중년 여성 근로자의 모바일 앱을 활용한 심뇌혈관질환 예방관리 프로그램 참여 경험

양혜경,Yang, Hye Kyung 국제문화기술진흥원 2021 The Journal of the Convergence on Culture Technolo Vol.7 No.3

This study is a qualitative study that conducted one-on-one in-depth interviews and focus group interviews to understand the meaning of the experience of participating in a cardio-cerebrovascular disease prevention management program using a mobile app for middle-aged female workers. The subjects of this study were 26 female workers over 50 years of age who participated in a cardio-cerebrovascular disease prevention program using a mobile app in a department store. Participating experience derived from the research result were 'Pleasure of getting to know', 'Activation of mutually friendly relations', 'health concerns take care of me ', 'Accepting an unfamiliar culture', 'Convenience as if receiving counseling anywhere. Through these results, it was shown that the mobile app improves the will to practice health behavior, and it is suggested that a standard to guarantee that the mobile app is a safe program is necessary to reduce anxiety about unfamiliar programs when installing the mobile app. 본 연구는 중년여성 근로자를 대상으로 모바일 앱을 활용한 심뇌혈관질환 예방관리 프로그램 참여 경험에 대한 의미를 파악하기 위해 일대일 심층면담 및 포커스 그룹 인터뷰(Focus Group Interview, FGI)를 실시한 질적 연구이다. 본 연구의 대상자는 일 백화점에서 모바일 앱을 활용하여 심뇌혈관질환 예방프로그램에 참여하고 있는 50세 이상의 여성 근로자 26명을 대상으로 하였다. 연구결과 도출된 참여경험은 '알아가는 것에 대한 즐거움', '상호 우호적 관계의 활성화', '건강에 대한 관심이 나를 관리하게 함', '익숙하지 않은 문화를 받아들임', '어디서나 상담을 받는 듯한 편리함'의 주제가 도출되었다. 이러한 결과를 통해 모바일 앱이 건강행위 실천의지를 향상시키는 것으로 나타났고, 모바일 앱을 설치 시 낯선 프로그램에 대한 불안을 감소하기 위해 안전한 프로그램임을 보증할 수 있는 인증기준이 필요함을 제언한다.

S-PARAFAC: 아파치 스파크를 이용한 분산 텐서 분해

양혜경(Hye-Kyung Yang),용환승(Hwan-Seung Yong) 한국정보과학회 2018 정보과학회논문지 Vol.45 No.3

최근 추천시스템과 데이터 분석 분야에서 고차원 형태의 텐서를 이용하는 연구가 증가하고 있다. 이는 고차원의 데이터인 텐서 분석을 통해 더 많은 잠재 요소와 잠재 패턴을 추출가능하기 때문이다. 그러나 고차원 형태인 텐서는 크기가 방대하고 계산이 복잡하기 때문에 텐서 분해를 통해 분석해야한다. 기존 텐서 도구들인 rTensor, pyTensor와 MATLAB은 단일 시스템에서 작동하기 때문에 방대한 양의 데이터를 처리하기 어렵다. 하둡을 이용한 텐서 분해 도구들도 있지만 처리 시간이 오래 걸린다. 따라서 본 논문에서는 인 메모리 기반의 빅데이터 시스템인 아파치 스파크를 기반으로 하는 텐서 분해 도구인 S-PARAFAC을 제안한다. S-PARAFAC은 텐서 분해 방법 중 PARAFAC 분해에 초점을 맞춰 아파치 스파크에 적합하게 변형하여 텐서 분해를 빠르게 분산 처리가능 하도록 하였다. 본 논문에서는 하둡을 기반의 텐서 분해 도구와 S-PARAFAC의 성능을 비교하여 약 4~25배 정도의 좋은 성능을 보였다. Recently, the use of a recommendation system and tensor data analysis, which has high-dimensional data, is increasing, as they allow us to analyze the tensor and extract potential elements and patterns. However, due to the large size and complexity of the tensor, it needs to be decomposed in order to analyze the tensor data. While several tools are used for tensor decomposition such as rTensor, pyTensor, and MATLAB, since such tools run on a single machine, they are unable to handle large data. Also, while distributed tensor decomposition tools based on Hadoop can handle a scalable tensor, its computing speed is too slow. In this paper, we propose S-PARAFAC, which is a tensor decomposition tool based on Apache Spark, in distributed in-memory environments. We converted the PARAFAC algorithm into an Apache Spark version that enables rapid processing of tensor data. We also compared the performance of the Hadoop based tensor tool and S-PARAFAC. The result showed that S-PARAFAC is approximately 4~25 times faster than the Hadoop based tensor tool.

