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심현,김계남,이갑호,윤견일,박이갑,한운섭 대한소화기내시경학회 1984 Clinical Endoscopy Vol.4 No.1
This report is an analysis of 108 cases of gastric adenocarcinoma diagnosed by gastrofiberscopy among whom the patients were visited or hoiipitalized at the Ewha Womane University Hospital from January, 1982 to March, 1984. The results obtained were summerized as follows. 1) In hiatologic subtypes of gastric adenocarcinoma, mucous cell carcinoma accounted for 67 cases(62%), pylorocardiac gland cell carcinoma 25 cases(23%), intestinal cell carcinoma 9 cases(8%), unclassified 8 cases(7%). 2) The male to female ratio was 1. 8: 1, the pylorocardiac gland cell carcinoma was more male predominant. 3) The peak age incidence was the 7th decade wiith 29%, the 6th decade with 28%, and 5th decade with 17%, The mucous cell carcinoma found at 30th decade but the pylorocardiac gland cell carcinoma and intestinal cell carcinoma were found after 50th deeade. 4) The localization of the gastric adenocarcinoma iin the stomach showed the antrum 55 cases(51%), most frequently and followed by body, cardia. The intestinal cell carcinoma wae not found at the cardia. 5) The macroscopic feature of the advanced gastric adenocarcinoma by gastrofiberscopy showed Borrmann's type III 39 caaea(35%), II and IV 29 cases(27% ) each other. The intestinal cell carcinoma was not formed an infiltrate of the type IV. 6) The marginal mucosa of gastric adenocarcinoma showed intestinal metaplasia(73%), and the intestinal cell carcinnma was more frequent relatively. 7) Alcian blue-PAS staining revealed more common in intestinal cell carcinoma than mucous cell carcinoma and pylorocardiae gland cell carcinoma of gastric adenocarcinoma.
Deoxycorticosterone acetate가 흰 생쥐의 신사구방세포에 미치는 영향
심현,오영,원경희,임정남,홍기숙 이화여자대학교 의과대학 1977 梨花醫學誌 Vol.- No.9
정상 및 부신을 적출한 숫 흰생쥐를 소정의 사료로 사육하면서 deoxycorticosterone acetate (DCA)를 1주간 투여하였다. 신장을 절취하여 Helly씨 용액으로 고정한 후 Wilson씨 방법으로 염색하여 사구방과립세포를 관찰하였으며 동시에 과립세포지수(GCI) 및 과립지수(JGI)를 조사하여 각 실험군을 비교하였다. 1. 정상군에 DCA를 투여한 결과 GCI 및 JGI의 수치는 의의있는 감소를 인정할 수 없었으며 또한 과립세포형의 출현빈도도 제 1형, 제2형, 제3형의 순으로 변화가 없었다. 2. 부신을 적출하면 GCI는 약간의 증가를 하고, JGI는 현저한 증가를 보이고 있었으며 각 세포형의 출현빈도는 제3형, 제2형, 제1형의 순으로 반전되었음을 보여주었다. 3. 부신을 적출한 흰생쥐에 DCA를 투여한 결과는 정상군에 DCA를 투여한 결과와 같이 GCI 및 JGI 양자 모두, 의의있는 감소를 보여주고 있지 않으며 각 과립세포형의 출현빈도에도 변화를 주고 있지 않다. 4. 이상의 결과는 사구방과립세포가 정상상태에 있건 부신을 적출하여 초래된 기능항진된 상태에 있건 간에 DCA 투여는 큰 영향을 주지 않는 것 같다. For the study of the juxtaglomerular granular cells deoxycorticosterone acetate(DCA), 2.5mg/day was administered to the normal and adrenalectomized mice for one week. The sections of renal tissues of all the experimental groups were stained by Wilson's method after the fixation with Helly's fluid, and the juxtaglomerular granular cell index (GCI) and juxtaglomerular granular index (JGI) were calculated at the magnification of 480 under the light microscope. And compared each other. The results observed were as follows. 1. There were not any significant decrease in both the GCI and JGI following the administration of DCA to normal animals, and the frequency of appearance of the various granular cell types in DCA-treated groups was in the order of Type1, Type 2, and type 3 as in the normal. 2. After adrenalectomy, significant increase in JGI was found and the order of the frequency of appearance of the various granular cell types was reversed. The GCI however, showed slight increase in number but is not significant. 3. The administration of DCA to adrenalectomized mice seemed not to show any significant decrease in GCI and JGI as in the DCA-treated normal group and the frequency of appearance of cell types was as same as in the DCA-treated adrenalectomized group. 4. The above results could show that the administration of DCA would not affect to decrease the granulation of juxtaglomerular granular cells in both the normal and adrenalectomized groups.
외과병리적 검사를 위해 적출된 난관의 임상 및 병리조직학적 연구
심현,오영,최태림,홍기숙 이화여자대학교 의과대학 1978 梨花醫學誌 Vol.- No.10
Few reports of collective review of resected fallopian tube have been made in our country. In this regard the authors have studied 74 cases of fallopian tube resected and sent for surgical pathologic examination during 6 months from January 1977 to June 1977. The results are as follows; 1. The two common clinical causes of salpingectomy were tubal ligation for sterilization (41.9%) and tubal ectopic pregnancy (25.7%). Their mean gaes were 32.4yrs. and 32.9yrs., respectrely. 2. Salpingitis was more frequently associated with ectopic pregnancy than other salpingectomized diseases. 3. The sites of ectopic pregnancy were ampulla (73.7%), isthmus(21.0%), fimbria(5.3%) in the order of frequency. 4. The chief complaints of ectopic pregnancy were lower abdominal pain (81.8%), vaginal spotting (63.6%) amenorrhea (81.8%). Mean duration of ectopic pregnancy was 4.9wks. 5. The morphologic changes of tubal epithelium were characteristic and commensurate with menstrual cycle.