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ENMC 진단기준을 이용한 다발성근염의 임상적, 병리학적 특성
오승헌 ( Seung Hun Oh ),김승민 ( Seung Min Kim ),선우일남 ( Il Nam Sunwoo ),이동현 ( Dong Hyun Lee ),김태승 ( Tae Seung Kim ),김세훈 ( Se Hun Kim ),최영철 ( Young Chul Choi ) 대한류마티스학회 2008 대한류마티스학회지 Vol.15 No.4
Objective: Polymyositis (PM) has known to be the most common type of idiopathic inflammatory myopathy (IIM). However, recent immunopathological studies demonstrated that PM was overdiagnosed previously due to suboptimal classification system. Using newly proposed classification system, we investigated the frequency, clinical and pathological characteristics of PM. Methods: Among the patients diagnosed as IIM during past 6 years, we classified a `definite` or `probable PM` using the European Neuromuscular Center (ENMC) diagnostic criteria. The findings of clinical, laboratory and pathological findings were analyzed. Response to treatment was assessed at 6 months after treatment. Results: Of total 97 cases with IIM, twenty-three cases (24%) were satisfactory to the diagnostic criteria for PM (definite=5 and probable=18). Most cases were young adults, and female predominance was found. All cases showed proximal muscle weakness, and about two-thirds of patients showed extramuscular manifestation. One (4%) had breast cancer, and accompanying connective tissue disorders (CTDs) were found in 3 cases (13%), two of which had systemic sclerosis. Interstitial pneumonia was found in one case (4%). All cases showed marked elevation of serum creatine kinase level. On muscle biopsy, there were endomysial mononuclear cell infiltrations in all cases. Three-fourths of patients responded to immunosuppressant therapy (74%). Conclusion: Using ENMC criteria, the frequency of PM was lower than that had been reported previously. The results of clinical characteristics, response to therapy and clinical outcome were similar to the previous reports. However, association of malignancy or CTDs was low in PM.
조영인(Young-In Cho),오승헌(Seung-Heon Oh),곽동훈(Dong-Hoon Kwak),최재호(Jae-Ho Choi),우종훈(Jong Hun Woo) (사)한국CDE학회 2022 한국CDE학회 논문집 Vol.27 No.2
In the shipbuilding, outfitting processes are mainly performed on ships moored by quays of the shipyard. Quays in shipyards have different lengths, depths, and facilities so that the allowable quays for each ship are limited. In addition, the working efficiency of the quay process depends on the kinds of the quays where the outfitting processes are performed. As a result, it is inevitable for ships to move around the quays to avoid delay in schedule while maximizing the working efficiency. The movements of ships should be minimized because it is a waste of cost and time. In most shipyards, the quay allocation is manually determined by planners using their own implicit rules. However, the optimal plan can’t be obtained by those heuristics which only considers limited problem space. In this study, the scheduling algorithm for the quay allocation problem is developed using a reinforcement learning approach. Based on the Markov decision process model using discrete-event simulation, the scheduling agent is trained by DRQN (Deep Recurrent Q-network) algorithm and tested with 10 scenarios. The proposed algorithm outperforms the reference value set by heuristic in terms of three KPIs-unallocated duration, the number of ship movements, and ship-quay priority ratio.
