The result of Radiotherapy in Mailgnant Thymona

Sung Ja Ahn(안성자),Charn Il Park(박찬일) 대한방사선종양학회 1990 Radiation Oncology Journal Vol.8 No.2

1979년부터 1987년까지 서울대학교병원 치료방사선과에서 흉선암으로 근치목적의 방사선치료를 받은 21명을 대상으로 조사하였다. 전체환자의 3년 생존율은 80.5%, 3년 무병생존율은 78.6%였다. 근무력증을 동반한 환자는 43.5%였고 치료후 40%(4/10)에서 증상의 호전을 보였다. 증상의 유무에 따른 3년 생존율을 비교하여 보면 각각 90%, 78.8%였으며 근무력증이 예후에 나쁜 영향을 주는 인자가 아님을 알 수 있었다. 방사선치료후 환전관해율 및 부분관해율은 (33% vs 56%) 89%였고 이에 따른 3년 생존율은 각각 88.9%, 81.7%로 통계학적으로 유의한 차이는 보이지 않았다. 수술정도에 따른 치료실패율을 비교하여 보면 절제가 가능한 환자에서는 치료실패가 없었으나, 절제가 불가능하였던 환자 15명중 4명에서 국소실패, 1명이 골전이 소견을 보였다. 국소치료실패가 대부분으로 원격전이율은 낮은 양상을 보였다. Twenty one patients of malignant thymoma treated with curative aim at the department of Therapeutic Radiotherapy of Seoul National University Hospital from 1979 to 1987 were analysed retrospectively. The 3 year overall and relapse free survival rate was 80.5% and 78.6%, respectively. Myasthenia gravis (MG) was seen in 43.5% at presentation and disappeard in 40% (4/10) after radiotherapy with or without operation. The 3 year cumulative survival rate with and without MG was 90% and 78.8%, respectively. We could consider that MG was no longer adverse prognostic factor. The complete response rate after partial resection was 100% (3/3), and that after biopsy was 20% (3/15). The overall local control rate including complete and partial response rate (33% vs 56%) was 89% and the 3 year actuarial survival rate by the response rate 88.9% and 81.7%, respectively. there was no statistically significant survival difference between two groups. The crude rate of relapse at 3 years was 23.8% (5/21), and 80% (4/5) were locoregional failures. All failures were observed in biopsy only group, while no failure was observed in resected group. The major pattern of the treatment failure was the locoregional failure and the distant metastases was rarely observed.

The Characteristics, Detection and Control of Bacteriophage in Fermented Dairy Products

안성일,리합 아조니,트란 티 탄 후옌,곽해수,Ahn, Sung-Il,Azzouny, Rehab A.,Huyen, Tran Thi Thanh,Kwak, Hae-Soo Korean Society for Food Science of Animal Resource 2009 한국축산식품학회지 Vol.29 No.1

This study was to review the classification, detection and control of bacteriophage in fermented dairy products. Bacteriophage has lytic and/or lysogenic life cycles. Epidemiologically speaking, detected major phages are c2, 936 and p335. Among them p335 has been the largest concern in dairy industry. Traditionally, various analytical technologies, such as spot, starter activity, indicator test, ATP measurement and conductimetric analysis, have been used for the phage detection. In recent years, advanced methods such as flow cytometric method, petrifilm, enzyme linked immunosorbent assay (ELISA) and multiflex PCR diagnostic kit have been deveoloped. The phage contamination has been controlled by using heat, high-pressure treatment, and the combinations of heat and pressure, and/or chemical. Also some starter cultures with phage-resistant character have been developed to minimize the concentration of phages in dairy product. Bacteriophage inhibition media such as calcium medium was also mentioned. To prevent the contamination of bacteriophage in dairy industry, further researches on the detection and control of phage, and phage resistant starters are necessary in the future.

기능성 향상 치즈 개발 연구

안성일 ( Sung Il Ahn ),최경훈 ( Kyung Hoon Choi ),곽해수 ( Hae Soo Kwak ) 한국유가공기술과학회 2011 Journal of Dairy Science and Biotechnology (JMSB) Vol.29 No.1

Cheese is a nutritious food with various balanced nutrients, such as proteins, peptides, amino acids, fats, fatty acids, vitamins and minerals. Domestic cheese varieties and quality need to be improved to prevent imported cheese. To develop those cheeses, search for previous works and research for new products are needed. In cheese ripening of hard cheese, such as Cheddar or Parmesan cheese, is ripened for 2 to 24 months at 2 to 16℃ to develop desired cheese flavor and body characteristics. Long time with low temperature to ripen the cheese requires high expenses. So accelerated cheese ripening is a good potential for saving in industry. Methods for acceleration of cheese ripening are temperature control, addition of bacteria or enzymes. To develop the functionality of cheese, addition of microencapsulated various probiotics and nutrients, such as iron, removal of cholesterol by crosslinked β-cyclodextrin, lowering blood cholesterol and serum glucose by nanopowdered functional materials et al. are necessary. Therefore, this review focused on the functionality of cheese, such as the acceleration of cheese ripening, microencapsulated probiotics and iron, and cholesterol removal.