박재삼 시의 설화 수용 양상

양혜경(Hye Kyung Yang) 수련어문학회 1999 睡蓮語文論集 Vol.25 No.-

N/A

소아의 폐색성 세기관지염의 단일 기관 경험

서혜경 ( Hye Kyung Seo ),김혜영 ( Hye Young Kim ),양혜경 ( Hea Kyoung Yang ),신성현 ( Sung Hyun Shin ),이병기 ( Byung Ki Lee ),김성헌 ( Seong Heon Kim ),김영미 ( Young Mi Kim ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2011 소아알레르기 및 호흡기학회지 Vol.21 No.2

Purpose: Although bronchiolitis obliterans (BO) most often occurs after infection, the incidence of post-transplant BO has recently increased due to the increase of organ and bone marrow transplantation. However, there is limited data on the responses to treatment using measurements of pulmonary function in patients with BO. This study aimed to describe clinical characteristics and pulmonary function in children with BO from a single institute and to compare the responses according to treatment modalities in children with post-infectious BO. Methods: This study was conducted on 22 children who were diagnosed with BO from January 2005 to December 2010. Based on the medical chart, treatment courses and prognosis of the patients were examined retrospectively. The severity of clinical symptoms was determined by the Denver symptom score, basal pulmonary function, and responses to bronchodilators; all parameters were measured and compared between the time of diagnoses and follow-up six months later. Results: The mean age of the patients when diagnosed with BO was 8.3±6.6 years; of those patients, sixteen were boys and six were girls. Nineteen cases of BO were associated with acute infection, and the most common cause of those cases was adenovirus. Three cases of BO occurred following allogeneic bone marrow transplantation for acute myelogenous leukemia. The Denver symptom scores at the time of diagnosis were averaged to 3.95±0.63, and the average symptom score after follow-up of six months was 2.15±0.73. The averages of the % forced vital capacity (FVC), % forced expiratory volume in 1 second (FEV1), and % forced expiratory flow, midexpiratory phase (FEF25-75%) at the time of diagnosis were 69±13%, 40.5±12.7%, and 17.6±7.8%, respectively, and FEV1/FVC was 56.7±10.9%. The averages of %FVC, % FEV1, and %FEF25-75% six months after diagnosis were 78±17.3%, 62.5±16.5%, and 35.6±9.5%, respectively, and FEV1/FVC was improved to 70.7±18.9%. Symptom scores of the group treated with high dose systemic steroids decreased significantly compared to those of the group treated with inhaled corticosteroids (P<0.05). Likewise, improvement of FEV1/FVC after treatment was greater in the group treated with high dose systemic steroids than in the group treated with inhaled corticosteroids (P<0.05). Conclusion: Infections are the more frequent causes of BO in our institute, and adenovirus ismost common. Six-month follow-up study results suggest high dose systemic steroids could lead to better improvement of clinical symptoms and pulmonary function in children with post-infectious BO. [Pediatr Allergy Respir Dis(Korea) 2011;21:123-130]

HaCaT 인간 각질세포에서 산화적 스트레스에 대한 머루근 수용성 추출물의 세포 보호 효과

최은옥(Eun Ok Choi),권다혜(Da Hye Kwon),황보현(Hyun Hwang-Bo),정진우(Jin-Woo Jeong),남원석(Won Sok Nam),이연희(Youn Hee Lee),양혜경(Hye Kyung Yang),황혜진(Hye Jin Hwang),김병우(Byung Woo Kim),이승훈(Seung Hun Lee),최영현(Yung Hyun Ch 한국식품영양과학회 2018 한국식품영양과학회지 Vol.47 No.1

