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BARODON<sup>®</sup> 에 의한 Human Gastric Adenocarcinoma AGS 세포고사
조은혜,최수일,김수림,조성대,안남식,정지원,양세란,박준석,황재웅,박용호,이영순,강경선,Jo Eun-Hye,Choi Soo-Il,Kim Soo-Rim,Cho Sung-Dae,Ahn Nam-Shic,Jung Ji-Won,Yang Se-Ran,Park Joon-Suk,Hwang Jae-Woong,Park Yong-Ho,Lee Yong-Soon,Kang Kyung 한국독성학회 2005 Toxicological Research Vol.21 No.2
[ $BARODON^{(R)}$ ] is a multi-purpose, high functional alkali solution made by mixing and liquid-ionizing silicon, calcium, sodium, borax, organic carbon chemicals and silver. In this study, we have investigated the apoptotic potential and mechanistic insights of $BARODON^{(R)}$ in human gastric cancer cell line (AGS cells). In MTT assay, $BARODON^{(R)}$ reduced cell viability in AGS cells. Morphological features of apoptosis with marked cytoplasmic vacuolation and appearance of apoptotic peaks in flow cytometry were observed in AGS cells with$BARODON^{(R)}$ treatment. In addition, $BARODON^{(R)}$ induced apoptosis of stomach cancer cell is related to bax up-regulation, caspase 7 protease activation and subsequent cleavage of poly (ADP-ribose) polymerase (PARP). These results suggest that BARODON can induce the apoptosis of AGS cells through modulation of bcl-2 family and the activation of intrinsic caspase cascades, indicating that it is potentially useful as a anti-cancer agent.
BARODON^®에 의한 Human Gastric Adenocarcinoma AGS 세포고사
조은혜(Eun-Hye Jo),최수일(Soo-Il Choi),김수림(Soo-Rim Kim),조성대(Sung-Dae Cho),안남식(Nam-Shic Ahn),정지원(Ji-Won Jung),양세란(Se-Ran Yang),박준석(Joon-Suk Park),황재웅(Jae-Woong Hwang),박용호(Yong-Ho Park),이영순(Yong-Soon Lee),강경선 한국독성학회 2005 Toxicological Research Vol.21 No.2
BARODON^® is a multi-purpose, high functional alkali solution made by mixing and liquid-ionizing silicon, calcium, sodium, borax, organic carbon chemicals and silver. In this study, we have investigated the apoptotic potential and mechanistic insights of BARODON^® in human gastric cancer cell line (AGS cells). In MTT assay, BARODON^® reduced cell viability in AGS cells. Morphological features of apoptosis with marked cytoplasmic vacuolation and appearance of apoptotic peaks in flow cytometry were observed in AGS cells with BARODON^® treatment. In addition, BARODON^®-induced apoptosis of stomach cancer cell is related to bax up-regulation, caspase 7 protease activation and subsequent cleavage of poly (ADP-ribose) polymerase (PARP). These results suggest that BARODON^® can induce the apoptosis of AGS cells through modulation of bcl-2 family and the activation of intrinsic caspase cascades, indicating that it is potentially useful as a anti-cancer agent.