from the esophagus appears to play a central role. Sjogren's syndrome is an autoimmune exocrinopathy that primarily affects the salivary glands but also involve almost any other part of the gut. The most distressing manifestation of Sjogren's syndrome is xerostomia secondary to destruction of the salivary glands. Another major problem is dysphagia due to the lack of saliva as well as esophageal dysmotility. We performed esophageal motility tests in three cases of Sjo¨gren's syndrome and found that patients with Sjo¨gren's syndrome had an esophageal dysmotility, an abnormal 24-hour esophageal pH, and delayed esophageal acid clearance.
원발성 간암환자의 간염 바이러스 감염유형에 따른 임상양상 및 예후
한광협(Kwang Hyub Han),문희용(Hee Yong Moon),김범수(Bum Soo Kim),백용한(Yong Han Paik),전재윤(Chae Yoon Chon),문영명(Young Myoung Moon),강진경(Jin Kyung Kang),박인서(In Suh Park) 대한내과학회 2001 대한내과학회지 Vol.60 No.1
N/A Background : Hepatocellular carcinoma(HCC) is one of the important causes of cancer-related mortality and morbidity in East Asia, including Korea. Most of the hepatocellular carcinoma in Korea are associated with hepatitis B and C virus infection. The clinical characteristics and prognosis of the patients with HCC were evaluated in relation to the type of hepatitis virus. Methods : A retrospective analysis of the clinical data and survival rate was done in 603 patients(M:F=4.9:1, mean age; 54.2 years) who were admitted to Yonsei medical center from April, 1991 through April, 1994. Results : Among 603 patients, tests for HBsAg and anti-HCV was done simultaneously in 455 patients. Out of the 455 HCC patients, 303 patients (66.6%) were classified as Group B(HBsAg+ve, anti-HCV-ve), 102 patients (22.4%) were classified as Group C (HBsAg-ve, anti-HCV+ve), 45 patients (9.9%) were classified as Group non-BC (HBsAg-ve, anti-HCV-ve), and 5 patients (1.1%) were classified as Group BC (HBsAg+ve, anti-HCV+ve). The mean age of the patients in Group C was older than that of Group B (64.9 vs. 51.3 yr) (p<0.05). Liver cirrhosis was frequently noticed in Group C than Group B (84.3 vs. 68.0%) (p<0.05). The number of the patients whose serum FP level was elevated (>400 ng/mL) was significantly higher in Group B than in Group C (70.0 vs. 52.0%)(p<0.05). According to the gross type, nodular type was more common in Group C than in Group B(72.0 vs. 38.1%) (p<0.01). The incidence of portal vein thrombosis was significantly lower in Group C compared with that in Group B (16.7 vs. 31.4%)(p<0.05). The number of the patients whose tumor size of less than 5 cm was significantly higher in Group C than in Group B (35.3 vs. 17.8%) (p<0.05). Using multivariant analysis, independent prognostic factors were found to be Child grading, FP level, size of the tumor, gross type, and the type of hepatitis virus. The cumulative survival rate of 1, 2, and 3 year in each Group was 31.5%, 17.5%, and 10.8%, respectively in Group B, and 55.7%, 30.2%, and 21.6%, respectively in Group C. The median duration of survival of Group B was significantly shorter than that of Group C(5.0 vs. 13 months)(p<0.05). Conclusion : About 90 % of HCC was associated with hepatitis B or C viral infection in Korea. Hepatitis B virus associated HCC had poorer prognosis compared with hepatitis C virus associated HCC in Korea.(Korean J Med 60:22-31, 2001)