왕머루(Vitis amurensis Rupr.)의 뿌리(머루근)는 한국을 비롯한 아시아 각국에서 다양한 질환의 예방과 치료의 목적으로 오랫동안 사용되어 왔다. 비록 머루근 추출물의 항산화 효과에 대한 몇몇 보고가 있었지만, 근본적인 분자생물학적 기전 연구는 아직 완전히 이해되지 못하고 있다. 본 연구에서는 HaCaT 각질세포에서 산화적 스트레스(H₂O₂)에 대한 머루근 열수 추출물(WEVA)의 세포 보호 효과를 조사하였다. 본 연구의 결과에 의하면 WEVA는 H2O2에 의한 HaCaT 각질세포의 생존력 저하를 현저하게 억제시켜 WEVA가 산화적 스트레스에 대한 보호 효과가 있음을 보여주었다. WEVA는 또한 H₂O₂에 의한 PARP 분해와 pro-caspase-9와 -3의 발현 억제를 차단함으로써 H₂O₂에 의한 apoptosis를 효과적으로 억제시켰다. 이러한 WEVA의 apoptosis 억제 효과는 H₂O₂에 자극받은 HaCaT 세포에서 미토콘드리아 기능손상의 감소 및 pro-apoptotic Bax와 anti-apoptotic Bcl-2의 발현 변화의 차단과 관련이 있었다. 또한, WEVA는 H2O2에 의해 유도된 세포 내 ROS 축적과 DNA 손상을 억제하였고, Nrf2의 발현 증가와 관련된 강력한 항산화 효소인 HO-1과 NQO-1의 발현을 유도하였다. 이러한 결과는 WEVA가 ROS의 생성 억제 및 Nrf2 신호 전달계 활성을 통하여 각질세포를 산화적 스트레스에 의한 apoptosis 및 DNA 손상으로부터 보호하였음을 의미한다. 따라서 본 연구의 결과는 WEVA가 산화적 스트레스로 인한 피부질환의 치료 및 예방을 위한 기능성 소재로 유용성이 있음을 보여주었다. Root of Vitis amurensis Rupr., a wild-growing grape species, has been used as a traditional medicine for the treatment of various diseases in Asian countries, including Korea. Although several studies on the antioxidant effects of V. amurensis root extracts have been carried out, the underlying molecular mechanisms remain largely unresolved. In the present study, we investigated the cytoprotective efficacies of water extract of V. amurensis root (WEVA) against oxidative stress (hydrogen peroxide, H₂O₂) in HaCaT human keratinocytes. Our data show that treatment with WEVA prior to H₂O₂ exposure significantly increased HaCaT cell viability, indicating that exposure of HaCaT cells to WEVA conferred a protective effect against oxidative stress. WEVA preconditioning also effectively inhibited H₂O2₂-induced apoptotic cell death by blocking degradation of poly (ADP-ribose) polymerase and down-regulation of pro-caspases-9 and -3. The anti-apoptotic effects of WEVA were associated with attenuation of mitochondrial dysfunction and normalization of expression changes of pro-apoptotic Bax and anti-apoptotic Bcl-2 in H₂O₂-stimulated HaCaT cells. In addition, WEVA abrogated H₂O₂-induced intracellular reactive oxygen species (ROS) accumulation and phosphorylation of histone H2AX at serine 139, a widely used marker of DNA damage. Moreover, WEVA increased the levels of hemeoxygenase-1 and NAD(P)H-quinone oxidoreductase-1, potent antioxidant enzymes associated with induction of nuclear transcription factor erythroid-2-like factor 2 (Nrf2). Thus, the present study demonstrates that WEVA protects human keratinocytes against oxidative stress-induced apoptosis and DNA damage, possibly through prevention of ROS generation and activation of Nrf2 signaling. Our data indicate that WEVA may potentially serve as an agent for treatment and prevention of skin disorders caused by oxidative stress.

소아에서 경구 마취 전처치의 효과

양혜경,이국현,김성덕,김종덕 대한마취과학회 1987 Korean Journal of Anesthesiology Vol.20 No.6

The effects of oral premedication with diazepam and atropine were evaluated. We made three kinds of syrup which were composed of diazepam 0.3mg/0.5cc, diazepam 0.3 mg mixed with atropine 0.001 mg in 0.5cc and diazepam 0.3mg mixed with atropine 0.03mg in 0.5cc, respectively. The 1st was administered to Group I (n=21), the second to group Ⅱ (n=21) and the last to group Ⅲ (n= 24) one and half to two hours before induction of anesthesia. Each child received 0.5 cc/kg. On arrival at pediatric operating room, anxiety levels, vital signs, antisalivatory effect and side effects were checked. The attitude of children was evaluated just before induction of anesthesia. In group Ⅰand Ⅲ, slight elevation of diastolic blood pressure was noticed. The satisfaotory levels, checked by anxiety level O, were 86% in group Ⅰ, 90% in group ll and 79% in group Ⅲ. The altitudes in the operating rooms just before induction of anesthesia were satisfactory and cooperative in 77 %, 81%, and 87% of patients in group Ⅰ, Ⅱ and Ⅲ, ely. Antisalivatory effect was not good in group Ⅰ, but satisfactory in 82% and 75% of cases in group Ⅱ and Ⅲ. But side effect was present in 25% of cases in group Ⅱ and Ⅲ, in spite of 10% in group Ⅰ. So we can conclude that preoperative oral diazepam in a dose of 0.3mg/0.5cc/kg is very good for the reduction of anxiety and the additiopn of atropine may increase the incidence of side effects. Threefore we recommend parentreral belladonna alkaloids just before induction instead of preoperative oral medication.