고압처리 원유로 제조한 발효유의 저장 중 유산균 수 변화와 이화학적 특성

안성일(Sung-Il Ahn),정인애(In-Ae Chung),정운시(Woon-Si Chung),주진우(Jin-Woo Jhoo),김거유(Gur-Yoo Kim),전정태(Jung-Tae Jeon) 한국식품영양과학회 2016 한국식품영양과학회지 Vol.45 No.6

본 연구에서는 고압처리(high pressure processing) 한 원유를 이용하여 발효유를 제조하고, 발효특성 및 저장 기간 물리 화학적 특성의 변화를 살펴보았다. 고압처리 한 원유를 이용하여 발효유 제조 시 발효 초반에 유산균이 급격히 증식됨을 확인하였으나, 발효 완료 후 총 유산균 수는 대조군과 크게 차이가 나지 않았다. 저장 기간 중 실험군과 대조군 모두 유산균 수가 서서히 감소하는 경향을 나타내었다. 또한 산도 및 pH는 각 군 모두 정상적인 발효유의 범위를 나타내었다. 각 군의 점도를 대조해 본 결과 대조군이 실험군보다 점도가 높게 나타났으나, syneresis는 450 MPa 처리군이 대조군보다 유의적으로 적게 발생한 것으로 나타났다(P<0.05). 따라서 적절한 압력을 이용한 원유의 고압처리는 발효유의 물성을 개선하는 데 효과가 있다고 할 수 있으며, 이 분야에 관한 연구가 좀 더 이루어져야 할 필요가 있다. This study was carried out to investigate the physicochemical and fermentation properties of yogurt made from high pressure processing (HPP) treated milk. Raw milk and commercial yogurt starter were used to make yogurt. Raw milk was HPP treated at 350 or 450 MPa (HPP 350 or 450) for 15 min or heat treated at 80°C for 10 min. The numbers of lactic acid bacteria of the HPP treated group (HPP yogurt) rapidly increased during 2∼4 h, whereas there was not significant difference from control (P<0.05). Titratable acidity of all samples increased, and pH decreased during storage from 0.99 to 1.24%, as well as from 4.59 to 4.20, respectively. It is confirmed that these values are in general ranges for yogurt. Control showed higher viscosity than HPP 350. Syneresis was significantly lower than that of the control (P<0.05). Based on the data obtained from the present study, HPP treatment was effective to enhance the quality of yogurt.

만성 신부전증 환자에서 혈액투석 중 발생한 천공성 모낭염

안성구(Sung Ku Ahn),전수일(Soo Il Chun) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.5

A 37-year-old man was diagnosed as having chronic renal failure received hemodialysis, Five months after starting hemodialysis developed rice to pea sized erythematous follicular papvles on the posterior neck and trunk which was accompanied by mild pruritus. Histopathologically the lesion showed typical finding of perforating folliculitis and Pickers nodule like changes in the adjacent epidermis.

Transparent Boundary Condition을 적용한 FDM-PE 기반 전파전파 해석

안성진(Ahn Sung Jin),김민각(Kim Min Gak),정용식(Chung Young Seek),권경일(Kwon Kyoung Il) 한국통신학회 2024 한국통신학회 학술대회논문집 Vol.2024 No.1

The result of Radiotherapy in Malignant Thymona

안성자,박찬일,Ahn, Sung-Ja,Park, Charn-Il The Korean Society for Radiation Oncology 1990 Radiation Oncology Journal Vol.8 No.2

