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Angiotensin 2 수용체 길항제 투여가 Cyclosporine 신독성에 의한 염증반응에 미치는 영향
송준창 ( Joon Chang Song ),신미정 ( Mi Jung Shin ),전연주 ( Yeon Joo Jun ),우성용 ( Seong Yong Woo ),형복진 ( Bok Jin Hyoung ),윤혜은 ( Hye Eun Yoon ),우현영 ( Hyun Young Woo ),최범순 ( Beum Soon Choi ),양철우 ( Chul Woo Yang ) 대한내과학회 2004 대한내과학회지 Vol.67 No.6
목적 : 신장 이식시 투여되는 cyclosporine (CsA)은 우수한 면역 억제제이지만 장기간 투여로 세뇨관 간질 섬유화와 염증반응을 유발한다. 만성 CsA 신독성 병태생리는 다양하게 제시되고 있으며 이중 레닌-안지오텐신계의 활성화가 중요한 역할을 하는 것으로 보고 되고 있다. 이에 본 연구에서는 안지오텐신 Ⅱ 수용체 길항제인 losartan (LSRT) 투여가 CsA에 의한 신장내 염증반응을 억제하는지 세뇨관 간질 섬유화와 대식세포 침윤의 지표인 Background : Long-term treatment of immunosuppresant CsA causes interstitial inflammation and fibrosis in the kidney. Renin-angiotensin system (RAS) plays the most important role in the pathogenesis CsA-induced renal injury. Accordingly we evaluated the a
김순섭 ( Kim Sun Seob ),윤선애 ( Yun Seon Ae ),김영수 ( Kim Yeong Su ),송준창 ( Song Jun Chang ),김현진 ( Kim Hyeon Jin ),장석태 ( Jang Seog Tae ),김영옥 ( Kim Yeong Og ),장윤식 ( Jang Yun Sig ),방병기 ( Bang Byeong Gi ) 대한신장학회 2004 Kidney Research and Clinical Practice Vol.23 No.3
Hemorrhagic fever with renal syndrome (HFRS) causes arrythmia, myocarditis, atrial hemorrhage, and heart failure as a cardiac complication. But, acute myocardial infarction has not been reported yet in patient with HFRS. We here report a case of acute myocardial infarction in a young adult with HFRS. A 43-year-old man was admitted with high fever and petechiae in the trunk and extremities. He had no history of hypertension, heart disease, and diabetes mellitus. Initial electrocardiographic finding was normal. On the 4th hospital days, sudden cardiac arrest developed and he recovered promptly with cardioversion. After recovery, electrocardiography revealed ST segment elevation in Ⅱ, Ⅲ, and aVF. Cardiac enzymes (CPK, LDH, CK-MB, and troponin-I) were also elevated. Echocardiography showed akinesia of inferior wall of heart. He was treated with continuous veno-venous hemodiafiltraion but he expired due to multiorgan failure on the 12th hospital days. (Korean J Nephrol 2004;23(3):488-491)