http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 여경아 ( Kyung Ah Yoh ) (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
여경아 ( Kyung Ah Yoh ),김지현 ( Jee Hyun Kim ) 대한내과학회 2014 대한내과학회지 Vol.87 No.5
유방암이 생물학적으로 매우 다양한 질환의 집합이듯이 노인 유방암 환자 역시 다양한 생리적 예비능력과 생리적나이를 가진 다양한 집단이다. 노인 유방암 환자의 접근에 있어 질병의 생물학적 특징 못지않게 환자의 생리적 기능, 인지 기능, 기동성, 동반 질환 등 환자의 다양한 요소를 포괄적으로 평가하여 맞춤 치료를 실현하여야 할 것이다. Due to its increasing incidence and longer life expectancy, more patients are being diagnosed with breast cancer at older ages. There are very limited data on the optimum management of older patients with advanced breast cancer, due to the under-representation of such individuals in clinical trials. Although older patients have more indolent disease with more Hormone Receptor positive disease and less HER2-positive disease, their disease-specific mortality remains lower than in younger patients, owing to the late diagnosis, under treatment due to age bias, reduced access to healthcare, and socioeconomic issues. Older patients with advanced breast cancer should be treated based on their biological tumor type, according to the patient`s general health and preferences: endocrine treatment for HR-positive disease; Human Epidermal Growth Factor Receptor 2-targeted agent with chemotherapy, endocrine therapy or HER2-targeted agent alone for HER2 positive disease. Chemotherapy should be considered for patients who are HR-negative, HR-positive but refractory to endocrine treatment, or with a rapidly progressing visceral crisis. Generally, sequential chemotherapy with a single agent is recommended over combination chemotherapy, and agents with known toxicities in older patients are recommended, including weekly taxane, vinorelbine, capecitabine, and liposomal doxorubicin. Some form of geriatric assessment should be performed for older patients to assess the patients` biological age, functional status, and address age-specific problems, leading to early interventions. The goal of therapy should be individualized to maintain the quality of life, function, and independence of older patients with cancer. (Korean J Med 2014;87:542-547)
-
난치성 다발성근염/피부근염 환자에서 정맥내 면역글로불린의 효과
이상헌 ( Sang Heon Lee ),여경아 ( Kyung Ah Yoh ),조영석 ( Young Suk Cho ),양형인 ( Hyung In Yang ),박성환 ( Sung Hwan Park ),조철수 ( Chul Soo Cho ),김호연 ( Ho Youn Kim ) 대한류마티스학회 1995 대한류마티스학회지 Vol.2 No.2
목적: 부신피질 호르몬 및 면역억제제에 반응이 없거나 사용이 제한되는 난치성 다발성근염/피부근염에서 정맥내 면역글로불린의 치료 효과를 알아보고자 하였다. 대상 및 방법: 1992년부터 1995년 현재까지가 톨력의대 부속 강남성모병원 내과에서 정맥내 면역글로불린 치료를 시행하였던 6명의 환자를 대상으로 면역글로불린을 정맥내로 매달 2g/kg의 용량을 6개 월간 투여하였다. 임상적 평가는 British Medical Research Council (BRC) muscle power score, timed stand test, functional grading scale, 생화학 검사로 혈청 CPK, aldolase를 조사하였다. 치료 효과의 판정은 입상적 개선이 치료전에 비해 20%이상 나타난 경우와 근효소치의 감소가 30% 이상인 경우로 하였다. 결과: BRC muscle power score는 대상 환자 6명중 5명에서 임상적 개선이 관찰되었고, timed stand test functional grading score는 6명 모두에서 유의한 임상적 호전을 보였다. 치료전 CPK가 정상범위이었던 2예를 제외한 4예 모두에서 근효소치의 유의한 감소가 있었는데 이중 3예에서는 50% 이상의 현저 한 감소를 보였다. aldolase를 측정하였던 5명 모두에서 치료전에 비해 50% 이상의 뚜렷한 감소가 나타났다. 치료전 prednisolone 평균 1일 투여 량은 39.2±9.2mg에서 치료 6개월 후 7.03±2mg으로 뚜렷한 스테로이드 감량(81.3%) 효과를 보였다. 부작용은 1예에서 경미한 호흡곤란 및 발한이 일시적으로 나타났으나 분할 투여하면서 사라졌다. 결론: 정맥내 면역글로불린 주사요법을 기존 약제에 반응이 없거나 사용이 제한될 경우, 유용하고 안전한 치료 방법으로 생각된다. Objectives: Polymyositis (PM) and dermatomyositis (DM) are inflammatory muscle diseases of presumed autoimmune origin. Many interventions including corticosteroids, immunosuppressive drug, and plasmapheresis to treat patients with PM/DM are not always effective, and may be associated with certain serious side effects. Intravenous immunoglobulin (IVIG) has been useful in a number of autoimmune diseases. An attempt was made to evaluate the efficacy of IVIG in refractory PM/DM. Methods: Six patients with conventional treatment-refractory PM/DM [1 man and 5 women; mean age of 