1979년부터 1987년까지의 서울대학교병원 치료방사선과에서 흉선암으로 근치목적의 방사선치료를 받은 21명을 대상으로 조사하였다. 전체환자의 3년생존율은 $80.5{\%}$, 3년 무병생존율은 $78.6{\%}$였다. 근무력증을 동반한 환자는 $43.5{\%}$였고 치료후 $40{\%}$ (4/10)에서 증상의 호전을 보였다. 증상의 유무에 따른 3년생존율을 비교하여보면 각각 $90{\%}$, $78.8{\%}$였으며 근무력증이 예후에 나쁜 영향을 주는 인자가 아님을 알 수 있었다. 방사선치료후 완전관해율은 절제술을 시행한 경우는 $100{\%}$(3/3)인 반면, 절제가 불가능한 경우는 $20{\%}$(3/15)였다. 완전관해율 및 부분관해율은($33{\%}$ vs $56{\%}$) $89{\%}$였고 이에 따른 3년생존율은 각각 $89.8{\%},\;81.7{\%}$로 통계학적으로 유의한 차이는 보이지 않았다. 수술정도에 따른 치료실패율을 비교하여보면 절제가 가능한 환자에서는 치료실패가 없었으나, 절제가 불가능하였던 환자 15명중 4명에서 국소실패, 1명이 골전이 소견을 보였다. 국소치료실패가 대부분으로 원격전이율은 낮은 양상을 보였다. Twenty one patients of malignant thymoma treated with curative aim at the Department of Therapeutic Radiology of Seoul National University Hospital from 1979 to 1987 were analysed retrospectively. The 3 year overall and relapse free survival rate was $80.5\%\;and\;78.6$, respectively. Myasthenia gravis (MG) was seen in $43.5\%$ at presentation and disappeared in $40\%$ (4/10) after radiotherapy with or without operation. The 3 year cumulative survival rate with and without MG was $90\;and\;78.8\%$, respectively. We could consider that MG was no longer adverse prognostic factor. The complete response rate after partial resection was $100\%$ (3/3), and that after biopsy was $20\%$(3/15). The overall local control rate including complete and partial response rate ($33\;vs\;56\%$)was$89\%$ and the 3 year actuarial survival rate by the response rate was $88.9\%\;and\;81.7\%$, respectively. There was no statistically significant survival difference between two groups. The crude rate of relapse at 3 years was $23.8\%$ (5/21), and $80\%$ (4/5) were locoregional failures. All failures were observed in biopsy only group, while no failure was observed in resected group. The major pattern of the treatment failure was the locoregional failure and the distant metastases was rarely observed.

주파수 집성 기술을 지원하는 LTE-A 시스템에서의 효율적인 PDCCH 탐색구간 설계

안성모(Sung Moe Ahn),이종근(Jong Keun Lee),이후일(Hu Il Lee),김윤희(Yun Hee Kim) 한국통신학회 2014 한국통신학회 학술대회논문집 Vol.2014 No.11

지능형 영상네트워크 연계형 PTZ카메라 기반 다중 이벤트 처리

장일식(Il-sik Chang),안성제(Seong-je Ahn),박광영(Gwang-yeong Park),차재상(Jae-sang Cha),박구만(Goo-man Park) 한국통신학회 2010 韓國通信學會論文誌 Vol.35 No.11

의약품 콜드체인 3자 물류업체의 선정요인이 만족도에 미치는 영향에 관한 실증연구

선일석(Il-Suck Sun),안성진(Sung-Jin Ahn) 한국항만경제학회 2018 韓國港灣經濟學會誌 Vol.34 No.3

고령화 사회 및 4차 산업혁명 이슈로 인하여 바이오의약품에 대한 수요가 증가하고 있다. 이에 전 세계적으로 바이오 의약품 산업규모가 지속적으로 증가하고 있으며, 바이오의약품 물류도 동반 성장하고 있다. 하지만 국내 의약품 유통구조는 선진국에 비해 낙후되어 있으며, 바이오 의약품취급에 대한 물류 규정이 엄격해지고 있어 체계적인 관리가 요구되고 있다. 이처럼 바이오 의약품 물류에 대한 철저한 관리의 필요성과 더불어 기업이 경영환경이 치열해 지면서 의약품 콜드체인 3자 물류업체의 역할의 중요성이 더욱 부각되고 있는 실정이다. 이에 본 연구에서는 의약품 콜드체인 3자 물류업체의 선택요인에 대한 연구를 수행하고자 하며 선택요인이 만족도에 미치는 영향력을 검증하여 중요한 선택요인을 파악하였다. 콜드체인 3자 물류 선정요인이 콜드체인 3자 물류 만족도에 어떠한 영향을 미치는지 알아보기 위하여 다중회귀분석을 실시하였는데 분석결과 전문성과 시설 및 연계성이 고객 만족도에 영향을 미치는 요인으로 나타났으며, 경영능력은 영향을 미치는 요인이 아닌 것으로 도출되었다. 이러한 연구 결과는 향후 의약품 콜드체인 산업이 나아가야할 방향성을 제시해 줄 수 있으며, 전략적 시사점을 제공할 수 있을 것으로 기대한다. The demand for biopharmaceuticals is on the rise spurred by the fourth industrial revolution and an aging society in Korea. Consequently, the scale of the biopharmaceutical industry is continuously increasing globally, thereby leading to an increase in the distribution of biopharmaceuticals. However, the relative inferiority of the domestic drug distribution structure, when compared to the advanced countries, and strict logistics regulations concerning the handling of biopharmaceuticals have raised the need for systematic management. Essentially, the significance of third-party logistics companies in the cold chain for pharmaceutical cold chain has increased with an intense management environment for pharmaceuticals. The purpose of this study is to investigate the selection factors of drug cold chain’s third-party logistics companies and to examine the influence of selection factors on satisfaction. A multiple regression analysis was conducted to investigate how cold chain third-party logistics factors affect the satisfaction of third-party logistics in cold chain. The results of analysis showed that expertise, facility, and linkage are factors affect customer satisfaction. The managerial capacity was derived not as an influential factor. These findings suggest that the future cold chain industry will be equipped to provide direction and strategic implications.