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약물 유도 망막변성 생쥐 모델에서 안구내 면역세포에서의 F4/80와 nestin 발현 양상
안상일,온영훈,박태관,Sang Il Ahn,MD,Young Hoon Ohn,MD,PhD,Tae Kwann Park,MD,PhD 대한안과학회 2013 대한안과학회지 Vol.54 No.6
Purpose: To evaluate the expression patterns of F4/80 and nestin in the ciliary body and the optic nerve following N-methyl- N-nitrosourea (NMU)-induced retinal degeneration in adult mice. Methods: After intraperitoneal injection of MNU (60 mg/kg) in adult mice, the eyes were enucleated at 2, 4, 7 and 30 days. Hematoxylin and eosin (H&E) stain, terminal deoxyribonucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) stain and immunohistochemical stains of F/80 and nestin were performed. Results: After MNU treatment, the photoreceptors were destroyed by cell apoptosis. According to immunohistochemistry, F4/80 and nestin were not co-expressed in the control group, but F4/80 was expressed within the ciliary body and optic nerve in the MNU-treated group; the expression of nestin also increased. In the outer nuclear layer, F4/80 and nestin co-expressing cells were observed. Conclusions: In response to retinal damage, the F4/80 and nestin co-expressing cells migrated to the retina from the ciliary body and optic nerve and were activated.
이동형 다목적실용위성 소형 관제국의 Playback 하향 링크 및 원격 명령 상향 링크 채널 설계
안상일(Sang-Il Ahn),박동철(Dong-Chul Park) 한국전자파학회 2009 한국전자파학회논문지 Vol.20 No.4
본 논문은 이동 가능한 다목적실용위성의 소형 관제국 개발을 위한 playback 신호의 하향 링크 및 원격 명령신호의 상향 링크에 대해 수행한 채널 설계를 기술한다. 하향 링크 채널 설계로서 playback 신호의 수신 임계신호 대 잡음비로부터 요구 수신 성능을 도출하여 1.5 m 안테나 기반의 하향 링크 수신 성능인 6.5 ㏈/K의 G/T이내에서 만족함을 확인하였다. 상향 링크 채널 설계를 통하여 원격 명령 신호에 대한 위성에서의 수신 신호대 잡음비로부터 40 ㏈W의 송신 EIRP를 유도하였다. 구축된 소형 관제국을 이용하여 다목적실용위성 및 다목적실용위성 2호에 대해 양 방향 통신시험 및 운영 결과, 고각 10° 이상에서 상향 링크 및 playback 신호의 하향링크 채널의 요구 성능이 일관성 있게 만족함을 확인하였고, 장기간에 걸친 시험 결과로부터 시스템의 성능 열화가 거의 없음을 확인함으로써 설계상으로 추가적인 3 ㏈ 링크 마진을 고려하지 않은 소형 관제국의 채널 설계가 다목적실용위성에 대해 적절하였음을 검증하였다. This paper describes playback downlink and telecommand uplink channel design performed for a transportable small -sized KOMPSAT(Korea Multi-Purpose Satellite) ground station. As a result of downlink channel design, required receiving performance was calculated from the threshold signal-to-noise ratio of playback signal and it was revealed that this performance can be guaranteed in 1.5 m ground station with 6.5 ㏈/K of G/T. For the uplink channel design, 40 ㏈W of EIRP was derived from the threshold signal-to-noise ratio of telecommand signal received at on-board receiver. The implemented small-sized ground station based on design was evaluated to be fully acceptable for KOMPSAT TT&C(Telemetry, Tracking and Command) system and playback downlink design without taking account of additional 3 ㏈ system link margin was shown to be effective because it had provided constantly initial channel performance without any remarkable degradation over several years of tests with KOMPSAT and KOMPSAT-2, for both uplink and playback downlink in the elevation angle above 10°.