환삼덩굴 ( Humulus Japonicus ) 화분에 대한 피부 반응도 및 특이 IgE 의 측정에 관한 연구
남동기(Dong Ki Nam),박해심(Hae Sim Park),오승헌(Seung hun Oh),홍천수(Chein Soo Hong) 대한내과학회 1988 대한내과학회지 Vol.35 No.2
N/A To assess the clinical contribution of Humulus japonicus pollen which is thought to be an important causative pollen of the pollinosis in Autumn as are ragweed and sagebrush in Korea, a total of 340 patients with allergic respiratory disease visiting the allergy clinic in Severance Hospital, Yonsei University College of Medicine from March 1986 to February 1987 were studied. These patients (bronchial asthma 108, allergic rhinitis 97, bronchial asthma with allergic rhinitis 41 and other 94 cases) were tested for their skin reactivity to the extracts of Korean and Torii`s Humulus japonicus pollen, Dermatophagoides farinae, sagebrush, and rag- weed. Micro-ELISA was used to determine the Humulus japonicus-specific IgE level in 120 sera from patients who showed a positive skin test (more than 2+) to the Torii`s Humulus japonicus. The following results were obtained: 1) The global results of the skin prick test to the extract of Korean pollen of Humulus japonicus were negative in 64.0%, 1+ in 22.1%, 2+ in 11.8%, 3+ in 1.8%, and 4+ in 0.3% of 340 cases. The positive skin test rate (more than 2+) among the disease entities for the Korean and Toriis extracts of Humulus japonicus pollens respectively were 14.9% and 8.4/o in bronchial asthma; 17.5% and 21.6% in allergic rhinitis; 17.1% and 26.9% in bronchial asthma with allergic rhinitis; and 7. 7% and 6.3% in the others 2) The positive skin test rate for Korean Humulus japonicus in those patients who showed a positive skin test to Torii`s Humulus japonicus was 42.6% and the positive skin test rate of for Torii`s Humulus japonicus in those patients who showed a psotive skin test to Korean Humulus japonicus was 42.6% also. The correlation between the skin test results of the extracts of Korean and Torii`s Humulus japonicus pollen was very weak (r=0.41, p<0.05). 3) The positive skin test rates for Korean Humulus japonicus in patients who showed positive (more than 2+) and negative (less than 1+) skin tests to D. fariae, sagebrush and ragweed were 23.5%, 6.3% and 33.3%, 9.6% and 46.4%, 9.4% respectively (p<0.01). 4) The cut-off value of optical density (OD) in ELISA for Humulus japonicus-specific IgE was calculated from 30 negative control sera by computing its mean and standard deviation (Mean+2.S.D.=0.012) and forty-five (37.5%) of 120 patients' sera were ELISA positive. And the correlation between wheal size resulting from the skin prick test and the OD value of ELISA for the specific IgE of Humulus japonicus pollen was very weak (r=0.23 with Korean; r=0.12 with Torii`s). 5) The ELISA positive rates in patients who showed a positive skin test (more than 2+) to Korean and Torii s Humulus japonicus respectively were 46.2% and 50.0 %; and the ELISA positive rate in the negative skin test group was 40.3% and 32.5%. 6) The ELISA inhibition test with sera from 4 patients with high OD value (more than 0.1) showed that 2 patients were definitely inhibited upon the addition of the extract of Korean Humulus japonicus pollen extract, demonstrating Humulus japonicus specific-IgE in the patients sera. 7) The correlation between total serum IgE level and the OD value of ELISA was very weak (r=0.17), showing little effect of a high total IgE level on the results of ELISA. The ELISA positive rate was 41.7% in 12 sera with total serum IgE level of more than 500 IU/ml and 40.0% in 75 sera with a level of less than 500 IU/ml. The author could conclude that both skin test reactivity and OD value using micro-ELISA with the extract of the Korean pollen of Humulus japonicus were relatively low and consequently the allergenicity of it was minimal with the above data. The ultimate outcome in the evaluation of the skin test result with OD value in micro-HLISA to determine the specific IgE level must await further exhaustive research using a more highly purified extract of Humulus japonicus pollen.
면역효소법에 의한 한국산 쑥 화분에 대한 특이 IgE 측정 및 Radioallergosorbent Test ( RAST ) 와의 상관성에 관한 연구
박해심(Hae Sim Park),홍천수(Chein Soo Hong),이수곤(Soo Kon Lee),오승헌(Seung Hun Oh) 대한내과학회 1988 대한내과학회지 Vol.34 No.2
N/A We developed a micro-KLISA assay by use of Korean sagebrush allergen to measure sagebrush-specific IgE. The assay was carried out in polyethylene flat microtitre plates by incubating the allergen, 10% new-born calf serum, test sera and finally horseradish peroxidase conjugated monoclonal anti-IgE. Preincubated with 1 mg/ml of the allergen we prepared, W5-RAST was inhibited by 80.9% and the inhibition curve showed dose-responsive pattern with serial dilution of crude lyophilized sagebrush extracts. The cut-off point for this assay for specific IgE was established by that mean and S.D values from 30 different negative control sera were 0,012 and 0,014 in absorbance value, respectively (Mean+ 2S.D. =0.041). The positive probability of ELISA and RAST assay was 76% and 74%, respectively in 52 patients with positive skin prick test with korean sagebrush extract. The influence from high levels of total IgE was negligible, ranged from 0.063 (5000 u/ml of IgE) to 0.082 (1000 u/ml of IgE). The coefficient variation for the intrassay and interassay reproducibility ranged from 2.83 to 24.14% and 9.64 to 27.03%, respectively. The absorbance value obtained in this assay correlated with the bound radioactivity (%) in RA5T assay (r= 0.553, p<0.05), This showed a higher degree of correlation (r=0.41) with the wheal size on skin prick test than that. This ELISA assay is well suited for mass screening and can be a useful method for measuring specific IgE. It compares favorable in sensitivity and specificity with RAST assay.