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이홍재(Hong Jai Lee),심영학(Young Hak Shim),김남동(Nam Dong Kim),임채선(Chae Seon Lim),이광훈(Kwang Hoon Lee),박금수(Kum Soo Park) 대한내과학회 1988 대한내과학회지 Vol.34 No.3
N/A In a study of about 1,000 bone marrow examinations performed in our haspital from 1981 to 1985, we selected 23 instances having 10 or more phagocytic histocytes in one bone marrow slide. The diagnosis, clinical features, laboratory findings and outcome of the patients with the phagocytic histiocytes were examined, and the results are as follows; 1) The disease were mainly infectious in orign, including typhoid fever, septicemia, leptospirosis, tuberculous pericarditis and EH fever, and the others were liver cirrhosis, Wilson's disease with hemolytic anemia, malignant lymphoma, myelodysplastic syndrome and agranulocytosis. 2) The clinica1 features were fever (86.8%), hepatomegaly (43.4%), splenomegaly (43.4%), lymphadenopathy (4.3%) and hemorrhagic tendency (4.3%). 3) The peripheral blood showed anemia in 82.6%, leukopenia in 39.1% and thrombocytopenia in 90.4% and reticulocytosis in some eases. 4) In blood chemistry studies, hypoalbuminemia was found in 86.8% and an increase of SGOT and alkaline phosphatase was noted in 95.7% and 78.9% respectively. LDH was increased in 100% (7/7). 5) The clinical courses of the patients with infectious diseases were good except 3 cases with fatal septicemia, and the other cases were not followed affer discharge.
박진현(Jin Hyun Park),심영학(Young Hak Shim),배선우(Sun Woo Bae),이광훈(Kwang Hoon Lee),조휘율(Whi Yul Cho),김호근(Ho Guen Kim) 대한내과학회 1989 대한내과학회지 Vol.37 No.3
N/A Soft tissue calcification may occur in association with certain diffuse connective tissue disease. However, the incidence of calcinosis cutis associated with systemic lupus erythematosus is low and it has not been reported in Korea. A 37-year-old woman was admitted due to a history of intermittent spiking fever and limitation of motion of both hip joints. Hard and nontender skin lesions were located at the left shoulder and both thighs. Radiologically soft tissue calcification was seen in the left shoulder, lower abdomen and both thighs. By histopathological study, systemic lupus erythematous associated with generalized calcification of the soft tissue was confirmed.
시뮬레이션을 활용한 흐름관점의 반도체 설비관리 기법에 관한 연구
이문수 ( Moon Su Lee ),심영학 ( Young Hak Shim ) 한국로지스틱스학회 2012 로지스틱스연구 Vol.20 No.2
최근 반도체 산업을 둘러싼 치열한 글로벌 경쟁환경으로 인한 끊임없는 원가혁신 요구로 반도체 메모리공정의 핵심공정인 Photo공정의 활용률(utilization) 극대화를 통한 loss의 최소화에 대한 관심이 높아지고 있다. 이러한 Photo공정설비의 loss분석은 설비 내 발생되는 변동을 시뮬레이션으로 구현하여 동적(dynamic)인 상황에서 발생되는 loss를 예상하고, scanner의 능력을 저해하는 원인을 인지하여 개선안을 적용했을 때의 효과를 예측하는 일련의 체계적인 절차를 통해서만 가능할 것이다. 본 연구에서는 이를 위해 새로운 Flow Balance Analysis(FBA) 기법을 제시하고 이를 활용하여 Photo설비 내 scanner의 능력저해로 인해 발생되는 loss를 최소화하기 위한 다양한 개선안을 도출하고 이를 검증함으로써 설비 내부의 웨이퍼 흐름과 관련하여 각 unit들 간의 비 동기화에 의해 발생하는 loss의 근원을 차단할 수 있는 새로운 가능성을 제시하였다. Since the global market environment around semiconductor industries has become intensively competitive lately, cost saving efforts become the one of the most successful factors in the semiconductor memory business. These cost saving efforts generally focus on “Photo process” step in the semiconductor memory business because the “Photo process” step is the one of most critical steps in the semiconductor memory manufacturing. To save “photo process” cost, the loss analysis of “Photo process” equipment is critical and the loss analysis of the equipment can only be possible when we develop an appropriate simulation model to detect possible causes for underutilization of the equipment(scanner) and expect the amount of possible losses due to that underutilization, and provide and a structural algorithm to improve the utilization of the equipment. In this study, Flow Balance Analysis (FBA) algorithm was proposed and tested with variety of plans to improve the Photo Equipment utilization, and thus we suggested new possibilities that can significantly reduce the losses caused by the non-synchronization between units inside of Photo Equipment system.
급성 간부전과 용혈성 빈혈로 증상 발현을 보인 Wilson 씨병
권상옥(Sang Ok Kwon),이광훈(Kwang Hoon Lee),심영학(Young Hak Shim),박진현(Jin Hyun Park),장우익(Woo Ik Jang),전근제(Geun Jae Jeon),최승옥(Seoung Ok Choi) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.1
The first manifestations of Wilsons disease are usually neuropsychiatric disorders and less fre- quently, hepatic disorders (cirrhosis or chronic hepatitis) or transient hemolytic anemia. The purpose of this work is to describe a less well known mode of onset of the disease characterized by the association of intravascular hemolysis and acute liver failure. The diagnosis of Wilson's disease was based in the presence of the Kayser-Fleischer ring and decreased serum ceruloplasmin, and acute intravascular hemolysis was based in the sudden develop- ment of anemia, the high value for the reticulocyte count, the absence of demonstrable bleeding, unconjugated hyperbilirubinemia. Necropsy revealed active liver cirrhosis, micronodular type with marked cholestasis. The mechanism of this syndrome is unknown. A hypothetical explanation might result from hepatic cell necrosis due to accumulation of copper, the consequences being acute liver failure and destruction of erythrocytes by the large amounts of copper released from the necrotic hepatic cells to the plasma. In conclusion: 1) The syndrome of acute intravascular hemolysis and acute liver failure is very suggestive of Wilsons disease. 2) This association can be the first clinical manifestation of the disease. 3) The treatment is generally unsuccessful, and the outcome is usually fatal.