부 반송파를 사용하는 이동형 다목적실용위성 관제국에 대한 하향 링크 채널 설계
안상일(Sang-Il Ahn),박동철(Dong-Chul Park) 한국전자파학회 2009 한국전자파학회논문지 Vol.20 No.3
본 논문은 부 반송파를 사용하는 이동 가능한 다목적실용위성 소형 관제국의 하향 링크 채널 설계 내용을 기술한다. 먼저 전송 신호 방식을 해석한 후 이 해석 결과를 단계별로 적용하는 방법으로 하향 링크 채널을 설계하였다. 하향 링크 전송 신호인 실시간(real-time) 2 kbps 위성 상태 측정 데이터의 수신 임계 신호 대 잡음비와 위성 거리 측정 요구 성능을 만족하는 신호 대 잡음비 해석 결과를 적용하여 6.5 ㏈/K의 G/T를 갖는 소형 관제국의 하향 링크 채널을 설계하였다. 설계에 따라 구현된 소형 관제국의 G/T는 태양을 이용한 측정 결과, 6.62 ㏈/K가 됨을 확인하였다. 또한, 위성과의 연동 시험을 통해, 부 반송파를 사용하는 위성 상태 데이터 요구 수신성능을 만족하여 다목적실용위성 관제국의 하향 링크 채널로 적합하게 평가되었다. This paper describes the downlink design of a transportable small-sized KOMPSAT ground station using sub-carrier signal. Based on the analysis of the transmission modes of satellite real-time telemetry and range measurement signals, the downlink channel design of KOMPSAT ground station using sub-carrier signal was processed. By considering the threshold signal-to-noise ratio of real-time 2 kbps telemetry signal and the required signal-to-noise ratio for satellite range measurement, the small-sized KOMPSAT downlink channel with G/T value of 6.5 ㏈/K was designed. The real G/T of implemented ground station was proven to be 6.62 ㏈/K when measured using the Sun. Moreover, through interface test with KOMPSAT, the ground station has shown the required link performance for real-time telemetry acquisition using sub-carrier and was consequently evaluated to be adequate for a transportable small-sized KOMPSAT ground station.
안상일,장지호,Sang Il Ahn,Jee Ho Chang 대한안과학회 2013 대한안과학회지 Vol.54 No.3
Purpose: To objectively define the degree of cupping, the authors extracted 3-dimensional slope surface maps from Cirrus HDTM-OCT data and assessed their differentiating characteristics between normal subjects and glaucomatous patients. Methods: One eye from each of 40 normal subjects and 1 eye from each of 39 patients with glaucoma were examined using automated visual field perimetry and Cirrus HDTM-OCT. The Optic Disc Cube 200 × 200 protocol was performed. The individual OCT data were reconstructed as the 3-dimensional surface maps of the optic disc cup and the slope of each contour was calculated using custom-developed software. Several disc cup slope parameters were derived. The parameters measuring the internal features of the optic disc cup were calculated and compared between groups. Results: Sum of cup slope, sum of thresholded cup slope, and sum of thresholded cup slope / thresholded cup area parameters were differentiating factors between the normal and glaucoma groups (p < 0.05). The area under the receiver operating characteristic curve (AUROC) value of the slope parameters ranged from 0.718 to 0.753. The sum of thresholded cup slope / thresholded cup area parameter was well correlated with visual field mean deviation (r = -0.250, p = 0.028). Conclusions: The optic disc cup slope parameter obtained with OCT may be a useful parameter for representing glaucomatous cupping.
통신해양기상위성 기하보정 영상의 라인 별 수신시각 계산
서석배,안상일,SEO, Seok-Bae,AHN, Sang-Il 항공우주시스템공학회 2009 항공우주시스템공학회지 Vol.3 No.2
MI LV1B images, geometric corrected data of COMS MI, has no time information per each line, but field of weather prediction using the MI LV1B images needs time information on it. This paper explains two calculation methods for receiving time on lines of MI LV1B images and analyzes difference between two calculation methods using simulated data.