27(7-49)years; PM(2), DM(2), juvenile DM(2)] received high doses of IVIG (2 mg/kg) dividing over consecutive 2 or 5 days. The IVIG infusion was conducted each month for 6 months. Clinical evaluations, including proximal muscle power, functional grading, and biochemical studies (creatine kinase (CK), aldolase) were performed before each or every IVIG infusion. Clinical evaluations were considered successful if more than 20% improvement of initial score was obtained. Biochemical results were considered good if muscle enzymes decreased more than 30% of initial values. Results: Clinical improvement of proximal muscle power was noted in 5 patients after 6 courses of IVIG infusion. Timed stand test and functional grading score were also improved in all patients. All patients showed good response of biochemical results, except two cases with normal initial CK levels. Mean daily prednisolone dosage was significantly reduced (before IVIG: 39.2±9.2 mg/day vs after 6th IVIG: 7.3±2 mg/day, p<0.0l). One patient experienced mild dyspnea and sweating during the course of IVIG infusion, which were disappeared with the reduction of daily IVIG dosage. Conclusions: These results suggest that IVIG is a safe and effective therapy in patients with PM/DM, who are resistant to traditional therapies or have limitations for their use.
-
항 인지질 항체 양성인 전신성 홍반성 루푸스 환자에서의 무도병
조영석 ( Young Suk Cho ),최범순 ( Bum Soon Choi ),여경아 ( Kyung Ah Yoh ),양형인 ( Hyung In Yang ),박성환 ( Sung Hwan Park ),이상헌 ( Sang Heon Lee ),조철수 ( Chul Soo Cho ),김호연 ( Ho Youn Kim ) 대한류마티스학회 1995 대한류마티스학회지 Vol.2 No.2
The neuropsychiatric manifestations of systemic lupus erythematosus (SLE) are diverse but, among them, movement disorders such as chorea, ataxia are uncommon. We describe a 16 year old female SLE patient with positive anticardiolipin antibody who developed sudden onset of chorea. The clinical and laboratory findings that positive anticardiolipin antibody, thrombocytopenia, chorea were suggested antiphospholipid syndrome. Although the pathophysiology of chorea in SLE is unknown, an association with antiphospholipid antibodies has been suggested. The underlying pathogenic mechanism of this case could not established but was most likely to have been an ischemia of the contralateral subthalamic nucleus. She was treated with corticosteroid, haloperidol and warfarin and now chorea is disappered.
-
자가면역 용혈성 빈혈과 심낭삼출이 동반된 하시모토 갑상선염 1예
이광우,손호영,강무일,유순집,강성구,박지원,여경아,차봉연,최주연,진종률 대한내분비학회 1998 Endocrinology and metabolism Vol.13 No.4
Hashimotos thyroiditis has been associated with a various autoimmune disorders. The immunologic mechanisms involved in the pathogenesis of these disorders have not always been thought to be the same. Although it was demonstrated that there were high prevalence of abnormal thyroid function and autoantibody in autoimmune hemolytic anemia(AIHA) and Fisher-Evans syndrome(FES), AIHA combined with Hashimotos thyroiditis is rare in Korean literature. It was suggested that a common immunologic mechanism may be involved in the pathogenesis of both disease and the possibility of multiple autoimmune syndrome might present in autoimmune hematologic disorders. We experienced a 74-year old woman with a 12-year history of a hypothyroidism due to Hashimotos thyroiditis was hospitalized with sudden development of warm AIHA with positive Direct & Indirect Coombs test and pericardial effusion. Her thyroid function test showed subclinical hypothyroidism with the maintenance dosage of levothyroxine(100pg/day). With glucocorticoid and plasmapheresis, AIHA and pericardial effusion were corrected successfully. It is suggested that the prudent immunologic study is needed for the anemia developed in patients with Hashimotos thyroiditis with or without hypothyroidism (J Kor Soc Endocrinol 13:622-628, 1998).
KCI
KISS연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
