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단치소요산(丹梔逍遙散)의 항(抗)스트레스 효과(效果)에 대한 실험적(實驗的) 연구(硏究)
심문기,박세기,김동우,한양희,전찬용,박종형,Shim, Mun-Ki,Park, Se-Ki,Kim, Dong-Woo,Han, Yang-Hee,Chun, Chan-Yong,Park, Chong-Hyeong 대한한방내과학회 1998 大韓韓方內科學會誌 Vol.19 No.2
This study was aimed to evaluate the anti-stress effect of danchisoyosan on the rats stressed by immobilization. The experimental animals were immobilized in the stress box($5{\times}5{\times}20cm$) for 12 hours in a day during 3 days, and administered $500mg/5m{\ell}/g$ of Danchisoyosan extract for 14 days before stress. There were measured the change of body weight and organ weight under immobilized-stress. The norepinephrine, epinephrine, dopamine, serotonine contents were measured by HPLC method in rat brain. There were measured the GOT, GPT contents in serum and tissue lipid peroxidation in the brain, liver, spleen, adrenalgland, pancreas, testes, thymus, heart. The following results were obtained: 1. The change of organ weight was significantly lower in control than normal group. Sample group inhibited decreased weight from stress comparing to control group. 2. Lipid peroxidation in the liver was significantly higher in control than normal group. Sample group shows significant decrease comparing to control group. 3. Lipid peroxidation in the kidney was significantly higher in control than normal group. Sample group shows significant decrease comparing to control group. 4. GPT contents in serum was significantly higher in control than normal group. Sample up shows significant decrease comparing to control group. 5. Dopamine contents in the brain was significantly higher in control than normal group. Sample group shows significant decrease comparing to control group. 6. Serotonine contents in the brain was significantly higher in control than normal group. Sample group shows significant decrease comparing to control group.
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뇌졸중환자(腦卒中患者)에 대한 연례보고(年例報告)(IV)
심문기,전찬용,박종형,Shim, Mun-Ki,Jun, Chan-Yong,Park, Chong-Hyeong 대한한의학회 1998 대한한의학회지 Vol.19 No.2
Clinical observation was done on 272 cases of patients who were diagnosed as CVA with brain CT, TCD, MRI scan and clinical observation. They were hospitalized in the oriental medical hospital of Kyung-Won University from 1st January to 31st December in 1997. 1. The cases were classified into the following kinds: cerebral infarction, cerebral hemorrhage. and transient ischemic attack. The most case of them was the cerebral infarction. 2. There is no significant difference in the frequency of strokes in male and female. And the frequency of strokes was highest in the aged over 50. 3. In cerebral infarction the most frequent lesion was the territory of middle cerebral artery, and in cerebral hemorrhage the most frequent lesion was the basal ganglia. 4. The most ordinary preceding disease was hypertension. and the next was diabetes. 5. The rate of recurrence was high in cerebral infarction. 6. The cerebral infarction occurred usually in resting and sleeping, and the cerebral hemorrhage in acting. 7. The common symptoms were motor disability and verbal disturbance. 8 The average time to start physical therapy was 1l.3rd day after stroke in cerebral infarction and it was 15.2th day after stroke in cerebral hemorrhage. 9. The common complications were urinary tract infection, pneumonia, myocardial infarction. 10. Hypercholesterolemia and hypertriglyceridemia are usually found more frequently in cerebral infarction than in hemorrhage. 11. In acute or subacute stage, the methods of smoothening the flow of ki(順氣), dispelling phlegm(祛痰), clearing away heat(淸熱) or purgation(瀉下) were frequently used. and in recovering stage, the methods of replenishing ki(補氣), tonifying the blood(補血) or tranquilization(安神) were frequently used.
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코로나-19가 응급실에 내원하는 중독환자의 특성에 미치는 영향: 단일 삼차 대학병원에서의 후향적 연구
심문기,김혁훈,민영기,안정환 대한응급의학회 2023 대한응급의학회지 Vol.34 No.3
Objective: The coronavirus disease 2019 (COVID-19) virus has adversely affected people in socioeconomic fields as well as mental health, thereby increasing suicidal attempts. This study analyzes the altered characteristics of drug-poisoned patients visiting the emergency department (ED) during the COVID-19 pandemic era in South Korea. Methods: This was a retrospective observational study using medical records of adults who visited the ED for intoxication. Data obtained were compared before and after the COVID-19 pandemic era. Results: In all, data from 1,102 drug-poisoned patients (586/516 during the pre-/post-COVID-19 periods, respectively) were included in the study. Despite a decrease in total ED visits, the pandemic period saw an increase in the proportion of poisoned patients visiting the ED. Young, female, and psychiatric patients accounted for a significant portion. Months, holidays, time zones, and urbanization showed no difference in the incidence of intoxication. Financial difficulty and couple and family troubles were determined to be frequent causes of intoxication during the COVID-19 pandemic. Comparing the drugs intoxicated, pesticide ingestion was decreased, while the ingestion of other less-fatal drugs was comparatively increased. Although there was an increase in the admission rate of poisoned patients, the severity during admission and outcomes at discharge were not worse after the COVID-19 pandemic era. Conclusion: The COVID-19 crisis has seriously impacted people, especially female, young-aged, and psychiatric patients.
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Wallenberg's Syndrome 환자(患者)의 1례(例)의 증례(症例) 보고(報告)
전찬용,박종형,심문기,Chun, Chan-Yong,Park, Jong-Hyeong,Shim, Mun-Ki 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.3
Wallenberg's syndrome is well known of dorsolateral medullary syndrome. A 56-year-old women was admitted because vertigo, vomitting, vertiginous ataxia, ipsilateral loss Rt. face and Lt. lower limb sense. The result of all performed laboratory tests were normal, but Sr-MRI scan was right lateral medullary infarction. And Br-MRA was focal stenosis of Lt. ICA. We present here one case of Wallenberg's syndrome, who was admitted at Kyungwon University Hospital From 25th Apr. to 21th May. 1998.
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삼봉강룡반어탕(三蓬薑龍半魚湯)과 가감소적백출산(加減消積白朮散)의 항암효과(抗癌效果)에 대(對)한 비교연구(比較硏究)
김동우,고승희,최유경,심문기,여은경,박세기,박종형,고재철,전찬용,한양희,이청정혜,Kim, Dong-Woo,Ko, Seung-Hi,Choi, You-Kyung,Shim, Mun-Ki,Yeo, Eun-Kyung,Park, Se-Ki,Park, Chong-Hyeong,Ko, Jae-Chul,Jun, Chan-Yong,Han, Yang-Hee,Lee, Chung- 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.3
Objective : It is well known that Gagamsojeokbackchool-san show antitumor effects and its activities are result from enhancement of immune function, we investigated the antitumor effects of Sambonggangyongbaneo-tang and its mechanism. Methods : We measured change of body weight, weight of immune organs (Spleen, Thymus), Liver, Kidney, tumor weight, cytotoxicity for investigation of antitumor effects of Sambonggangyongbaneo-tang. Results : 1. The body weight of mouse has no significant difference between control and sample groups. 2. The weights of immune organs (Spleen and Thymus) decreased significantly in sample groups. The weights of Liver and Kidney have no significant difference. 3. The tumor weights in mouse decreased significantly in sample groups and showed dose-dependent effect. 4. Cell viability of Sarcoma 180 has no significant difference in sample groups. 5. HeLa cell viability has no significant difference in low concentration, but it decreased significantly in high concentration. Conclusions : According to the above results, it could be suggested that Sambonggangyongbaneo-tang has prominant antitumor effects and cytotoxicity.
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