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인슐린 비의존형 당뇨병환자들에서의 Euglobulin 섬유소 용해능
조용욱(Y . W . Cho),오도연(D . Y . Oh),김선주(S . J . Kim),홍세용(S . Y . Hong) 대한내과학회 1990 대한내과학회지 Vol.39 No.1
N/A Defective fibrinolysis, which has been associated with an increased risk of thromboembolic disease, may be relevant to the vascular complications of diabetes. The euglobulin lysis area was measured in 56 NIDDM patients and 116 healthy controls before and after a venous occlusion, and the following results were obtained: 1) Compared to the control groups, there were significantly lower basal and stimulated euglobulin lysis areas in diabetics. The serum fibrinogen Are you malang a garacl stctement lee which wrtrasts with the net og the sentane, on it gyyoset to be tendel, as pant of you ieult? tends be lower in diabetes, but there was no statistical significance. 2) No relation of fibrinolytic activity to age, duration of diabetes, sugar, serum lipid, or obesity was found. 3) Both basal and stimulated fibrinolytic activity were significantly lower in diabeics who developed retinopathy than in diabetics who were fuee of retinopathy, In diabetics, serum fibrinolytic activity is lower than in healthy controls, a finding which could play a role in the development of diabetic retinopathy.
Lumbricus Rubellus 가 인체의 섬유소 용해력에 미치는 영향
홍세용(S . Y . Hong),양동호(D . H . Yang),오도연(D . Y . Oh),박선양(S . Y . Park) 대한내과학회 1991 대한내과학회지 Vol.40 No.1
N/A To evaluate the lumbrikinase effect on plasmin (ogen) related physiologic fibrinolytic activity, we measured euglobulin fibrinolytic activity, t-PA activity and t-PA antigen during lumbrikinase therapy and the results were compared with the data of control day of before and after lumbrikinase ingestion. Serial dilution of lumbrikinase showed the fibrinolytic activity on fibrin plate by dose dependent pattern between 375㎍/ml and 1㎍/ml concentration. In regard to the fibrinolytic area, 300㎍ of lunbrikinase equivalent to 25 unit of t-PA and 75㎍ of lumbrikinase equivalent to 5 unit of t-PA. Euglobulin fibrinolytic activity increased in all cases by two or three days after lumbrikinase ingestion but decreased to basal level 36 hours after discontinuation of lunbrikinase. The lumbrikinase added to plasma did not influence to the euglobulin fibrinolytic activity. t-PA ag was increased in 5 out of 6 cases and t-PA activity was increased all of the cases after lumbrikinase ingestion. There was direct correlation between euglobulin fibrinolytic activity and t-PA activity. This finding suggest that the increased fibrinolytic activity of euglobulin after lumbrikinase ingestion is due to increased t-PA rather than direct effect of lumbrikinase itself.
Urokinase loading Dose와 Maintenance Dose를 위한 연구
홍세용,양동호,신현길,김순길,오도연,김기용,기은경,정광회,신상구 대한내과학회 1992 대한내과학회지 Vol.42 No.1
저자들은 two chain urokinase의 loading dose 및 maintenance dose를 결정하기 위하여 성인 뇌졸중 환자 6예를 대상으로 urokinase 300,000units를 주입하고(Ⅳ boluse), 60분간 혈중 urokinase의 변동을 관찰하여 two compartment model을 이용한 pharmacokinetic study를 하여 다음과 같은 결과를 얻었다. 체중의 55~65㎏ 정도이고 간 기능이 정상인 한국인 성인에서 urokinase의 Vc(central compartment volume)은 4.56L 이었고 반감기는 distribution phase에서 2.3분, elimination phase에서 33.1분이었다. Total boidy clearance(CL)은 244/min이었고 area under the concentration time curve(AUC)는 1,349units/㎖.min이었다. 이를 근거로 하였을때 시험관에서 free form plasmin을 유리하는 urokinase의 최소 농도인 10units를 maintenance dose로 시간당 146,400units를 주입하는 것이 적절한 것으로 판단되었으며 이는 외국 성서에서 추천하는 시간당 4,400units/㎏(60㎏×4,400=264,00units)에 비하여 약 절반 정도에 해당하는 양이다. 이렇게 차이가 나는 이유는 명확하지 않으나 본 연구에서 desired concentration으로 사용한 10units/㎖은 소위 therapeutic window의 lower margin에 해당되기 때문일 것으로 생각되며 therapeutic window의 upper magrin을 규명하기 위한 연구가 뒤따라야 할 것으로 사료된다. A Pharmacokinetic study was performed .for two-chain UK(M.W.53,000) in 6 Korean adults with body weight between 55~65㎏ Following intravenous administration of 300,000 units of UK, concentration declined rapidly. The half life showed two-compartment disposition with mean initial and terminal half-lives of 2.3 and 33.1 minutes. Total body clearance was about 244㎖/min and the steady state volume of distribution (Vdss) was 9.46L. In conjunction with our previous finding that free form plasmin begin to form at a urokinase concentration of 5~10units/㎖, our results suggests that the loading dose and maintenance dose of urokinase during systemic intravenous administration should be about 45, 610unit and 146,400unit/hr in a Korean adult.