http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 안상묵 (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
안상묵,김대중,양승하,김의한 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1
Background: The function of p53 protein was known to accelerate the apoptosis while bcl-2 protein was known to suppress the apoptosis. The patterns of expression of mutant p53 and bcl-2 protein has been reported in various malignant tumors. Although the mechanisms of the p53 and bcl-2 protein in tumorgenesis has not been completely proved, the bcl-2 positive tumors appeared to have good prognosis than tumors with mutant p53 expression. The authors analyzed immunohistochemical expression of mutant p53 and bcl-2 protein in epithelial lesions of uterine cervix. Method: Nine cases of squamous metaplasia, 9 cases of mild dysplasia(CIN Ⅰ), 11 cases of moderate dysplasia(CIN Ⅱ), 16 cases of carcinoina in situ(CIS) and 13 cases invasive squamous cell carcinoma(SCC) were immunohistochemically stained with p53 and bcl-2 monoclonal antibodies. Result: 1. The p53 was weakly positive in 3 out of 9 cases(33%) of squamous metaplasia, and the positive cells were observed only in the basal layer. 3 out of 9 cases(33%) in mild dysplasia and 4 out of 11 cases(36%) in moderate dysplasia showed weakly positive reaction. 2. The p53 showed weakly positive reaction in 7 out of 16(44%) CIS cases and in 9 out of 23(38%) cases the invasive SCC and the positive cells were observed in the tumor cells. 3. The bcl-2 protein showed positive reaction of the reserve cells and along the basal layer of the uterine cervix. However, the positive reactions disappeared in reserve cells and basal cells in 3 out of 9 cases(33%) in squamous metaplasia, 3 out of 9 cases in mild dysplasia(33%), 5 out of 9 cases(56%) in moderate dysplasia, 9 out of 16 cases(56%) in CIS and 14 out of 23 cases(54%) in invasive SCC. This meaned that the positive rate of the bcl-2 protein appeared to decrease according to the progression of the lesion. Above result suggested that the expression of the mutant p53 in the epithelial lesions uterine cervix could be different from those of the other organs in view of tumorgenesis and prognosis; the expression of p53 in the epithelial lesion of the uterine cervix have no significant meaning in progression and prognosis of the lesions. The disappearance of the bcl-2 of the basal cells and reserve cells in the epithelial lesions of uterine cervix suggested a relationship with the prognosis of the lesios, however, not statistically significant.
-
안상묵,김의한,정재삼,최희수,권재욱,성병년 순천향대학교 1987 논문집 Vol.10 No.1
A Malignant Schwannoma is rarely tumor. Since these tumors are derived from nerve sheathes and not from axons, there is controversy in regarding histogenesis and terminology. The diagnosis of malignant Schwannoma is very difficult. Because, similar morphologic pattern in that tumors of the smooth muscles and tumors originated from the nerve. There was no significant predilection in age and sex distribution. These tumor are occasionally associated with von Recklinghausens disease, and the exciion or amputation is recommended in the case of large or recurred tumor. regional lymph node excision is unnecessary. The authors have experienced one case of maligant Schwannoma in sciatic nerve not associated with von Recklinghausens disease.
-
-
김대중,양승하,안상묵,강상균,김의한 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.1
To investigate the effect of Cyprinus carpio bile acid on human liver, concentrated and 10:1 diluted Cyprinus carpio bile acid were injected at the dose of 10ul at mouse tail vein One, three, five, seven and nine days after injection, the mice were sarcificed. The change in hepatic function were estimated by determining GOT, GPT and compared to histologic findings of liver tissue. The results of GOT level was not consistent, but the GPT was significant. From these, we concluded. 1. In concentrated injected group (A), the GPT level was highest in first day and the increased level lasted through observation. 2. In 10:1 diluted injected group (B), the GPT level was only high above normal in first day. Thereafter, the GPT level curiously decreased below the normal, which need more study. 3. Histologic hepatic changes in A group, until 3 days, hepatic cell cord disarrary and marked hepatic cellular degeneration around the central vein were seen. Therefater, although elevated GPT level, the hepatic changes showed only mild regenerated change Histologic hepatic change in B group showed no remarkable change. Above findings suggested that the liver injury was dependent on injected concentration and the hepatic injury, which was observed in early phase, appeared to be reversible. So the hepatic injury by the Cyprinus carpio bile acid appeared complete recovery course without specific complication.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
